{"id":6708,"date":"2026-03-09T20:07:28","date_gmt":"2026-03-09T17:07:28","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=6708"},"modified":"2026-03-09T20:09:10","modified_gmt":"2026-03-09T17:09:10","slug":"tenaya-tn-301-beats-givinostat-in-improving-dmd-muscle-function","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/tenaya-tn-301-beats-givinostat-in-improving-dmd-muscle-function\/","title":{"rendered":"Tenaya\u516c\u53f8\u7684TN-301\u5728\u6539\u5584DMD\u808c\u8089\u529f\u80fd\u65b9\u9762\u4f18\u4e8eGivinostat\u3002"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong>Tenaya Therapeutics \u5728 2026 \u5e74\u808c\u8089\u840e\u7f29\u75c7\u534f\u4f1a\u4e34\u5e8a\u4e0e\u79d1\u5b66\u4f1a\u8bae (MDA 2026) \u4e0a\u516c\u5e03\u4e86\u4ee4\u4eba\u9f13\u821e\u7684\u4e34\u5e8a\u524d\u6570\u636e\uff0c\u8bc4\u4f30\u4e86\u8be5\u516c\u53f8\u7684\u9ad8\u9009\u62e9\u6027 HDAC6 \u6291\u5236\u5242 TN-301\u3002.<\/strong> \u5728\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7 (DMD) \u7684\u4f53\u5916\u548c\u4f53\u5185\u6a21\u578b\u4e2d\uff0cTN-301 \u6539\u5584\u4e86\u808c\u8089\u529f\u80fd\uff0c\u5e76\u7ea0\u6b63\u4e86 DMD \u5fc3\u808c\u75c5\u7684\u5173\u952e\u9a71\u52a8\u56e0\u7d20\u3002.<\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u76ee\u5f55<\/h2><nav><ul><li><a href=\"#dmd-cardiomyopathy-and-muscle-degeneration\">DMD\u5fc3\u808c\u75c5\u548c\u808c\u8089\u9000\u5316<\/a><\/li><li><a href=\"#tn-301-vs-givinostat\">TN-301 \u4e0e Givinostat \u7684\u6bd4\u8f83<\/a><\/li><li><a href=\"#what-is-tn-301\">TN-301\u662f\u4ec0\u4e48\uff1f<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>TN-301 \u662f Tenaya \u516c\u53f8\u7814\u53d1\u7684\u4e00\u79cd\u5f3a\u6548\u4e14\u9ad8\u5ea6\u9009\u62e9\u6027\u7684\u5c0f\u5206\u5b50 HDAC6 \u6291\u5236\u5242\uff0c\u5177\u6709\u591a\u6a21\u5f0f\u4f5c\u7528\u673a\u5236\uff0c\u5305\u62ec\u51cf\u5c11\u708e\u75c7\u3001\u4ee3\u8c22\u548c\u7ebf\u7c92\u4f53\u5931\u8c03\u4ee5\u53ca\u7ea4\u7ef4\u5316\uff0c\u5e76\u6539\u5584\u81ea\u566c\uff0c\u8fd9\u53ef\u80fd\u5bf9\u7f55\u89c1\u6216\u5e38\u89c1\u7684\u5fc3\u810f\u3001\u4ee3\u8c22\u3001\u808c\u8089\u548c\u80ba\u90e8\u75be\u75c5\u5177\u6709\u6f5c\u5728\u76ca\u5904\u3002.<\/strong> \u5728\u4e00\u9879\u9488\u5bf9\u5065\u5eb7\u6210\u5e74\u4eba\u7684 I \u671f\u5b89\u5168\u6027\u7814\u7a76\u4e2d\uff0cTN-301 \u5728\u8f83\u5bbd\u7684\u5242\u91cf\u8303\u56f4\u5185\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\uff0c\u672a\u51fa\u73b0\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u6216\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\u3002\u57fa\u4e8e\u6b64\uff0cTenaya \u516c\u53f8\u5df2\u786e\u5b9a\u4e86\u51e0\u4e2a\u6f5c\u5728\u7684\u9002\u5e94\u75c7\uff0c\u8fd9\u4e9b\u9002\u5e94\u75c7\u4e5f\u5f97\u5230\u4e86\u8be5\u516c\u53f8\u6b64\u524d\u53d1\u8868\u7684\u5173\u4e8e\u5c04\u8840\u5206\u6570\u4fdd\u7559\u578b\u5fc3\u529b\u8870\u7aed (HFpEF) \u548c\u9057\u4f20\u6027\u6269\u5f20\u578b\u5fc3\u808c\u75c5\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u7ed3\u679c\u7684\u652f\u6301\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"dmd-cardiomyopathy-and-muscle-degeneration\">DMD\u5fc3\u808c\u75c5\u548c\u808c\u8089\u9000\u5316<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4eca\u5929\u5728 MDA 2026 \u4e0a\u7684\u6f14\u8bb2\u8fdb\u4e00\u6b65\u4e30\u5bcc\u4e86\u8fd9\u9879\u7814\u7a76\uff0c\u7a81\u51fa\u4e86 TN-301 \u5728 DMD \u5fc3\u808c\u75c5\u548c\u808c\u8089\u9000\u5316\u65b9\u9762\u7684\u6f5c\u529b\u3002.