{"id":5285,"date":"2025-12-03T17:41:43","date_gmt":"2025-12-03T14:41:43","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=5285"},"modified":"2025-12-03T17:52:01","modified_gmt":"2025-12-03T14:52:01","slug":"capricor-therapeutics-announces-positive-topline-results","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/capricor-therapeutics-announces-positive-topline-results\/","title":{"rendered":"Capricor Therapeutics\u516c\u53f8\u516c\u5e03Deramiocel\u6cbb\u7597\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u5173\u952e\u60273\u671fHOPE-3\u7814\u7a76\u7684\u79ef\u6781\u9876\u7ebf\u7ed3\u679c"},"content":{"rendered":"

HOPE-3 \u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684 III \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30 Deramiocel \u6cbb\u7597\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7537\u5b69\u548c\u5e74\u8f7b\u7537\u6027\u7684\u7597\u6548\u3002\u8be5\u7814\u7a76\u5728\u7f8e\u56fd 20 \u4e2a\u9886\u5148\u7684\u4e34\u5e8a\u4e2d\u5fc3\u968f\u673a\u7eb3\u5165\u4e86 106 \u540d\u53d7\u8bd5\u8005\u3002\u53d7\u8bd5\u8005\u6bcf\u4e09\u4e2a\u6708\u63a5\u53d7\u4e00\u6b21\u9759\u8109\u6ce8\u5c04 Deramiocel\uff08\u6bcf\u6b21\u8f93\u6ce8 1.5 \u4ebf\u4e2a\u7ec6\u80de\uff09\u6216\u5b89\u6170\u5242\uff0c\u7597\u7a0b\u4e3a 12 \u4e2a\u6708\u3002.<\/p>\n\n\n\n

\u53c2\u4e0e\u8005\u7684\u5e73\u5747\u5e74\u9f84\u7ea6\u4e3a15\u5c81\uff0c\u6240\u6709\u53c2\u4e0e\u8005\u5728\u6574\u4e2a\u7814\u7a76\u671f\u95f4\u5747\u63a5\u53d7\u7a33\u5b9a\u7684\u76ae\u8d28\u7c7b\u56fa\u9187\u6cbb\u7597\u65b9\u6848\u3002\u5404\u6cbb\u7597\u7ec4\u7684\u57fa\u7ebf\u4eba\u53e3\u7edf\u8ba1\u5b66\u7279\u5f81\u5747\u8861\uff0c\u7ea690%\u7684\u53c2\u4e0e\u8005\u5728\u57fa\u7ebf\u65f6\u6b63\u5728\u670d\u7528\u5fc3\u810f\u836f\u7269\uff0c\u8d85\u8fc775%\u7684\u53c2\u4e0e\u8005\u6709\u5fc3\u808c\u75c5\u7684\u4e34\u5e8a\u8bca\u65ad\u3002Deramiocel\u4fdd\u6301\u4e86\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u4e0e\u65e2\u5f80\u4e34\u5e8a\u7ecf\u9a8c\u4e00\u81f4\u3002\u00a0\u4ec0\u4e48\u662f Deramiocel\uff1fCAP-1002 \u6709\u4ec0\u4e48\u4f5c\u7528\uff1f<\/a><\/p>\n\n\n\n

\u521d\u6b65\u7597\u6548\u7ed3\u679c<\/h2>\n\n\n\n
\u7aef\u70b9<\/strong><\/td>% \u8fdb\u5c55\u51cf\u7f13<\/strong>3<\/strong><\/sup>
\uff08Deramiocel \u4e0e\u5b89\u6170\u5242\u5bf9\u6bd4\uff09<\/strong><\/td>		p\u503c<\/strong><\/td><\/tr>
\u4e0a\u80a2\u529f\u80fd\uff08PUL v2.0\uff09\u603b\u5206<\/strong>\u00b9
\uff08\u4e3b\u8981\u7814\u7a76\uff0cn=105\uff09<\/td>		54%<\/td>p=0.029<\/td><\/tr>
\u5de6\u5fc3\u5ba4\u5c04\u8840\u5206\u6570\uff08LVEF %\uff09<\/strong>\u00b2
\uff08\u5173\u952e\u6b21\u8981\u56e0\u7d20\uff0cn=83\uff09<\/td>		91%<\/td>p=0.041<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

\u00b9 n \u53cd\u6620\u4e86 ITT \u4eba\u7fa4\u4e2d\u5728 12 \u4e2a\u6708\u65f6\u53ef\u8fdb\u884c PUL v2.0 \u8bc4\u4f30\u7684\u60a3\u8005\u4eba\u6570\u3002.
\u00b2 n \u53cd\u6620\u4e86 ITT \u4eba\u7fa4\u4e2d\u5728 12 \u4e2a\u6708\u65f6\u63a5\u53d7\u4e2d\u5fc3\u5ba1\u67e5\u548c\u53ef\u8bc4\u4f30\u7684\u5fc3\u810f MRI LVEF \u8bc4\u4f30\u7684\u60a3\u8005\u4eba\u6570\u3002.
3 <\/sup>\u51cf\u7f13\u767e\u5206\u6bd4\u7684\u8ba1\u7b97\u65b9\u6cd5\u662f\uff1a\u6cbb\u7597\u7ec4\u4e0e\u57fa\u7ebf\u76f8\u6bd4\u7684\u53d8\u5316\u91cf\u9664\u4ee5\u5b89\u6170\u5242\u7ec4\u4e0e\u57fa\u7ebf\u76f8\u6bd4\u7684\u53d8\u5316\u91cf\u3002.<\/p>\n\n\n\n

\u5173\u6ce8\u6b64\u9875\u9762<\/strong> >>> \u6240\u6709\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/a><\/p>","protected":false},"excerpt":{"rendered":"

HOPE-3 is a randomized, double-blind, placebo-controlled, Phase 3 clinical trial evaluating Deramiocel in boys and young men with Duchenne muscular dystrophy. The study randomized 106 participants across 20 leading U.S. clinical sites. Participants received intravenous Deramiocel at 150 million cells per infusion or placebo every three months for a 12-month period. The average age of […]<\/p>\n","protected":false},"author":1,"featured_media":5287,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[86,87,303,137,85],"class_list":["post-5285","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-capricor","tag-capricor-therapeutics","tag-cell-therapy","tag-clinical-trial","tag-deramiocel"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/5285","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=5285"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/5285\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/5287"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=5285"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=5285"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=5285"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}