{"id":8834,"date":"2026-10-01T15:39:32","date_gmt":"2026-10-01T12:39:32","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=8834"},"modified":"2026-10-01T15:39:36","modified_gmt":"2026-10-01T12:39:36","slug":"brogidirsen-5-year-dmd-clinical-data","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/brogidirsen-5-year-dmd-clinical-data\/","title":{"rendered":"NS Pharma \u7684 Brogidirsen \u5c55\u793a\u4e86\u9002\u7528\u4e8e\u5916\u663e\u5b50 44 \u8df3\u8dc3\u7597\u6cd5\u7684 DMD \u60a3\u8005\u7684 5 \u5e74\u4e34\u5e8a\u6570\u636e"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong>NS Pharma \u516c\u53f8\u7684 brogidirsen (NS-089\/NCNP-02) \u662f\u4e00\u79cd\u7528\u4e8e\u6cbb\u7597\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7 (DMD) \u7684\u7814\u7a76\u6027\u7597\u6cd5\uff0c\u4e13\u4e3a\u60a3\u6709\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u57fa\u56e0\u7a81\u53d8\u4e14\u9002\u5408\u8fdb\u884c\u5916\u663e\u5b50 44 \u8df3\u8dc3\u6cbb\u7597\u7684\u60a3\u8005\u800c\u8bbe\u8ba1\u3002.<\/strong> 2026 \u5e74 9 \u6708 29 \u65e5\u81f3 10 \u6708 3 \u65e5\uff0c\u5728\u65e5\u672c\u5e7f\u5c9b\u4e3e\u884c\u7684\u7b2c 31 \u5c4a\u4e16\u754c\u808c\u8089\u534f\u4f1a\u56fd\u9645\u5e74\u4f1a\u4e0a\uff0c\u516c\u5e03\u4e86 brogidirsen \u4e34\u5e8a\u5f00\u53d1\u7684\u4e94\u5e74\u7597\u6548\u548c\u5b89\u5168\u6027\u6570\u636e\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">NS Pharma\u516c\u53f8\u603b\u90e8\u4f4d\u4e8e\u65b0\u6cfd\u897f\u5dde\u5e15\u62c9\u59c6\u65af\uff0c\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u7f55\u89c1\u75c5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u662f\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\u4eac\u90fd\u7684Nippon Shinyaku\u682a\u5f0f\u4f1a\u793e\u7684\u5b50\u516c\u53f8\u3002Brogidirsen\u7531Nippon Shinyaku\u516c\u53f8\u548c\u65e5\u672c\u56fd\u7acb\u7cbe\u795e\u795e\u7ecf\u533b\u7597\u7814\u7a76\u4e2d\u5fc3\uff08NCNP\uff09\u5171\u540c\u53d1\u73b0\uff0c\u662f\u4e00\u79cd\u7528\u4e8e\u6cbb\u7597DMD\u60a3\u8005\u7684\u8bd5\u9a8c\u6027\u836f\u7269\uff0c\u8fd9\u4e9b\u60a3\u8005\u7684\u57fa\u56e0\u7a81\u53d8\u9002\u5408\u8fdb\u884c\u5916\u663e\u5b5044\u8df3\u8dc3\u7597\u6cd5\u3002. <strong>\u4e86\u89e3\u66f4\u591a<\/strong>:\u00a0<a href=\"https:\/\/dmdwarrior.com\/zh\/mutations-and-deletions-amenable-to-exon-44-skipping-therapies-dmd\/\" target=\"_blank\" rel=\"noopener\">\u9002\u5408\u5916\u663e\u5b5044\u8df3\u8dc3\u7597\u6cd5\u7684\u7a81\u53d8\u548c\u7f3a\u5931<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6700\u65b0\u516c\u5e03\u7684\u7ed3\u679c\u6765\u81eaNCNP\u5f00\u5c55\u7684\u4e00\u9879\u7814\u7a76\u8005\u53d1\u8d77\u7684\u4e34\u5e8a\u8bd5\u9a8c\u53ca\u5176\u7531Nippon Shinyaku\u5f00\u5c55\u7684\u5f00\u653e\u6807\u7b7e\u6269\u5c55\u7814\u7a76\u3002\u8fd9\u4e24\u9879\u7814\u7a76\u8bc4\u4f30\u4e86\u63a5\u53d7\u6bcf\u5468\u4e00\u6b21\u9759\u8109\u6ce8\u5c04\uff08IV\uff09\u6cbb\u7597\u7684\u516d\u540d\u53d7\u8bd5\u8005\u670d\u7528brogidirsen\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u8fd0\u52a8\u529f\u80fd\u7ef4\u6301\u4e94\u5e74\u4ee5\u4e0a<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5176\u4e2d\u4e00\u9879\u5173\u952e\u53d1\u73b0\u662f\uff0c\u5728\u7814\u7a76\u671f\u95f4\u80fd\u591f\u884c\u8d70\u7684\u53c2\u4e0e\u8005\u7684\u8fd0\u52a8\u529f\u80fd\u5f97\u4ee5\u7ef4\u6301\u3002\u8bc4\u4f30\u7ed3\u679c\u663e\u793a\uff0c\u8fd9\u4e9b\u53c2