{"id":5095,"date":"2025-11-04T10:21:05","date_gmt":"2025-11-04T07:21:05","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=5095"},"modified":"2025-11-04T10:21:20","modified_gmt":"2025-11-04T07:21:20","slug":"agamree-vamorolone-five-year-data","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/agamree-vamorolone-five-year-data\/","title":{"rendered":"AGAMREE\uff08vamorolone\uff09\u6cbb\u7597DMD\u60a3\u8005\u7684\u4e94\u5e74\u6570\u636e\u663e\u793a\uff0c\u5176\u5b89\u5168\u6027\u5f97\u5230\u6539\u5584\uff0c\u7597\u6548\u4e0e\u6807\u51c6\u6cbb\u7597\u76ae\u8d28\u7c7b\u56fa\u9187\u76f8\u5f53\u3002"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Santhera\u516c\u53f8\u516c\u5e03\u4e86\u957f\u671f\u6570\u636e\u5206\u6790\u7684\u79ef\u6781\u521d\u6b65\u7ed3\u679c\uff0c\u5176\u4e2d\u5305\u62ec\u6b63\u5728\u8fdb\u884c\u7684\u5f00\u653e\u6807\u7b7e\u3001\u591a\u4e2d\u5fc3GUARDIAN\u7814\u7a76\u7684\u9996\u6b21\u8bc4\u4f30\u7ed3\u679c\u3002\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30AGAMREE\uff08vamorolone\uff09\u6cbb\u7597\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff08DMD\uff09\u60a3\u8005\u7684\u7597\u6548\u3002 <a href=\"https:\/\/dmdwarrior.com\/zh\/what-is-agamree-vamorolone-what-is-agamree-used-for\/\" target=\"_blank\" data-type=\"post\" data-id=\"2333\" rel=\"noreferrer noopener\">\u4ec0\u4e48\u662f Agamree\uff1f<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7cbe\u9009\u7ed3\u679c<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4e94\u5e74\u5185\u4e0e\u6807\u51c6\u6cbb\u7597\u76ae\u8d28\u7c7b\u56fa\u9187\u5177\u6709\u76f8\u5f53\u7684\u957f\u671f\u7597\u6548<\/li>\n\n\n\n<li>\u4e0e\u4f7f\u7528\u6807\u51c6\u76ae\u8d28\u7c7b\u56fa\u9187\u6cbb\u7597\u901a\u5e38\u5bfc\u81f4\u7684\u751f\u957f\u6291\u5236\u4e0d\u540c\uff0c\u8be5\u7597\u6cd5\u7ef4\u6301\u4e86\u6b63\u5e38\u7684\u751f\u957f\u53d1\u80b2\u3002<\/li>\n\n\n\n<li>\u4f7f\u7528 AGAMREE \u6cbb\u7597\u540e\uff0c\u690e\u4f53\u9aa8\u6298\u53d1\u751f\u7387\u663e\u8457\u964d\u4f4e\u3002<\/li>\n\n\n\n<li>\u4e0e\u670d\u7528\u76ae\u8d28\u7c7b\u56fa\u9187\u7684DMD\u60a3\u8005\u76f8\u6bd4\uff0c\u767d\u5185\u969c\u7684\u53d1\u751f\u7387\u8f83\u4f4e<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">\u5bf9110\u4f8b\u60a3\u8005\u8fdb\u884c\u4e86\u5206\u6790\u3002<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u957f\u671f\u5206\u6790\u5305\u62ec\u4e34\u5e8a\u7814\u7a76\u4e2d 4 \u81f3 7 \u5c81\u5f00\u59cb\u63a5\u53d7 AGAMREE \u6cbb\u7597\u4e14\u672a\u4f7f\u7528\u8fc7\u76ae\u8d28\u7c7b\u56fa\u9187\u7684\u60a3\u8005\uff0c\u4ee5\u53ca\u901a\u8fc7\u5404\u79cd\u51c6\u5165\u8ba1\u5212\uff08\u5305\u62ec GUARDIAN \u7814\u7a76\uff09\u7ee7\u7eed\u63a5\u53d7\u6cbb\u7597\u7684\u60a3\u8005\u3002. <strong>\u672c\u7814\u7a76\u5206\u6790\u4e86\u591a\u8fbe110\u4f8b\u60a3\u8005\u7684\u6570\u636e\uff0c\u5177\u4f53\u60a3\u8005\u6570\u91cf\u56e0\u6570\u636e\u53ef\u7528\u6027\u800c\u5f02\u3002\u5728\u8fd9\u9879\u957f\u671f\u5206\u6790\u4e2d\uff0c\u60a3\u8005\u63a5\u53d7AGAMREE\u6cbb\u7597\u7684\u65f6\u95f4\u6700\u957f\u8fbe8\u5e74\uff0c\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u7ea6\u4e3a5\u5e74\u3002.<\/strong> \u5728\u89c2\u5bdf\u671f\u5185\uff0c\u5927\u591a\u6570\u60a3\u8005\u5728\u771f\u5b9e\u4e34\u5e8a\u73af\u5883\u4e2d\u4ecd\u4fdd\u6301\u8f83\u9ad8\u5242\u91cf\uff084-6 mg\/kg\/\u5929\uff09\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u63a5\u53d7 AGAMREE \u6cbb\u7597\u7684\u60a3\u8005\u5728\u957f\u671f\u968f\u8bbf\u4e2d\u4fdd\u6301\u4e86\u8fd0\u52a8\u529f\u80fd\uff0c\u8bc1\u660e\u5176\u5177\u6709\u6301\u4e45\u7597\u6548\uff0c\u4ee5\u4e27\u5931\u884c\u8d70\u80fd\u529b\u7684\u65f6\u95f4\u8861\u91cf\uff0c\u4e0e\u6807\u51c6\u6cbb\u7597\u76ae\u8d28\u7c7b\u56fa\u9187\u76f8\u5f53\uff08p=0.91\uff09\u3002<\/strong>. \u5728\u9884\u5148\u8bbe\u5b9a\u7684\u4e9a\u7ec4\u5206\u6790\u4e2d\uff0c\u4e0e\u6bcf\u65e5\u670d\u7528\u5730\u592b\u53ef\u7279\u6216\u6cfc\u5c3c\u677e\u76f8\u6bd4\uff0c\u672a\u89c2\u5bdf\u5230\u4efb\u4f55\u5dee\u5f02\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u91cd\u8981\u7684\u662f\uff0c\u6570\u636e\u7ee7\u7eed\u652f\u6301\u5176\u4e0e\u4f20\u7edf\u76ae\u8d28\u7c7b\u56fa\u9187\u76f8\u6bd4\u5177\u6709\u5dee\u5f02\u5316\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u7279\u5f81\u3002. <strong>\u63a5\u53d7 