{"id":5450,"date":"2026-01-08T22:29:00","date_gmt":"2026-01-08T19:29:00","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=5450"},"modified":"2026-01-09T09:46:48","modified_gmt":"2026-01-09T06:46:48","slug":"entrada-therapeutics-announced-company-will-report-data-from-its-exon-skipping-studies-in-2026","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/entrada-therapeutics-announced-company-will-report-data-from-its-exon-skipping-studies-in-2026\/","title":{"rendered":"Entrada Therapeutics\u516c\u53f8\u5ba3\u5e03\u5c06\u4e8e2026\u5e74\u516c\u5e03\u5176\u5916\u663e\u5b50\u8df3\u8dc3\u7814\u7a76\u7684\u6570\u636e\u3002"},"content":{"rendered":"<p class=\"wp-block-paragraph\">\u6839\u636e Entrada Therapeutics \u7684\u516c\u544a\uff0c\u20192026 \u5e74\u5c06\u662f\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u6570\u636e\u4e30\u5bcc\u7684\u4e00\u5e74\uff1bELEVATE-44-201 \u7b2c\u4e00\u6279\u961f\u5217\u7684\u6570\u636e\u9884\u8ba1\u5c06\u4e8e 2026 \u5e74\u7b2c\u4e8c\u5b63\u5ea6\u53d1\u5e03\uff0cELEVATE-45-201 \u7684\u6570\u636e\u9884\u8ba1\u5c06\u4e8e 2026 \u5e74\u5e74\u4e2d\u53d1\u5e03\u3002\u201c<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ELEVATE-44-201\uff1a<\/strong> \u516c\u53f8\u5df2\u5b8c\u6210\u9488\u5bf9\u9002\u5408\u63a5\u53d744\u53f7\u5916\u663e\u5b50\u8df3\u8dc3\u7597\u6cd5\u7684DMD\u53ef\u6d3b\u52a8\u60a3\u8005\u7684ENTR-601-44\u5168\u74031\/2\u671f\u591a\u5242\u91cf\u9012\u589e\uff08MAD\uff09\u4e34\u5e8a\u7814\u7a76\u7684\u7b2c\u4e00\u7ec4\u60a3\u8005\u7684\u7ed9\u836f\uff0c\u5e76\u5df2\u8f6c\u5165\u8be5\u7814\u7a76\u7684\u5f00\u653e\u6807\u7b7e2\u671f\u90e8\u5206\u3002\u516c\u53f8\u9884\u8ba1\u5c06\u4e8e2026\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u516c\u5e03\u7b2c\u4e00\u7ec4\uff086 mg\/kg\uff09\u7684\u6570\u636e\uff0c\u5e74\u5e95\u524d\u516c\u5e03\u7b2c\u4e8c\u7ec4\uff08\u6700\u9ad8\u5242\u91cf12 mg\/kg\uff09\u7684\u6570\u636e\uff0c\u968f\u540e\u516c\u5e03\u7b2c\u4e09\u7ec4\uff08\u6700\u9ad8\u5242\u91cf18 mg\/kg\uff09\u7684\u6570\u636e\u30022025\u5e7412\u6708\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\uff08FDA\uff09\u6388\u4e88ENTR-601-44\u7f55\u89c1\u513f\u79d1\u75be\u75c5\u8ba4\u5b9a\u3002. <strong>\u4e86\u89e3\u66f4\u591a\uff1a<\/strong> <a href=\"https:\/\/dmdwarrior.com\/zh\/mutations-and-deletions-amenable-to-exon-44-skipping-therapies-dmd\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u53ef\u901a\u8fc7\u5916\u663e\u5b5044\u8df3\u8dc3\u7597\u6cd5\u6cbb\u7597\u7684\u7f3a\u5931<\/a><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ELEVATE-44-102\uff1a<\/strong> \u516c\u53f8\u9884\u8ba1\u5c06\u4e8e 2026 \u5e74\u4e0a\u534a\u5e74\u5728\u7f8e\u56fd\u542f\u52a8\u4e00\u9879\u9488\u5bf9\u60a3\u6709 DMD \u7684\u53ef\u884c\u8d70\u548c\u975e\u53ef\u884c\u8d70\u6210\u5e74\u4eba\u7684 1b \u671f MAD \u4e34\u5e8a\u7814\u7a76\u3002.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ELEVATE-45-201\uff1a<\/strong> \u516c\u53f8\u5df2\u542f\u52a8ENTR-601-45\u5168\u74031\/2\u671f\u591a\u5242\u91cf\u9012\u589e\uff08MAD\uff09\u4e34\u5e8a\u7814\u7a76\u7684\u60a3\u8005\u7ed9\u836f\u9636\u6bb5\uff0c\u8be5\u7814\u7a76\u9488\u5bf9\u7684\u662f\u9002\u5408\u63a5\u53d745\u53f7\u5916\u663e\u5b50\u8df3\u8dc3\u7597\u6cd5\u7684\u3001\u53ef\u72ec\u7acb\u884c\u8d70\u7684\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff08DMD\uff09\u60a3\u8005\u3002\u516c\u53f8\u9884\u8ba1\u5c06\u4e8e2026\u5e74\u4e2d\u671f\u516c\u5e03\u7b2c\u4e00\u7ec4\uff085 mg\/kg\uff09\u7684\u6570\u636e\uff0c\u968f\u540e\u5c06\u516c\u5e03\u7b2c\u4e8c\u7ec4\u548c\u7b2c\u4e09\u7ec4\uff08\u5206\u522b\u6700\u9ad8\u5242\u91cf\u4e3a10 mg\/kg\u548c15 mg\/kg\uff09\u7684\u6570\u636e\u3002. <strong>\u4e86\u89e3\u66f4\u591a\uff1a<\/strong> <a