\u4e0e\u8005\u7684\u8fd0\u52a8\u529f\u80fd\u5f97\u5230\u7ef4\u6301\u6216\u6539\u5584\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6240\u6709\u53c2\u4e0e\u8005\u7684\u4e0a\u80a2\u529f\u80fd\u5747\u5f97\u4ee5\u7ef4\u6301\uff0c\u5305\u62ec\u5728\u7814\u7a76\u8fc7\u7a0b\u4e2d\u4e27\u5931\u884c\u8d70\u80fd\u529b\u7684\u53c2\u4e0e\u8005\u3002\u8fd9\u4e9b\u53d1\u73b0\u662f\u63a5\u53d7\u957f\u671f\u5e03\u7f57\u5409\u5730\u5c14\u68ee\u6cbb\u7597\u7684\u53c2\u4e0e\u8005\u4e94\u5e74\u8bc4\u4f30\u7684\u4e00\u90e8\u5206\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7814\u7a76\u7ed3\u679c\u63d0\u4f9b\u4e86\u957f\u671f\u6cbb\u7597\u7684\u529f\u80fd\u6027\u7ed3\u679c\u7684\u4e34\u5e8a\u6570\u636e\uff0c\u5e76\u8868\u660e\u5bf9\u4e8e\u9002\u5408\u8fdb\u884c\u5916\u663e\u5b50 44 \u8df3\u8dc3\u7684 DMD \u60a3\u8005\uff0cbrogidirsen \u6709\u53ef\u80fd\u51cf\u7f13\u75be\u75c5\u8fdb\u5c55\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u672a\u62a5\u544a\u4e25\u91cd\u6216\u91cd\u5ea6\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e94\u5e74\u5b89\u5168\u6027\u7814\u7a76\u7ed3\u679c\u662f\u672c\u6b21\u62a5\u544a\u7684\u53e6\u4e00\u91cd\u8981\u90e8\u5206\u3002\u53d7\u8bd5\u8005\u63a5\u53d7\u5e03\u7f57\u5409\u5730\u5c14\u68ee\u6cbb\u7597\u4e94\u5e74\u540e\uff0c\u672a\u51fa\u73b0\u4e0e\u957f\u671f\u670d\u7528\u5e03\u7f57\u5409\u5730\u5c14\u68ee\u76f8\u5173\u7684\u4e25\u91cd\u6216\u91cd\u5ea6\u4e0d\u826f\u4e8b\u4ef6\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8be5\u7814\u7a76\u8fd8\u62a5\u544a\u79f0\uff0c\u6ca1\u6709\u53d1\u751f\u4e0e\u6cbb\u7597\u76f8\u5173\u7684\u8fc7\u654f\u53cd\u5e94\uff0c\u5e76\u4e14\u5728\u4e94\u5e74\u671f\u95f4\u6ca1\u6709\u51fa\u73b0\u505c\u836f\u60c5\u51b5\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6839\u636e\u6240\u63d0\u4f9b\u7684\u6570\u636e\uff0c\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u5bf9\u4e8e\u7814\u7a76\u4e2d\u8bc4\u4f30\u7684\u53c2\u4e0e\u8005\u800c\u8a00\uff0c\u957f\u671f\u7528\u836f\u5177\u6709\u53ef\u63a5\u53d7\u7684\u5b89\u5168\u6027\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u4e0eDMD\u81ea\u7136\u53f2\u7684\u6bd4\u8f83<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u7814\u7a76\u4eba\u5458\u8fd8\u5c06\u51e0\u9879\u529f\u80fd\u6307\u6807\u4e0e\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u81ea\u7136\u75c5\u7a0b\u6570\u636e\u8fdb\u884c\u4e86\u6bd4\u8f83\u3002\u5728\u591a\u9879\u6307\u6807\u4e2d\uff0c\u672c\u7814\u7a76\u89c2\u5bdf\u5230\u7684\u529f\u80fd\u7ed3\u679c\u4e0e\u8be5\u75be\u75c5\u7684\u81ea\u7136\u75c5\u7a0b\u76f8\u6bd4\u5747\u8868\u73b0\u826f\u597d\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8be5\u516c\u53f8\u8868\u793a\uff0c\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u5bf9\u4e8e\u7a81\u53d8\u9002\u5408\u8fdb\u884c\u5916\u663e\u5b50 44 \u8df3\u8dc3\u7684 DMD \u60a3\u8005\uff0cbrogidirsen \u53ef\u80fd\u5177\u6709\u51cf\u7f13\u75be\u75c5\u8fdb\u5c55\u7684\u6f5c\u529b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7136\u800c\uff0c\u6269\u5c55\u8bd5\u9a8c\u4ecd\u5728\u8fdb\u884c\u4e2d\u3002\u8be5\u7814\u7a76\u5c06\u7ee7\u7eed\u8c03\u67e5\u957f\u671f\u670d\u7528\u5e03\u7f57\u5409\u5730\u5c14\u68ee\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u5168\u7403\u4e8c\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u9664\u4e86\u6b63\u5728\u8fdb\u884c\u7684\u6269\u5c55\u7814\u7a76\u5916\uff0cNippon Shinyaku \u53ca\u5176\u5b50\u516c\u53f8 NS Pharma \u6b63\u5728\u8fdb\u884c brogidirsen \u7684\u5168\u7403 II \u671f\u7814\u7a76\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u4e16\u754c\u808c\u8089\u5b66\u4f1a\u5927\u4f1a\u4e0a\u516c\u5e03\u7684\u4e94\u5e74\u6570\u636e\u663e\u793a\uff0c\u63a5\u53d7\u6bcf\u5468\u4e00\u6b21\u9759\u8109\u6ce8\u5c04\u5e03\u7f57\u5409\u5730\u5c14\u68ee\u6cbb\u7597\u7684\u516d\u540d\u60a3\u8005\u83b7\u5f97\u4e86\u66f4\u957f\u671f\u7684\u4e34\u5e8a\u4fe1\u606f\u3002\u7814\u7a76\u7ed3\u679c\u5305\u62ec\u5bf9\u8fd0\u52a8\u529f\u80fd\u3001\u4e0a\u80a2\u529f\u80fd\u3001\u5b89\u5168\u6027\u4ee5\u53ca\u4e0e\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff08DMD\uff09\u81ea\u7136\u75c5\u7a0b\u6570\u636e\u7684\u6bd4\u8f83\u89c2\u5bdf\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Brogidirsen \u4ecd\u662f\u4e00\u79cd\u7814\u7a76\u6027\u7597\u6cd5\uff0c\u6b63\u5728\u8fdb\u884c\u7684\u7814\u7a76\u5c06\u63d0\u4f9b\u6709\u5173\u5176\u5bf9\u9002\u5408\u8fdb\u884c\u5916\u663e\u5b50 44 \u8df3\u8dc3\u7684 DMD \u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u66f4\u591a\u4fe1\u606f\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4e86\u89e3\u66f4\u591a<\/strong>:\u00a0<a href=\"https:\/\/dmdwarrior.com\/clinical-trials\/map\/\" target=\"_blank\" rel=\"noopener\">\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u4e34\u5e8a\u8bd5\u9a8c\u5730\u70b9\u5730\u56fe<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>NS Pharma\u2019s brogidirsen (NS-089\/NCNP-02) is an investigational therapy for Duchenne muscular dystrophy (DMD) designed for patients with dystrophin gene mutations amenable to exon 44 skipping. Five-year efficacy and safety data from the clinical development of brogidirsen were presented at the 31st annual International Congress of the World Muscle Society, held in Hiroshima, Japan, from September [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":8835,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[138,137,141,127,246,136,924,140],"class_list":["post-8834","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-brogidirsen","tag-clinical-trial","tag-exon-44","tag-exon-44-skipping","tag-exon-44-skipping-therapies","tag-nippon-shinyaku","tag-ns-pharma","tag-ns-089-ncnp-02"],"subtitle":"Brogidirsen \u5728\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7814\u7a76\u9886\u57df\u5907\u53d7\u5173\u6ce8\u3002\u6700\u65b0\u7684\u4e94\u5e74\u6570\u636e\u663e\u793a\uff0c\u8be5\u836f\u7269\u5bf9\u9002\u5408\u8fdb\u884c\u5916\u663e\u5b50 44 \u8df3\u8dc3\u79fb\u690d\u7684\u60a3\u8005\u5177\u6709\u6f5c\u5728\u7597\u6548\uff0c\u5728\u8fd0\u52a8\u529f\u80fd\u548c\u957f\u671f\u5b89\u5168\u6027\u65b9\u9762\u5747\u53d6\u5f97\u4e86\u4ee4\u4eba\u9f13\u821e\u7684\u53d1\u73b0\u3002.","_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/8834","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=8834"}],"version-history":[{"count":2,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/8834\/revisions"}],"predecessor-version":[{"id":8837,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/8834\/revisions\/8837"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/8835"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=8834"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=8834"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=8834"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}