{"id":7976,"date":"2026-05-14T20:35:20","date_gmt":"2026-05-14T17:35:20","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=7976"},"modified":"2026-06-24T22:01:14","modified_gmt":"2026-06-24T19:01:14","slug":"avidity-biosciences-aoc-1044-safari44-phase-3-dmd-trial-nct07587242","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/avidity-biosciences-aoc-1044-safari44-phase-3-dmd-trial-nct07587242\/","title":{"rendered":"Del-Zota SAFARI44 \u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff1a\u4e00\u9879\u9488\u5bf9\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u65b0\u578b\u5916\u663e\u5b50 44 \u8df3\u8dc3\u7597\u6cd5\u7814\u7a76"},"content":{"rendered":"<p class=\"wp-block-paragraph\">\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7 (DMD) \u7684\u7814\u7a76\u6301\u7eed\u63a8\u8fdb\uff0c\u76ee\u524d\u6b63\u5728\u542f\u52a8\u4e00\u9879\u540d\u4e3a Del-Zota SAFARI44 \u7684 III \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30 AOC 1044\uff08\u4e5f\u79f0\u4e3a delpacibart zotadirsen\uff09\u3002\u8fd9\u9879\u7814\u7a76\u6027\u7597\u6cd5\u6b63\u5728\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u643a\u5e26 DMD \u7a81\u53d8\u4e14\u9002\u5408\u8fdb\u884c 44 \u53f7\u5916\u663e\u5b50\u8df3\u8dc3\u624b\u672f\u7684\u60a3\u8005\u3002.<\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u76ee\u5f55<\/h2><nav><ul><li><a href=\"#what-is-the-safari-44-trial\">SAFARI44\u8bd5\u9a8c\u662f\u4ec0\u4e48\uff1f<\/a><\/li><li><a href=\"#what-is-aoc-1044-delpacibart-zotadirsen\">\u4ec0\u4e48\u662f Del-Zota (Delpacibart Zotadirsen)\uff1f<\/a><\/li><li><a href=\"#how-the-study-will-work\">\u7814\u7a76\u5c06\u5982\u4f55\u8fdb\u884c<\/a><ul><li><a href=\"#randomized-treatment-period\">\u968f\u673a\u6cbb\u7597\u671f<\/a><\/li><li><a href=\"#open-label-extension-ole\">\u5f00\u653e\u6807\u7b7e\u6269\u5c55\uff08OLE\uff09<\/a><\/li><li><a href=\"#independent-safety-monitoring\">\u72ec\u7acb\u5b89\u5168\u76d1\u6d4b<\/a><\/li><\/ul><\/li><li><a href=\"#safari-44-timeline\">SAFARI44 \u65f6\u95f4\u7ebf<\/a><ul><li><a href=\"#estimated-study-dates\">\u9884\u8ba1\u5b66\u4e60\u65e5\u671f<\/a><\/li><li><a href=\"#planned-enrollment\">\u8ba1\u5212\u5165\u5b66<\/a><\/li><\/ul><\/li><li><a href=\"#who-can-participate\">\u8c01\u53ef\u4ee5\u53c2\u52a0\uff1f<\/a><ul><li><a href=\"#key-inclusion-criteria\">\u5173\u952e\u7eb3\u5165\u6807\u51c6<\/a><\/li><li><a href=\"#key-exclusion-criteria\">\u4e3b\u8981\u6392\u9664\u6807\u51c6<\/a><\/li><\/ul><\/li><li><a href=\"#why-this-trial-matters-for-the-dmd-community\">\u4e3a\u4ec0\u4e48\u8fd9\u6b21\u5ba1\u5224\u5bf9\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff08DMD\uff09\u60a3\u8005\u7fa4\u4f53\u81f3\u5173\u91cd\u8981<\/a><\/li><li><a href=\"#contact-information\">\u8054\u7cfb\u4fe1\u606f<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<h2 id=\"what-is-the-safari-44-trial\" class=\"wp-block-heading\">SAFARI44\u8bd5\u9a8c\u662f\u4ec0\u4e48\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">SAFARI44 \u7814\u7a76\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684 