{"id":6211,"date":"2026-02-17T15:37:49","date_gmt":"2026-02-17T12:37:49","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=6211"},"modified":"2026-02-17T15:39:39","modified_gmt":"2026-02-17T12:39:39","slug":"data-monitoring-committee-recommended-initiating-an-increased-dose-for-group-2-in-entrada-therapeutics-exon-44-skipping-study","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/data-monitoring-committee-recommended-initiating-an-increased-dose-for-group-2-in-entrada-therapeutics-exon-44-skipping-study\/","title":{"rendered":"\u6570\u636e\u76d1\u6d4b\u59d4\u5458\u4f1a\u5efa\u8bae\u5728 Entrada&#039; \u5916\u663e\u5b50 44 \u8df3\u8dc3\u7814\u7a76\u4e2d\uff0c\u5bf9\u7b2c 2 \u7ec4\u60a3\u8005\u542f\u52a8\u589e\u52a0\u5242\u91cf\u6cbb\u7597"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong>Entrada Therapeutics \u5ba3\u5e03\uff0c\u6839\u636e\u7814\u7a76\u65b9\u6848\uff0c\u72ec\u7acb\u7684\u6570\u636e\u76d1\u6d4b\u59d4\u5458\u4f1a (DMC) \u5df2\u5ba1\u67e5\u4e86 ELEVATE-44-201 \u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u591a\u6b21\u9012\u589e\u5242\u91cf (MAD) \u90e8\u5206\u961f\u5217 1 \u4e2d\u5b8c\u6210\u7ed9\u836f\u7684 8 \u540d\u60a3\u8005\u7684\u6240\u6709\u53ef\u7528\u5b89\u5168\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u6570\u636e\u3002.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u5efa\u8bae\u589e\u52a0\u5242\u91cf\u662f\u7597\u6548\u79ef\u6781\u7684\u6807\u5fd7\u3002<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u201c\u6211\u4eec\u5f88\u9ad8\u5174\uff0c\u5728\u5ba1\u67e5\u4e86\u6211\u4eec ELEVATE-44-201 \u7814\u7a76\u7684 Cohort 1 \u6570\u636e\u540e\uff0c\u72ec\u7acb\u6570\u636e\u76d1\u6d4b\u59d4\u5458\u4f1a\u652f\u6301\u4ee5 12 mg\/kg \u7684\u5242\u91cf\u542f\u52a8 Cohort 2 \u7ed9\u836f\uff0c\u201dEntrada Therapeutics \u7814\u53d1\u603b\u88c1 Natarajan Sethuraman \u535a\u58eb\u8bf4\u3002. <strong>\u201c\u7531\u4e8e Entrada \u7684\u6240\u6709\u795e\u7ecf\u808c\u8089\u6cbb\u7597\u65b9\u6848\u90fd\u5229\u7528\u4e86\u76f8\u540c\u7684\u5185\u4f53\u9003\u9038\u8f7d\u4f53\uff0c\u6211\u4eec\u76f8\u4fe1\u8fd9\u9879\u7814\u7a76\u7684\u8fdb\u5c55\u5927\u5927\u964d\u4f4e\u4e86\u6211\u4eec\u4e34\u5e8a\u9879\u76ee\u7684\u98ce\u9669\uff0c\u5e76\u6807\u5fd7\u7740\u6211\u4eec\u516c\u53f8\u4e34\u5e8a\u53d1\u5c55\u7684\u4e00\u4e2a\u91cd\u8981\u8f6c\u6298\u70b9\u3002.<\/strong> \u8bc1\u5b9e ENTR-601-44 \u5728 6 mg\/kg \u5242\u91cf\u4e0b\u5b89\u5168\u6709\u6548\uff0c\u662f\u8be5\u9879\u76ee\u7684\u4e00\u4e2a\u91cd\u8981\u91cc\u7a0b\u7891\u3002\u6211\u4eec\u9884\u8ba1\uff0c\u5728\u7b2c\u4e8c\u5b63\u5ea6\u516c\u5e03\u6570\u636e\u65f6\uff0c6 mg\/kg \u5242\u91cf\u7ec4 1 \u7684\u6570\u636e\u5c06\u663e\u793a\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u4ea7\u91cf\u8fbe\u5230\u4e24\u4f4d\u6570\u3002\u968f\u7740\u5242\u91cf\u9012\u589e\u81f3 12 mg\/kg\uff0c\u6211\u4eec\u76f8\u4fe1\uff0c\u5728\u4eca\u5e74\u665a\u4e9b\u65f6\u5019\u516c\u5e03\u7ec4 2 \u6570\u636e\u65f6\uff0c\u6211\u4eec\u5c06\u5b9e\u73b0\u540c\u7c7b\u6700\u4f73\u7684\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u6062\u590d\u6548\u679c\u3002\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">ELEVATE-44-201 \u662f\u4e00\u9879\u5168\u7403\u6027\u7684\u3001\u5206\u4e3a\u4e24\u90e8\u5206\u7684\u3001\u968f\u673a\u7684\u3001\u53cc\u76f2\u7684\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684 1\/2 \u671f\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30 ENTR-601-44 \u5728\u9002\u5408\u8fdb\u884c\u5916\u663e\u5b50 44 \u8df3\u8dc3\u6cbb\u7597\u7684 DMD \u53ef\u884c\u8d70\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u6709\u6548\u6027\u3002. <strong>\u516c\u53f8\u5df2\u5b8c\u6210\u7b2c\u4e00\u7ec4\u53d7\u8bd5\u8005MAD\u9636\u6bb5\u7684\u7ed9\u836f\uff0c\u53d7\u8bd5\u8005\u5df2\u8f6c\u5165\u7b2c\u4e8c\u9636\u6bb5\u76846\u5242\u5f00\u653e\u6807\u7b7e\u7814\u7a76\u3002\u516c\u53f8\u9884\u8ba1\u5c06\u4e8e2026\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u516c\u5e03\u7b2c\u4e00\u7ec4\uff086 mg\/kg\uff09\u7684\u6570\u636e\uff0c\u5e74\u5e95\u524d\u516c\u5e03\u7b2c\u4e8c\u7ec4\uff0812 mg\/kg\uff09\u7684\u6570\u636e\uff0c\u968f\u540e\u516c\u5e03\u7b2c\u4e09\u7ec4\uff08\u6700\u9ad8\u5242\u91cf18 