{"id":4676,"date":"2025-09-29T17:43:53","date_gmt":"2025-09-29T14:43:53","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=4676"},"modified":"2025-11-18T12:55:13","modified_gmt":"2025-11-18T09:55:13","slug":"tevard-biosciences-presents-data-demonstrating-production-of-full-length-protein-with-trna-based-therapy-for-duchenne-muscular-dystrophy","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/tevard-biosciences-presents-data-demonstrating-production-of-full-length-protein-with-trna-based-therapy-for-duchenne-muscular-dystrophy\/","title":{"rendered":"Tevard Biosciences \u516c\u5e03\u6570\u636e\uff0c\u8bc1\u660e\u57fa\u4e8e tRNA \u7684\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7597\u6cd5\u80fd\u591f\u4ea7\u751f\u5168\u957f\u86cb\u767d\u8d28"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong>Tevard Biosciences \u5ba3\u5e03\u5c55\u793a\u65b0\u7684\u4e34\u5e8a\u524d\u6570\u636e\uff0c\u663e\u793a\u5728\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7 (DMD) \u548c\u6269\u5f20\u578b\u5fc3\u808c\u75c5 (DCM-TTNtv) \u6a21\u578b\u4e2d\u5168\u957f\u529f\u80fd\u86cb\u767d\u7684\u5f3a\u6548\u6062\u590d\u3002<\/strong> \u91cd\u8981\u7684\u662f\uff0c\u7814\u7a76\u7ed3\u679c\u5305\u62ec\u6570\u636e\u663e\u793a\uff0c\u4f7f\u7528\u6700\u65b0\u4e00\u4ee3\u6291\u5236\u6027 tRNA\uff08suptRNA\uff09\u7684 DMD \u6a21\u578b\u4e2d\u91ce\u751f\u578b\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u5e73\u5747\u6062\u590d 70%\uff0c\u652f\u6301\u5728\u8f83\u4f4e\u5242\u91cf\u4e0b\u83b7\u5f97\u6709\u610f\u4e49\u7684\u4e34\u5e8a\u7ed3\u679c\u7684\u6f5c\u529b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u4e9b\u6570\u636e\u7531Tevard Biosciences\u9996\u5e2d\u79d1\u5b66\u5b98Elisabeth Gardiner\u535a\u58eb\u5728\u9898\u4e3a\u201c\u6cbb\u7597\u6027\u6291\u5236\u6027tRNA\u5728\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u548c\u6269\u5f20\u578b\u5fc3\u808c\u75c5\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\u201d\u7684\u53d7\u9080\u53e3\u5934\u62a5\u544a\u548c\u6d77\u62a5\u5c55\u793a\u4f1a\u4e0a\u53d1\u5e03\u3002\u6b64\u6b21\u62a5\u544a\u4e8e2025\u5e749\u670828\u65e5\u81f310\u67083\u65e5\u5728\u514b\u7f57\u5730\u4e9a\u675c\u5e03\u7f57\u592b\u5c3c\u514b\u4e3e\u884c\u76842025\u5e74\u6b27\u6d32\u751f\u7269\u5316\u5b66\u5b66\u4f1a\u8054\u5408\u4f1a\uff08FEBS\uff09\u7279\u522b\u4f1a\u8bae\u201c\u62d3\u5c55\u6c28\u9170-tRNA\u5408\u6210\u9176\u7814\u7a76\u524d\u6cbf\u201d\u4e0a\u8fdb\u884c\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u52a0\u5fb7\u7eb3\u535a\u58eb\u8bf4\uff1a\u201c\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u6211\u4eec\u8bbe\u8ba1\u7684\u6291\u5236\u6027 tRNA \u80fd\u591f\u6062\u590d\u5168\u957f\u3001\u5929\u7136\u86cb\u767d\u8d28\u7684\u8868\u8fbe\uff0c\u5176\u6c34\u5e73\u4e0d\u4ec5\u5177\u6709\u751f\u7269\u5b66\u610f\u4e49\uff0c\u800c\u4e14\u5177\u6709\u4e34\u5e8a\u524d\u666f\u3002\u201d<\/strong> \u201c\u5728\u5904\u7406\u50cf\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u548c\u808c\u8054\u86cb\u767d\u8fd9\u6837\u7684\u7ed3\u6784\u86cb\u767d\u65f6\uff0c\u6b63\u786e\u7684\u6298\u53e0\u3001\u5b9a\u4f4d\u548c\u86cb\u767d\u8d28\u95f4\u76f8\u4e92\u4f5c\u7528\u81f3\u5173\u91cd\u8981\uff0c\u6062\u590d\u5168\u957f\u86cb\u767d\u8d28\u81f3\u5173\u91cd\u8981\u3002\u6211\u4eec\u7684\u5e73\u53f0\u5229\u7528\u539f\u751f\u7ec6\u80de\u673a\u5236\u6765\u751f\u4ea7\u7b26\u5408\u4eba\u4f53\u9884\u671f\u529f\u80fd\u7684\u5929\u7136\u86cb\u767d\u8d28\u3002\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u4e3b\u8981\u53d1\u73b0<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5728 DMD \u8ba1\u5212\u4e2d\uff0cAAV \u4f20\u9012\u7684\u9488\u5bf9 Gln-TAA \u548c Arg-TGA \u65e0\u4e49\u7a81\u53d8\u7684 suptRNA \u5e73\u5747\u6062\u590d\u4e86\u4f53\u5185\u5168\u957f\u91ce\u751f\u578b\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u6c34\u5e73\u7684 