{"id":6765,"date":"2026-03-12T17:37:47","date_gmt":"2026-03-12T14:37:47","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=6765"},"modified":"2026-03-12T17:46:08","modified_gmt":"2026-03-12T14:46:08","slug":"z-endoxifen-duchenne-muscular-dystrophy-study","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/z-endoxifen-duchenne-muscular-dystrophy-study\/","title":{"rendered":"Atossa \u5c55\u793a\u4e86\u65b0\u7684 (Z)-Endoxifen \u7814\u7a76\uff0c\u7ed3\u679c\u663e\u793a\u5176\u5728\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u5c0f\u9f20\u6a21\u578b\u4e2d\u6539\u5584\u4e86\u808c\u8089\u529f\u80fd\u3002"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong>\u5728\u5965\u5170\u591a\u4e3e\u884c\u7684 2026 \u5e74 MDA \u4e34\u5e8a\u4e0e\u79d1\u5b66\u4f1a\u8bae\u4e0a\uff0cAtossa Therapeutics \u7684\u7814\u7a76\u4eba\u5458\u5c55\u793a\u4e86\u6709\u5173 (Z)-endoxifen \u53ca\u5176\u5728\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7 (DMD) \u4e2d\u7684\u6f5c\u5728\u7528\u9014\u7684\u6700\u65b0\u4e34\u5e8a\u524d\u6570\u636e\u3002.<\/strong><\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u76ee\u5f55<\/h2><nav><ul><li><a href=\"#what-is-z-endoxifen\">\u4ec0\u4e48\u662f (Z)-Endoxifen\uff1f<\/a><\/li><li><a href=\"#new-duchenne-research-z-endoxifen-improves-muscle-strength-in-preclinical-study\">(Z)-Endoxifen \u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u663e\u793a\u51fa\u589e\u5f3a\u808c\u8089\u529b\u91cf\u7684\u4f5c\u7528<\/a><\/li><li><a href=\"#improvements-in-muscle-strength-and-performance\">\u808c\u8089\u529b\u91cf\u548c\u8fd0\u52a8\u8868\u73b0\u7684\u63d0\u5347<\/a><\/li><li><a href=\"#reduced-muscle-damage-and-healthier-body-composition\">\u51cf\u5c11\u808c\u8089\u635f\u4f24\uff0c\u6539\u5584\u8eab\u4f53\u6210\u5206<\/a><\/li><li><a href=\"#safety-findings\">\u5b89\u5168\u8c03\u67e5\u7ed3\u679c<\/a><\/li><li><a href=\"#what-happens-next\">\u63a5\u4e0b\u6765\u4f1a\u53d1\u751f\u4ec0\u4e48\uff1f<\/a><\/li><li><a href=\"#why-new-duchenne-treatments-are-still-needed\">\u4e3a\u4ec0\u4e48\u4ecd\u7136\u9700\u8981\u65b0\u7684\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u6cbb\u7597\u65b9\u6cd5<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-is-z-endoxifen\">\u4ec0\u4e48\u662f (Z)-Endoxifen\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>(Z)-endoxifen \u662f\u4e00\u79cd\u4e0e\u4ed6\u83ab\u6614\u82ac\u76f8\u5173\u7684\u5316\u5408\u7269\uff0c\u5c5e\u4e8e\u9009\u62e9\u6027\u96cc\u6fc0\u7d20\u53d7\u4f53\u8c03\u8282\u5242 (SERM) \u7c7b\u836f\u7269\u3002.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7814\u7a76\u4eba\u5458\u8ba4\u4e3a\u5b83\u53ef\u80fd\u5f71\u54cd\u4ee5\u4e0b\u751f\u7269\u901a\u8def\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u808c\u8089\u708e\u75c7<\/li>\n\n\n\n<li>\u7ea4\u7ef4\u5316\uff08\u808c\u8089\u7622\u75d5\uff09<\/li>\n\n\n\n<li>\u808c\u8089\u518d\u751f<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e0e\u4e00\u4e9b\u9488\u5bf9\u7279\u5b9a\u57fa\u56e0\u7a81\u53d8\u7684\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u6cbb\u7597\u65b9\u6cd5\u4e0d\u540c\uff0c(Z)-endoxifen \u53ef\u80fd\u5bf9\u8bb8\u591a\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7a81\u53d8\u6709\u6548\uff0c\u8fd9\u53ef\u80fd\u4f7f\u5176\u9002\u7528\u4e8e\u66f4\u5e7f\u6cdb\u7684\u60a3\u8005\u7fa4\u4f53\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8be5\u836f\u7269\u76ee\u524d\u5c1a\u672a\u83b7\u51c6\u7528\u4e8e\u6cbb\u7597\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u6216\u5176\u4ed6\u4efb\u4f55\u75be\u75c5\u3002.<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"new-duchenne-research-z-endoxifen-improves-muscle-strength-in-preclinical-study\">(Z)-Endoxifen \u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u663e\u793a\u51fa\u589e\u5f3a\u808c\u8089\u529b\u91cf\u7684\u4f5c\u7528<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u8be5\u7814\u7a76\u91c7\u7528\u4e86 mdx5Cv \u5c0f\u9f20\u6a21\u578b\uff0c\u8fd9\u662f\u7814\u7a76\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u8fdb\u5c55\u6700\u5e7f\u6cdb\u4f7f\u7528\u7684\u5b9e\u9a8c\u5ba4\u6a21\u578b\u4e4b\u4e00\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7ed3\u679c\u663e\u793a\u51fa\u51e0\u4e2a\u4ee4\u4eba\u9f13\u821e\u7684\u6548\u679c\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u672c\u7814\u7a76\u91c7\u7528\u4e86mdx5Cv\u808c\u8425\u517b\u4e0d\u826f\u5c0f\u9f20\u6a21\u578b\uff0c\u8be5\u6a21\u578b\u662f\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff08DMD\uff09\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u503c\u5f97\u4fe1\u8d56\u4e14\u53ef\u91cd\u590d\u7684\u6807\u51c6\u6a21\u578b\u3002<\/li>\n\n\n\n<li>(Z)-Endoxifen \u6539\u5584\u4e86\u5e7c\u5e74\u548c\u6210\u5e74\u8425\u517b\u4e0d\u826f\u5c0f\u9f20\u7684\u808c\u8089\u529b\u91cf\u548c\u8fd0\u52a8\u80fd\u529b\u3002<\/li>\n\n\n\n<li>\u6cbb\u7597\u589e\u5f3a\u4e86\u5bf9\u6536\u7f29\u8bf1\u53d1\u6027\u808c\u8089\u635f\u4f24\u7684\u62b5\u6297\u529b<\/li>\n\n\n\n<li>\u8eab\u4f53\u6210\u5206\u51fa\u73b0\u4e86\u6709\u5229\u7684\u53d8\u5316\uff0c\u5305\u62ec\u7626\u4f53\u91cd\u589e\u52a0\u548c\u8102\u80aa\u91cf\u51cf\u5c11\u3002<\/li>\n\n\n\n<li>\u808c\u8089\u635f\u4f24\u7684\u5173\u952e\u751f\u5316\u548c\u7ec4\u7ec7\u5b66\u6807\u5fd7\u7269\u5747\u6709\u6240\u964d\u4f4e\u3002<\/li>\n\n\n\n<li>\u8be5\u7597\u6cd5\u8010\u53d7\u6027\u826f\u597d\uff0c\u7814\u7a76\u671f\u95f4\u672a\u89c2\u5bdf\u5230\u4e0d\u826f\u53cd\u5e94\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e86\u89e3\u66f4\u591a\uff1a\u00a0<a href=\"https:\/\/dmdwarrior.com\/zh\/biomarkers-in-duchenne-muscular-dystrophy\/\" target=\"_blank\" rel=\"noreferrer noopener\">DMD\u4e2d\u7684\u751f\u7269\u6807\u5fd7\u7269<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"improvements-in-muscle-strength-and-performance\">\u808c\u8089\u529b\u91cf\u548c\u8fd0\u52a8\u8868\u73b0\u7684\u63d0\u5347<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7814\u7a76\u53d1\u73b0\uff0c\u5e7c\u5e74\u548c\u6210\u5e74\u8425\u517b\u4e0d\u826f\u5c0f\u9f20\u5728\u63a5\u53d7 (Z)-endoxifen \u6cbb\u7597\u540e\uff0c\u808c\u8089\u529f\u80fd\u5747\u5f97\u5230\u6539\u5584\u3002.