<\/strong> Tenaya \u8ba1\u5212\u63a8\u8fdb TN-301 \u5728\u60a3\u8005\u8eab\u4e0a\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u76ee\u524d\u5df2\u786e\u5b9a\u7684\u6700\u6709\u5e0c\u671b\u7684\u6f5c\u5728\u9002\u5e94\u75c7\u5305\u62ec HFpEF \u548c DMD\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cDMD\u76f8\u5173\u5fc3\u808c\u75c5\u662fDMD\u60a3\u8005\u6700\u5e38\u89c1\u7684\u6b7b\u4ea1\u539f\u56e0\uff0c\u5c3d\u7ba1\u6cbb\u7597\u65b9\u9762\u53d6\u5f97\u4e86\u8fdb\u5c55\uff0c\u4f46\u76ee\u524d\u4ecd\u8feb\u5207\u9700\u8981\u80fd\u591f\u540c\u65f6\u89e3\u51b3\u9aa8\u9abc\u808c\u840e\u7f29\u548c\u5fc3\u810f\u529f\u80fd\u8870\u9000\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u201dTenaya Therapeutics\u516c\u53f8\u9ad8\u7ea7\u526f\u603b\u88c1\u517c\u7814\u53d1\u8d1f\u8d23\u4ebaKathy Ivey\u535a\u58eb\u8868\u793a\u3002\u201c\u6211\u4eec\u8ba4\u8bc6\u5230\uff0cDMD\u76f8\u5173\u5fc3\u808c\u75c5\u548c\u9aa8\u9abc\u808c\u9000\u5316\u7684\u8bb8\u591a\u9a71\u52a8\u56e0\u7d20\u4e0eTN-301\u7684\u591a\u6a21\u5f0f\u4f5c\u7528\u673a\u5236\u76f8\u543b\u5408\uff0c\u56e0\u6b64\u6211\u4eec\u5f00\u5c55\u4e86\u4e00\u7cfb\u5217\u7814\u7a76\uff0c\u53d1\u73b0TN-301\u7684\u7597\u6548\u4f18\u4e8e\u5df2\u83b7\u6279\u51c6\u7684\u836f\u7269givinostat\uff0c\u5b83\u4e0d\u4ec5\u80fd\u591f\u6539\u5584mdx\u5c0f\u9f20\u7684\u529f\u80fd\uff0c\u4f7f\u5176\u808c\u8089\u529f\u80fd\u6062\u590d\u5230\u91ce\u751f\u578b\u6c34\u5e73\uff0c\u8fd8\u80fd\u7ea0\u6b63DMD\u76f8\u5173\u5fc3\u808c\u7ec6\u80de\u7684\u5173\u952e\u7f3a\u9677\u3002\u2019<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6cdb HDAC \u6291\u5236\u5242 givinostat \u5df2\u5728\u7f8e\u56fd\u548c\u6b27\u76df\u83b7\u51c6\u7528\u4e8e\u6cbb\u7597 DMD\uff0c\u5e76\u4e14\u5df2\u8bc1\u660e\u53ef\u4ee5\u51cf\u7f13 DMD \u60a3\u8005\u7684\u9aa8\u9abc\u808c\u8870\u9000\uff0c\u8fd9\u5df2\u901a\u8fc7 4 \u7ea7\u722c\u697c\u68af (4SC) \u548c\u5317\u6781\u661f\u6b65\u884c\u8bc4\u4f30 (NSAA) \u7684\u4e34\u5e8a\u7ed3\u679c\u5f97\u5230\u8bc1\u5b9e\u3002. <strong>\u7136\u800c\uff0c\u5176\u4f7f\u7528\u53d7\u5230\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u7b49\u526f\u4f5c\u7528\u4ee5\u53ca QT \u95f4\u671f\u5ef6\u957f\u98ce\u9669\u7684\u9650\u5236\u2014\u2014\u8fd9\u4e9b\u526f\u4f5c\u7528\u5728 TN-301 \u7684 1 \u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u5e76\u672a\u89c2\u5bdf\u5230\u3002.