{"id":4860,"date":"2025-10-22T15:58:01","date_gmt":"2025-10-22T12:58:01","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=4860"},"modified":"2025-11-03T19:58:19","modified_gmt":"2025-11-03T16:58:19","slug":"lymphatic-system-duchenne-muscular-dystrophy-dmd","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/lymphatic-system-duchenne-muscular-dystrophy-dmd\/","title":{"rendered":"\u6dcb\u5df4\u7cfb\u7edf\u53ef\u80fd\u662f DMD \u8fdb\u5c55\u80cc\u540e\u7684\u9a71\u52a8\u529b"},"content":{"rendered":"<p class=\"wp-block-paragraph\">\u5728\u6700\u8fd1\u7684\u4e24\u9879\u7814\u7a76\u4e2d\uff0c\u7531\u5fb7\u514b\u8428\u65af A&amp;M \u5927\u5b66 Naresh K. Vashisht \u533b\u5b66\u9662\u7684 Mendell Rimer \u535a\u58eb\u548c Mariappan Muthuchamy \u535a\u58eb\u4ee5\u53ca\u5fb7\u514b\u8428\u65af A&amp;M \u5927\u5b66\u517d\u533b\u5b66\u9662\u548c Biomedical \u79d1\u5b66\u5b66\u9662\u7684 Peter Nghiem \u535a\u58eb\u6307\u5bfc\u7684\u79d1\u5b66\u5bb6\u56e2\u961f\u53d1\u73b0\uff0c\u6dcb\u5df4\u7f51\u7edc\uff08\u6709\u52a9\u4e8e\u8c03\u8282\u4f53\u6db2\u5e73\u8861\u548c\u514d\u75ab\u529f\u80fd\uff09\u4e2d\u7684\u95ee\u9898\u53ef\u80fd\u79ef\u6781\u4fc3\u6210\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7 (DMD) \u548c\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7 (ALS) \u7684\u53d1\u5c55\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u9879\u5f00\u521b\u6027\u7684\u7814\u7a76\u8868\u660e\uff0c\u6dcb\u5df4\u529f\u80fd\u969c\u788d\u53ef\u80fd\u4e0d\u4ec5\u4ec5\u662f\u6162\u6027\u708e\u75c7\u7684\u526f\u4f5c\u7528\uff0c\u800c\u4e14\u662f\u75be\u75c5\u8fdb\u5c55\u7684\u9a71\u52a8\u529b\uff0c\u53d1\u8868\u5728\u300a\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a\u300b\uff08PNAS\uff09\u548c\u300a\u75be\u75c5\u6a21\u578b\u4e0e\u673a\u5236\u300b\uff08DMM\uff09\u4e0a\u3002\uff08<a href=\"https:\/\/journals.biologists.com\/dmm\/article\/18\/7\/dmm052148\/368598\/Lymphatic-dysfunction-correlates-with-inflammation?searchresult=1\" target=\"_blank\" rel=\"noreferrer noopener\">\u6570\u5b57\u4e07\u7528\u8868<\/a> \u548c <a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2505656122\" target=\"_blank\" rel=\"noreferrer noopener\">\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a<\/a>)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201c\u8fd9\u662f\u6dcb\u5df4\u7cfb\u7edf\u9996\u6b21\u88ab\u76f4\u63a5\u8bc1\u660e\u4e0e\u8fd9\u4e9b\u75be\u75c5\u6709\u5173\uff0c\u201d\u7a46\u56fe\u67e5\u7c73\u8bf4\u3002\u201c\u6211\u4eec\u7684\u53d1\u73b0\u5f00\u8f9f\u4e86\u65b0\u7684\u7814\u7a76\u9014\u5f84\uff0c\u5e76\u53ef\u80fd\u6700\u7ec8\u5e26\u6765\u65b0\u7684\u8bca\u65ad\u6216\u6cbb\u7597\u65b9\u6cd5\u3002\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff08DMD\uff09\u5f71\u54cd\u7740\u5168\u7403\u6bcf5000\u540d\u7537\u5b69\u4e2d\u7ea61\u4eba\uff0c\u5e76\u5bfc\u81f4\u4e25\u91cd\u7684\u808c\u8089\u9000\u5316\u3002\u867d\u7136\u4f20\u7edf\u7814\u7a76\u4e3b\u8981\u96c6\u4e2d\u5728\u808c\u8089\u7ec4\u7ec7\u672c\u8eab\uff0c\u4f46\u5fb7\u514b\u8428\u65af\u519c\u5de5\u5927\u5b66\u7684\u7814\u7a76\u56e2\u961f\u5c06\u6ce8\u610f\u529b\u8f6c\u5411\u4e86\u6dcb\u5df4\u7cfb\u7edf\uff0c\u8be5\u7cfb\u7edf\u8d1f\u8d23\u5faa\u73af\u514d\u75ab\u7ec6\u80de\u5e76\u6e05\u9664\u5e9f\u7269\u3002<a href=\"https:\/\/dmdwarrior.com\/zh\/what-is-duchenne\/\" target=\"_blank\" data-type=\"post\" data-id=\"588\" rel=\"noreferrer noopener\">\u4ec0\u4e48\u662f\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff1f<\/a>)<\/p>\n\n\n\n<div><a href=\"https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/10\/lymphatic-system-1-1024x673.jpg\" class=\"td-modal-image\"><figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"673\" src=\"https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/10\/lymphatic-system-1-1024x673.jpg\" alt=\"\u6dcb\u5df4\u7cfb\u7edf\u548c\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff08DMD\uff09\" class=\"wp-image-4865\" title=\"\" srcset=\"https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/10\/lymphatic-system-1-1024x673.jpg 1024w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/10\/lymphatic-system-1-300x197.jpg 300w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/10\/lymphatic-system-1-768x505.jpg 768w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/10\/lymphatic-system-1-1536x1010.jpg 1536w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/10\/lymphatic-system-1-18x12.jpg 