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e3b\u8981\u7814\u7a76\u7ed3\u679c\u5305\u62ec\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u808c\u8089\u529b\u91cf\u589e\u5f3a<\/li>\n\n\n\n<li>\u66f4\u597d\u7684\u7535\u673a\u6027\u80fd<\/li>\n\n\n\n<li>\u6536\u7f29\u8fc7\u7a0b\u4e2d\u5bf9\u808c\u8089\u635f\u4f24\u7684\u62b5\u6297\u529b\u66f4\u5f3a<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u4e9b\u6539\u5584\u8868\u660e\uff0c\u8be5\u7597\u6cd5\u53ef\u80fd\u6709\u52a9\u4e8e\u4fdd\u62a4\u808c\u8089\u7ea4\u7ef4\u514d\u53d7\u635f\u4f24\u3002.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"reduced-muscle-damage-and-healthier-body-composition\">\u51cf\u5c11\u808c\u8089\u635f\u4f24\uff0c\u6539\u5584\u8eab\u4f53\u6210\u5206<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u7814\u7a76\u4eba\u5458\u8fd8\u89c2\u5bdf\u5230\u4e0e\u808c\u8089\u635f\u4f24\u76f8\u5173\u7684\u51e0\u79cd\u751f\u7269\u6807\u5fd7\u7269\u6709\u6240\u6539\u5584\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6cbb\u7597\u7ed3\u679c\u663e\u793a\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u808c\u8089\u635f\u4f24\u751f\u7269\u6807\u5fd7\u7269\u6c34\u5e73\u964d\u4f4e<\/li>\n\n\n\n<li>\u66f4\u5065\u5eb7\u7684\u808c\u8089\u7ec4\u7ec7\u7ed3\u6784<\/li>\n\n\n\n<li>\u589e\u52a0\u7626\u808c\u8089\u91cf<\/li>\n\n\n\n<li>\u51cf\u5c11\u4f53\u8102<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u5171\u540c\u8868\u660e\uff0c\u8be5\u836f\u7269\u53ef\u80fd\u6709\u52a9\u4e8e\u89e3\u51b3\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u8fdb\u5c55\u7684\u591a\u4e2a\u65b9\u9762\u3002.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"safety-findings\">\u5b89\u5168\u8c03\u67e5\u7ed3\u679c<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u52a8\u7269\u5b9e\u9a8c\u8868\u660e\uff0c\u8be5\u7597\u6cd5\u8010\u53d7\u6027\u826f\u597d\uff0c\u7814\u7a76\u4eba\u5458\u62a5\u544a\u79f0\uff0c\u6cbb\u7597\u671f\u95f4\u672a\u51fa\u73b0\u660e\u663e\u4e0d\u826f\u53cd\u5e94\u3002.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5c3d\u7ba1\u8fd9\u4e9b\u7ed3\u679c\u4ee4\u4eba\u9f13\u821e\uff0c\u4f46\u8fd9\u9879\u7814\u7a76\u4ecd\u5904\u4e8e\u4e34\u5e8a\u524d\u9636\u6bb5\uff0c\u8fd9\u610f\u5473\u7740\u5b83\u662f\u5728\u5b9e\u9a8c\u5ba4\u6a21\u578b\u4e2d\u8fdb\u884c\u7684\uff0c\u8fd8\u6ca1\u6709\u5728\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u60a3\u8005\u8eab\u4e0a\u8fdb\u884c\u3002.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-happens-next\">\u63a5\u4e0b\u6765\u4f1a\u53d1\u751f\u4ec0\u4e48\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ee4\u4eba\u9f13\u821e\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u7ed3\u679c\u652f\u6301\u5f00\u5c55\u8fdb\u4e00\u6b65\u7814\u7a76\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u540e\u7eed\u6b65\u9aa4\u53ef\u80fd\u5305\u62ec\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5176\u4ed6\u5b9e\u9a8c\u5ba4\u7814\u7a76<\/li>\n\n\n\n<li>\u5b89\u5168\u6d4b\u8bd5<\/li>\n\n\n\n<li>\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40 (FDA) \u5df2\u6388\u4e88 (Z)-endoxifen \u6cbb\u7597\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u5b64\u513f\u836f\u8d44\u683c\uff0c\u4ee5\u8868\u5f70\u5176\u5bf9\u8fd9\u79cd\u7f55\u89c1\u75be\u75c5\u65b0\u7597\u6cd5\u7684\u8feb\u5207\u9700\u6c42\u3002.