{"id":3455,"date":"2025-03-31T13:16:29","date_gmt":"2025-03-31T10:16:29","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=3455"},"modified":"2025-11-03T20:22:57","modified_gmt":"2025-11-03T17:22:57","slug":"keros-therapeutics-announces-initial-topline-results-from-the-phase-1-clinical-trial-of-ker-065-in-healthy-volunteers","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/keros-therapeutics-announces-initial-topline-results-from-the-phase-1-clinical-trial-of-ker-065-in-healthy-volunteers\/","title":{"rendered":"Keros Therapeutics \u516c\u5e03 KER-065 \u5728\u5065\u5eb7\u5fd7\u613f\u8005\u4e2d\u8fdb\u884c\u7684 1 \u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u521d\u6b65\u7ed3\u679c"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Keros Therapeutics \u662f\u4e00\u5bb6\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u65b0\u578b\u7597\u6cd5\uff0c\u7528\u4e8e\u6cbb\u7597\u4e0e\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b2\uff08\u201cTGF-\u03b2\u201d\uff09\u86cb\u767d\u5bb6\u65cf\u4fe1\u53f7\u4f20\u5bfc\u529f\u80fd\u969c\u788d\u76f8\u5173\u7684\u5404\u79cd\u75be\u75c5\u60a3\u8005\u3002\u8be5\u516c\u53f8\u4eca\u5929\u516c\u5e03\u4e86 KER-065 \u5728\u5065\u5eb7\u5fd7\u613f\u8005\u4e2d\u8fdb\u884c\u7684 1 \u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u521d\u6b65\u9876\u7ebf\u7ed3\u679c\u3002\u8fd9\u9879\u6b63\u5728\u8fdb\u884c\u7684\u8bd5\u9a8c\u7684\u9876\u7ebf\u7ed3\u679c\u6765\u81ea\u591a\u6b21\u9012\u589e\u5242\u91cf\uff08\u201cMAD\u201d\uff09\u6cbb\u7597\u671f\uff08\u7b2c 85 \u5929\uff09\u3002<\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u76ee\u5f55<\/h2><nav><ul><li><a href=\"#key-findings-from-ker-065-include\">KER-065 \u7684\u4e3b\u8981\u53d1\u73b0<\/a><\/li><li><a href=\"#about-the-ker-065-phase-1-clinical-trial\">\u5173\u4e8eKER-065 1\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/a><\/li><li><a href=\"#about-ker-065\">\u5173\u4e8eKER-065<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"key-findings-from-ker-065-include\">KER-065 \u7684\u4e3b\u8981\u53d1\u73b0<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>KER-065 \u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\uff0c\u8fc4\u4eca\u4e3a\u6b62\u672a\u89c2\u5bdf\u5230\u91cd\u5927\u5b89\u5168\u4fe1\u53f7\n<ul class=\"wp-block-list\">\n<li>\u672a\u62a5\u544a\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u6216\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\u6709\u8bc1\u636e\u8868\u660e\uff0c\u5728\u611f\u5174\u8da3\u7684\u7ec4\u7ec7\u4e2d\u5b58\u5728\u6fc0\u6d3b\u7d20\u6291\u5236\uff0c\u5982 KER-065 \u6240\u5f15\u53d1\u7684\uff1a\n<ul class=\"wp-block-list\">\n<li>\u9aa8\u7279\u5f02\u6027\u78b1\u6027\u78f7\u9178\u9176 (BSAP)\uff08\u9aa8\u5f62\u6210\u7684\u751f\u7269\u6807\u5fd7\u7269\uff09\u589e\u52a0\uff0cC \u672b\u7aef\u80bd (CTX)\uff08\u9aa8\u5438\u6536\u7684\u751f\u7269\u6807\u5fd7\u7269\uff09\u51cf\u5c11<\/li>\n\n\n\n<li>\u8102\u80aa\u52a8\u5458\u7684\u751f\u7269\u6807\u5fd7\u7269\u8102\u8054\u7d20\u589e\u52a0\uff0c\u8102\u80aa\u91cf\u7684\u751f\u7269\u6807\u5fd7\u7269\u7626\u7d20\u51cf\u5c11<\/li>\n\n\n\n<li>\u8eab\u4f53\u6210\u5206\u7684\u53d8\u5316\uff0c\u8868\u73b0\u4e3a\u9aa8\u5bc6\u5ea6\u548c\u808c\u8089\u8d28\u91cf\u589e\u52a0\uff0c\u8102\u80aa\u8d28\u91cf\u51cf\u5c11\uff0c\u603b\u4f53\u4e0a\u4e0e\u6fc0\u6d3b\u7d20\u6291\u5236\u4e00\u81f4<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"about-the-ker-065-phase-1-clinical-trial\">\u5173\u4e8eKER-065 