III \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30 AOC 1044 (Del-Zota) \u5728\u7b26\u5408\u5916\u663e\u5b50 44 \u8df3\u8dc3\u6cbb\u7597\u6761\u4ef6\u7684\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7537\u5b69\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u4e86\u89e3\u66f4\u591a\uff1a&nbsp;<a href=\"https:\/\/dmdwarrior.com\/zh\/del-zota-explore44-provides-nearly-30-normal-dystrophin-production-in-patients-amenable-to-exon-44-skipping\/\" target=\"_blank\" rel=\"noreferrer noopener\">Del-zota (EXPLORE44) \u53ef\u63d0\u4f9b\u63a5\u8fd1 30% \u6b63\u5e38\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u7684\u4ea7\u91cf<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8be5\u8bd5\u9a8c\u5c06\u7814\u7a76\u9759\u8109\u6ce8\u5c04AOC 1044\u662f\u5426\u80fd\u5e2e\u52a9\u6539\u5584\u643a\u5e26\u7279\u5b9a\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u57fa\u56e0\u7a81\u53d8\u7684\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff08DMD\uff09\u60a3\u8005\u7684\u75c5\u60c5\u3002\u8be5\u7597\u6cd5\u6bcf\u516d\u5468\u901a\u8fc7\u9759\u8109\u8f93\u6ce8\u7ed9\u836f\u4e00\u6b21\u3002.<\/p>\n\n\n\n<h2 id=\"what-is-aoc-1044-delpacibart-zotadirsen\" class=\"wp-block-heading\">\u4ec0\u4e48\u662f Del-Zota (Delpacibart Zotadirsen)\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Del-Zota \u662f\u4e00\u79cd\u5728\u7814\u7684\u5916\u663e\u5b50\u8df3\u8dc3\u7597\u6cd5\uff0c\u65e8\u5728\u9776\u5411\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u57fa\u56e0\u4e2d\u53ef\u901a\u8fc7\u5916\u663e\u5b50 44 \u8df3\u8dc3\u83b7\u76ca\u7684\u7a81\u53d8\u3002\u5916\u663e\u5b50\u8df3\u8dc3\u7597\u6cd5\u7684\u76ee\u6807\u662f\u5e2e\u52a9\u4eba\u4f53\u4ea7\u751f\u66f4\u77ed\u4f46\u529f\u80fd\u6b63\u5e38\u7684\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\uff0c\u4ece\u800c\u53ef\u80fd\u5ef6\u7f13\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u60a3\u8005\u7684\u808c\u8089\u9000\u5316\u3002\u4e86\u89e3\u66f4\u591a\uff1a&nbsp;<a href=\"https:\/\/dmdwarrior.com\/zh\/mutations-and-deletions-amenable-to-exon-44-skipping-therapies-dmd\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u9002\u5408\u5916\u663e\u5b5044\u8df3\u8dc3\u7597\u6cd5\u7684\u7a81\u53d8\u548c\u7f3a\u5931<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"968\" height=\"1024\" src=\"https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-968x1024.jpg\" alt=\"\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u53ef\u901a\u8fc7\u5916\u663e\u5b50 44 \u8df3\u8dc3\u7597\u6cd5\u6cbb\u7597\u7684\u7a81\u53d8\u548c\u7f3a\u5931\" class=\"wp-image-5275\" title=\"\" srcset=\"https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-968x1024.jpg 968w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-284x300.jpg 284w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-768x813.jpg 768w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-1452x1536.jpg 1452w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-11x12.jpg 11w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-397x420.jpg 