18w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/10\/lymphatic-system-1-639x420.jpg 639w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/10\/lymphatic-system-1-150x99.jpg 150w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/10\/lymphatic-system-1-696x458.jpg 696w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/10\/lymphatic-system-1-1068x702.jpg 1068w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/10\/lymphatic-system-1-1920x1262.jpg 1920w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/10\/lymphatic-system-1.jpg 2000w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/a><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u7531\u535a\u58eb\u540e\u79d1\u5b66\u5bb6 Bhuvaneshwaran Subramanian \u535a\u58eb\u3001\u7814\u7a76\u751f Shedreanna Johnson \u548c Akshaya Narayanan \u9886\u5bfc\u7684 DMD \u7814\u7a76\u4e2d\uff0cMuthuchamy\u3001Rimer \u548c Peter P. Nghiem \u4e5f\u53c2\u4e0e\u4e86\u7814\u7a76\u3002\u7814\u7a76\u56e2\u961f\u53d1\u73b0\uff0cDMD \u4e2d\u7f3a\u5931\u7684\u6297\u808c\u840e\u7f29\u86cb\u767d (dystrophin) \u7684\u7f3a\u5931\u4f1a\u7834\u574f\u6dcb\u5df4\u7cfb\u7edf\u7684\u7ed3\u6784\u548c\u529f\u80fd\u3002\u8fd9\u4e9b\u7834\u574f\u51fa\u73b0\u5f97\u8f83\u65e9\uff0c\u751a\u81f3\u5728\u708e\u75c7\u5f00\u59cb\u4e4b\u524d\u5c31\u5df2\u51fa\u73b0\uff0c\u8fd9\u8868\u660e\u6dcb\u5df4\u7cfb\u7edf\u529f\u80fd\u969c\u788d\u53ef\u80fd\u5f15\u53d1 DMD \u4e2d\u51fa\u73b0\u7684\u808c\u8089\u635f\u4f24\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u663e\u5fae\u955c\u56fe\u50cf\u663e\u793a\uff0c\u60a3\u75c5\u52a8\u7269\u6a21\u578b\u4e2d\u7684\u6dcb\u5df4\u7ba1\u5931\u53bb\u6b63\u5e38\u6392\u5217\uff0c\u7ba1\u58c1\u7ea4\u7ef4\u6392\u5217\u7d0a\u4e71\u3002\u5728\u67d0\u4e9b\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff08DMD\uff09\u6a21\u578b\u4e2d\uff0c\u4f7f\u7528\u5fae\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\uff08microdystrophin\uff0c\u4e00\u79cd\u6709\u52a9\u4e8e\u6539\u5584\u808c\u8089\u529f\u80fd\u7684\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u57fa\u56e0\u7684\u8f83\u5c0f\u7248\u672c\uff09\u6cbb\u7597\uff0c\u4e5f\u51cf\u5c11\u4e86\u6709\u5bb3\u708e\u75c7\u548c\u6dcb\u5df4\u7ba1\u7684\u5f02\u5e38\u751f\u957f\u3002\u8fd9\u4e00\u53d1\u73b0\u8868\u660e\u6dcb\u5df4\u7cfb\u7edf\u548c\u808c\u8089\u7cfb\u7edf\u7d27\u5bc6\u76f8\u8fde\uff0c\u4e3a\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff08DMD\uff09\u7684\u65b0\u6cbb\u7597\u53ef\u80fd\u6027\u6253\u5f00\u4e86\u5927\u95e8\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201c\u5982\u679c\u6211\u4eec\u80fd\u591f\u6062\u590d\u6dcb\u5df4\u529f\u80fd\uff0c\u6216\u8bb8\u5c31\u80fd\u51cf\u8f7b\u708e\u75c7\uff0c\u51cf\u7f13\u75be\u75c5\u8fdb\u5c55\uff0c\u201d\u7a46\u56fe\u67e5\u7c73\u8bf4\u3002\u201c\u8fd9\u4e3a\u6211\u4eec\u7406\u89e3\u8fd9\u4e9b\u75be\u75c5\u7684\u53d1\u751f\u53d1\u5c55\u548c\u6cbb\u7597\u65b9\u6cd5\u63d0\u4f9b\u4e86\u4e00\u79cd\u5168\u65b0\u7684\u601d\u8def\u3002\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u9605\u8bfb\u66f4\u591a<\/strong>:\u00a0<a href=\"https:\/\/dmdwarrior.com\/zh\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u4e34\u5e8a\u8bd5\u9a8c\uff08\u6240\u6709\u7814\u7a76\u5217\u8868\uff09<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>In two recent studies, a team of scientists under the guidance of Mendell Rimer, PhD, and Mariappan Muthuchamy, PhD, at the Texas A&amp;M University Naresh K. Vashisht College of Medicine and Peter Nghiem, DVM, PhD, at the Texas A&amp;M College of Veterinary Medicine and Biomedical Sciences, revealed that problems in the lymphatic network\u2014which helps regulate [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4862,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[118,444],"class_list":["post-4860","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-duchenne","tag-lymphatic-system"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/4860","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=4860"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/4860\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/4862"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=4860"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=4860"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=4860"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}