{"id":4466,"date":"2025-09-10T14:49:23","date_gmt":"2025-09-10T11:49:23","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=4466"},"modified":"2025-09-10T15:50:17","modified_gmt":"2025-09-10T12:50:17","slug":"avidity-biosciences-del-zota-increase-dystrophin-phase-1-2-clinical-trial","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/avidity-biosciences-del-zota-increase-dystrophin-phase-1-2-clinical-trial\/","title":{"rendered":"Del-zota\uff08\u5916\u663e\u5b5044\u8df3\u8dc3\u7597\u6cd5\uff09\u57281\/2\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8bc1\u5b9e\u53ef\u9006\u8f6c\u5173\u952e\u529f\u80fd\u7ec8\u70b9\u7684\u75be\u75c5\u8fdb\u5c55"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Avidity Biosciences \u5ba3\u5e03\u4e86\u6765\u81ea EXPLORE44 \u548c EXPLORE44-OLE \u8bd5\u9a8c\u4e2d\u8fde\u7eed\u63a5\u53d7 del-zota \u6cbb\u7597\u4e00\u5e74\u7684\u53d7\u8bd5\u8005\u7684\u79ef\u6781\u65b0\u6570\u636e\u3002\u8fd9\u4e9b\u6570\u636e\u8868\u660e\uff0c\u75c5\u60c5\u8fdb\u5c55\u5f97\u5230\u9006\u8f6c\uff0c\u5e76\u4e14\u4e0e\u57fa\u7ebf\u548c\u81ea\u7136\u75c5\u7a0b\u76f8\u6bd4\uff0c\u591a\u9879\u529f\u80fd\u6307\u6807\u5747\u53d6\u5f97\u4e86\u524d\u6240\u672a\u6709\u7684\u6539\u5584\u3002EXPLORE44 \u9879\u76ee\u7684\u66f4\u591a\u6570\u636e\u5c06\u5728\u5373\u5c06\u53ec\u5f00\u7684\u79d1\u5b66\u5927\u4f1a\u4e0a\u516c\u5e03\u3002\u2014\u2014 \u9605\u8bfb\u66f4\u591a\uff1a <a href=\"https:\/\/dmdwarrior.com\/zh\/fda-designates-avidity-biosciences-delpacibart-zotadirsen-del-zota-as-a-breakthrough-therapy-for-the-treatment-of-dmd-in-individuals-with-mutations-that-allow-for-exon-44-skipping\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u7a81\u7834\u6027\u7597\u6cd5\uff1a\u5916\u663e\u5b5044\u8df3\u8dc3\u7597\u6cd5<\/a> \u2013<\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u76ee\u5f55<\/h2><nav><ul><li><a href=\"#del-zota-exon-44-skipping-therapy\">\u5fb7\u5c14\u4f50\u5854\uff1a\u5916\u663e\u5b5044\u8df3\u8dc3\u7597\u6cd5<\/a><\/li><li><a href=\"#del-zota-phase-1-2-clinical-trial\">Del-zota\uff1a1\/2 \u671f\u4e34\u5e8a\u8bd5\u9a8c<\/a><\/li><li><a href=\"#biologics-license-application-bla-to-fda\">\u751f\u7269\u5236\u54c1\u8bb8\u53ef\u8bc1\u7533\u8bf7\uff08BLA\uff09FDA<\/a><\/li><li><a href=\"#explore-44-exon-44-skipping-program\">EXPLORE44\uff1a\u5916\u663e\u5b5044\u8df3\u8dc3\u7a0b\u5e8f<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"del-zota-exon-44-skipping-therapy\">\u5fb7\u5c14\u4f50\u5854\uff1a\u5916\u663e\u5b5044\u8df3\u8dc3\u7597\u6cd5<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">DMD \u662f\u4e00\u79cd\u7f55\u89c1\u7684\u9057\u4f20\u75c5\uff0c\u5176\u7279\u5f81\u662f\u7531\u4e8e\u51fa\u751f\u65f6\u7f3a\u4e4f\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\uff0c\u5bfc\u81f4\u808c\u8089\u4ece\u5f88\u5c0f\u7684\u65f6\u5019\u5c31\u5f00\u59cb\u51fa\u73b0\u8fdb\u884c\u6027\u635f\u4f24\u548c\u65e0\u529b\u3002 <strong>Del-zota \u65e8\u5728\u5c06\u78f7\u9178\u4e8c\u9170\u80fa\u5417\u5549\u4f4e\u805a\u7269 (PMO) \u8f93\u9001\u5230\u9aa8\u9abc\u808c\u548c\u5fc3\u810f\u7ec4\u7ec7\uff0c\u4ee5\u4e13\u95e8\u8df3\u8fc7\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d mRNA \u7684\u5916\u663e\u5b50 44\uff0c\u5e76\u80fd\u591f\u4ea7\u751f\u529f\u80fd\u6027\u3001\u63a5\u8fd1\u5168\u957f\u7684\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u3002<\/strong> \u63a5\u8fd1\u5168\u957f\u7684\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u4fdd\u7559\u4e86\u5173\u952e\u7684\u529f\u80fd\u57df\uff0c\u5e76\u53ef\u80fd\u4e3a\u60a3\u6709 DMD44 \u7684\u4eba\u63d0\u4f9b\u66f4\u597d\u7684\u808c\u8089\u4fdd\u62a4\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"del-zota-phase-1-2-clinical-trial\">Del-zota\uff1a1\/2 \u671f\u4e34\u5e8a\u8bd5\u9a8c<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4e0e\u57fa\u7ebf\u548c\u81ea\u7136\u75c5\u53f2\u76f8\u6bd4\uff0c\u7ea6\u4e00\u5e74\u540e\u591a\u9879\u529f\u80fd\u6307\u6807\u5747\u51fa\u73b0\u524d\u6240\u672a\u6709\u7684\u6539\u5584\uff0c\u5305\u62ec\u4ece\u5730\u677f\u8d77\u8eab\u65f6\u95f4 (TTR)\u3001\u722c 4 \u7ea7\u697c\u68af\u65f6\u95f4 (4SC)\u3001\u4e0a\u80a2\u8868\u73b0 (PUL) \u548c 10 \u7c73\u6b65\u884c\/\u8dd1\u6b65\u6d4b\u8bd5 (10mWRT)<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u808c\u9178\u6fc0\u9176 (CK) \u524d\u6240\u672a\u6709\u7684\u5feb\u901f\u964d\u4f4e\u81f3\u63a5\u8fd1\u6b63\u5e38\u6c34\u5e73\uff0c\u5e76\u5728 16 \u4e2a\u6708\u7684\u968f\u8bbf\u4e2d\u7ef4\u6301\uff0c\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u7684\u4ea7\u751f\u4e5f\u589e\u52a0\u4e86 25%\uff0c\u53cd\u6620\u4e86\u6301\u7eed\u7684\u808c\u8089\u7ea4\u7ef4\u4fdd\u62a4<\/strong><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Avidity \u6709\u671b\u5728 2025 \u5e74\u5e95\u63d0\u4ea4\u751f\u7269\u5236\u5242\u8bb8\u53ef\u7533\u8bf7 (BLA) \u4ee5\u83b7\u5f97\u52a0\u901f\u6279\u51c6<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"biologics-license-application-bla-to-fda\">\u751f\u7269\u5236\u54c1\u8bb8\u53ef\u8bc1\u7533\u8bf7\uff08BLA\uff09FDA<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Avidity \u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98 Sarah Boyce \u8868\u793a\uff1a\u201c\u6211\u4eec\u9996\u6b21\u6709\u6570\u636e\u8868\u660e\uff0c\u6301\u7eed\u7684\u808c\u8089\u4fdd\u62a4\u53ef\u4ee5\u663e\u8457\u6539\u5584 DMD \u7684\u591a\u9879\u5173\u952e\u529f\u80fd\u6307\u6807\u3002\u201d<strong>\u8fd9\u4e9b\u524d\u6240\u672a\u6709\u7684\u6570\u636e\u5f3a\u8c03\u4e86\u6211\u4eec\u5c06 RNA \u76f4\u63a5\u8f93\u9001\u5230\u808c\u8089\u7684\u9769\u547d\u6027\u9776\u5411\u65b9\u6cd5\u7684\u5f71\u54cd\u3002<\/strong> \u6211\u4eec\u6b63\u7d27\u6025\u884c\u52a8\uff0c\u5feb\u901f\u63a8\u8fdbdel-zota\u5f00\u53d1\u9879\u76ee\uff0c\u5e76\u6309\u8ba1\u5212\u57282025\u5e74\u5e95\u63d0\u4ea4FDA\u7684\u751f\u7269\u5236\u54c1\u8bb8\u53ef\u7533\u8bf7(BLA)\uff0c\u4ee5\u83b7\u5f97\u52a0\u901f\u5ba1\u6279\u3002\u6211\u4eec\u8877\u5fc3\u611f\u8c22\u7814\u7a76\u4eba\u5458\u53ca\u5176\u56e2\u961f\u7684\u6301\u7eed\u5949\u732e\uff0c\u6700\u91cd\u8981\u7684\u662f\uff0c\u611f\u8c22\u4e34\u5e8a\u8bd5\u9a8c\u7684\u53c2\u4e0e\u8005\u53ca\u5176\u5bb6\u5c5e\uff0c\u611f\u8c22\u4ed6\u4eec\u4e3a\u8fd9\u4e00\u987d\u56fa\u4e14\u6781\u5177\u7834\u574f\u6027\u7684\u75be\u75c5\u5bfb\u6c42\u65b0\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"explore-44-exon-44-skipping-program\">EXPLORE44\uff1a\u5916\u663e\u5b5044\u8df3\u8dc3\u7a0b\u5e8f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u63a5\u53d7 del-zota \u6cbb\u7597\u7684\u8bd5\u9a8c\u53c2\u4e0e\u8005\u7684\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u751f\u6210\u91cf\u663e\u8457\u589e\u52a0\uff0c\u7ea6\u4e3a\u6b63\u5e38\u503c\u7684 25%\uff0c\u5e76\u4e14\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u603b\u91cf\u6062\u590d\u81f3\u6b63\u5e38\u503c\u7684 58%\u3002<\/strong> \u808c\u9178\u6fc0\u9176 (CK) \u6c34\u5e73\u8f83\u57fa\u7ebf\u8fc5\u901f\u4e0b\u964d\u8d85\u8fc7 80%\uff0c\u5e76\u5728\u6574\u4e2a\u8bc4\u4f30\u671f\u95f4\u7ef4\u6301\u5728\u63a5\u8fd1\u6b63\u5e38\u6c34\u5e73\uff0c\u968f\u8bbf\u671f\u957f\u8fbe 16 \u4e2a\u6708\u3002\u6b64\u5916\uff0c50% \u7684\u53c2\u4e0e\u8005\u5728\u6cbb\u7597\u4e00\u5e74\u540e CK \u6c34\u5e73\u6062\u590d\u81f3\u6b63\u5e38\u8303\u56f4\u3002 <a href=\"https:\/\/dmdwarrior.com\/zh\/what-is-creatine-kinase-ck\/\" target=\"_blank\" data-type=\"post\" data-id=\"2167\" rel=\"noreferrer noopener\">\u4ec0\u4e48\u662f\u808c\u9178\u6fc0\u9176\uff08CK\uff09<\/a> \u2013<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5171\u670917\u540d\u53c2\u4e0e\u8005\uff0812\u540d\u53ef\u884c\u8d70\uff0c5\u540d\u4e0d\u53ef\u884c\u8d70\uff09\u5f00\u59cb\u63a5\u53d7EXPLORE44\u00ae\u7684del-zota\u6cbb\u7597\uff0c\u5e76\u7ee7\u7eed\u63a5\u53d7EXPLORE44-OLE\u2122\u6cbb\u7597\uff0c\u76ee\u524d\u5df2\u968f\u8bbf\u7ea6\u4e00\u5e74\u3002\u9274\u4e8e\u7814\u7a76\u8bbe\u8ba1\uff0c\u90e8\u5206\u53c2\u4e0e\u8005\u5728EXPLORE44\u6cbb\u7597\u671f\u95f4\uff0c\u6bcf\u516d\u5468\uff08Q6W\uff09\u63a5\u53d7\u4e00\u6b215\u6beb\u514b\/\u5343\u514b\u7684\u5242\u91cf\uff0c\u90e8\u5206\u53c2\u4e0e\u8005\u6bcf\u516b\u5468\u63a5\u53d7\u4e00\u6b2110\u6beb\u514b\/\u5343\u514b\u7684\u5242\u91cf\u3002\u6240\u6709\u53c2\u4e0e\u8005\u5728EXPLORE44-OLE\u6cbb\u7597\u671f\u95f4\u5747\u8fc7\u6e21\u81f35\u6beb\u514b\/\u5343\u514