{"id":8921,"date":"2026-11-06T15:18:24","date_gmt":"2026-11-06T12:18:24","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=8921"},"modified":"2026-11-06T15:27:18","modified_gmt":"2026-11-06T12:27:18","slug":"satellos-basecamp-phase-2-mri-muscle-fat-fraction","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/satellos-basecamp-phase-2-mri-muscle-fat-fraction\/","title":{"rendered":"Satellos\u62a5\u544a\u79f0\uff0c\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u80b1\u4e8c\u5934\u808cMRI\u663e\u793a\u808c\u8089\u8102\u80aa\u542b\u91cf\u964d\u4f4e\uff0c\u808c\u9178\u6fc0\u9176\u6c34\u5e73\u4e5f\u964d\u4f4e\u3002"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong>Satellos Bioscience Inc. \u5ba3\u5e03\uff0c\u6839\u636e\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40 ( FDA) \u7684\u53cd\u9988\uff0c\u5176 BASECAMP 2 \u671f\u513f\u79d1\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u5df2\u53d1\u751f\u6539\u53d8\uff0c\u8be5\u8bd5\u9a8c\u65e8\u5728\u8bc4\u4f30 Forazapadin \u5bf9\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7 (DMD) \u7684\u7597\u6548\u3002<\/strong> \u8be5\u516c\u53f8\u9009\u62e9 MRI \u6d4b\u91cf\u7684\u808c\u8089\u8102\u80aa\u5206\u6570\u4f5c\u4e3a\u65b0\u7684\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\uff0c\u53d6\u4ee3\u4e86\u6d4b\u529b\u6cd5\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6b64\u524d\uff0c\u8be5\u516c\u53f8\u9488\u5bf9\u60a3\u6709 DMD \u7684\u6210\u5e74\u4eba\u5f00\u5c55\u7684 2 \u671fTRAILHEAD\u7814\u7a76\u53d6\u5f97\u4e86\u4ee4\u4eba\u9f13\u821e\u7684\u6210\u679c\uff0c\u8be5\u7814\u7a76\u901a\u8fc7\u78c1\u5171\u632f\u6210\u50cf (MRI) \u6d4b\u91cf\u80b1\u4e8c\u5934\u808c\u7684\u808c\u8089\u8102\u80aa\u5206\u6570\uff0c\u7ed3\u679c\u663e\u793a\u808c\u8089\u8102\u80aa\u5206\u6570\u6709\u6240\u964d\u4f4e\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7ecf\u8fc7\u4e94\u4e2a\u591a\u6708\u7684 Forazapadin \u6cbb\u7597\uff0c TRAILHEAD \u7814\u7a76\u4e2d\u7684\u53c2\u4e0e\u8005\u901a\u8fc7 MRI \u6d4b\u91cf\u53d1\u73b0\uff0c\u80b1\u4e8c\u5934\u808c\u8102\u80aa\u5206\u6570\u5e73\u5747\u964d\u4f4e\u4e86 3.7 \u4e2a\u767e\u5206\u70b9\uff0c\u4ece\u57fa\u7ebf\u65f6\u7684 49.7% \u964d\u81f3\u7b2c 140 \u5929\u7684 46.0%\u3002\u8fd9\u4e00\u53d1\u73b0\u8868\u660e\u808c\u8089\u6210\u5206\u5f97\u5230\u4e86\u6539\u5584\u3002<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Satellos\u5728TRAILHEAD\u7814\u7a76\u4e2d\u8fd8\u62a5\u544a\u79f0\uff0c\u53d7\u8bd5\u8005\u7684\u603b\u8fd0\u52a8\u91cf\u589e\u52a0\uff0c\u808c\u8089\u529b\u91cf\u4fdd\u6301\u7a33\u5b9a\uff0c\u808c\u9178\u6fc0\u9176\uff08CK\uff09\u6c34\u5e73\u964d\u4f4e\u3002\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u4e0e\u5148\u524d\u62a5\u544a\u7684\u6570\u636e\u4e00\u81f4\u3002\u8fd9\u4e9b\u53d1\u73b0\u4e0eMRI\u6d4b\u91cf\u7684\u808c\u8089\u8102\u80aa\u5206\u6570\u964d\u4f4e\u4e00\u8d77\uff0c\u63d0\u4f9b\u4e86\u989d\u5916\u7684\u4e34\u5e8a\u89c2\u5bdf\u7ed3\u679c\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">BASECAMP \u4e8c\u671f\u8bd5\u9a8c\uff1a\u65b0\u7684\u4e3b\u8981\u7ec8\u70b9<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">BASECAMP \u7814\u7a76\u662f\u4e00\u9879\u5168\u7403\u6027\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684 2 \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30 Forazapadin \u5bf9 53 \u540d 7\u30018 \u6216 9 \u5c81\u60a3\u6709 DMD \u7684\u53ef\u884c\u8d70\u7537\u5b69\u7684\u7597\u6548\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8be5\u7814\u7a76\u5305\u62ec\u4e00\u4e2a\u4e3a\u671f 12 \u5468\u7684\u521d\u59cb\u5b89\u6170\u5242\u5bf9\u7167\u6cbb\u7597\u671f\uff0c\u968f\u540e\u662f\u4e00\u4e2a\u4e3a\u671f 36 \u5468\u7684\u6d3b\u6027\u6cbb\u7597\u671f\uff0c\u5728\u6b64\u671f\u95f4\u6240\u6709\u53c2\u4e0e\u8005\u5747\u63a5\u53d7\u798f\u62c9\u624e\u5e15\u5b9a\u6cbb\u7597\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6839\u636eFDA\u7684\u53cd\u9988\uff0c\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u5c06\u91c7\u7528MRI\u6d4b\u91cf\u80a1\u5916\u4fa7\u808c\u8102\u80aa\u5206\u6570\u7684\u53d8\u5316\u3002\u6b21\u8981\u548c\u63a2\u7d22\u6027\u7ec8\u70b9\u5c06\u8bc4\u4f30\u808c\u8089\u8d28\u91cf\u3001\u529f\u80fd\u7ed3\u679c\u548c\u808c\u8089\u518d\u751f\u751f\u7269\u6807\u5fd7\u7269\uff0c\u5305\u62ecSatellos\u516c\u53f8\u4e13\u6709\u7684\u518d\u751f\u6307\u6570\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8102\u80aa\u5206\u6570\u662f\u78c1\u5171\u632f\u6210\u50cf\uff08MRI\uff09\u5bf9\u808c\u8089\u7ec4\u7ec7\u5185\u8102\u80aa\u6bd4\u4f8b\u7684\u5ba2\u89c2\u6d4b\u91cf\u3002\u5728\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u4e2d\uff0c\u5065\u5eb7\u7684\u808c\u8089\u4f1a\u9010\u6e10\u88ab\u8102\u80aa\u7ec4\u7ec7\u53d6\u4ee3\uff0c\u56e0\u6b64\u808c\u8089\u8102\u80aa\u5206\u6570\u7684\u53d8\u5316\u662f\u8861\u91cf\u75be\u75c5\u8fdb\u5c55\u548c\u808c\u8089\u6210\u5206\u7684\u91cd\u8981\u6307\u6807\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Satellos\u9884\u8ba1\u5c06\u4e8e 2027 \u5e74\u7b2c\u4e00\u5b63\u5ea6\u516c\u5e03\u4e3a\u671f 12 \u5468\u7684\u5b89\u6170\u5242\u5bf9\u7167 BASECAMP \u8bd5\u9a8c\u7684\u4e3b\u8981\u7ed3\u679c\u3002<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Forazapadin\u662f\u4e00\u79cd\u5728\u7814\u7684\u53e3\u670d\u5c0f\u5206\u5b50AAK1\u6291\u5236\u5242\uff0c\u65e8\u5728\u589e\u5f3a\u4eba\u4f53\u81ea\u8eab\u4fee\u590d\u548c\u518d\u751f\u9aa8\u9abc\u808c\u7684\u80fd\u529b\u3002\u5b83\u6b63\u88ab\u5f00\u53d1\u4e3a\u4e00\u79cd\u6f5c\u5728\u7684\u3001\u4e0d\u4f9d\u8d56\u4e8e\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u7684\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4e86\u89e3\u66f4\u591a<\/strong>:&nbsp;<a href=\"https:\/\/dmdwarrior.com\/clinical-trials\/map\/\" target=\"_blank\" rel=\"noopener\">\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u4e34\u5e8a\u8bd5\u9a8c\u5730\u70b9\u5730\u56fe<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Satellos Bioscience Inc. has announced a change to the primary efficacy endpoint of its BASECAMP Phase 2 pediatric clinical trial evaluating Forazapadin in Duchenne muscular dystrophy (DMD), following feedback from the U.S. Food and Drug Administration (FDA). The company has selected MRI-measured muscle fat fraction as the new primary efficacy endpoint, replacing dynamometry. The decision [&hellip;]<\/p>\n","protected":false},"author":10,"featured_media":8922,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[922,903,251,252,253,829],"class_list":["post-8921","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-basecamp","tag-forazapadin","tag-sat-3247","tag-satellos","tag-satellos-bioscience","tag-trailhead"],"subtitle":"Satellos\u62a5\u544a\u4e86\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7814\u7a76\u4e2d\u4ee4\u4eba\u9f13\u821e\u7684\u53d1\u73b0\uff0c\u91cd\u70b9\u5173\u6ce8MRI\u6d4b\u91cf\u7684\u80b1\u4e8c\u5934\u808c\u8102\u80aa\u542b\u91cf\u964d\u4f4e\u548c\u808c\u9178\u6fc0\u9176\uff08CK\uff09\u6c34\u5e73\u6301\u7eed\u964d\u4f4e\u3002\u8fd9\u4e9b\u53d1\u73b0\u6b63\u5728\u5f71\u54cdBASECAMP II\u671f\u8bd5\u9a8c\u65b0\u7684\u4e3b\u8981\u7ec8\u70b9\u3002","_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/8921","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=8921"}],"version-history":[{"count":2,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/8921\/revisions"}],"predecessor-version":[{"id":8924,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/8921\/revisions\/8924"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/8922"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=8921"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=8921"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=8921"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}