{"id":8859,"date":"2026-10-14T14:50:29","date_gmt":"2026-10-14T11:50:29","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=8859"},"modified":"2026-10-14T15:34:05","modified_gmt":"2026-10-14T12:34:05","slug":"entrada-therapeutics-entr-601-44-highest-dose-dmd-trial","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/entrada-therapeutics-entr-601-44-highest-dose-dmd-trial\/","title":{"rendered":"Entrada Therapeutics \u5728\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u5916\u663e\u5b50 44 \u8df3\u8dc3\u7814\u7a76\u4e2d\u5c06 ENTR-601-44 \u7684\u5242\u91cf\u63d0\u9ad8\u81f3 18 mg\/kg"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong>Entrada Therapeutics \u5df2\u83b7\u51c6\u5728\u5176\u9488\u5bf9\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7 (DMD) \u7684 Exon 44 \u8df3\u8dc3\u7814\u7a76\u4e2d\u6d4b\u8bd5\u6700\u9ad8\u5242\u91cf\u3002.<\/strong> \u72ec\u7acb\u6570\u636e\u76d1\u6d4b\u59d4\u5458\u4f1a (DMC) \u5728\u5ba1\u67e5\u4e86\u6765\u81ea\u7b2c 2 \u7ec4\u53c2\u4e0e\u8005\u7684\u73b0\u6709\u5b89\u5168\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u6570\u636e\u540e\uff0c\u5efa\u8bae\u5728 ELEVATE-44-201 \u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u7b2c 3 \u7ec4\u4ece 18 mg\/kg \u5f00\u59cb\u3002.<\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u76ee\u5f55<\/h2><nav><ul><li><a href=\"#entrada-advances-to-the-18-mg-kg-dose\">Entrada \u5242\u91cf\u63a8\u8fdb\u81f3 18 mg\/kg<\/a><\/li><li><a href=\"#what-is-entr-601-44\">ENTR-601-44\u662f\u4ec0\u4e48\uff1f<\/a><\/li><li><a href=\"#what-does-the-higher-dose-mean\">\u9ad8\u5242\u91cf\u610f\u5473\u7740\u4ec0\u4e48\uff1f<\/a><\/li><li><a href=\"#when-will-more-data-be-available\">\u4f55\u65f6\u624d\u80fd\u83b7\u5f97\u66f4\u591a\u6570\u636e\uff1f<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<h2 id=\"entrada-advances-to-the-18-mg-kg-dose\" class=\"wp-block-heading\">Entrada \u5242\u91cf\u63a8\u8fdb\u81f3 18 mg\/kg<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u6570\u636e\u76d1\u6d4b\u59d4\u5458\u4f1a (DMC) \u5ba1\u67e5\u4e86\u8be5\u8bd5\u9a8c\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u591a\u6b21\u9012\u589e\u5242\u91cf\u7814\u7a76\u7b2c\u4e8c\u7ec4\u6240\u6709\u516b\u540d\u53d7\u8bd5\u8005\u7684\u5b89\u5168\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66 (PK) \u6570\u636e\u3002\u4e86\u89e3\u66f4\u591a\uff1a <a href=\"https:\/\/dmdwarrior.com\/zh\/duchenne-exon-deletion-tool\/\" target=\"_blank\" rel=\"noreferrer noopener\">DMDWarrior \u5916\u663e\u5b50\u5220\u9664\u5de5\u5177<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7ecf\u8fc7\u6b64\u6b21\u5ba1\u67e5\uff0c\u59d4\u5458\u4f1a\u5efa\u8bae\u5c06\u7b2c 3 \u7ec4\u5242\u91cf\u8c03\u6574\u81f3 18 mg\/kg\uff0c\u8fd9\u662f\u8be5\u7814\u7a76\u8fc4\u4eca\u4e3a\u6b62\u8ba1\u5212\u7684\u6700\u9ad8\u5242\u91cf\u3002.