mg\/kg\uff09\u7684\u6570\u636e\u3002. <\/strong>\u516c\u53f8\u8fd8\u8ba1\u5212\u5728\u4eca\u5e74\u665a\u4e9b\u65f6\u5019\u5f00\u8bbe\u4e00\u4e2a\u6269\u5c55\u961f\u5217\uff0c\u4ee5\u589e\u52a0 ELEVATE-44-201 \u7814\u7a76\u4e2d\u63a5\u53d7\u6cbb\u7597\u7684\u53c2\u4e0e\u8005\u4eba\u6570\uff0c\u56e0\u4e3a\u8fd9\u9879\u7814\u7a76\u65e8\u5728\u652f\u6301\u5728\u7f8e\u56fd\u83b7\u5f97\u52a0\u901f\u6279\u51c6\u30022025 \u5e74 12 \u6708\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40 (FDA) \u6388\u4e88 ENTR-601-44 \u7f55\u89c1\u513f\u79d1\u75be\u75c5\u8ba4\u5b9a (FDA)\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4e86\u89e3\u66f4\u591a<\/strong>:\u00a0<a href=\"https:\/\/dmdwarrior.com\/zh\/upcoming-exon-44-skipping-therapies-for-dmd\/\">\u5373\u5c06\u63a8\u51fa\u7684\u7528\u4e8e\u6cbb\u7597\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u5916\u663e\u5b5044\u8df3\u8dc3\u7597\u6cd5<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u53ef\u901a\u8fc7\u5916\u663e\u5b50 44 \u8df3\u8dc3\u7597\u6cd5\u6cbb\u7597\u7684\u7a81\u53d8\u548c\u7f3a\u5931<\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"968\" height=\"1024\" src=\"https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-968x1024.jpg\" alt=\"\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u53ef\u901a\u8fc7\u5916\u663e\u5b50 44 \u8df3\u8dc3\u7597\u6cd5\u6cbb\u7597\u7684\u7a81\u53d8\u548c\u7f3a\u5931\" class=\"wp-image-5275\" title=\"\" srcset=\"https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-968x1024.jpg 968w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-284x300.jpg 284w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-768x813.jpg 768w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-1452x1536.jpg 1452w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-11x12.jpg 11w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-397x420.jpg 397w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-150x159.jpg 150w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-300x317.jpg 300w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-696x737.jpg 696w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-1068x1130.jpg 1068w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping.jpg 1890w\" sizes=\"(max-width: 968px) 100vw, 968px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5173\u6ce8\u6b64\u9875\u9762<\/strong>\u00a0>>>\u00a0<a href=\"https:\/\/dmdwarrior.com\/zh\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u6240\u6709\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Entrada Therapeutics announced that an independent Data Monitoring Committee (DMC), per study protocol, has reviewed all available safety and PK data from the eight patients who completed dosing in Cohort 1 of the double-blinded, placebo-controlled, multiple ascending dose (MAD) portion of ELEVATE-44-201. Dose increase recommendation is an indicator of positive results \u201cWe are pleased that [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":6213,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[233,234,141,127,246],"class_list":["post-6211","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-entrada","tag-entrada-therapeutics","tag-exon-44","tag-exon-44-skipping","tag-exon-44-skipping-therapies"],"subtitle":"\u72ec\u7acb\u6570\u636e\u76d1\u6d4b\u59d4\u5458\u4f1a\u5efa\u8bae\u4ece\u7b2c 2 \u7ec4\u5f00\u59cb\uff0c\u5242\u91cf\u4e3a 12 mg\/kg\uff0c\u6bd4\u7b2c 1 \u7ec4\u7684 6 mg\/kg \u5242\u91cf\u9012\u589e\u3002ELEVATE-44-201 \u662f\u4e00\u9879 1\/2 \u671f MAD \u4e34\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30 ENTR-601-44 \u6cbb\u7597\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7 (DMD) \u7684\u6f5c\u5728\u7597\u6548\uff0c\u7814\u7a76\u5bf9\u8c61\u4e3a\u5df2\u786e\u8bca DMD \u57fa\u56e0\u7a81\u53d8\u4e14\u9002\u5408\u8fdb\u884c\u5916\u663e\u5b50 44 \u8df3\u8dc3\u7684\u60a3\u8005\u3002.","_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/6211","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=6211"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/6211\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/6213"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=6211"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=6211"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=6211"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}