{"id":4264,"date":"2025-08-02T11:30:03","date_gmt":"2025-08-02T08:30:03","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=4264"},"modified":"2025-08-02T12:04:33","modified_gmt":"2025-08-02T09:04:33","slug":"high-anti-aav-antibodies-may-not-prevent-elevidys-administration","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/high-anti-aav-antibodies-may-not-prevent-elevidys-administration\/","title":{"rendered":"\u9ad8\u6297AAV\u6297\u4f53\u53ef\u80fd\u4e0d\u518d\u662fElevidys\u7ed9\u836f\u7684\u969c\u788d"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Elevidys\u57fa\u56e0\u7597\u6cd5\u5e94\u7528\u4e8e\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff08Duchenne muscular dystrophy\uff09\u7684\u6700\u5927\u969c\u788d\u4e4b\u4e00\u662f\u9ad8\u6297AAV\u6297\u4f53\u3002Hansa Biopharma\u516c\u5e03\u4e86\u5728\u8fdb\u884c\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u57fa\u56e0\u6cbb\u7597\u524d\u4f7f\u7528imlifidase\u6cbb\u7597\u7684\u652f\u6301\u6570\u636e\u3002\u4e09\u4f8b\u60a3\u8005\u63a5\u53d7imlifidase\u6cbb\u7597\u540e\uff0c\u5148\u524d\u5b58\u5728\u7684\u6297AAV\u6297\u4f53\u6ef4\u5ea6\u964d\u81f31:400\u4ee5\u4e0b\uff0c\u4ece\u800c\u53ef\u4ee5\u4f7f\u7528ELEVIDYS\u8fdb\u884c\u6cbb\u7597\u3002<\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u76ee\u5f55<\/h2><nav><ul><li><a href=\"#hansa-biopharma-reports-encouraging-results-from-imlifidase-treatment\">Hansa Biopharma \u62a5\u544a\u4e86 imlifidase \u7684\u4ee4\u4eba\u9f13\u821e\u7684\u7ed3\u679c<\/a><\/li><li><a href=\"#what-does-imlifidase-do-in-gene-therapies\">Imlifidase \u5728\u57fa\u56e0\u6cbb\u7597\u4e2d\u8d77\u4ec0\u4e48\u4f5c\u7528\uff1f<\/a><\/li><li><a href=\"#what-is-the-srp-9001-104-clinical-trial\">\u4ec0\u4e48\u662f SRP-9001-104 \u4e34\u5e8a\u8bd5\u9a8c\uff1f<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Hansa Biopharma \u516c\u5e03\u4e86 SRP-9001-104 \u8bd5\u9a8c\u4e2d\u4e09\u540d\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7 (DMD) \u60a3\u8005\u7684\u9876\u7ebf\u7ed3\u679c\uff0c\u8fd9\u4e9b\u60a3\u8005\u5728\u63a5\u53d7 Sarepta \u7684 ELEVIDYS (delandistrogene moxeparvovec-rokl) \u6cbb\u7597\u4e4b\u524d\uff0c\u5148\u7528 Hansa \u7684 imlifidase \u6cbb\u7597\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"hansa-biopharma-reports-encouraging-results-from-imlifidase-treatment\">Hansa Biopharma \u62a5\u544a\u4e86 imlifidase \u7684\u4ee4\u4eba\u9f13\u821e\u7684\u7ed3\u679c<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u5242\u4f0a\u7c73\u66ff\u5c3c (imlifidase) \u6cbb\u7597\u540e\uff0c\u4e09\u4f8b\u60a3\u8005\u7684 IgG \u6297\u4f53\u8fc5\u901f\u964d\u4f4e\uff0c\u81f3\u4f4e\u4e8e\u57fa\u7ebf\u6c34\u5e73\u226595%\u3002\u6b64\u5916\uff0c\u8fd9\u4e09\u4f8b\u60a3\u8005\u539f\u6709\u7684\u6297 AAV \u6297\u4f53\u6ef4\u5ea6\u4e5f\u964d\u81f3 1:400 \u4ee5\u4e0b\uff0c\u4ece\u800c\u80fd\u591f\u63a5\u53d7 ELEVIDYS \u6cbb\u7597\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Imlifidase \u7684\u5b89\u5168\u6027\u4e0e\u65e2\u5f80\u7ecf\u9a8c\u4e00\u81f4\uff0c\u4e14\u8bd5\u9a8c\u672a\u53d1\u73b0\u4efb\u4f55\u65b0\u7684\u5b89\u5168\u4fe1\u53f7\u3002\u57fa\u56e0\u6cbb\u7597\u7ed9\u836f 12 \u5468\u540e\uff0c\u8bd5\u9a8c\u60a3\u8005\u663e\u793a\u51fa AAV \u4ecb\u5bfc\u7684\u5fae\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u8f6c\u5bfc\u548c\u8868\u8fbe\u7684\u8bc1\u636e\uff0c\u4f46\u5176\u6c34\u5e73\u4f4e\u4e8e\u5176\u4ed6 ELEVIDYS \u8bd5\u9a8c\u7684\u7ed3\u679c\u3002\u57fa\u4e8e\u8fd9\u4e9b\u7ed3\u679c\uff0cHansa \u548c Sarepta \u5c06\u8ba8\u8bba\u8be5\u9879\u76ee\u7684\u540e\u7eed\u6b65\u9aa4\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-does-imlifidase-do-in-gene-therapies\">Imlifidase \u5728\u57fa\u56e0\u6cbb\u7597\u4e2d\u8d77\u4ec0\u4e48\u4f5c\u7528\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Imlifidase \u76ee\u524d\u6b63\u5728\u88ab\u8bc4\u4f30\u4f5c\u4e3a\u57fa\u56e0\u6cbb\u7597\u7684\u9884\u5904\u7406\u65b9\u6cd5\uff0c\u7528\u4e8e\u6cbb\u7597\u672a\u6ee1\u8db3\u9700\u6c42\u7a0b\u5ea6\u8f83\u9ad8\u7684\u9886\u57df\u3002<\/strong> \u8bb8\u591a\u57fa\u56e0\u7597\u6cd5\u57fa\u4e8e\u817a\u76f8\u5173\u75c5\u6bd2 (AAV) \u8f7d\u4f53\u3002\u90e8\u5206\u60a3\u8005\u514d\u75ab\u7cfb\u7edf\u643a\u5e26\u7684\u6297\u4f53\u4f1a\u62b5\u6d88\u57fa\u56e0\u7597\u6cd5\u7684\u6548\u679c\uff0c\u4ece\u800c\u963b\u788d\u5176\u6210\u529f\u3002\u5728\u63a5\u53d7 AAV \u57fa\u56e0\u7597\u6cd5\u6cbb\u7597\u4e4b\u524d\uff0c\u4f7f\u7528\u4f0a\u7c73\u5229\u83f2\u8fbe\u9176 (imlifidase) \u8fdb\u884c\u9884\u5904\u7406\uff0c\u6709\u53ef\u80fd\u706d\u6d3b\u6297\u4f53\uff0c\u4ece\u800c\u4f7f\u5df2\u5b58\u5728 AAV \u57fa\u56e0\u7597\u6cd5\u6297\u4f53\u7684\u60a3\u8005\u80fd\u591f\u63a5\u53d7\u57fa\u56e0\u7597\u6cd5\u6cbb\u7597\u3002\u76ee\u524d\uff0c\u636e\u4f30\u8ba1\uff0c\u5e73\u5747\u6bcf 3 \u4eba\u4e2d\u5c31\u6709 1 \u4eba\u56e0\u4e2d\u548c\u6297\u4f53 (NAb) \u800c\u65e0\u6cd5\u4ece\u57fa\u56e0\u7597\u6cd5\u4e2d\u83b7\u76ca\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-is-the-srp-9001-104-clinical-trial\">\u4ec0\u4e48\u662f SRP-9001-104 \u4e34\u5e8a\u8bd5\u9a8c\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>SRP-9001-104 \u662f\u4e00\u9879\u9488\u5bf9 4 \u81f3 9 \u5c81\u60a3\u6709 DMD \u4e14\u5df2\u5b58\u5728 ELEVIDYS \u6297\u4f53\u7684\u7537\u6027\u95e8\u8bca\u60a3\u8005\u7684\u5f00\u653e\u6807\u7b7e\u8bd5\u9a8c\u3002<\/strong> \u6700\u591a\u516d\u540d\u60a3\u8005\u5c06\u63a5\u53d7imlifidase\u6cbb\u7597\uff0c\u968f\u540e\u63a5\u53d7ELEVIDYS\u6cbb\u7597\u3002\u7531\u4e8e\u5b58\u5728\u9488\u5bf9AAVrh74\uff08\u7528\u4e8e\u9012\u9001Sarepta\u57fa\u56e0\u7597\u6cd5\u7684\u8f7d\u4f53\uff09\u7684\u6297\u4f53\uff0c\u6240\u6709\u53c2\u4e0e\u8bd5\u9a8c\u7684\u60a3\u8005\u76ee\u524d\u5747\u4e0d\u7b26\u5408ELEVIDYS\u6cbb\u7597\u7684\u8d44\u683c\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e86\u89e3\u66f4\u591a\uff1a <a href=\"https:\/\/dmdwarrior.com\/zh\/frequently-asked-questions-about-elevidys-used-for-duchenne-muscular-dystrophy\/\">\u5173\u4e8e Elevidys \u7684\u5e38\u89c1\u95ee\u9898\u89e3\u7b54<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>One of the most significant obstacles to the application of Elevidys gene therapy developed for Duchenne muscular dystrophy disease is the high anti-AAV antibodies. Hansa Biopharma announces supportive data from treatment with imlifidase prior to the administration of gene therapy for Duchenne muscular dystrophy. Following imlifidase therapy in three patients, pre-existing anti-AAV antibodies decreased to [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4270,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[33,61,401,400,65],"class_list":["post-4264","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-elevidys","tag-gene-therapy","tag-hansa-biopharma","tag-imlifidase","tag-sarepta"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/4264","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=4264"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/4264\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/4270"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=4264"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=4264"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=4264"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}