<\/strong> \u8fd9\u6bd4\u7b2c\u4e8c\u7ec4\u7684 12 mg\/kg \u548c\u7b2c\u4e00\u7ec4\u7684 6 mg\/kg \u6709\u6240\u589e\u52a0\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">ELEVATE-44-201 \u662f\u4e00\u9879 1\/2 \u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30 ENTR-601-44 \u5728\u60a3\u6709\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7 (DMD) \u4e14\u5df2\u786e\u8bca DMD \u57fa\u56e0\u7a81\u53d8\u9002\u5408\u8fdb\u884c\u5916\u663e\u5b50 44 \u8df3\u8dc3\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u7684\u7597\u6548\u3002.<\/p>\n\n\n\n<h2 id=\"what-is-entr-601-44\" class=\"wp-block-heading\">ENTR-601-44\u662f\u4ec0\u4e48\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">ENTR-601-44 \u662f\u7531 Entrada Therapeutics \u5f00\u53d1\u7684\u4e00\u79cd\u5b9e\u9a8c\u6027\u7597\u6cd5\uff0c\u7528\u4e8e\u6cbb\u7597\u643a\u5e26\u9002\u5408\u5916\u663e\u5b50 44 \u8df3\u8dc3\u7a81\u53d8\u7684\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u60a3\u8005\u3002\u8be5\u7fa4\u4f53\u7ea6\u5360\u5168\u7403\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u60a3\u8005\u603b\u6570\u7684 8% \u4f8b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8be5\u7597\u6cd5\u4f7f\u7528\u5185\u4f53\u9003\u9038\u8f7d\u4f53 (EEV\u2122) \u5076\u8054\u5be1\u6838\u82f7\u9178\uff0c\u65e8\u5728\u5e2e\u52a9\u4eba\u4f53\u81ea\u7136\u4ea7\u751f\u7684 DMD \u57fa\u56e0\u4ea7\u751f\u529f\u80fd\u6027\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u662f\u808c\u8089\u529f\u80fd\u7684\u91cd\u8981\u86cb\u767d\u8d28\uff0c\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u662f\u7531 DMD \u57fa\u56e0\u7a81\u53d8\u5f15\u8d77\u7684\uff0c\u8fd9\u4e9b\u7a81\u53d8\u4f1a\u5f71\u54cd\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u7684\u4ea7\u751f\u6216\u529f\u80fd\u3002.<\/p>\n\n\n\n<h2 id=\"what-does-the-higher-dose-mean\" class=\"wp-block-heading\">\u9ad8\u5242\u91cf\u610f\u5473\u7740\u4ec0\u4e48\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u636e Entrada Therapeutics \u7814\u53d1\u603b\u88c1 Natarajan Sethuraman \u535a\u58eb\u79f0\uff0c\u5242\u91cf\u8fbe\u5230 18 mg\/kg \u662f ENTR-601-44 \u4e34\u5e8a\u5f00\u53d1\u7684\u91cd\u8981\u4e00\u6b65\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8be5\u516c\u53f8\u9884\u8ba1\uff0c\u66f4\u9ad8\u7684\u5242\u91cf\u53ef\u80fd\u4f1a\u5e26\u6765\u66f4\u9ad8\u7684\u836f\u7269\u66b4\u9732\u91cf\u3001\u66f4\u591a\u7684\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u751f\u6210\u4ee5\u53ca\u6f5c\u5728\u7684\u529f\u80fd\u6027\u76ca\u5904\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u53ea\u662f\u6b63\u5728\u8fdb\u884c\u7684\u7814\u7a76\u65e8\u5728\u63a2\u7d22\u7684\u53ef\u80fd\u6027\uff0c\u800c\u975e\u5df2\u786e\u5b9a\u7684\u4e34\u5e8a\u7ed3\u679c\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5242\u91cf\u9012\u589e\u8fd8\u6709\u52a9\u4e8e\u7814\u7a76\u4eba\u5458\u66f4\u597d\u5730\u4e86\u89e3\u8be5\u7597\u6cd5\u7684\u5b89\u5168\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u548c\u836f\u6548\u5b66\u4f5c\u7528\u3002.<\/p>\n\n\n\n<h2 id=\"when-will-more-data-be-available\" class=\"wp-block-heading\">\u4f55\u65f6\u624d\u80fd\u83b7\u5f97\u66f4\u591a\u6570\u636e\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Entrada Therapeutics \u9884\u8ba1\u5c06\u4e8e 2026 \u5e74\u665a\u4e9b\u65f6\u5019\u62a5\u544a\u961f\u5217 1 \u53c2\u4e0e\u8005\u5728\u5f00\u653e\u6807\u7b7e\u671f\u63a5\u53d7\u4e00\u5e74\u6cbb\u7597\u540e\u7684\u6570\u636e\u3002. <strong>\u7b2c\u4e8c\u6279\u6570\u636e\u9884\u8ba1\u5c06\u4e8e 2027 \u5e74\u7b2c\u4e00\u5b63\u5ea6\u516c\u5e03\u3002.