AGAMREE \u6cbb\u7597\u7684\u60a3\u8005\u690e\u4f53\u9aa8\u6298\u53d1\u751f\u7387\u663e\u8457\u964d\u4f4e (p=0.0061)\uff0c\u4fdd\u6301\u6b63\u5e38\u751f\u957f\uff0c\u6ca1\u6709\u51fa\u73b0\u6807\u51c6\u6cbb\u7597\u76ae\u8d28\u7c7b\u56fa\u9187\u6240\u89c1\u7684\u751f\u957f\u8fdf\u7f13 (p&lt;0.0001)\uff0c\u5e76\u4e14\u767d\u5185\u969c\u75c5\u4f8b\u5c11\u4e8e\u63a5\u53d7\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u5176\u4e2d\u4e0e\u5730\u592b\u53ef\u7279\u76f8\u6bd4\uff0c\u767d\u5185\u969c\u53d1\u751f\u7387\u660e\u663e\u964d\u4f4e (p&lt;0.015)\u3002.<\/strong> \u6b64\u5916\uff0c\u8fc4\u4eca\u4e3a\u6b62\uff0c\u672a\u89c2\u5bdf\u5230\u9752\u5149\u773c\u75c5\u4f8b\u3002\u5e73\u5747\u800c\u8a00\uff0c\u6309\u8eab\u9ad8\u5339\u914d\u540e\uff0c\u4f53\u91cd\u6307\u6570\u6216\u4f53\u91cd\u7684\u53d8\u5316\u65e0\u663e\u8457\u5dee\u5f02\uff0c\u4e5f\u672a\u89c2\u5bdf\u5230\u65b0\u7684\u5b89\u5168\u4fe1\u53f7\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8be6\u7ec6\u7814\u7a76\u7ed3\u679c\u5df2\u63d0\u4ea4\u81f32026\u5e74\u7b2c\u4e00\u5b63\u5ea6\u7684\u4e00\u9879\u91cd\u8981\u56fd\u9645\u79d1\u5b66\u4f1a\u8bae\u4e0a\u8fdb\u884c\u5c55\u793a\u3002\u6309\u7167\u79d1\u5b66\u60ef\u4f8b\uff0c\u4f1a\u8bae\u7ed3\u675f\u540e\uff0c\u5f85\u7ec4\u7ec7\u65b9\u5b8c\u6210\u5ba1\u6838\u548c\u5c55\u793a\u6d41\u7a0b\u540e\uff0c\u6240\u6709\u6570\u636e\u5c06\u5411\u516c\u4f17\u516c\u5f00\u3002\u6b64\u5916\uff0cGUARDIAN\u7814\u7a76\u8ba1\u5212\u5728\u672a\u6765\u4e09\u5e74\u5185\u53d1\u5e03\u66f4\u591a\u6570\u636e\uff0c\u91cd\u70b9\u5173\u6ce8\u66f4\u5e7f\u6cdb\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u6307\u6807\uff0c\u5305\u62ec\u4e0a\u80a2\u529f\u80fd\u3001\u9752\u6625\u671f\u53d1\u80b2\u3001\u773c\u90e8\u5065\u5eb7\u548c\u5fc3\u810f\u529f\u80fd\u4ee5\u53ca\u5176\u4ed6\u76f8\u5173\u53c2\u6570\u7684\u8bc4\u4f30\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5173\u6ce8\u6b64\u9875\u9762<\/strong> >>> <a href=\"https:\/\/dmdwarrior.com\/zh\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u6240\u6709\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Santhera reported positive topline results from an analysis of long-term data, including first assessments from the ongoing, open-label, multicenter GUARDIAN study evaluating AGAMREE (vamorolone) in patients with Duchenne muscular dystrophy (DMD). >>> What is Agamree? Featured Results 110 patients were analyzed The long-term analysis included corticosteroid-na\u00efve patients who began AGAMREE treatment between four and seven [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":5097,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[42,124,41,43],"class_list":["post-5095","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-agamree","tag-corticosteroid","tag-santhera","tag-vamorolone"],"subtitle":"Agamree\uff08vamorolone\uff09\u7684 5 \u5e74\u6570\u636e\u7ee7\u7eed\u652f\u6301\u5176\u4e0e\u4f20\u7edf\u76ae\u8d28\u7c7b\u56fa\u9187\u76f8\u6bd4\u5177\u6709\u5dee\u5f02\u5316\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u7279\u5f81\u3002.","_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/5095","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=5095"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/5095\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/5097"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=5095"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=5095"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=5095"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}