{"id":8885,"date":"2026-10-26T14:47:35","date_gmt":"2026-10-26T11:47:35","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=8885"},"modified":"2026-10-26T14:47:38","modified_gmt":"2026-10-26T11:47:38","slug":"rycarma-surlorian-arm-210-duchenne-muscular-dystrophy","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/rycarma-surlorian-arm-210-duchenne-muscular-dystrophy\/","title":{"rendered":"RyCarma\u516c\u53f8\u7684Surlorian\uff08ARM 210\uff09\u5728\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7814\u7a76\u65b9\u9762\u53d6\u5f97\u8fdb\u5c55"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong>RyCarma Therapeutics \u6b63\u5728\u5f00\u53d1 Surlorian (ARM 210)\uff0c\u8fd9\u662f\u4e00\u79cd\u5b9e\u9a8c\u6027\u836f\u7269\uff0c\u4e5f\u53ef\u80fd\u7528\u4e8e\u6cbb\u7597\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7 (DMD)\u3002.<\/strong> \u57282026\u5e7410\u670826\u65e5\u7684\u516c\u544a\u4e2d\uff0c\u8be5\u516c\u53f8\u786e\u8ba4\u9996\u4f8b\u60a3\u8005\u5df2\u5728RYR1\u76f8\u5173\u808c\u75c5\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u63a5\u53d7\u6cbb\u7597\u3002RyCarma\u516c\u53f8\u540c\u65f6\u786e\u8ba4\uff0c\u5176\u5df2\u63d0\u4ea4\u7814\u7a76\u6027\u65b0\u836f\uff08IND\uff09\u7533\u8bf7\uff0c\u7528\u4e8e\u8bc4\u4f30Surlorian\u5728\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u60a3\u8005\u4e2d\u7684\u7597\u6548\u3002.<\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u76ee\u5f55<\/h2><nav><ul><li><a href=\"#what-is-surlorian-arm-210\">Surlorian (ARM 210) \u662f\u4ec0\u4e48\uff1f<\/a><\/li><li><a href=\"#surlorian-and-duchenne-muscular-dystrophy\">Surlorian \u548c\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7<\/a><ul><li><a href=\"#ry-carmas-dmd-program-is-phase-2-ready\">RyCarma\u7684DMD\u9879\u76ee\u5df2\u51c6\u5907\u597d\u8fdb\u5165\u4e8c\u671f\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5<\/a><\/li><li><a href=\"#what-do-we-know-about-surlorians-clinical-results\">\u6211\u4eec\u5bf9 Surlorian \u7684\u4e34\u5e8a\u7ed3\u679c\u4e86\u89e3\u591a\u5c11\uff1f<\/a><\/li><\/ul><\/li><li><a href=\"#what-happens-next\">\u63a5\u4e0b\u6765\u4f1a\u53d1\u751f\u4ec0\u4e48\uff1f<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<h2 id=\"what-is-surlorian-arm-210\" class=\"wp-block-heading\">Surlorian (ARM 210) \u662f\u4ec0\u4e48\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Surlorian \u662f\u4e00\u79cd\u5b9e\u9a8c\u6027\u7684\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u65e8\u5728\u901a\u8fc7\u9776\u5411\u5170\u5c3c\u78b1\u53d7\u4f53 (RyR) \u6765\u6539\u5584\u808c\u8089\u529f\u80fd\uff0c\u5170\u5c3c\u78b1\u53d7\u4f53\u6709\u52a9\u4e8e\u63a7\u5236\u808c\u8089\u7ec6\u80de\u5185\u7684\u9499\u91ca\u653e\u3002.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u4e9b\u53d7\u4f53\u5728\u808c\u8089\u6536\u7f29\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002Surlorian\u65e8\u5728\u7a33\u5b9a\u8fd9\u4e9b\u53d7\u4f53\u5e76\u51cf\u5c11\u5f02\u5e38\u7684\u9499\u79bb\u5b50\u6cc4\u6f0f\uff0c\u4ece\u800c\u53ef\u80fd\u5e2e\u52a9\u808c\u8089\u7ec6\u80de\u66f4\u6709\u6548\u5730\u53d1\u6325\u529f\u80fd\u3002\u4e0e\u57fa\u56e0\u7597\u6cd5\u4e0d\u540c\uff0cSurlorian\u5e76\u975e\u65e8\u5728\u76f4\u63a5\u66ff\u4ee3\u7f3a\u5931\u7684\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u3002.