{"id":4004,"date":"2025-06-26T19:44:06","date_gmt":"2025-06-26T16:44:06","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=4004"},"modified":"2025-06-26T19:56:53","modified_gmt":"2025-06-26T16:56:53","slug":"edgewise-therapeutics-reports-positive-results-on-sevasemten-program-for-becker-and-duchenne-muscular-dystrophies","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/edgewise-therapeutics-reports-positive-results-on-sevasemten-program-for-becker-and-duchenne-muscular-dystrophies\/","title":{"rendered":"Edgewise Therapeutics \u62a5\u544a Sevasemten \u6cbb\u7597\u8d1d\u514b\u5c14\u578b\u548c\u675c\u6c0f\u578b\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u65b9\u6848\u53d6\u5f97\u79ef\u6781\u6210\u679c"},"content":{"rendered":"<p class=\"wp-block-paragraph\">\u9886\u5148\u7684\u808c\u8089\u75be\u75c5\u751f\u7269\u5236\u836f\u516c\u53f8 Edgewise Therapeutics \u4eca\u5929\u516c\u5e03\u4e86\u5176\u9488\u5bf9\u8d1d\u514b\u5c14\u548c\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684 sevasemten \u9879\u76ee\u53d6\u5f97\u7684\u79ef\u6781\u6210\u679c\u3002<\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u76ee\u5f55<\/h2><nav><ul><li><a href=\"#what-is-sevasemten\">Sevasemten \u662f\u4ec0\u4e48\uff1f<\/a><\/li><li><a href=\"#sevasemten\">\u8981\u70b9\uff1aNSAA \u5206\u6570<\/a><\/li><li><a href=\"#phase-2-duchenne-trials\">\u7b2c\u4e8c\u9636\u6bb5\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u8bd5\u9a8c<\/a><\/li><li><a href=\"#sevasemten-1\">\u53c2\u4e0e Sevasemten \u4e34\u5e8a\u8bd5\u9a8c\u7684\u513f\u7ae5\u5e74\u9f84<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-is-sevasemten\">Sevasemten \u662f\u4ec0\u4e48\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sevasemten \u662f\u4e00\u79cd\u53e3\u670d\u7684\u9996\u521b\u5feb\u901f\u9aa8\u9abc\u808c\u7403\u86cb\u767d\u6291\u5236\u5242\uff0c\u65e8\u5728\u9884\u9632\u5305\u62ec\u8d1d\u514b\u5c14\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u548c\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u5728\u5185\u7684\u6536\u7f29\u5f15\u8d77\u7684\u808c\u8089\u635f\u4f24\u3002<\/strong> \u53f8\u74e6\u53f8\u5766 (Sevasemten) \u5177\u6709\u65b0\u9896\u7684\u4f5c\u7528\u673a\u5236\uff0c\u65e8\u5728\u9009\u62e9\u6027\u5730\u9650\u5236\u56e0\u529f\u80fd\u6027\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u7f3a\u5931\u6216\u4e27\u5931\u800c\u5bfc\u81f4\u7684\u8fc7\u5ea6\u808c\u8089\u635f\u4f24\u3002\u5176\u72ec\u7279\u7684\u4f5c\u7528\u673a\u5236\u4f7f\u5176\u6709\u671b\u6210\u4e3a\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u57fa\u7840\u7597\u6cd5\uff0c\u65e2\u53ef\u4ee5\u4f5c\u4e3a\u5355\u836f\u6cbb\u7597\uff0c\u4e5f\u53ef\u4ee5\u4e0e\u73b0\u6709\u7597\u6cd5\u53ca\u5728\u7814\u7597\u6cd5\u8054\u5408\u4f7f\u7528\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"sevasemten\">\u8981\u70b9\uff1aNSAA \u5206\u6570<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">MESA \u6570\u636e\u663e\u793a\u75c5\u60c5\u6301\u7eed\u7a33\u5b9a\uff0c\u5f3a\u5316\u4e86\u5148\u524d ARCH \u548c CANYON \u7684\u7814\u7a76\u7ed3\u679c\u3002\u91cd\u8981\u7684\u662f\uff0c\u4ece CANYON \u8f6c\u4e3a MESA \u7684\u53c2\u4e0e\u8005\u5728 18 \u4e2a\u6708\u5185\u5317\u6781\u661f\u95e8\u8bca\u8bc4\u4f30 (NSAA) \u8bc4\u5206\u6709\u6240\u63d0\u9ad8\uff08\u8f83\u57fa\u7ebf\u63d0\u9ad8\u4e86 0.8 \u5206\uff09\uff0c\u800c\u4ece\u5b89\u6170\u5242\u7ec4\u8f6c\u4e3a\u53f8\u74e6\u53f8\u5766\u7684\u53c2\u4e0e\u8005\u4e5f\u5448\u73b0\u51fa\u6539\u5584\u8d8b\u52bf\uff08\u81ea\u5f00\u59cb\u670d\u7528\u53f8\u74e6\u53f8\u5766\u4ee5\u6765\u63d0\u9ad8\u4e86 0.2 \u5206\uff09\u3002\u5728 18 \u4e2a\u6708\u7684\u53f8\u74e6\u53f8\u5766\u6cbb\u7597\u671f\u95f4\uff0c\u53c2\u4e0e\u8005\u7684 NSAA \u8bc4\u5206\u76f8\u5bf9\u4e8e\u591a\u9879\u8d1d\u514b\u5c14\u81ea\u7136\u53f2\u7814\u7a76\u4e2d\u89c2\u5bdf\u5230\u7684\u9884\u671f\u529f\u80fd\u8870\u9000\u6301\u7eed\u5b58\u5728\u5dee\u5f02\u3002\u6b64\u5916\uff0c\u4ece ARCH \u8f6c\u4e3a MESA \u7684\u53c2\u4e0e\u8005\u7684 NSAA \u8bc4\u5206\u5728\u6cbb\u7597\u4e09\u5e74\u540e\u4fdd\u6301\u7a33\u5b9a\u3002\u5728\u957f\u8fbe\u4e09\u5e74\u7684\u6cbb\u7597\u540e\uff0c\u53f8\u74e6\u53f8\u5766\u4ecd\u8868\u73b0\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Edgewise \u6700\u8fd1\u4e0e\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40 (FDA) \u6210\u529f\u5b8c\u6210\u4e86 C \u7c7b\u4f1a\u8bae (FDA)\uff0c\u8fd9\u4e3a\u585e\u74e6\u53f8\u7f8e\u6c40\u4f5c\u4e3a\u8d1d\u514b\u5c14\u75c5\u7684\u9996\u4e2a\u7597\u6cd5\u7684\u6ce8\u518c\u63d0\u4f9b\u4e86\u6e05\u6670\u7684\u9014\u5f84\u3002\u867d\u7136 FDA \u8ba4\u4e3a\u4ec5\u51ed CANYON \u6570\u636e\u4e0d\u8db3\u4ee5\u83b7\u5f97\u52a0\u901f\u5ba1\u6279\uff0c\u4f46 FDA \u91cd\u7533\uff0cNSAA \u662f\u4f20\u7edf\u5ba1\u6279\u7684\u4e00\u4e2a\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u7ec8\u70b9\u3002FDA \u9f13\u52b1 Edgewise \u5728 GRAND CANYON \u5b8c\u6210\u4e4b\u524d\u7ee7\u7eed\u5206\u4eab MESA \u6570\u636e\u548c\u81ea\u7136\u53f2\u524d\u77bb\u6027\u6a21\u578b\u3002\u6b64\u5916\uff0cFDA \u5f3a\u8c03\u4e86\u4ed6\u4eec\u5bf9\u6b63\u5728\u8fdb\u884c\u7684\u5168\u7403\u5173\u952e\u5b89\u6170\u5242\u5bf9\u7167\u961f\u5217 GRAND CANYON \u7684\u652f\u6301\uff0c\u4ee5\u53ca\u5176\u4f5c\u4e3a\u4e00\u9879\u5355\u72ec\u7684\u3001\u5145\u5206\u7684\u3001\u63a7\u5236\u826f\u597d\u7684\u7814\u7a76\u6765\u652f\u6301\u6ce8\u518c\u7684\u6f5c\u529b\u3002GRAND CANYON \u5177\u6709\u5f88\u9ad8\u7684\u6548\u529b\uff0c\u80fd\u591f\u5728 18 \u4e2a\u6708\u5185\u663e\u793a NSAA \u4e0e\u5b89\u6170\u5242\u4e4b\u95f4\u7684\u7edf\u8ba1\u5b66\u663e\u8457\u5dee\u5f02\uff0c\u5e76\u6709\u671b\u5728 2026 \u5e74\u7b2c\u56db\u5b63\u5ea6\u83b7\u5f97\u9876\u7ebf\u6570\u636e\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"phase-2-duchenne-trials\">\u7b2c\u4e8c\u9636\u6bb5\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u8bd5\u9a8c<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u8be5\u516c\u53f8\u8fd8\u516c\u5e03\u4e86\u51762\u671f\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff08Duchenne\uff09\u8bd5\u9a8cLYNX\u548cFOX\u4ee4\u4eba\u9f13\u821e\u7684\u9876\u7ebf\u6570\u636e\u3002\u8bd5\u9a8c\u65e8\u5728\u63a2\u7d22\u4e00\u7cfb\u5217\u5242\u91cf\u4ee5\u8bc4\u4f30\u5b89\u5168\u6027\uff0c\u5e76\u786e\u5b9a3\u671f\u8bd5\u9a8c\u7684\u6f5c\u5728\u83b7\u76ca\u5242\u91cf\u3002\u8be5\u8bd5\u9a8c\u7684\u5242\u91cf\u9012\u589e\u6a21\u5f0f\u63d0\u4f9b\u4e86\u4e3a\u671f\u4e09\u4e2a\u6708\u7684\u5b89\u6170\u5242\u5bf9\u7167\u671f\uff0c\u7528\u4e8e\u8bc4\u4f30\u7528\u4e8e\u5242\u91cf\u9009\u62e9\u7684\u751f\u7269\u6807\u5fd7\u7269\uff0c\u968f\u540e\u662f\u5f00\u653e\u6807\u7b7e\u671f\u3002\u5728\u8fd9\u4e24\u9879\u7814\u7a76\u4e2d\uff0c\u76ee\u6807\u5242\u91cf\u7684\u53f8\u74e6\u53f8\u5766\u5747\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">LYNX \u662f\u4e00\u9879\u6b63\u5728\u8fdb\u884c\u7684\u591a\u4e2d\u5fc3\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u5242\u91cf\u63a2\u7d22\u6027 II \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u585e\u74e6\u53f8\u6c40\u5bf9 4 \u81f3 9 \u5c81\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u60a3\u8005\u7684\u5b89\u5168\u6027\u3001\u808c\u8089\u635f\u4f24\u751f\u7269\u6807\u5fd7\u7269\u53ca\u529f\u80fd\u7684\u5f71\u54cd\u3002\u8be5\u8bd5\u9a8c\u662f\u4e00\u9879\u4e3a\u671f\u4e09\u4e2a\u6708\u7684\u5b89\u6170\u5242\u5bf9\u7167\u5242\u91cf\u8303\u56f4\u7814\u7a76\uff0c\u7814\u7a76\u5bf9\u8c61\u4e3a\u63a5\u53d7\u585e\u74e6\u53f8\u6c40\u6cbb\u7597\u7684 4 \u81f3 9 \u5c81\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u60a3\u8005\u3002\u5728\u5305\u62ec\u6b65\u901f 95 \u767e\u5206\u4f4d\u6570 (SV95C)\u3001NSAA \u548c 4 \u7ea7\u722c\u697c\u68af\u7b49\u529f\u80fd\u6307\u6807\u65b9\u9762\uff0c\u7814\u7a76\u7ed3\u679c\u4e00\u81f4\uff0c\u56e0\u6b64\u786e\u5b9a\u4e86 10 \u6beb\u514b\u7684 III \u671f\u8bc4\u4f30\u5242\u91cf\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"sevasemten-1\">\u53c2\u4e0e Sevasemten \u4e34\u5e8a\u8bd5\u9a8c\u7684\u513f\u7ae5\u5e74\u9f84<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e0eLYNX\u7684\u8bbe\u8ba1\u7c7b\u4f3c\uff0cFOX\u662f\u4e00\u9879\u6b63\u5728\u8fdb\u884c\u7684\u591a\u4e2d\u5fc3\u3001\u5b89\u6170\u5242\u5bf9\u7167\u76842\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u53f8\u74e6\u53f8\u5766\u5bf96\u81f314\u5c81\u66fe\u63a5\u53d7\u8fc7\u57fa\u56e0\u6cbb\u7597\u7684\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u60a3\u8005\u7684\u5b89\u5168\u6027\u3001\u808c\u8089\u635f\u4f24\u751f\u7269\u6807\u5fd7\u7269\u548c\u529f\u80fd\u7684\u5f71\u54cd\u3002FOX\u53c2\u4e0e\u8005\u5e73\u5747\u5e74\u9f84\u8d85\u8fc710\u5c81\uff0c\u8ddd\u79bb\u63a5\u53d7\u57fa\u56e0\u6cbb\u7597\u5df2\u8fc7\u53bb\u56db\u5e74\u3002\u5c3d\u7