Sarepta to Lay Off About 500 Employees After Duchenne Gene Therapy Setbacks

Following a string of disappointments and the fall of the company's share price this year, Sarepta Therapeutics is reducing its employment by approximately 500 personnel.

Sarepta stated that company intends to halt development on a number of medicinal products and lay off about 36% of its employees. By 2026, the business anticipates that the two actions taken combined will save over $400 million annually.

“Failure to adapt” to recent failures “would risk our long-term viability as an organization and decrease the opportunity to bring the greatest benefit to the greatest number of patients living with rare disease,” Sarepta CEO Doug Ingram stated on a conference call on Wednesday afternoon.

Strategic Restructuring

  • A 36% workforce reduction, impacting approximately 500 employees, projected to generate approximately 120 million USD in annual cash cost savings in 2026
  • Pipeline reprioritization expected to deliver approximately 300 million USD in annual non-personnel cost savings starting in 2026
  • Over 100 million USD in cost savings anticipated through the end of 2025, net of estimated severance and one-time charges totaling 32-37 million USD
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