{"id":4416,"date":"2025-09-08T15:27:01","date_gmt":"2025-09-08T12:27:01","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=4416"},"modified":"2025-09-08T15:27:03","modified_gmt":"2025-09-08T12:27:03","slug":"keros-therapeutics-presents-additional-clinical-data-its-ker-065","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/keros-therapeutics-presents-additional-clinical-data-its-ker-065\/","title":{"rendered":"Keros Therapeutics \u5728\u7f8e\u56fd\u9aa8\u4e0e\u77ff\u7269\u8d28\u7814\u7a76\u5b66\u4f1a 2025 \u5e74\u5e74\u4f1a\u4e0a\u5c55\u793a\u4e86\u5176 KER-065 \u9879\u76ee\u7684\u66f4\u591a\u4e34\u5e8a\u6570\u636e"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Keros Therapeutics \u5ba3\u5e03\uff0c\u5b83\u5c06\u5728 2025 \u5e74 9 \u6708 6 \u65e5\u661f\u671f\u516d\u4e3e\u884c\u7684\u7f8e\u56fd\u9aa8\u77ff\u7814\u7a76\u5b66\u4f1a 2025 \u5e74\u5e74\u4f1a\u4e0a\u516c\u5e03\u5176\u5728\u5065\u5eb7\u7537\u6027\u5fd7\u613f\u8005\u4e2d\u8fdb\u884c\u7684 KER-065 \u7b2c 1 \u9636\u6bb5\u4e34\u5e8a\u8bd5\u9a8c\u7684\u66f4\u591a\u4e34\u5e8a\u6570\u636e\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201c\u6211\u4eec\u5f88\u9ad8\u5174\u80fd\u591f\u63d0\u4f9b\u66f4\u591a\u6570\u636e\uff0c\u51f8\u663eKER-065\u7684\u5e7f\u6cdb\u6cbb\u7597\u6f5c\u529b\uff0c\u5305\u62ec\u5176\u5f3a\u5927\u7684\u9aa8\u5408\u6210\u4ee3\u8c22\u6d3b\u6027\uff0c\u201d\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98Jasbir S. Seehra\u8868\u793a\u3002\u201c\u8fd9\u4e9b\u6570\u636e\u8fdb\u4e00\u6b65\u8bc1\u660e\u4e86KER-065\u5728\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff08\u4e00\u79cd\u56e0\u8fdb\u884c\u6027\u808c\u8089\u65e0\u529b\u548c\u957f\u671f\u4f7f\u7528\u76ae\u8d28\u7c7b\u56fa\u9187\u800c\u5bfc\u81f4\u9aa8\u8d28\u6d41\u5931\u7684\u75be\u75c5\uff09\u6cbb\u7597\u4e2d\u7684\u6f5c\u529b\u3002\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">KER-065\u4e34\u5e8a\u8868\u73b0<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u98791\u671f\u4e34\u5e8a\u8bd5\u9a8c\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u4e24\u90e8\u5206\u5242\u91cf\u9012\u589e\uff08\u5355\u6b21\u548c\u591a\u6b21\u9012\u589e\u5242\u91cf\uff09\u8bd5\u9a8c\uff0c\u53d7\u8bd5\u8005\u4e3a\u5065\u5eb7\u7537\u6027\u5fd7\u613f\u8005\u3002\u8be5\u8bd5\u9a8c\u7684\u4e3b\u8981\u76ee\u7684\u662f\u8bc4\u4f30KER-065\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u3002\u63a2\u7d22\u6027\u7ec8\u70b9\u5305\u62ec\u8bc4\u4f30\u5176\u5bf9\u9aa8\u9abc\u3001\u8102\u80aa\u3001\u808c\u8089\u3001\u5fc3\u810f\u7ec4\u7ec7\u548c\u7ea4\u7ef4\u5316\u7684\u836f\u6548\u52a8\u529b\u5b66\u6548\u5e94\u3002\u8be5\u8bd5\u9a8c\u7684\u521d\u59cb\u9876\u7ebf\u6570\u636e\u5df2\u4e8e2025\u5e743\u6708\u516c\u5e03\u3002 <a href=\"https:\/\/dmdwarrior.com\/zh\/keros-therapeutics-announces-initial-topline-results-from-the-phase-1-clinical-trial-of-ker-065-in-healthy-volunteers\/\">\u9605\u8bfb\u66f4\u591a<\/a> \u2013<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u622a\u81f32025\u5e744\u670829\u65e5\u6700\u7ec8\u6570\u636e\u622a\u6b62\u65e5\u671f\uff0cKER-065\u6cbb\u7597\u5728\u6240\u6709\u5242\u91cf\u6c34\u5e73\u4e0b\u5747\u8868\u73b0\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\u3002\u672a\u62a5\u544a\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\u6216\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002\u89c2\u5bdf\u5230\u4e00\u4f8b4\u7ea7\