1\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">KER-065 1 \u671f\u4e34\u5e8a\u8bd5\u9a8c\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u4e24\u90e8\u5206\u5242\u91cf\u9012\u589e\uff08\u5355\u6b21\u9012\u589e\u5242\u91cf\u548c MAD\uff09\u8bd5\u9a8c\uff0c\u53d7\u8bd5\u8005\u4e3a\u5065\u5eb7\u5fd7\u613f\u8005\u3002\u8be5\u8bd5\u9a8c\u7684\u4e3b\u8981\u76ee\u7684\u662f\u8bc4\u4f30 KER-065 \u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u3002\u63a2\u7d22\u6027\u7ec8\u70b9\u5305\u62ec\u8bc4\u4f30\u5bf9\u9aa8\u9abc\u3001\u8102\u80aa\u3001\u808c\u8089\u3001\u5fc3\u810f\u7ec4\u7ec7\u548c\u7ea4\u7ef4\u5316\u7684\u836f\u6548\u5b66\u5f71\u54cd\u3002\uff08<a href=\"https:\/\/ir.kerostx.com\/news-releases\/news-release-details\/keros-therapeutics-announces-initial-topline-results-phase-1\" target=\"_blank\" rel=\"noreferrer noopener\">\u9605\u8bfb\u66f4\u591a<\/a>)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"about-ker-065\">\u5173\u4e8eKER-065<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">KER-065 \u662f\u4e00\u79cd\u65b0\u578b\u914d\u4f53\u9677\u9631\uff0c\u7531\u6765\u81ea\u6fc0\u6d3b\u7d20\u53d7\u4f53 IIA \u578b\u548c\u6fc0\u6d3b\u7d20\u53d7\u4f53 IIB \u578b\u7684\u6539\u826f\u914d\u4f53\u7ed3\u5408\u57df\u7ec4\u6210\uff0c\u8be5\u57df\u4e0e\u4eba\u7c7b\u6297\u4f53\u7684 Fc \u57df\u90e8\u5206\u878d\u5408\u3002KER-065 \u65e8\u5728\u5145\u5f53\u914d\u4f53\u9677\u9631\uff0c\u6291\u5236\u808c\u751f\u957f\u6291\u5236\u7d20\u548c\u6fc0\u6d3b\u7d20 A\uff08\u4e24\u79cd\u901a\u8fc7\u6fc0\u6d3b\u7d20\u53d7\u4f53\u53d1\u51fa\u4fe1\u53f7\u7684\u914d\u4f53\uff09\u7684\u751f\u7269\u5b66\u6548\u5e94\uff0c\u4ee5\u589e\u52a0\u9aa8\u9abc\u808c\u518d\u751f\u3001\u589e\u52a0\u808c\u8089\u5927\u5c0f\u548c\u5f3a\u5ea6\u3001\u51cf\u5c11\u4f53\u8102\u3001\u51cf\u5c11\u9aa8\u9abc\u808c\u7ea4\u7ef4\u5316\u5e76\u589e\u52a0\u9aa8\u9abc\u5f3a\u5ea6\u3002\u6211\u4eec\u6b63\u5728\u5f00\u53d1 KER-065 \u7528\u4e8e\u6cbb\u7597\u795e\u7ecf\u808c\u8089\u75be\u75c5\uff0c\u6700\u521d\u7684\u91cd\u70b9\u662f DMD\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u9605\u8bfb\u66f4\u591a<\/strong>:\u00a0<a href=\"https:\/\/dmdwarrior.com\/zh\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u4e34\u5e8a\u8bd5\u9a8c\uff08\u6240\u6709\u7814\u7a76\u5217\u8868\uff09<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Keros Therapeutics, a clinical-stage biopharmaceutical company focused on developing and commercializing novel therapeutics to treat a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (\u201cTGF-\u00df\u201d) family of proteins, today announced initial topline results from the Phase 1 clinical trial of KER-065 in healthy volunteers. Topline results [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3457,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[137,337,336],"class_list":["post-3455","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-clinical-trial","tag-ker-065","tag-keros-therapeutics"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/3455","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=3455"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/3455\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/3457"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=3455"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=3455"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=3455"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}