b\uff08Q6W\uff09\u7684\u7ed9\u836f\u65b9\u6848\u3002\u5e76\u975e\u6240\u6709\u53c2\u4e0e\u8005\u90fd\u80fd\u5b8c\u6210\u6240\u6709\u8bc4\u4f30\u3002\u4e0eDMD44\u81ea\u7136\u53f2\uff08PRO-DMD-01\uff09\u76f8\u6bd4\uff0c\u8fd9\u4e9bdel-zota\u6cbb\u7597\u53c2\u4e0e\u8005\u7684\u6c47\u603b\u7ed9\u836f\u961f\u5217\u7684\u529f\u80fd\u6570\u636e\u663e\u793a\uff0c\u60a3\u8005\u75c5\u60c5\u6709\u6240\u6539\u5584\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u722c\u56db\u7ea7\u697c\u68af\uff084SC\uff09<\/strong>\uff1a\u8f83\u57fa\u7ebf\u63d0\u9ad8\u4e86 2.1 \u79d2\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u81ea\u7136\u75c5\u7a0b\u7ec4\u8f83\u57fa\u7ebf\u4e0b\u964d\u4e86 2.7 \u79d2\uff08DMD44 Nat Hx N=22\uff1bdel-zota N=10\uff09\u3002<\/li>\n\n\n\n<li><strong>10\u7c73\u6b65\u884c\/\u8dd1\u6b65\u6d4b\u8bd5\uff0810mWRT\uff09<\/strong>\uff1a\u8f83\u57fa\u7ebf\u63d0\u9ad8\u4e86 0.7 \u79d2\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u81ea\u7136\u75c5\u7a0b\u7ec4\u8f83\u57fa\u7ebf\u4e0b\u964d\u4e86 1.5 \u79d2\uff08DMD44 Nat Hx N=22\uff1bdel-zota N=10\uff09\u3002<\/li>\n\n\n\n<li><strong>\u4ece\u5730\u677f\u8d77\u7acb\u65f6\u95f4 (TTR)<\/strong>\uff1a\u8f83\u57fa\u7ebf\u63d0\u9ad8\u4e86 3.2 \u79d2\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u81ea\u7136\u75c5\u7a0b\u7ec4\u8f83\u57fa\u7ebf\u4e0b\u964d\u4e86 1.6 \u79d2\uff08DMD Nat Hx N=19\uff1bdel-zota N=6\uff09\u3002<\/li>\n\n\n\n<li><strong>\u5317\u6781\u661f\u52a8\u6001\u8bc4\u4f30 (NSAA)<\/strong>\uff1a\u4fdd\u6301\u7a33\u5b9a\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u81ea\u7136\u75c5\u53f2\u7ec4\u8f83\u57fa\u7ebf\u4e0b\u964d\u4e86 2.4 \u5206\uff08DMD44 Nat Hx N=20\uff1bdel-zota N=10\uff09\u3002<\/li>\n\n\n\n<li><strong>\u4e0a\u80a2\u8868\u73b0\uff08PUL2\uff09<\/strong>\uff1a\u8f83\u57fa\u7ebf\u63d0\u9ad8 1.5 \u5206\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u81ea\u7136\u75c5\u7a0b\u7ec4\u8f83\u57fa\u7ebf\u4e0b\u964d 0.7 \u5206\u3002ii \u884c\u8d70\u548c\u975e\u884c\u8d70\u53c2\u4e0e\u8005\u7684 PUL \u6539\u5584\u5747\u76f8\u4f3c (DMD44 Nat Hx N=27; del-zota N=17)\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>EXPLORE44-OLE \u8bd5\u9a8c\u4e2d\u6240\u6709\u53c2\u4e0e\u8005\u7684\u5b89\u5168\u6027\u90fd\u5f97\u5230\u4e86\u8bc4\u4f30\uff0cdel-zota \u7ee7\u7eed\u8868\u73b0\u51fa\u826f\u597d\u7684\u957f\u671f\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002<\/strong> \u5927\u591a\u6570\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6 (TEAE) \u4e3a\u8f7b\u5ea6\u6216\u4e2d\u5ea6\uff0c\u6700\u5e38\u89c1\u7684 TEAE\uff08\u53d1\u751f\u4e8e 3 \u4f8b\u4ee5\u4e0a\u53d7\u8bd5\u8005\uff09\u5305\u62ec\u4e0a\u547c\u5438\u9053\u75c7\u72b6\u3001\u8179\u6cfb\u3001\u8dcc\u5012\u3001\u80cc\u75db\u548c\u5934\u75db\u3002\u4e00\u540d\u53d7\u8bd5\u8005\u56e0\u51fa\u73b0\u8fc7\u654f\u53cd\u5e94\u800c\u505c\u6b62\u670d\u7528 