{"id":4576,"date":"2025-09-25T16:23:32","date_gmt":"2025-09-25T13:23:32","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=4576"},"modified":"2025-09-25T16:23:33","modified_gmt":"2025-09-25T13:23:33","slug":"spot-mrna03-gene-therapy-early-phase-1-clinical-trial-nct07188012","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/spot-mrna03-gene-therapy-early-phase-1-clinical-trial-nct07188012\/","title":{"rendered":"SPOT-mRNA03\u57fa\u56e0\u7597\u6cd5\u6cbb\u7597\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u542f\u52a81\u671f\u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Shanghai Siponuoyin\u751f\u7269\u6280\u672f\u516c\u53f8\u5f00\u53d1\u7684SPOT-mRNA03\u57fa\u56e0\u6cbb\u7597\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff08DMD\uff09\u7684\u65e9\u671f1\u671f\u7814\u7a76\uff08NCT07188012\uff09\u662f\u5bf9\u7ed9\u836f\u540e\u7684\u5b89\u5168\u6027\u548c\u9aa8\u9abc\u808c\u4e2d\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u7684\u8868\u8fbe\u60c5\u51b5\u8fdb\u884c\u521d\u6b65\u7814\u7a76\u3002<\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u76ee\u5f55<\/h2><nav><ul><li><a href=\"#what-is-spot-m-rna-03-gene-therapy\">\u4ec0\u4e48\u662fSPOT-mRNA03\u57fa\u56e0\u6cbb\u7597<\/a><\/li><li><a href=\"#spot-m-rna-03-gene-therapy-early-phase-1-nct-07188012\">SPOT-mRNA03\u57fa\u56e0\u6cbb\u7597\u65e9\u671f1\u671f \u2013 NCT07188012<\/a><\/li><li><a href=\"#how-to-participate-in-the-sgt-003-clinical-trial\">\u5982\u4f55\u53c2\u4e0e SPOT-mRNA03 \u4e34\u5e8a\u8bd5\u9a8c<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-is-spot-m-rna-03-gene-therapy\"><strong>\u4ec0\u4e48\u662fSPOT-mRNA03\u57fa\u56e0\u6cbb\u7597<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>SPOT-mRNA03 \u662f\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7 (DMD) \u7684\u57fa\u56e0\u6cbb\u7597\u4ea7\u54c1\u3002<\/strong> \u5728\u7ed9 DMD \u60a3\u8005\u65bd\u7528\u540e\uff0cEV \u819c\u4e0a\u7684\u5206\u5b50\u9776\u5411\u80bd\u53ef\u4ee5\u5c06 SPOT-mRNA03 \u5f15\u5bfc\u5230\u60a3\u8005\u7684\u808c\u8089\u7ec6\u80de\u4e2d\uff0c\u4ece\u800c\u4f7f\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u7f3a\u9677\u578b\u53d7\u4f53\u7ec6\u80de\u80fd\u591f\u5229\u7528\u7ec6\u80de\u5185\u6838\u7cd6\u4f53\u548c\u6c28\u57fa\u9178\u7ffb\u8bd1\u548c\u5206\u6ccc\u5185\u6e90\u6027\u5168\u957f\u5b8c\u6574\u7684\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"spot-m-rna-03-gene-therapy-early-phase-1-nct-07188012\"><strong>SPOT-mRNA03\u57fa\u56e0\u6cbb\u7597\u65e9\u671f1\u671f \u2013 NCT07188012<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u662f\u4e00\u9879\u5355\u81c2\u3001\u5f00\u653e\u6807\u7b7e\u3001FIH\u3001\u5355\u4e2d\u5fc3\u7684\u63a2\u7d22\u6027\u4e34\u5e8a\u7814\u7a76\uff0c\u5c06SPOT-mRNA03\u9759\u8109\u6ce8\u5c04\u7ed9\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff08DMD\uff09\u60a3\u8005\u3002\u5168\u957f\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767dmRNA\u88ab\u5305\u542b\u5728\u4e00\u79cd\u540d\u4e3aSPOT-mRNA03\u7684\u9776\u5411\u808c\u8089\u7684\u7ec6\u80de\u5916\u56ca\u6ce1\uff08EV\uff09\u4e2d\u3002EV\u819c\u4e0a\u7684\u5206\u5b50\u9776\u5411\u80bd\u8d4b\u4e88SPOT-mRNA03\u9776\u5411\u80fd\u529b\uff0c\u8fd9\u4f7f\u5f97\u5c06\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767dmRNA\u4f5c\u4e3aDMD\u7684\u57fa\u56e0\u6cbb\u7597\u4ea7\u54c1\u8fdb\u884c\u9012\u9001\u6210\u4e3a\u53ef\u80fd\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5b66\u4e60\u5f00\u59cb\u65f6\u95f4\uff08\u9884\u8ba1\uff09<\/strong>: 