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2025 \u5e74 12 \u6708\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40 (FDA) \u6388\u4e88 ENTR-601-44 \u7f55\u89c1\u513f\u79d1\u75be\u75c5\u8ba4\u5b9a\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5242\u91cf\u63d0\u5347\u81f3\u6700\u9ad8\u6c34\u5e73\u6807\u5fd7\u7740ENTR-601-44\u7814\u53d1\u7684\u53c8\u4e00\u91cd\u8981\u8fdb\u5c55\u3002\u672a\u6765\u7684\u4e34\u5e8a\u6570\u636e\u5bf9\u4e8e\u4e86\u89e3\u5176\u5b89\u5168\u6027\u4ee5\u53ca\u5bf9\u7b26\u5408\u5916\u663e\u5b5044\u8df3\u8dc3\u6cbb\u7597\u6761\u4ef6\u7684\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u60a3\u8005\u7684\u6f5c\u5728\u76ca\u5904\u81f3\u5173\u91cd\u8981\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4e86\u89e3\u66f4\u591a<\/strong>:&nbsp;<a href=\"https:\/\/dmdwarrior.com\/clinical-trials\/map\/\" target=\"_blank\" rel=\"noopener\">\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u4e34\u5e8a\u8bd5\u9a8c\u5730\u70b9\u5730\u56fe<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Entrada Therapeutics has received clearance to test the highest dose in its Exon 44 Skipping Study for Duchenne muscular dystrophy (DMD). The independent Data Monitoring Committee (DMC) has recommended starting Cohort 3 at 18 mg\/kg in the ELEVATE-44-201 clinical trial, following its review of available safety and pharmacokinetic data from participants in Cohort 2. Entrada [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":8861,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[235,265,234,141,127,246],"class_list":["post-8859","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-elevate-44-201","tag-entr-601-44","tag-entrada-therapeutics","tag-exon-44","tag-exon-44-skipping","tag-exon-44-skipping-therapies"],"subtitle":"Entrada Therapeutics \u5df2\u83b7\u51c6\u5728\u5176\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u5916\u663e\u5b50 44 \u8df3\u8dc3\u7814\u7a76\u4e2d\u6d4b\u8bd5\u6700\u9ad8\u5242\u91cf\u7684 ENTR-601-44\u3002ELEVATE-44-201 \u8bd5\u9a8c\u73b0\u5728\u5c06\u63a8\u8fdb\u81f3 18 mg\/kg \u5242\u91cf\u3002\u8fd9\u4e00\u91cc\u7a0b\u7891\u5bf9\u672a\u6765\u7684\u6cbb\u7597\u524d\u666f\u610f\u5473\u7740\u4ec0\u4e48\uff1f","_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/8859","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=8859"}],"version-history":[{"count":5,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/8859\/revisions"}],"predecessor-version":[{"id":8871,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/8859\/revisions\/8871"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/8861"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=8859"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=8859"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=8859"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}