href=\"https:\/\/dmdwarrior.com\/zh\/mutations-amenable-to-exon-45-skipping\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u54ea\u4e9b\u7a81\u53d8\u9002\u5408\u5916\u663e\u5b50 45 \u8df3\u8dc3\uff1f<\/a><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ELEVATE-50-201\uff1a<\/strong> \u516c\u53f8\u5df2\u83b7\u5f97\u82f1\u56fd\u836f\u54c1\u548c\u4fdd\u5065\u4ea7\u54c1\u76d1\u7ba1\u5c40 (MHRA) \u548c\u7814\u7a76\u4f26\u7406\u59d4\u5458\u4f1a\u7684\u76d1\u7ba1\u6279\u51c6\uff0c\u542f\u52a8\u4e00\u9879\u9488\u5bf9\u9002\u5408\u63a5\u53d7\u5916\u663e\u5b50 50 \u8df3\u8dc3\u624b\u672f\u7684\u3001\u53ef\u72ec\u7acb\u884c\u8d70\u7684\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7 (DMD) \u60a3\u8005\u7684 ENTR-601-50 \u7684 1\/2 \u671f\u591a\u5b66\u79d1\u8054\u5408\u7814\u7a76 (MAD) \u4e34\u5e8a\u7814\u7a76\u3002\u516c\u53f8\u9884\u8ba1\u5c06\u4e8e 2026 \u5e74\u4e0b\u534a\u5e74\u5411\u6b27\u76df\u63d0\u4ea4 ENTR-601-50 \u7684\u76d1\u7ba1\u7533\u8bf7\uff0c\u5e76\u4e8e 2026 \u5e74\u5e95\u524d\u542f\u52a8\u8be5\u7814\u7a76\u3002. <strong>\u4e86\u89e3\u66f4\u591a\uff1a<\/strong> <a href=\"https:\/\/dmdwarrior.com\/zh\/mutations-amenable-to-exon-50-skipping\/\">\u53ef\u901a\u8fc7\u5916\u663e\u5b5050\u8df3\u8dc3\u7597\u6cd5\u6cbb\u7597\u7684\u7f3a\u5931<\/a><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ENTR-601-51\uff1a<\/strong> \u516c\u53f8\u9884\u8ba1\u5c06\u4e8e2026\u5e74\u63d0\u4ea4ENTR-601-51\u7684\u5168\u7403\u76d1\u7ba1\u7533\u8bf7\u3002\u4e86\u89e3\u66f4\u591a\uff1a <a href=\"https:\/\/dmdwarrior.com\/zh\/mutations-and-deletions-amenable-to-exon-51-skipping-therapies-dmd\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u53ef\u901a\u8fc7\u5916\u663e\u5b5051\u8df3\u8dc3\u7597\u6cd5\u6cbb\u7597\u7684\u7f3a\u5931<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u9605\u8bfb\u66f4\u591a<\/strong>:&nbsp;<a href=\"https:\/\/dmdwarrior.com\/zh\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u4e34\u5e8a\u8bd5\u9a8c\uff08\u6240\u6709\u7814\u7a76\u5217\u8868\uff09<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>\u6839\u636e Entrada Therapeutics \u7684\u516c\u544a\uff0c\u20192026 \u5e74\u5c06\u662f\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u6570\u636e\u4e30\u5bcc\u7684\u4e00\u5e74\uff1bELEVATE-44-201 \u7684\u9996\u6279\u961f\u5217\u6570\u636e\u9884\u8ba1\u5c06\u4e8e 2026 \u5e74\u7b2c\u4e8c\u5b63\u5ea6\u53d1\u5e03\uff0cELEVATE-45-201 \u7684\u6570\u636e\u9884\u8ba1\u5c06\u4e8e 2026 \u5e74\u5e74\u4e2d\u53d1\u5e03\u3002\u201c \u9605\u8bfb\u66f4\u591a\uff1a\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u4e34\u5e8a\u8bd5\u9a8c\uff08\u6240\u6709\u7814\u7a76\u5217\u8868\uff09<\/p>","protected":false},"author":1,"featured_media":5452,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[242,233,234,246,319,475,421],"class_list":["post-5450","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-clinical-trials","tag-entrada","tag-entrada-therapeutics","tag-exon-44-skipping-therapies","tag-exon-45-skipping-therapy","tag-exon-50-skipping-therapy","tag-exon-51-skipping-therapy"],"subtitle":"Entrada Therapeutic \u8ba1\u5212\u4e8e 2026 \u5e74\u516c\u5e03\u5916\u663e\u5b50 44\u300145\u300150 \u548c 51 \u8df3\u8dc3\u7597\u6cd5\u7684\u7814\u7a76\u7ed3\u679c\u3002.","_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/5450","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=5450"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/5450\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/5452"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=5450"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=5450"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=5450"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}