<\/p>\n\n\n\n<h2 id=\"surlorian-and-duchenne-muscular-dystrophy\" class=\"wp-block-heading\">Surlorian \u548c\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7<\/h2>\n\n\n\n<h3 id=\"ry-carmas-dmd-program-is-phase-2-ready\" class=\"wp-block-heading\">RyCarma\u7684DMD\u9879\u76ee\u5df2\u51c6\u5907\u597d\u8fdb\u5165\u4e8c\u671f\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6839\u636e RyCarma \u7684\u5b98\u65b9\u7814\u53d1\u8ba1\u5212\uff0c\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u9879\u76ee\u5df2\u88ab\u5217\u4e3a\u201c\u7b2c\u4e8c\u9636\u6bb5\u51c6\u5907\u5c31\u7eea\u201d\u3002.<\/strong> \u8be5\u516c\u53f8\u6700\u65b0\u516c\u544a\u8fd8\u786e\u8ba4\uff0c\u5176\u5df2\u63d0\u4ea4\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\uff08IND\uff09\uff0c\u7528\u4e8e\u8bc4\u4f30 Surlorian \u5728\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff08DMD\uff09\u60a3\u8005\u4e2d\u7684\u7597\u6548\u3002\u4e86\u89e3\u66f4\u591a\uff1a <a href=\"https:\/\/rycarma.com\/pipeline\/\" target=\"_blank\" rel=\"noreferrer noopener\">RyCarma\u7ba1\u9053<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u8fdb\u5c55\uff0c\u56e0\u4e3a\u5b83\u8868\u660eRyCarma\u516c\u53f8\u6b63\u5728\u63a8\u8fdb\u8be5\u836f\u7269\u7684\u7814\u53d1\uff0c\u800c\u4e0d\u4ec5\u4ec5\u5c40\u9650\u4e8e\u5176\u6700\u521d\u7684RYR1\u76f8\u5173\u808c\u75c5\u9879\u76ee\u3002\u7136\u800c\uff0c\u8be5\u516c\u53f8\u5c1a\u672a\u516c\u5e03\u9488\u5bf9\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff08DMD\uff09\u7684\u4e34\u5e8a\u8bd5\u9a8c\u542f\u52a8\u65e5\u671f\u3001\u7814\u7a76\u8bbe\u8ba1\u6216\u60a3\u8005\u5165\u7ec4\u6807\u51c6\u3002.<\/p>\n\n\n\n<h3 id=\"what-do-we-know-about-surlorians-clinical-results\" class=\"wp-block-heading\">\u6211\u4eec\u5bf9 Surlorian \u7684\u4e34\u5e8a\u7ed3\u679c\u4e86\u89e3\u591a\u5c11\uff1f<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u65e9\u671f\u4e00\u9879\u9488\u5bf9RYR1\u76f8\u5173\u808c\u75c5\u60a3\u8005\u76841b\u671f\u7814\u7a76\u4e2d\uff0c\u63a5\u53d7\u8f83\u9ad8\u5242\u91cf\u6cbb\u7597\u7684\u53d7\u8bd5\u8005\u8fd1\u7aef\u808c\u8089\u529b\u91cf\u6709\u6240\u6539\u5584\uff0c\u4e14\u75b2\u52b3\u611f\u6709\u6240\u51cf\u8f7b\u3002\u6b64\u524d\u7684\u7814\u7a76\u4e5f\u62a5\u544a\u4e86\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8fd9\u4e9b\u53d1\u73b0\u662f\u521d\u6b65\u7684\uff0c\u5e76\u4e14\u6765\u81ea\u5bf9 RYR1 \u76f8\u5173\u808c\u75c5\u7684\u7814\u7a76\uff0c\u800c\u4e0d\u662f\u5bf9\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u7814\u7a76\u3002.<\/strong> \u4ed6\u4eec\u5e76\u672a\u8bc1\u5b9e Surlorian \u5bf9 DMD \u60a3\u8005\u6709\u6548\u6216\u5b89\u5168\u3002.