{"id":5177,"date":"2025-11-18T18:34:47","date_gmt":"2025-11-18T15:34:47","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=5177"},"modified":"2025-11-18T18:34:48","modified_gmt":"2025-11-18T15:34:48","slug":"potential-of-sat-3247-to-restore-muscle-regeneration-in-duchenne-published-in-nature","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/potential-of-sat-3247-to-restore-muscle-regeneration-in-duchenne-published-in-nature\/","title":{"rendered":"SAT-3247 \u5177\u6709\u6062\u590d\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u60a3\u8005\u808c\u8089\u518d\u751f\u7684\u6f5c\u529b\uff0c\u76f8\u5173\u7814\u7a76\u53d1\u8868\u4e8e\u300a\u81ea\u7136\u300b\u6742\u5fd7\u3002"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Satellos\u516c\u53f8\u5ba3\u5e03\uff0c\u6e25\u592a\u534e\u533b\u9662\u7814\u7a76\u6240\uff08OHRI\uff09\u7684\u4e00\u4e2a\u79d1\u7814\u56e2\u961f\u5728\u300a\u81ea\u7136\u901a\u8baf\u300b\u6742\u5fd7\u4e0a\u53d1\u8868\u4e86\u4e00\u9879\u65b0\u7814\u7a76\uff0c\u8be5\u7814\u7a76\u9a8c\u8bc1\u4e86\u8be5\u516c\u53f8\u6cbb\u7597\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u548c\u5176\u4ed6\u75be\u75c5\u6839\u672c\u75c5\u56e0\u7684\u65b0\u65b9\u6cd5\u3002 <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-64999-3\" target=\"_blank\" rel=\"noreferrer noopener\">\u51fa\u7248\u7269\u53ef\u5728\u6b64\u5904\u83b7\u53d6<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u7bc7\u7531OHRI\u7814\u7a76\u4eba\u5458\u64b0\u5199\u7684\u8bba\u6587\u2014\u2014\u5176\u4e2d\u5305\u62ecSatellos\u8054\u5408\u521b\u59cb\u4eba\u517c\u9996\u5e2d\u53d1\u73b0\u5b98\u3001OHRI\u9ad8\u7ea7\u79d1\u5b66\u5bb6\u517c\u65af\u666e\u7f57\u7279\u5e72\u7ec6\u80de\u7814\u7a76\u4e2d\u5fc3\u4e3b\u4efb\u8fc8\u514b\u5c14\u00b7\u9c81\u5fb7\u5c3c\u57fa\u535a\u58eb\u2014\u2014\u63ed\u793a\u4e86\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff08DMD\uff0c\u7b80\u79f0\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff09\u59cb\u4e8e\u80ce\u513f\u53d1\u80b2\u671f\uff0c\u662f\u4e00\u79cd\u4ee5\u808c\u8089\u5e72\u7ec6\u80de\u5185\u5728\u529f\u80fd\u969c\u788d\u4e3a\u7279\u5f81\u7684\u5e72\u7ec6\u80de\u75be\u75c5\u3002\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u5728\u7f3a\u4e4f\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u7684\u60c5\u51b5\u4e0b\uff0c\u808c\u8089\u5e72\u7ec6\u80de\u4f1a\u5931\u53bb\u6781\u6027\uff0c\u4ea7\u751f\u7684\u6210\u808c\u7956\u7ec6\u80de\u6570\u91cf\u51cf\u5c11\uff0c\u6700\u7ec8\u5bfc\u81f4\u808c\u7ea4\u7ef4\u6570\u91cf\u51cf\u5c11\u4e14\u4f53\u79ef\u7f29\u5c0f\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8fd9\u4e9b\u53d8\u5316\u53d1\u751f\u5728\u80ce\u513f\u808c\u8089\u53d1\u80b2\u8fc7\u7a0b\u4e2d\uff0c\u65e9\u4e8e\u708e\u75c7\u6216\u7ec4\u7ec7\u9000\u5316\u51fa\u73b0\u7684\u65f6\u95f4\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u91cd\u8981\u7684\u662f\uff0c\u7814\u7a76\u4eba\u5458\u8bc1\u660e\uff0c\u901a\u8fc7\u963b\u65ad AAK1 \u86cb\u767d\u7684\u6d3b\u6027\uff0c\u53ef\u4ee5\u8bf1\u5bfc\u7f3a\u4e4f\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u7684\u808c\u8089\u5e72\u7ec6\u80de\u83b7\u5f97\u6781\u6027\uff0c\u4ea7\u751f\u65b0\u7684\u7956\u7ec6\u80de\uff0c\u5e76\u5f62\u6210\u6b63\u5e38\u6570\u91cf\u7684\u808c\u8089\u3002\u8fd9\u4e9b\u53d1\u73b0\u652f\u6301\u4e86 AAK1 \u6291\u5236\u5242\uff08\u5982 SAT-3247\uff09\u5728\u6062\u590d\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u60a3\u8005\u808c\u8089\u518d\u751f\u65b9\u9762\u7684\u6f5c\u529b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e0e\u76ee\u524d\u9488\u5bf9\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7 (DMD) \u5f00\u53d1\u7684\u6cbb\u7597\u65b9\u6cd5\u4e0d\u540c\uff0c\u540e\u8005\u4fa7\u91cd\u4e8e\u5e2e\u52a9 DMD \u60a3\u8005\u4ea7\u751f\u4e00\u79cd\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u6765\u5e2e\u52a9\u4fdd\u62a4\u808c\u8089\uff0c\u800c Satellos&#039; \u7684\u5dee\u5f02\u5316\u65b9\u6cd5\u65e8\u5728\u901a\u8fc7\u9776\u5411\u6291\u5236 AAK1 \u6765\u6062\u590d\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u60a3\u8005\u7684\u808c\u8089\u518d\u751f\u80fd\u529b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201c\u8fd9\u4e9b\u53d1\u73b0\u6e05\u695a\u5730\u8868\u660e\uff0c\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u8d77\u56e0\u662f\u808c\u8089\u5e72\u7ec6\u80de\u65e0\u6cd5\u6784\u5efa\u548c\u7ef4\u6301\u808c\u8089\u2014\u2014\u800c\u6ca1\u6709\u4efb\u4f55\u808c\u7ea4\u7ef4\u8106\u5f31\u6216\u635f\u4f24\u7684\u8ff9\u8c61\uff0c\u201d\u8be5\u8bba\u6587\u7684\u8d44\u6df1\u4f5c\u8005\u9c81\u5fb7\u5c3c\u57fa\u535a\u58eb\u8bf4\u3002\u201c\u901a\u8fc7\u8c03\u8282AAK1\uff0c\u6211\u4eec\u5df2\u7ecf\u5c55\u793a\u4e86\u4e00\u79cd\u5f3a\u5927\u7684\u65b9\u6cd5\u6765\u8c03\u8282\u6781\u6027\u3001\u4f7f\u5e72\u7ec6\u80de\u529f\u80fd\u6b63\u5e38\u5316\u5e76\u589e\u5f3a\u8425\u517b\u4e0d\u826f\u6a21\u578b\u4e2d\u7684\u808c\u8089\u5f62\u6210\uff0c\u8fd9\u4e3a\u518d\u751f\u6cbb\u7597\u7b56\u7565\u6307\u660e\u4e86\u4e00\u6761\u4ee4\u4eba\u4fe1\u670d\u7684\u9053\u8def\u3002\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Satellos\u8054\u5408\u521b\u59cb\u4eba\u517c\u9996\u5e2d\u6267\u884c\u5b98\u5f17\u5170\u514b\u00b7\u683c\u91cc\u68ee\u8865\u5145\u9053\uff1a\u201c\u8fd9\u4e9b\u53d1\u73b0\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86\u6211\u4eec\u4e00\u76f4\u4ee5\u6765\u7684\u4fe1\u5ff5\uff0c\u5373\u7ea0\u6b63\u5e72\u7ec6\u80de\u529f\u80fd\u969c\u788d\u5bf9\u4e8e\u6539\u53d8\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u75c5\u7a0b\u81f3\u5173\u91cd\u8981\u3002\u6211\u4eec\u795d\u8d3a\u9c81\u5fb7\u5c3c\u57fa\u535a\u58eb\u53ca\u5176OHRI\u540c\u4e8b\u4eec\u53d1\u73b0\u5e76\u8bc1\u5b9e\u4e86\u808c\u8089\u751f\u7269\u5b66\u65b9\u9762\u7684\u65b0\u53d1\u73b0\uff0c\u8fd9\u53ef\u80fd\u4e3a\u66f4\u6709\u6548\u7684\u5e72\u9884\u63aa\u65bd\u6253\u5f00\u5927\u95e8\u3002\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5173\u6ce8\u6b64\u9875\u9762<\/strong>&nbsp;&gt;&gt;&gt;&nbsp;<a href=\"https:\/\/dmdwarrior.com\/zh\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u6240\u6709\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Satellos announced the publication in Nature Communications of new research from a scientific team at the Ottawa Hospital Research Institute (OHRI) that validates the company\u2019s novel approach to treating the underlying cause of Duchenne muscular dystrophy and other diseases. >> Publication available here. The paper \u2014 authored by OHRI researchers, including Satellos co-founder and Chief [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":5179,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[456,254,40,251,252,253],"class_list":["post-5177","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-aak1-inhibitor","tag-frank-gleeson","tag-michael-rudnicki","tag-sat-3247","tag-satellos","tag-satellos-bioscience"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/5177","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=5177"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/5177\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/5179"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=5177"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=5177"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=5177"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}