70%\uff0c\u4e0e\u8fd0\u52a8\u529f\u80fd\u6062\u590d\u548c\u86cb\u767d\u8d28\u7ec4\u751f\u7269\u6807\u5fd7\u7269\u7684\u6b63\u5e38\u5316\u5bc6\u5207\u76f8\u5173\u3002<\/strong><\/li>\n\n\n\n<li>\u5728DCM-TTNtv\u9879\u76ee\u4e2d\uff0csuptRNA\u6cbb\u7597\u5728\u56db\u5929\u5185\u6062\u590d\u4e86iPSC\u884d\u751f\u7684\u4eba\u7c7b\u5fc3\u808c\u7ec6\u80de\u4e2d\u5168\u957f\u808c\u8054\u86cb\u767d\u7684\u8868\u8fbe\u548c\u6536\u7f29\u6027\u3002\u5728TTNtv\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0cAAV\u9012\u9001\u7684Arg-TGA suptRNA\u5728\u516d\u5468\u5185\u4fc3\u8fdb\u4e86\u5168\u957f\u808c\u8054\u86cb\u767d\u7684\u7a33\u5b9a\u751f\u6210\uff0c\u5e76\u6062\u590d\u4e86\u5fc3\u810f\u86cb\u767d\u8d28\u7ec4\u7a33\u6001\u3002<\/li>\n\n\n\n<li>\u8fd9\u4e24\u4e2a\u7a0b\u5e8f\u90fd\u8868\u73b0\u51fa\u5242\u91cf\u4f9d\u8d56\u6027\u8f6c\u5bfc\u3001\u86cb\u767d\u8d28\u62ef\u6551\u548c\u5168\u8eab\u7ed9\u836f\u540e\u7684\u529f\u80fd\u6539\u5584\uff0c\u5e76\u4e14\u6ca1\u6709\u53ef\u68c0\u6d4b\u5230\u7684\u6bd2\u6027\u6216\u8131\u9776\u6548\u5e94\u3002<\/li>\n\n\n\n<li>\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0csuptRNA \u8868\u8fbe\u548c\u86cb\u767d\u8d28\u62ef\u6551\u5728\u6cbb\u7597\u540e\u6301\u7eed\u957f\u8fbe 12 \u5468\uff0c\u7a81\u51fa\u4e86\u5355\u6b21\u9759\u8109\u6ce8\u5c04\u540e\u6cbb\u7597\u6548\u679c\u7684\u6301\u4e45\u6027\u3002<\/li>\n\n\n\n<li>\u8fd9\u4e9b\u6570\u636e\u6807\u5fd7\u7740 Tevard \u9996\u6b21\u62ab\u9732\u5176 DCM-TTNtv \u9879\u76ee\uff08\u5176\u4e3b\u8981\u5f00\u53d1\u5de5\u4f5c\u4e4b\u4e00\uff09\u7684\u7ed3\u679c\uff0c\u8fdb\u4e00\u6b65\u51f8\u663e\u4e86\u5176\u6291\u5236 tRNA \u5e73\u53f0\u5728\u4e0d\u540c\u57fa\u56e0\u9002\u5e94\u75c7\u4e2d\u7684\u591a\u529f\u80fd\u6027\u548c\u6210\u719f\u5ea6\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Tevard Biosciences\u8054\u5408\u521b\u59cb\u4eba\u3001\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98Daniel Fischer\u8868\u793a\uff1a\u201c\u80fd\u591f\u5165\u9009\u6b64\u6b21\u4e16\u754c\u7ea7\u4f1a\u8bae\u7684\u7279\u8272\u53e3\u5934\u62a5\u544a\u548c\u6d77\u62a5\u5c55\u793a\uff0c\u51f8\u663e\u4e86\u6211\u4eec\u6291\u5236\u578btRNA\u5e73\u53f0\u7684\u5f71\u54cd\u529b\u3002\u6211\u4eec\u6700\u8fd1\u5728\u6291\u5236\u578btRNA\u548c\u8f7d\u4f53\u8bbe\u8ba1\u65b9\u9762\u53d6\u5f97\u7684\u7a81\u7834\uff0c\u5df2\u7ecf\u8fbe\u5230\u4e86\u6240\u9700\u7684\u86cb\u767d\u8d28\u62ef\u6551\u6c34\u5e73\uff0c\u8ba9\u6211\u4eec\u80fd\u591f\u81ea\u4fe1\u5730\u5c06DMD\u548cDCM-TTNtv\u9879\u76ee\u4ee5\u5b89\u5168\u6709\u6548\u7684\u5242\u91cf\u63a8\u8fdb\u5230\u4e34\u5e8a\u5e94\u7528\u3002\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u9605\u8bfb\u66f4\u591a<\/strong>:\u00a0<a href=\"https:\/\/dmdwarrior.com\/zh\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u4e34\u5e8a\u8bd5\u9a8c\uff08\u6240\u6709\u7814\u7a76\u5217\u8868\uff09<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Tevard Biosciences announced the presentation of new preclinical data showing potent restoration of full-length functional proteins in models of Duchenne muscular dystrophy (DMD) and dilated cardiomyopathy (DCM-TTNtv). Importantly, the findings include data showing on average 70% restoration of wild-type dystrophin protein in DMD models with the latest generation of suppressor tRNAs (suptRNA), supporting the potential [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4677,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[359,357,271,358],"class_list":["post-4676","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-full-length-dystrophin","tag-tevard-biosciences","tag-trna","tag-trna-therapy"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/4676","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=4676"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/4676\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/4677"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=4676"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=4676"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=4676"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}