{"id":5295,"date":"2025-12-08T16:05:39","date_gmt":"2025-12-08T13:05:39","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=5295"},"modified":"2025-12-08T16:08:05","modified_gmt":"2025-12-08T13:08:05","slug":"dyne-therapeutics-to-apply-for-accelerated-approval-in-q2-2026-for-exon-51-skipping-therapy-dyne-251-z-rostudirsen","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/dyne-therapeutics-to-apply-for-accelerated-approval-in-q2-2026-for-exon-51-skipping-therapy-dyne-251-z-rostudirsen\/","title":{"rendered":"Dyne Therapeutics \u5c06\u4e8e 2026 \u5e74\u7b2c\u4e8c\u5b63\u5ea6\u7533\u8bf7\u52a0\u901f\u5ba1\u6279\uff0c\u7528\u4e8e\u5916\u663e\u5b50 51 \u8df3\u8dc3\u7597\u6cd5 (DYNE-251)"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Dyne Therapeutics \u516c\u5e03\u4e86\u5176 1\/2 \u671f DELIVER \u8bd5\u9a8c\u6ce8\u518c\u6269\u5c55\u961f\u5217 (REC) \u7684\u79ef\u6781\u9876\u7ebf\u7ed3\u679c\uff0c\u8be5\u8bd5\u9a8c\u8bc4\u4f30\u4e86 zeleciment rostudirsen (z-rostudirsen\uff0c\u4e5f\u79f0\u4e3a DYNE-251) \u5bf9\u9002\u5408\u5916\u663e\u5b50 51 \u8df3\u8dc3\u6cbb\u7597\u7684\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7 (DMD) \u60a3\u8005\u7684\u7597\u6548\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7acb\u5373\u53d1\u73b0\uff1a<\/strong> <a href=\"https:\/\/dmdwarrior.com\/zh\/mutations-and-deletions-amenable-to-exon-51-skipping-therapies-dmd\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u9002\u5408\u5916\u663e\u5b50 51 \u8df3\u8dc3\u7597\u6cd5\u7684\u7a81\u53d8\u548c\u7f3a\u5931<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">DYNE-251\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6ce8\u518c\u6269\u5c55\u961f\u5217\uff08REC\uff09\u8fbe\u5230\u4e86\u4e3b\u8981\u7ec8\u70b9\uff0c\u5728 6 \u4e2a\u6708\u65f6\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u663e\u8457\u589e\u52a0\u81f3 5.46%\uff08\u808c\u8089\u542b\u91cf\u8c03\u6574\u540e\uff1bp&lt;0.0001\uff09\uff0c\u4e0e\u4e4b\u524d\u5728\u6ce8\u518c\u5242\u91cf\u4e0b\u89c2\u5bdf\u5230\u7684\u57fa\u7ebf 7 \u500d\u53d8\u5316\u76f8\u540c \u2013<\/li>\n\n\n\n<li><strong>\u5728REC\u7ec4\u4e2d\uff0c6\u4e2a\u6708\u65f6\u591a\u4e2a\u4e34\u5e8a\u7ec8\u70b9\u6307\u6807\u5747\u89c2\u5bdf\u5230\u529f\u80fd\u6539\u5584\uff1b6\u4e2a\u6708\u65f6\u80ba\u529f\u80fd\u4fdd\u6301\u826f\u597d\u2014\u2014<\/strong><\/li>\n\n\n\n<li>DELIVER\u8bd5\u9a8c\u7684\u6700\u65b0\u79ef\u6781\u957f\u671f\u7ed3\u679c\u663e\u793a\uff0c\u572824\u4e2a\u6708\u5185\uff0c\u6240\u6709\u8bc4\u4f30\u7ec8\u70b9\u7684\u529f\u80fd\u5747\u6301\u7eed\u6539\u5584\u2014\u2014<\/li>\n\n\n\n<li><strong>\u6301\u7eed\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u2014\u2014<\/strong><\/li>\n\n\n\n<li>\u9884\u8ba12026\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u5c06\u5411\u7f8e\u56fd\u63d0\u4ea4\u52a0\u901f\u5ba1\u6279\u7533\u8bf7\u2014\u2014<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5173\u6ce8\u6b64\u9875\u9762<\/strong>&nbsp;&gt;&gt;&gt;&nbsp;<a href=\"https:\/\/dmdwarrior.com\/zh\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u6240\u6709\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Dyne Therapeutics announced positive topline results from the Registrational Expansion Cohort (REC) of its Phase 1\/2 DELIVER trial evaluating zeleciment rostudirsen (z-rostudirsen, also known as DYNE-251) in individuals with Duchenne muscular dystrophy (DMD) amenable to exon 51 skipping. Discover Now: Mutations and Deletions Amenable to Exon 51 Skipping Therapies Results of DYNE-251 Clinical Trial Follow [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":5297,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[143,208,145,122,193,421,194,460],"class_list":["post-5295","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-dyne","tag-dyne-therapeutics","tag-dyne-251","tag-exon-51","tag-exon-51-skipping","tag-exon-51-skipping-therapy","tag-exon-51-treatment","tag-z-rostudirsen"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/5295","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=5295"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/5295\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/5297"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=5295"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=5295"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=5295"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}