Duvyzat is a groundbreaking nonsteroidal oral medication used to treat Duchenne muscular dystrophy (DMD), a severe and progressive muscle-wasting condition primarily affecting boys. But what is Duvyzat, and how does it help those living with DMD? Duvyzat contains the active ingredient givinostat, a novel drug that targets the underlying processes of muscle degeneration in DMD. By inhibiting specific enzymes responsible for muscle inflammation and fibrosis, Givinostat works to slow down the progression of the disease, improving mobility and quality of life for patients. In this article, we’ll explore the benefits of Duvyzat and answer the key question: What is Givinostat?
Frequently Asked Questions About Duvyzat
What is Duvyzat used for?
Duvyzat is primarily used in the treatment of Duchenne muscular dystrophy (DMD), a rare and progressive genetic disorder that causes muscle weakness and degeneration over time. It is the first nonsteroidal oral medication developed to treat DMD. Duvyzat helps to slow down the progression of the disease by targeting the underlying muscle inflammation and fibrosis processes that contribute to the breakdown of muscle fibers.
Duvyzat is used to treat Duchenne muscular dystrophy DMD in patients 6 years and older who are able to walk. – Read More: European Commission Approves Duvyzat –
The active ingredient in Duvyzat, givinostat, works by inhibiting specific enzymes that promote muscle damage, thus improving muscle function and potentially enhancing the patient’s mobility and overall quality of life. While Duvyzat is not a cure for DMD, it plays a critical role in managing the symptoms and delaying the onset of more severe complications.
In summary, Duvyzat is used to slow disease progression, preserve muscle strength, and provide better long-term outcomes for those with Duchenne muscular dystrophy.
What are Duvyzat side effects?
Like any medication, Duvyzat (givinostat) can cause side effects, although not everyone experiences them. The side effects associated with Duvyzat are generally mild to moderate, but it’s important for patients and caregivers to be aware of them in order to monitor health during treatment. Some of the common side effects include:
Mild side effects of Duvyzat
- diarrhea
- nausea and vomiting
- fever
- constipation
- abdominal pain
- skin rash
- fatigue
- reduced appetite
- muscle or joint pain
Serious side effects of Duvyzat
- severe abdominal pain, diarrhea, or nausea and vomiting
- long QT syndrome (a type of irregular heart rhythm)
- high triglyceride levels
- low levels of platelets, red blood cells, or white blood cells
- underactive thyroid
Monitoring and Management
Patients on Duvyzat should have regular check-ups, including blood tests to monitor liver function, blood cell counts, and other vital parameters. Early detection of any side effects can allow for timely management, and adjustments to the treatment plan can be made if necessary. As with any medication, it’s essential to consult with a healthcare provider about potential side effects, especially if any unusual symptoms or signs of an allergic reaction occur.
Read More: Prescribing Information and Medication Guide.
Recommended Dosage
Recommended Dosage of Duvyzat in Patients 6 Years of Age and Older for the Treatment of DMD.
| Weight | Dosage | Oral Suspension Volume |
| 10 kg to less than 20 kg | 22.2 mg twice daily | 2.5 mL twice daily |
| 20 kg to less than 40 kg | 31 mg twice daily | 3.5 mL twice daily |
| 40 kg to less than 60 kg | 44.3 mg twice daily | 5 mL twice daily |
| 60 kg or more | 53.2 mg twice daily | 6 mL twice daily |
See full prescribing information for DUVYZAT. – FDA –
FAQ About Duvyzat (Givinostat)
Should I take Duvyzat with food?
Yes, you’ll take each dose of Duvyzat with food.
Is there a best time of day to take Duvyzat?
Duvyzat will be taken twice a day. Taking it at roughly the same time every day is ideal. This keeps the amount of the medication in your body constant, which facilitates Duvyzat’s efficient action.
What if I miss a dose of Duvyzat?
Take Duvyzat as soon as you remember if you missed a dose. However, if your next dose is soon due, skip the missed one and take it at the scheduled time. To make up for a missing dose, you shouldn’t take two doses at once. You may be more susceptible to adverse effects if you do this.
Will I need to use Duvyzat long term?
Usually, duvyzat is taken as a long-term remedy. You’ll probably take it for a long time if you and your doctor agree that it’s safe and effective for your condition.
How long does Duvyzat take to work?
Once you take your first dose of Duvyzat, it starts to work. However, you probably won’t notice any effects of the medication. Throughout your course of therapy, your doctor will keep an eye on your health to see whether Duvyzat is having the desired effect.
At what temperature should the Duvyzat bottle be Stored?
Store at 20°C to 25°C (68°F to 77°F), excursions permitted to 15°C to 30°C (59°F to 86°F) Do not freeze. Store upright. Discard any unused DUVYZAT remaining after 60 days of first opening of the bottle.
Can pregnant women use Duvyzat?
To evaluate the usage of DUVYZAT in pregnant women, sufficient data is not yet available. Oral givinostat administration during organogenesis had been shown to reduce fetal body weight and increase structural variations in animal studies; oral givinostat administration during pregnancy and lactation was linked to increased embryofetal and offspring mortality as well as neurobehavioral changes in the offspring.
Can breastfeeding mothers use Duvyzat?
There are no human or animal studies to evaluate how DUVYZAT or its metabolites affect milk supply, if givinostat is present in milk, or how they affect a breastfed baby. The mother’s clinical requirement for DUVYZAT, the developmental and health advantages of nursing, and any possible negative effects of DUVYZAT or the underlying maternal disease on the breastfed child should all be taken into account.
What should I know about Duvyzat before using it?
- Duvyzat should only be taken as directed by a healthcare professional. As directed, take it.
- Even if someone else has the same condition as you, do not give them Duvyzat. It could hurt them.
- Don’t let kids get their hands on Duvyzat.
- Make sure you understand how to use Duvyzat by reading and following the directions. Speak with your healthcare practitioner if you have any queries.
- Duvyzat is taken orally as a drink. Duvyzat should not be combined with water or any other liquid. Shake the bottle of Duvyzat to mix the medication evenly before taking each dose. For at least 30 seconds, turn the bottle up and down. Before measuring each dose, the medication should appear to be uniformly blended.
- To measure the right dosage of Duvyzat, use the oral syringe that comes with the medication. A household spoon can lead to incorrect dosage because it is not a precise measurement tool. To find out how to use the syringe, ask your pharmacist.
- After 60 days of opening the bottle, discard any Duvyzat that is still in it.
- Prior to and throughout your Duvyzat therapy, keep all of your appointments with your doctor. To determine whether taking this medication is safe for you or whether you require a different dosage, your doctor may prescribe tests like blood testing.
How much does Duvyzat cost?
The price of Duvyzat can vary, just like the price of any medication. Your location, the drugstore you use, and your insurance plan will all affect the final cost.
Financial and insurance support: Assistance is available if you require financial support to pay for Duvyzat or if you require clarification regarding your insurance coverage.
For Duvyzat, there is a web page called ITF ARC. To learn more and determine your eligibility for assistance, visit the program website or give 855-448-3272 a call. – ITF ARC –