397w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-150x159.jpg 150w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-300x317.jpg 300w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-696x737.jpg 696w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-1068x1130.jpg 1068w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping.jpg 1890w\" sizes=\"auto, (max-width: 968px) 100vw, 968px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e0e\u4f20\u7edf\u7684\u5916\u663e\u5b50\u8df3\u8dc3\u836f\u7269\u4e0d\u540c\uff0cDel-Zota \u91c7\u7528\u6297\u4f53\u5be1\u6838\u82f7\u9178\u5076\u8054\u6280\u672f\uff0c\u65e8\u5728\u6539\u5584\u836f\u7269\u5411\u808c\u8089\u7ec4\u7ec7\u7684\u8f93\u9001\u3002.<\/p>\n\n\n\n<h2 id=\"how-the-study-will-work\" class=\"wp-block-heading\">\u7814\u7a76\u5c06\u5982\u4f55\u8fdb\u884c<\/h2>\n\n\n\n<h3 id=\"randomized-treatment-period\" class=\"wp-block-heading\">\u968f\u673a\u6cbb\u7597\u671f<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u53c2\u4e0e SAFARI44 \u7814\u7a76\u7684\u53d7\u8bd5\u8005\u5c06\u63a5\u53d7\u4ee5\u4e0b\u5176\u4e2d\u4e00\u9879\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Del-Zota\uff08\u5fb7\u5c14\u5e15\u897f\u5df4\u7279\u4f50\u5854\u8fea\u68ee\uff09<\/li>\n\n\n\n<li>\u5b89\u6170\u5242<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u7814\u7a76\u7684\u524d 54 \u5468\u5185\uff0c\u5c06\u6bcf\u516d\u5468\u8fdb\u884c\u4e00\u6b21\u6cbb\u7597\uff0c\u603b\u5171\u8fdb\u884c\u4e5d\u6b21\u6cbb\u7597\u3002.<\/p>\n\n\n\n<h3 id=\"open-label-extension-ole\" class=\"wp-block-heading\">\u5f00\u653e\u6807\u7b7e\u6269\u5c55\uff08OLE\uff09<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u968f\u673a\u5206\u7ec4\u9636\u6bb5\u7ed3\u675f\u540e\uff0c\u6240\u6709\u53c2\u4e0e\u8005\u5747\u53ef\u8fdb\u5165\u4e3a\u671f54\u5468\u7684\u5f00\u653e\u6807\u7b7e\u6269\u5c55\u9636\u6bb5\u3002\u5728\u6b64\u671f\u95f4\uff0c\u65e0\u8bba\u6700\u521d\u88ab\u5206\u914d\u5230\u54ea\u4e2a\u6cbb\u7597\u7ec4\uff0c\u6240\u6709\u53c2\u4e0e\u8005\u90fd\u5c06\u63a5\u53d7Del-Zota\u6cbb\u7597\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9884\u8ba1\u5728\u7b2c 102 \u5468\u8fdb\u884c\u6700\u540e\u4e00\u6b21\u6cbb\u7597\u5242\u91cf\uff0c\u968f\u540e\u5728\u7b2c 114 \u5468\u8fdb\u884c\u989d\u5916\u7684\u8bc4\u4f30\u548c\u5b89\u5168\u6027\u76d1\u6d4b\u3002.<\/p>\n\n\n\n<h3 id=\"independent-safety-monitoring\" class=\"wp-block-heading\">\u72ec\u7acb\u5b89\u5168\u76d1\u6d4b<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u72ec\u7acb\u6570\u636e\u76d1\u5bdf\u59d4\u5458\u4f1a (IDMC) \u5c06\u5728\u6574\u4e2a\u7814\u7a76\u8fc7\u7a0b\u4e2d\u5b9a\u671f\u5ba1\u67e5\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u6709\u6548\u6027\u6570\u636e\u3002.