ba1\u7f3a\u4e4f\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u57fa\u56e0\u6cbb\u7597\u7537\u5b69\u7684\u5e7f\u6cdb\u81ea\u7136\u75c5\u53f2\uff0c\u4f46FOX\u7814\u7a76\u7684\u521d\u6b65\u7ed3\u679c\u8868\u660e\uff0c10\u6beb\u514b\u53f8\u74e6\u53f8\u5766\u6709\u53ef\u80fd\u964d\u4f4e\u529f\u80fd\u8870\u9000\u7684\u901f\u5ea6\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201c\u6211\u4eec\u5df2\u7ecf\u5bf9\u585e\u74e6\u53f8\u6c40\u5728\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u4e2d\u7684\u5e94\u7528\u8fdb\u884c\u4e86\u91cd\u8981\u7684\u4e8c\u671f\u4e34\u5e8a\u63a2\u7d22\uff0c\u201d\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98Kevin Koch\u535a\u58eb\u8868\u793a\u3002\u201c10\u6beb\u514b\u5242\u91cf\u4e0b\u89c2\u5bdf\u5230\u7684\u529f\u80fd\u6027\u53cd\u5e94\u4ee4\u6211\u4eec\u5907\u53d7\u9f13\u821e\uff0c\u6211\u4eec\u671f\u5f85\u4eca\u5e74\u665a\u4e9b\u65f6\u5019\u4e0eFDA\u8fdb\u884c\u8ba8\u8bba\u3002\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u516c\u53f8\u8ba1\u5212\u4e8e 2025 \u5e74\u7b2c\u56db\u5b63\u5ea6\u4e0e FDA \u4f1a\u9762\uff0c\u8ba8\u8bba\u7b2c 3 \u9636\u6bb5\u8bbe\u8ba1\uff0c\u5305\u62ec\u60a3\u8005\u4eba\u7fa4\u548c\u7ec8\u70b9\u7684\u610f\u89c1\uff0c\u5e76\u8ba1\u5212\u4e8e 2026 \u5e74\u542f\u52a8\u5173\u952e\u7814\u7a76\u3002\u6b64\u5916\uff0c\u516c\u53f8\u8ba1\u5212\u7ee7\u7eed\u6536\u96c6\u957f\u671f\u5f00\u653e\u6807\u7b7e\u6269\u5c55\u6570\u636e\uff0c\u8fd9\u5c06\u4e3a\u8bd5\u9a8c\u53c2\u4e0e\u8005\u63d0\u4f9b\u8fdb\u4e00\u6b65\u4f7f\u7528\u8be5\u836f\u7269\u7684\u673a\u4f1a\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>Edgewise Therapeutics, a leading muscle disease biopharmaceutical company, today unveiled positive results in its sevasemten program for Becker and Duchenne muscular dystrophies. What is Sevasemten? Sevasemten is an orally administered first-in-class fast skeletal myosin inhibitor designed to protect against contraction-induced muscle damage in muscular dystrophies including Becker and Duchenne. Sevasemten presents a novel mechanism of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4005,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[67,137,242,66,151,152,150],"class_list":["post-4004","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-becker-muscular-dystrophy","tag-clinical-trial","tag-clinical-trials","tag-duchenne-muscular-dystrophy","tag-edgewise","tag-edgewise-therapeutics","tag-sevasemten"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/4004","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=4004"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/4004\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/4005"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=4004"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=4004"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=4004"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}