{"id":8910,"date":"2026-11-05T15:48:02","date_gmt":"2026-11-05T12:48:02","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=8910"},"modified":"2026-11-05T16:24:26","modified_gmt":"2026-11-05T13:24:26","slug":"duvyzat-givinostat-safety-alert","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/duvyzat-givinostat-safety-alert\/","title":{"rendered":"Duvyzat \uff08\u5409\u7ef4\u8bfa\u53f8\u4ed6\uff09\u5b89\u5168\u8b66\u793a\uff1a\u5728\u51fa\u73b0\u60a3\u8005\u6b7b\u4ea1\u62a5\u544a\u540e\uff0cMHRA\u547c\u5401\u52a0\u5f3a\u5fc3\u810f\u76d1\u6d4b"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong>\u82f1\u56fd\u836f\u54c1\u548c\u4fdd\u5065\u4ea7\u54c1\u76d1\u7ba1\u5c40 (MHRA) \u53d1\u5e03\u4e86\u4e00\u9879\u5173\u4e8eDuvyzat \uff08givinostat\uff09\u7684\u91cd\u8981\u836f\u7269\u5b89\u5168\u66f4\u65b0\uff0c\u8be5\u836f\u7528\u4e8e\u6cbb\u7597\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7 (DMD)\u3002\u6b64\u524d\u6709\u62a5\u9053\u79f0\uff0c\u56fd\u9645\u4e0a\u6709\u591a\u540d\u63a5\u53d7\u8be5\u836f\u7269\u6cbb\u7597\u7684\u60a3\u8005\u6b7b\u4ea1\u3002<\/strong> \u8be5\u516c\u544a\u5f3a\u8c03\u4e86\u52a0\u5f3a\u5fc3\u810f\u76d1\u6d4b\u548c\u66f4\u9891\u7e41\u7684\u8840\u6db2\u68c0\u67e5\u7684\u5fc5\u8981\u6027\uff0c\u4ee5\u964d\u4f4e\u6f5c\u5728\u7684\u4e25\u91cd\u6cbb\u7597\u76f8\u5173\u98ce\u9669\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u91cd\u8981\u7684\u662f\uff0c\u5df2\u62a5\u544a\u7684\u6b7b\u4ea1\u75c5\u4f8b\u672c\u8eab\u5e76\u4e0d\u80fd\u8bc1\u660e\u5409\u7ef4\u8bfa\u53f8\u4ed6\u5bfc\u81f4\u4e86\u8fd9\u4e9b\u6b7b\u4ea1\u3002\u82f1\u56fd\u836f\u54c1\u548c\u4fdd\u5065\u4ea7\u54c1\u76d1\u7ba1\u7f72\uff08MHRA\uff09\u5df2\u5ba1\u67e5\u4e86\u73b0\u6709\u75c5\u4f8b\uff0c\u5e76\u5c31\u62df\u8bae\u7684\u836f\u7269\u76d1\u6d4b\u8981\u6c42\u53d8\u66f4\u505a\u51fa\u4e86\u51b3\u5b9a\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u53d8\u66f4\u7684\u5b9e\u65bd\u4ecd\u9700\u7ecf\u8fc7\u72ec\u7acb\u5ba1\u67e5\uff0c\u76ee\u524d\u7684\u5efa\u8bae\u4ec5\u4e3a\u4e34\u65f6\u63aa\u65bd\u3002<\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u76ee\u5f55<\/h2><nav><ul><li><a href=\"#key-safety-concern-q-tc-prolongation-and-cardiac-arrhythmias\">\u4e3b\u8981\u5b89\u5168\u9690\u60a3\uff1aQTc\u95f4\u671f\u5ef6\u957f\u548c\u5fc3\u5f8b\u5931\u5e38<\/a><\/li><li><a href=\"#essential-risk-mitigation-and-monitoring-recommendations\">\u5173\u952e\u98ce\u9669\u7f13\u89e3\u548c\u76d1\u6d4b\u5efa\u8bae<\/a><\/li><li><a href=\"#what-should-patients-and-families-do\">\u60a3\u8005\u53ca\u5176\u5bb6\u5c5e\u5e94\u8be5\u600e\u4e48\u505a\uff1f<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u4e3b\u8981\u5b89\u5168\u9690\u60a3\uff1aQTc\u95f4\u671f\u5ef6\u957f\u548c\u5fc3\u5f8b\u5931\u5e38<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e3b\u8981\u62c5\u5fe7\u4e4b\u4e00\u662f\u5409\u7ef4\u8bfa\u4ed6\u53ef\u80fd\u5ef6\u957fQTc\u95f4\u671f\uff0cQTc\u95f4\u671f\u662f\u8861\u91cf\u5fc3\u810f\u7535\u6d3b\u52a8\u7684\u6307\u6807\u3002QTc\u95f4\u671f\u663e\u8457\u5ef6\u957f\u4f1a\u589e\u52a0\u5371\u9669\u6027\u5ba4\u6027\u5fc3\u5f8b\u5931\u5e38\u7684\u98ce\u9669\uff0c\u5e76\u53ef\u80fd\u5bfc\u81f4\u5371\u53ca\u751f\u547d\u7684\u5e76\u53d1\u75c7\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u82f1\u56fd\u836f\u54c1\u548c\u4fdd\u5065\u4ea7\u54c1\u76d1\u7ba1\u7f72 (MHRA) \u5efa\u8bae\uff0c\u5bf9\u4e8e\u5ba4\u6027\u5fc3\u5f8b\u5931\u5e38\u98ce\u9669\u8f83\u9ad8\u7684\u60a3\u8005\uff0c\u5c24\u5176\u662f\u4ee5\u4e0b\u60a3\u8005\uff0c\u4e0d\u5e94\u4f7f\u7528Duvyzat \uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5148\u5929\u6027\u957fQT\u95f4\u671f\u7efc\u5408\u5f81\u3002<\/li>\n\n\n\n<li>\u51a0\u72b6\u52a8\u8109\u75be\u75c5\u3002<\/li>\n\n\n\n<li>\u7535\u89e3\u8d28\u5931\u8861\uff0c\u7279\u522b\u662f\u94be\u3001\u9541\u6216\u9499\u7684\u5931\u8861\u3002<\/li>\n\n\n\n<li>\u540c\u65f6\u670d\u7528\u5df2\u77e5\u4f1a\u5ef6\u957f QT \u95f4\u671f\u7684\u836f\u7269\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u4e9b\u98ce\u9669\u56e0\u7d20\u9700\u8981\u5728\u6cbb\u7597\u5f00\u59cb\u524d\u548c\u6574\u4e2a\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u8fdb\u884c\u4ed4\u7ec6\u8bc4\u4f30\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u5173\u952e\u98ce\u9669\u7f13\u89e3\u548c\u76d1\u6d4b\u5efa\u8bae<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u82f1\u56fd\u836f\u54c1\u548c\u4fdd\u5065\u4ea7\u54c1\u76d1\u7ba1\u7f72 (MHRA) \u5f3a\u8c03\u4e86\u533b\u7597\u4fdd\u5065\u4e13\u4e1a\u4eba\u5458\u5e94\u91c7\u53d6\u7684\u51e0\u9879\u63aa\u65bd\uff0c\u4ee5\u63d0\u9ad8\u60a3\u8005\u5b89\u5168\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">1. \u5b9a\u671f\u5fc3\u7535\u56fe\u76d1\u6d4b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5e94\u8fdb\u884c\u5fc3\u7535\u56fe\uff08ECG\uff09\u68c0\u67e5\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5728\u5f00\u59cb\u5409\u7ef4\u8bfa\u53f8\u4ed6\u6cbb\u7597\u4e4b\u524d\u3002<\/li>\n\n\n\n<li>\u6cbb\u7597\u5f00\u59cb\u540e 2-4 \u5468\u5185\u3002<\/li>\n\n\n\n<li>\u6b64\u540e\u6bcf6\u4e2a\u6708\u4e00\u6b21\u3002<\/li>\n\n\n\n<li>\u51e1\u6709\u4e34\u5e8a\u6307\u5f81\u65f6\uff0c\u5305\u62ec\u5242\u91cf\u8c03\u6574\u540e\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u6b64\u5916\uff0cMHRA\u5efa\u8bae\u5728\u6cbb\u7597\u524d\u8fdb\u884c24\u5c0f\u65f6\u52a8\u6001\u5fc3\u7535\u56fe\uff08Holter\uff09\u76d1\u6d4b\uff0c\u5e76\u5728\u60a3\u8005\u8fbe\u5230\u7a33\u5b9a\u7684\u836f\u7269\u5242\u91cf\u540e\u91cd\u590d\u8fdb\u884c\u76d1\u6d4b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2. \u66f4\u9891\u7e41\u7684\u7535\u89e3\u8d28\u68c0\u6d4b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5e94\u6309\u4ee5\u4e0b\u65f6\u95f4\u8868\u8fdb\u884c\u6d4b\u91cf\u94be\u3001\u9541\u548c\u9499\u6c34\u5e73\u7684\u8840\u6db2\u68c0\u67e5\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u524d\u4e24\u4e2a\u6708\u6bcf\u4e24\u5468\u4e00\u6b21\u3002<\/li>\n\n\n\n<li>\u7b2c 3 \u4e2a\u6708\u3002<\/li>\n\n\n\n<li>\u6b64\u540e\u6bcf\u4e09\u4e2a\u6708\u4e00\u6b21\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u4e9b\u68c0\u67e5\u81f3\u5173\u91cd\u8981\uff0c\u56e0\u4e3a\u7535\u89e3\u8d28\u5931\u8861\u4f1a\u589e\u52a0\u53d1\u751f\u5fc3\u5f8b\u5931\u5e38\u7684\u98ce\u9669\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3. \u5ba1\u67e5\u6240\u6709\u5408\u5e76\u7528\u836f<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u533b\u62a4\u4eba\u5458\u5e94\u4ed4\u7ec6\u5ba1\u67e5\u60a3\u8005\u670d\u7528\u7684\u6240\u6709\u836f\u7269\uff0c\u5305\u62ec\u65b0\u5904\u65b9\u836f\u7269\u548c\u73b0\u6709\u6cbb\u7597\u65b9\u6848\u7684\u53d8\u66f4\u3002\u5c24\u5176\u5e94\u5173\u6ce8\u53ef\u80fd\u5ef6\u957fQT\u95f4\u671f\u7684\u836f\u7269\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">4. \u4e13\u79d1\u5fc3\u810f\u8bc4\u4f30<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u60a3\u8005\u5e94\u63a5\u53d7\u9002\u5f53\u7684\u5fc3\u810f\u8bc4\u4f30\uff0c\u5f53\u5fc3\u7535\u56fe\u7ed3\u679c\u6216\u4e34\u5e8a\u60c5\u51b5\u63d0\u793a\u98ce\u9669\u589e\u52a0\u65f6\uff0c\u5e94\u7531\u5fc3\u810f\u79d1\u533b\u751f\u53c2\u4e0e\u3002\u6cbb\u7597\u7684\u542f\u52a8\u548c\u6301\u7eed\u5e94\u9075\u5faa\u65e2\u5b9a\u7684QTc\u95f4\u671f\u5b89\u5168\u9608\u503c\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u60a3\u8005\u53ca\u5176\u5bb6\u5c5e\u5e94\u8be5\u600e\u4e48\u505a\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u82f1\u56fd\u836f\u54c1\u548c\u4fdd\u5065\u4ea7\u54c1\u76d1\u7ba1\u7f72 (MHRA) \u5efa\u8bae\u60a3\u8005\u4e0d\u8981\u81ea\u884c\u505c\u7528\u675c\u7ef4\u624e\u7279 (Duvyzat) \u3002\u60a3\u8005\u5e94\u7ee7\u7eed\u6309\u7167\u533b\u5631\u63a5\u53d7\u6cbb\u7597\uff0c\u6309\u65f6\u53c2\u52a0\u6240\u6709\u9884\u7ea6\u7684\u968f\u8bbf\uff0c\u5e76\u544a\u77e5\u5176\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u4e13\u79d1\u56e2\u961f\u6240\u670d\u7528\u7684\u6240\u6709\u836f\u7269\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5bb6\u5c5e\u4e5f\u5e94\u8be5\u53ca\u65f6\u4e0e\u533b\u7597\u56e2\u961f\u8ba8\u8bba\u4efb\u4f55\u65b0\u51fa\u73b0\u7684\u75c7\u72b6\u6216\u7591\u8651\uff0c\u800c\u4e0d\u662f\u7b49\u5230\u4e0b\u6b21\u9884\u7ea6\u65f6\u95f4\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6240\u6709\u7591\u4f3c\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u5747\u5e94\u901a\u8fc7\u76f8\u5e94\u7684\u56fd\u5bb6\u836f\u7269\u8b66\u6212\u7cfb\u7edf\u8fdb\u884c\u62a5\u544a\u3002\u5728\u82f1\u56fd\uff0c\u8be5\u7cfb\u7edf\u4e3aMHRA\u9ec4\u5361\u8ba1\u5212\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>The UK Medicines and Healthcare products Regulatory Agency (MHRA) has issued an important drug safety update concerning Duvyzat (givinostat), a treatment for Duchenne muscular dystrophy (DMD), following reports of several deaths internationally among patients receiving the medication. The announcement highlights the need for enhanced cardiac monitoring and more frequent blood tests to reduce potentially serious [&hellip;]<\/p>\n","protected":false},"author":10,"featured_media":8911,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[282],"tags":[46,47,50],"class_list":["post-8910","post","type-post","status-publish","format-standard","has-post-thumbnail","category-editorials","tag-duvyzat","tag-givinostat","tag-mhra"],"subtitle":"\u82f1\u56fd\u836f\u54c1\u548c\u4fdd\u5065\u4ea7\u54c1\u76d1\u7ba1\u7f72 (MHRA) \u9488\u5bf9Duvyzat \uff08givinostat\uff09\u53d1\u5e03\u4e86\u4e34\u65f6\u5b89\u5168\u8b66\u793a\uff0c\u6b64\u524d\u6709\u62a5\u544a\u79f0\uff0c\u5728\u82f1\u56fd\u5883\u5916\u63a5\u53d7\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u51fa\u73b0\u4e86\u6b7b\u4ea1\u75c5\u4f8b\u3002\u65b0\u7684\u5efa\u8bae\u5f3a\u8c03\u4e86\u5fc3\u810f\u98ce\u9669\u3001\u5fc3\u7535\u56fe\u548c\u52a8\u6001\u5fc3\u7535\u56fe\u76d1\u6d4b\u4ee5\u53ca\u5b9a\u671f\u7535\u89e3\u8d28\u68c0\u6d4b\uff0c\u4ee5\u5e2e\u52a9\u4fdd\u62a4\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7 (DMD) \u60a3\u8005\u3002","_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/8910","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=8910"}],"version-history":[{"count":4,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/8910\/revisions"}],"predecessor-version":[{"id":8917,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/8910\/revisions\/8917"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/8911"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=8910"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=8910"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=8910"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}