<\/p>\n\n\n\n<h2 id=\"safari-44-timeline\" class=\"wp-block-heading\">SAFARI44 \u65f6\u95f4\u7ebf<\/h2>\n\n\n\n<h3 id=\"estimated-study-dates\" class=\"wp-block-heading\">\u9884\u8ba1\u5b66\u4e60\u65e5\u671f<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5f00\u8bfe\u65f6\u95f4\uff1a2026\u5e746\u6708<\/li>\n\n\n\n<li>\u4e3b\u8981\u7ae3\u5de5\u65e5\u671f\uff1a2029\u5e745\u6708<\/li>\n\n\n\n<li>\u7814\u7a76\u5b8c\u6210\u65f6\u95f4\uff1a2030\u5e747\u6708<\/li>\n<\/ul>\n\n\n\n<h3 id=\"planned-enrollment\" class=\"wp-block-heading\">\u8ba1\u5212\u5165\u5b66<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u7814\u7a76\u4eba\u5458\u8ba1\u5212\u5728\u8fd9\u9879 3 \u671f\u5e72\u9884\u7814\u7a76\u4e2d\u62db\u52df\u7ea6 70 \u540d\u53c2\u4e0e\u8005\u3002.<\/p>\n\n\n\n<h2 id=\"who-can-participate\" class=\"wp-block-heading\">\u8c01\u53ef\u4ee5\u53c2\u52a0\uff1f<\/h2>\n\n\n\n<h3 id=\"key-inclusion-criteria\" class=\"wp-block-heading\">\u5173\u952e\u7eb3\u5165\u6807\u51c6<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u8981\u7b26\u5408 SAFARI44 \u7814\u7a76\u7684\u53c2\u4e0e\u8d44\u683c\uff0c\u53c2\u4e0e\u8005\u5fc5\u987b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u80fd\u591f\u884c\u8d70\u7684\u7537\u6027\uff0c\u88ab\u8bca\u65ad\u60a3\u6709\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7<\/li>\n\n\n\n<li>\u5df2\u786e\u8bca\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u57fa\u56e0\u7a81\u53d8\uff0c\u9002\u5408\u8fdb\u884c\u7b2c44\u53f7\u5916\u663e\u5b50\u8df3\u8dc3\u624b\u672f<\/li>\n\n\n\n<li>\u5e74\u9f84\u57282\u5c81\u53ca\u4ee5\u4e0a\uff08\u513f\u7ae5\u3001\u6210\u4eba\u3001\u8001\u5e74\u4eba\uff09<\/li>\n\n\n\n<li>\u5728\u7b5b\u67e5\u671f\u95f4\u5b8c\u6210\u6240\u9700\u7684\u5168\u90e8\u529f\u80fd\u8bc4\u4f30<\/li>\n\n\n\n<li>\u6cbb\u7597\u5f00\u59cb\u524d\u81f3\u5c11\u516d\u4e2a\u6708\u9700\u4fdd\u6301\u7a33\u5b9a\u7684\u76ae\u8d28\u7c7b\u56fa\u9187\u6cbb\u7597\u65b9\u6848\u3002<\/li>\n<\/ul>\n\n\n\n<h3 id=\"key-exclusion-criteria\" class=\"wp-block-heading\">\u4e3b\u8981\u6392\u9664\u6807\u51c6<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u7b26\u5408\u4ee5\u4e0b\u6761\u4ef6\u7684\u53c2\u4e0e\u8005\u53ef\u80fd\u4e0d\u7b26\u5408\u8d44\u683c\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5148\u524d\u63a5\u53d7\u8fc7\u57fa\u56e0\u6cbb\u7597\u6216\u7ec6\u80de\u6cbb\u7597<\/li>\n\n\n\n<li>\u5165\u7ec4\u524d\u516d\u4e2a\u6708\u5185\u4f7f\u7528\u8fc7\u5176\u4ed6\u5be1\u6838\u82f7\u9178\u7597\u6cd5<\/li>\n\n\n\n<li>\u5b9e\u9a8c\u5ba4\u6570\u503c\u8d85\u51fa\u534f\u8bae\u9650\u503c<\/li>\n\n\n\n<li>\u8fd1\u671f\u6539\u53d8\u7684\u6cbb\u7597\u65b9\u6cd5\u5305\u62ec\u4f7f\u7528\u751f\u957f\u6fc0\u7d20\u3001\u777e\u916e\u6216\u5409\u7ef4\u8bfa\u53f8\u4ed6\u3002<\/li>\n<\/ul>\n\n\n\n<h2 id=\"why-this-trial-matters-for-the-dmd-community\" class=\"wp-block-heading\">\u4e3a\u4ec0\u4e48\u8fd9\u6b21\u5ba1\u5224\u5bf9\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff08DMD\uff09\u60a3\u8005\u7fa4\u4f53\u81f3\u5173\u91cd\u8981<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5916\u663e\u5b50\u8df3\u8dc3\u7597\u6cd5\u4ecd\u7136\u662f\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7814\u7a76\u4e2d\u6700\u91cd\u8981\u7684\u6cbb\u7597\u65b9\u6cd5\u4e4b\u4e00\u3002\u867d\u7136\u9488\u5bf9\u5176\u4ed6\u5916\u663e\u5b50\u9776\u70b9\u5df2\u6709\u591a\u79cd\u5916\u663e\u5b50\u8df3\u8dc3\u836f\u7269\uff0c\u4f46\u5bf9\u4e8e\u643a\u5e26\u9002\u5408\u5916\u663e\u5b5044\u8df3\u8dc3\u7a81\u53d8\u7684\u60a3\u8005\u800c\u8a00\uff0c\u6cbb\u7597\u9009\u62e9\u4ecd\u7136\u6709\u9650\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">SAFARI44 \u8bd5\u9a8c\u53ef\u4ee5\u63d0\u4f9b\u91cd\u8981\u4fe1\u606f\uff0c\u4ee5\u4e86\u89e3 AOC 1044 \u662f\u5426\u80fd\u591f\u5b89\u5168\u5730\u6539\u5584\u8be5\u60a3\u8005\u7fa4\u4f53\u7684\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u6062\u590d\u548c\u4e34\u5e8a\u7ed3\u679c\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e86\u89e3\u66f4\u591a\uff1a&nbsp;<a href=\"https:\/\/dmdwarrior.com\/zh\/upcoming-exon-44-skipping-therapies-for-dmd\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u5373\u5c06\u63a8\u51fa\u7684\u7528\u4e8e\u6cbb\u7597\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u5916\u663e\u5b5044\u8df3\u8dc3\u7597\u6cd5<\/a><\/p>\n\n\n\n<h2 id=\"contact-information\" class=\"wp-block-heading\">\u8054\u7cfb\u4fe1\u606f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u8be5\u7814\u7a76\u7531 Avidity Biosciences \u8d5e\u52a9\u3002.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7535\u8bdd\uff1a858-771-7038<\/li>\n\n\n\n<li>\u7535\u5b50\u90ae\u4ef6\uff1a <a>medinfo@aviditybio.com<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u76ee\u524d\uff0c\u5c1a\u672a\u516c\u5f00\u4efb\u4f55\u5b66\u4e60\u5730\u70b9\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5173\u6ce8\u6b64\u9875\u9762<\/strong>&nbsp;&gt;&gt;&gt;&nbsp;<a href=\"https:\/\/dmdwarrior.com\/zh\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u6240\u6709\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Duchenne muscular dystrophy (DMD) research continues to move forward with the launch of the Del-Zota SAFARI44 Phase 3 clinical trial evaluating AOC 1044, also known as delpacibart zotadirsen. This investigational therapy is being developed for individuals with DMD mutations amenable to exon 44 skipping. What Is the SAFARI44 Trial? The SAFARI44 study is a randomized, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":7979,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[459,126,137,298,397,141,127,246,77,178,779],"class_list":["post-7976","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-aoc-1044","tag-avidity-biosciences","tag-clinical-trial","tag-del-zota","tag-delpacibart-zotadirsen","tag-exon-44","tag-exon-44-skipping","tag-exon-44-skipping-therapies","tag-exon-skipping","tag-exon-skipping-therapies","tag-safari44"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/7976","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=7976"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/7976\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/7979"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=7976"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=7976"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=7976"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}