<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"why-new-duchenne-treatments-are-still-needed\">\u4e3a\u4ec0\u4e48\u4ecd\u7136\u9700\u8981\u65b0\u7684\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u6cbb\u7597\u65b9\u6cd5<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u9057\u4f20\u6027\u75be\u75c5\uff0c\u7531\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u57fa\u56e0\u7a81\u53d8\u5f15\u8d77\u3002\u5b83\u4f1a\u5bfc\u81f4\u4ece\u5e7c\u513f\u65f6\u671f\u5f00\u59cb\u7684\u8fdb\u884c\u6027\u808c\u8089\u9000\u5316\u3002.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u60a3\u6709\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u513f\u7ae5\u4f1a\u9010\u6e10\u4e27\u5931\u808c\u8089\u529b\u91cf\uff0c\u8fd9\u53ef\u80fd\u5bfc\u81f4\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4e27\u5931\u884c\u8d70\u80fd\u529b<\/li>\n\n\n\n<li>\u5fc3\u810f\u5e76\u53d1\u75c7<\/li>\n\n\n\n<li><a href=\"https:\/\/dmdwarrior.com\/zh\/respiratory-health-care-in-duchenne-muscular-dystrophy\/\" target=\"_blank\" data-type=\"post\" data-id=\"6477\" rel=\"noreferrer noopener\">\u547c\u5438\u95ee\u9898<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u5c3d\u7ba1\u57fa\u56e0\u7597\u6cd5\u548c\u5916\u663e\u5b50\u8df3\u8dc3\u836f\u7269\u7b49\u6cbb\u7597\u65b9\u6cd5\u53d6\u5f97\u4e86\u8fdb\u5c55\uff0c\u4f46\u8bb8\u591a\u5bb6\u5ead\u4ecd\u7136\u9700\u8981\u989d\u5916\u7684\u6cbb\u7597\u9009\u62e9\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5173\u6ce8\u6b64\u9875\u9762<\/strong>&nbsp;&gt;&gt;&gt;&nbsp;<a href=\"https:\/\/dmdwarrior.com\/zh\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u6240\u6709\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>At the 2026 MDA Clinical &amp; Scientific Conference in Orlando, researchers from Atossa Therapeutics presented new preclinical data about (Z)-endoxifen and its potential use for Duchenne muscular dystrophy (DMD). What Is (Z)-Endoxifen? (Z)-endoxifen is a compound related to Tamoxifen and belongs to a group of medicines called Selective Estrogen Receptor Modulators (SERMs). Researchers believe it [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":6767,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[461,462,464,463],"class_list":["post-6765","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-z-endoxifen","tag-atossa-therapeutics","tag-endoxifen","tag-tamoxifen"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/6765","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=6765"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/6765\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/6767"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=6765"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=6765"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=6765"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}