EXPLORE44-OLE\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Avidity \u4ecd\u6709\u671b\u5728 2025 \u5e74\u5e95\u5411\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40 (FDA) \u63d0\u4ea4 BLA (FDA)\u3002<\/strong> \u8fd9\u5c06\u662f\u8be5\u516c\u53f8\u8ba1\u5212\u572812\u4e2a\u6708\u5185\u63d0\u4ea4\u4e09\u4efd\u751f\u7269\u5236\u54c1\u8bb8\u53ef\u7533\u8bf7\uff08BLA\uff09\u4e2d\u7684\u9996\u4efd\u3002Avidity \u6b63\u5728\u7ee7\u7eed\u51c6\u5907\u4e00\u9879\u9a8c\u8bc1\u6027\u7814\u7a76\uff0c\u4ee5\u652f\u6301\u5176\u83b7\u5f97\u5168\u7403\u5168\u9762\u6279\u51c6\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u9605\u8bfb\u66f4\u591a<\/strong>: <a href=\"https:\/\/dmdwarrior.com\/zh\/upcoming-exon-44-skipping-therapies-for-dmd\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u5373\u5c06\u63a8\u51fa\u7684\u7528\u4e8e\u6cbb\u7597\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u5916\u663e\u5b50 44 \u8df3\u8dc3\u7597\u6cd5<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4e86\u89e3\u66f4\u591a<\/strong>: <a href=\"https:\/\/dmdwarrior.com\/zh\/mutations-and-deletions-amenable-to-exon-44-skipping-therapies-dmd\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u53ef\u901a\u8fc7\u5916\u663e\u5b50 44 \u8df3\u8dc3\u7597\u6cd5\u6cbb\u7597\u7684\u7a81\u53d8\u548c\u7f3a\u5931<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Avidity Biosciences announced positive new data from participants treated continuously with del-zota for one year in the EXPLORE44 and EXPLORE44-OLE trials. These data demonstrated reversal of disease progression and unprecedented improvement compared to baseline and natural history across multiple functional measures. Additional data from the EXPLORE44 program will be presented at upcoming scientific congresses. &#8211; [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4468,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[126,298,129,73,141,127,246,299,359],"class_list":["post-4466","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-avidity-biosciences","tag-del-zota","tag-dmd44","tag-dystrophin","tag-exon-44","tag-exon-44-skipping","tag-exon-44-skipping-therapies","tag-explore44","tag-full-length-dystrophin"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/4466","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=4466"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/4466\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/4468"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=4466"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=4466"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=4466"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}