<\/p>\n\n\n\n<h2 id=\"what-happens-next\" class=\"wp-block-heading\">\u63a5\u4e0b\u6765\u4f1a\u53d1\u751f\u4ec0\u4e48\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>RyCarma \u76ee\u524d\u6b63\u5728\u63a8\u8fdb\u5176 RYR1 \u76f8\u5173\u808c\u75c5\u7684 2 \u671f\u7814\u7a76\uff0c\u9884\u8ba1\u5c06\u4e8e 2027 \u5e74\u4e0b\u534a\u5e74\u516c\u5e03\u521d\u6b65\u7ed3\u679c\u3002.<\/strong> \u8be5\u516c\u53f8\u5728\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u65b9\u9762\u7684\u4e0b\u4e00\u6b65\u4e3e\u63aa\u503c\u5f97\u5173\u6ce8\uff0c\u7279\u522b\u662f\u4e34\u5e8a\u8bd5\u9a8c\u65b9\u6848\u7684\u516c\u5e03\u548c\u60a3\u8005\u62db\u52df\u8ba1\u5212\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5bf9\u4e8e DMD \u60a3\u8005\u7fa4\u4f53\u800c\u8a00\uff0cSurlorian \u4ee3\u8868\u4e86\u53e6\u4e00\u79cd\u6f5c\u5728\u7684\u76d1\u6d4b\u7814\u7a76\u65b9\u6cd5\u3002.<\/strong> \u7136\u800c\uff0c\u8fd9\u4ecd\u7136\u662f\u4e00\u79cd\u7814\u7a76\u6027\u6cbb\u7597\u65b9\u6cd5\uff0c\u8fd8\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u4e34\u5e8a\u7814\u7a76\u6765\u786e\u5b9a\u5b83\u662f\u5426\u80fd\u4e3a\u60a3\u6709\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u4eba\u5e26\u6765\u6709\u610f\u4e49\u7684\u76ca\u5904\u3002.<\/p>","protected":false},"excerpt":{"rendered":"<p>RyCarma Therapeutics is developing Surlorian (ARM 210), an experimental drug that may also be evaluated in Duchenne muscular dystrophy (DMD). In its October 26, 2026, announcement, the company confirmed that the first patient had received treatment in a Phase 2 clinical trial for RYR1-related myopathy. RyCarma also confirmed that it has an open Investigational New [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":8888,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[934,935,936,933],"class_list":["post-8885","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-arm-210","tag-rycarma-therapeutics","tag-ryr1-myopathy","tag-surlorian"],"subtitle":"RyCarma Therapeutics\u516c\u53f8\u6b63\u5728\u63a8\u8fdbSurlorian\uff08ARM 210\uff09\u7684\u7814\u53d1\uff0c\u8fd9\u662f\u4e00\u79cd\u5177\u6709\u6cbb\u7597\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff08DMD\uff09\u6f5c\u529b\u7684\u5b9e\u9a8c\u6027\u836f\u7269\u3002\u8be5\u516c\u53f8\u7684DMD\u9879\u76ee\u5df2\u88ab\u5217\u4e3a\u201c\u5df2\u51c6\u5907\u597d\u8fdb\u5165\u4e8c\u671f\u4e34\u5e8a\u8bd5\u9a8c\u201d\uff0c\u4f46\u8fd9\u5bf9\u4e8e\u60a3\u8005\u53ca\u5176\u5bb6\u5c5e\u610f\u5473\u7740\u4ec0\u4e48\u5462\uff1f","_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/8885","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=8885"}],"version-history":[{"count":3,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/8885\/revisions"}],"predecessor-version":[{"id":8890,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/8885\/revisions\/8890"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/8888"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=8885"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=8885"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=8885"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}