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u808c\u9178\u6fc0\u9176\u6c34\u5e73\u5347\u9ad8\u4e0d\u826f\u4e8b\u4ef6\uff0c\u4f46\u88ab\u8ba4\u4e3a\u4e0e\u6cbb\u7597\u65e0\u5173\u3002\u89c2\u5bdf\u5230\u7684\u5927\u591a\u6570\u4e0d\u826f\u4e8b\u4ef6\u4e25\u91cd\u7a0b\u5ea6\u4e3a\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\uff0c\u5e76\u5df2\u5f97\u5230\u7f13\u89e3\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u622a\u81f3\u6570\u636e\u622a\u6b62\u65e5\u671f\uff0c\u8be5\u8bd5\u9a8c\u7684\u5176\u4ed6\u7ed3\u679c\u8868\u660e\uff0c\u4f7f\u7528 KER-065 \u6cbb\u7597\u53ef\u4ea7\u751f\u4ee5\u4e0b\u6548\u679c\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u9aa8\u751f\u7269\u6807\u5fd7\u7269\u7684\u53d8\u5316\u8868\u660e\u9aa8\u5f62\u6210\u589e\u52a0\u3001\u9aa8\u5438\u6536\u51cf\u5c11\uff0c\u8fd9\u4e0e\u7ec4\u7ec7\u6c34\u5e73\u7684\u53d8\u5316\u4e00\u81f4\uff0c\u5982\u89c2\u5bdf\u5230\u7684\u9aa8\u77ff\u7269\u8d28\u5bc6\u5ea6\uff08\u201cBMD\u201d\uff09\u7684\u589e\u52a0\u6240\u8bc1\u5b9e<\/li>\n\n\n\n<li>\u7b2c 85 \u5929\u5168\u8eab BMD \u6539\u5584\u6301\u7eed\u81f3\u7b2c 141 \u5929\uff08\u591a\u6b21\u9012\u589e\u5242\u91cf\u7ec4\u4e2d\u6700\u540e\u4e00\u6b21\u7ed9\u836f\u540e\u4e09\u4e2a\u6708\uff09\uff0c\u8868\u660e\u6210\u9aa8\u7ec6\u80de\u548c\u7834\u9aa8\u7ec6\u80de\u6d3b\u6027\u4e4b\u95f4\u8fbe\u5230\u5e73\u8861<\/li>\n\n\n\n<li>\u6301\u7eed\u670d\u7528\u4e09\u5242\u81f3\u7b2c 141 \u5929\u540e\uff0c\u8170\u690e BMD \u6709\u6240\u589e\u52a0<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">KER-065\u662f\u4ec0\u4e48\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">KER-065 \u662f\u4e00\u79cd\u65b0\u578b\u914d\u4f53\u9677\u9631\uff0c\u7531\u6e90\u81ea\u6fc0\u6d3b\u7d20\u53d7\u4f53 IIA \u578b\u548c\u6fc0\u6d3b\u7d20\u53d7\u4f53 IIB \u578b\u7684\u4fee\u9970\u914d\u4f53\u7ed3\u5408\u57df\u7ec4\u6210\uff0c\u8be5\u57df\u4e0e\u4eba\u6e90\u6297\u4f53\u7684 Fc \u7ed3\u6784\u57df\u878d\u5408\u3002KER-065 \u65e8\u5728\u5145\u5f53\u914d\u4f53\u9677\u9631\uff0c\u6291\u5236\u808c\u751f\u957f\u6291\u5236\u7d20\u548c\u6fc0\u6d3b\u7d20 A\uff08\u4e24\u79cd\u901a\u8fc7\u6fc0\u6d3b\u7d20\u53d7\u4f53\u53d1\u51fa\u4fe1\u53f7\u7684\u914d\u4f53\uff09\u7684\u751f\u7269\u5b66\u6548\u5e94\uff0c\u4ece\u800c\u589e\u52a0\u9aa8\u9abc\u808c\u518d\u751f\u3001\u589e\u52a0\u808c\u8089\u5927\u5c0f\u548c\u529b\u91cf\u3001\u51cf\u5c11\u4f53\u8102\u3001\u51cf\u5c11\u9aa8\u9abc\u808c\u7ea4\u7ef4\u5316\u5e76\u589e\u52a0\u9aa8\u9abc\u5f3a\u5ea6\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>Keros Therapeutics announced that it presented additional clinical data from its Phase 1 clinical trial of KER-065 in healthy male volunteers at the American Society of Bone and Mineral Research 2025 Annual Meeting on Saturday, September 6, 2025. \u201cWe are pleased to present additional data that highlights the broad therapeutic potential of KER-065, including its [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4439,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[337,336],"class_list":["post-4416","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-ker-065","tag-keros-therapeutics"],"subtitle":"KER-065\uff08\u4e00\u79cd\u6539\u826f\u7684\u6fc0\u6d3b\u7d20\u53d7\u4f53\u914d\u4f53\u9677\u9631\uff09\u5728\u5065\u5eb7\u53c2\u4e0e\u8005\u4e2d\u8fdb\u884c\u7684 I 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