<\/strong> \u4e3a\u4e86\u9a8c\u8bc1TN-301\u662f\u5426\u80fd\u591f\u5ef6\u7f13\u6216\u9006\u8f6cDMD\u60a3\u8005\u7684\u9aa8\u9abc\u808c\u75c5\u53d8\u548c\u5fc3\u808c\u75c5\u53d8\uff0cTenaya\u516c\u53f8\u7684\u7814\u7a76\u4eba\u5458\u5f00\u5c55\u4e86TN-301\u4e0egivinostat\u7684\u5bf9\u6bd4\u7814\u7a76\u3002\u57282026\u5e74MDA\u5927\u4f1a\u4e0a\u516c\u5e03\u7684\u4e3b\u8981\u7814\u7a76\u7ed3\u679c\u5305\u62ec\uff1a<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"tn-301-vs-givinostat\">TN-301 \u4e0e Givinostat \u7684\u6bd4\u8f83<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>TN-301 \u6cbb\u7597\u5242\u91cf\u4f4e\u81f3 3 mg\/kg\uff0c\u53ef\u5728\u4e94\u5468\u5185\u5c06\u63e1\u529b\u63d0\u9ad8\u5230\u91ce\u751f\u578b\u6c34\u5e73\uff0c\u800c\u63a5\u53d7 givinostat\uff0810 mg\/kg\uff0c\u63a5\u8fd1\u4e34\u5e8a\u66b4\u9732\u91cf\uff09\u6cbb\u7597\u7684 mdx \u5c0f\u9f20\u672a\u80fd\u8fbe\u5230\u91ce\u751f\u578b\u6c34\u5e73\u3002.<\/strong><\/li>\n\n\n\n<li>TN-301 \u4ecb\u5bfc\u7684\u529f\u80fd\u6539\u5584\u4f34\u968f\u7740\u5faa\u73af\u808c\u9178\u6fc0\u9176\u6d3b\u6027\u7684\u964d\u4f4e\u548c\u57fa\u56e0\u8868\u8fbe\u7684\u6709\u5229\u53d8\u5316\uff0c\u8868\u660e\u808c\u8089\u7ec6\u80de\u635f\u4f24\u51cf\u5c11\u3002.<\/li>\n\n\n\n<li><strong>\u5728\u6e90\u81ea\u4eba\u7c7b DMD \u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\u7684\u5fc3\u808c\u7ec6\u80de\u4e2d\uff0cTN-301 \u7ea0\u6b63\u4e86\u9499\u5904\u7406\u5f02\u5e38\u548c\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\uff0c\u800c givinostat \u5219\u52a0\u5267\u4e86\u8fd9\u4e9b\u5df2\u786e\u5b9a\u7684 DMD \u5fc3\u808c\u75c5\u9a71\u52a8\u56e0\u7d20\u3002.<\/strong><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u4e9b\u79ef\u6781\u7684\u4e34\u5e8a\u524d\u6570\u636e\uff0c\u4ee5\u53ca\u5176\u4ed6\u4f7f\u7528 HDAC6 \u6291\u5236\u5242\u6cbb\u7597 DMD \u75be\u75c5\u6a21\u578b\u7684\u7814\u7a76\u6570\u636e\uff0c\u5171\u540c\u8868\u660e HDAC6 \u6291\u5236\u53ef\u80fd\u662f\u8fc4\u4eca\u4e3a\u6b62\u5728 DMD \u4e34\u5e8a\u7814\u7a76\u4e2d\u89c2\u5bdf\u5230\u7684\u6cdb HDAC \u6291\u5236\u5242\u7597\u6548\u7684\u4e3b\u8981\u9a71\u52a8\u56e0\u7d20\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-is-tn-301\">TN-301\u662f\u4ec0\u4e48\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">TN-301 \u662f Tenaya \u516c\u53f8\u7814\u53d1\u7684\u4e00\u79cd\u9ad8\u5ea6\u7279\u5f02\u6027\u7684\u5c0f\u5206\u5b50\u7ec4\u86cb\u767d\u53bb\u4e59\u9170\u5316\u9176 (HDAC) 6 \u6291\u5236\u5242\uff0c\u5df2\u663e\u793a\u51fa\u5728\u6cbb\u7597\u5c04\u8840\u5206\u6570\u4fdd\u7559\u7684\u5fc3\u529b\u8870\u7aed (HFpEF) \u548c\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7 (DMD) \u65b9\u9762\u5177\u6709\u826f\u597d\u7684\u4e34\u5e8a\u524d\u6f5c\u529b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u4e00\u9879\u9488\u5bf9\u5065\u5eb7\u5fd7\u613f\u8005\u7684 I \u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0cTN-301 \u5728\u6240\u7814\u7a76\u7684\u5e7f\u6cdb\u5242\u91cf\u8303\u56f4\u5185\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\uff0c\u5176\u836f\u4ee3\u52a8\u529b\u5b66\u5448\u5242\u91cf\u4f9d\u8d56\u6027\uff0c\u534a\u8870\u671f\u652f\u6301\u6bcf\u65e5\u4e00\u6b21\u7ed9\u836f\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cTN-301 \u672a\u5f15\u8d77\u7ec4\u86cb\u767d\u4e59\u9170\u5316\u6c34\u5e73\u7684\u53d8\u5316\uff0c\u8fd9\u51f8\u663e\u4e86 TN-301 \u5bf9 HDAC6 \u7684\u9009\u62e9\u6027\u6bd4\u5176\u4ed6 HDAC \u9ad8\u51fa 3000 \u500d\u4ee5\u4e0a\uff0c\u5e76\u652f\u6301\u5176\u907f\u514d\u4f7f\u7528\u9009\u62e9\u6027\u8f83\u4f4e\u7684 HDAC6 \u6291\u5236\u5242\u6216\u6cdb HDAC \u6291\u5236\u5242\u65f6\u89c2\u5bdf\u5230\u7684\u8131\u9776\u6548\u5e94\u7684\u6f5c\u529b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">HDAC6 \u6291\u5236\u5242\u901a\u8fc7\u6539\u53d8\u7ec6\u80de\u9aa8\u67b6\u548c\u5176\u4ed6\u86cb\u767d\u8d28\u6765\u534f\u8c03\u7ec6\u80de\u8fc7\u7a0b\uff0c\u4ece\u800c\u53d1\u6325\u5176\u5bf9\u5fc3\u810f\u548c\u8eab\u4f53\u5176\u4ed6\u5668\u5b98\u7684\u76ca\u5904\uff0c\u5176\u4f5c\u7528\u673a\u5236\u662f\u591a\u6a21\u5f0f\u7684\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\uff0cTenaya \u7684 HDAC6 \u6291\u5236\u5242\u5df2\u88ab\u8bc1\u5b9e\u80fd\u591f\u51cf\u8f7b\u708e\u75c7\u3001\u6c27\u5316\u5e94\u6fc0\u3001\u7ea4\u7ef4\u5316\u548c\u4ee3\u8c22\u7d0a\u4e71\uff0c\u5e76\u6539\u5584\u81ea\u566c\u3001\u86cb\u767d\u8d28\u8d28\u91cf\u63a7\u5236\u3001\u7ebf\u7c92\u4f53\u4ee3\u8c22\u548c\u8102\u8d28\u4ee3\u8c22\u3002Tenaya \u81f4\u529b\u4e8e\u63a2\u7d22\u5c06 TN-301 \u63a8\u8fdb\u81f3\u4e34\u5e8a\u7814\u7a76\u7684\u673a\u4f1a\uff0c\u4ee5\u6cbb\u7597\u5fc3\u810f\u3001\u4ee3\u8c22\u3001\u808c\u8089\u6216\u80ba\u90e8\u75be\u75c5\u60a3\u8005\uff0c\u5c24\u5176\u5173\u6ce8 HDAC6 \u6291\u5236\u6d3b\u6027\u4e0e\u75be\u75c5\u75c5\u7406\u751f\u7406\u673a\u5236\u9ad8\u5ea6\u5951\u5408\u7684\u75be\u75c5\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5173\u6ce8\u6b64\u9875\u9762<\/strong>&nbsp;&gt;&gt;&gt;&nbsp;<a href=\"https:\/\/dmdwarrior.com\/zh\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u6240\u6709\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Tenaya Therapeutics presented encouraging preclinical data evaluating TN-301, the company\u2019s highly selective HDAC6 inhibitor, at the Muscular Dystrophy Association\u2019s Clinical &amp; Scientific Conference 2026 (MDA 2026). In in vitro and in vivo models of Duchenne muscular dystrophy (DMD), TN-301 improved muscle performance and corrected key drivers of DMD cardiomyopathy. TN-301 is Tenaya\u2019s potent and highly [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":6710,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[362,46,47,521,519,520],"class_list":["post-6708","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-dmd-cardiomyopathy","tag-duvyzat","tag-givinostat","tag-muscle-degeneration","tag-tenaya","tag-tn-301"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/6708","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=6708"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/6708\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/6710"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=6708"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=6708"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=6708"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}