2025-08-06<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5c0f\u5b66\u5b8c\u6210\u60c5\u51b5\uff08\u9884\u8ba1\uff09<\/strong>: 2026-12<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7814\u7a76\u5b8c\u6210\u60c5\u51b5\uff08\u9884\u8ba1\uff09<\/strong>: 2026-12<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u53c2\u4e0e\u4eba\u6570\uff08\u9884\u8ba1\uff09<\/strong>: 6<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5b66\u4e60\u7c7b\u578b<\/strong>\uff1a\u7b2c\u4e00\u9636\u6bb5\u65e9\u671f<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5730\u70b9<\/strong>: <a href=\"https:\/\/maps.app.goo.gl\/Z2CyEqLydJ4Kxh9aA\" target=\"_blank\" rel=\"noreferrer noopener\">\u4e0a\u6d77\u513f\u7ae5\u533b\u5b66\u4e2d\u5fc3<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u9002\u5408\u5b66\u4e60\u7684\u5e74\u9f84<\/strong>\uff1a2\u5c81\u81f36\u5c81\uff08\u80fd\u8d70\u52a8\u7684\u96c4\u6027\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e3b\u8981\u7eb3\u5165\u548c\u6392\u9664\u6807\u51c6\u3002\u2013 <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT07188012\" target=\"_blank\" rel=\"noreferrer noopener\">NCT07188012<\/a> \u2013<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"how-to-participate-in-the-sgt-003-clinical-trial\"><strong>\u5982\u4f55\u53c2\u4e0e SPOT-mRNA03 \u4e34\u5e8a\u8bd5\u9a8c<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5982\u9700\u53c2\u52a0SPOT-mRNA03\u57fa\u56e0\u6cbb\u7597\u65e9\u671f1\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u60a8\u53ef\u4ee5\u4f7f\u7528\u4ee5\u4e0b\u8054\u7cfb\u4fe1\u606f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u59d3\u540d<\/strong>\uff1a\u6e29\u65af\u987f\u9547<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7535\u8bdd\u53f7\u7801<\/strong>: 212-920-5501<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7535\u5b50\u90ae\u4ef6<\/strong>: Winston.town@spotbiosystems.com<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>The early phase 1 study (NCT07188012) of SPOT-mRNA03 gene therapy for Duchenne Muscular Dystrophy (DMD) developed by Shanghai Siponuoyin Biotechnology is a pilot study of the safety and expression of dystrophin in skeletal muscles after administration. What is SPOT-mRNA03 Gene Therapy SPOT-mRNA03 is the gene therapy product for Duchenne Muscular Dystrophy (DMD). Following administration to [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4580,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[123,137,242,359,61,424,423,425],"class_list":["post-4576","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-china","tag-clinical-trial","tag-clinical-trials","tag-full-length-dystrophin","tag-gene-therapy","tag-shanghai-siponuoyin","tag-spot-mrna03","tag-spot-mrna03-gene-therapy"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/4576","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=4576"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/4576\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/4580"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=4576"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=4576"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=4576"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}