{"id":3240,"date":"2025-03-17T16:51:32","date_gmt":"2025-03-17T13:51:32","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=3240"},"modified":"2025-03-17T16:59:56","modified_gmt":"2025-03-17T13:59:56","slug":"capricor-therapeutics-announces-positive-data-demonstrating-long-term-efficacy-of-deramiocel-for-the-treatment-of-duchenne-muscular-dystrophy","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/capricor-therapeutics-announces-positive-data-demonstrating-long-term-efficacy-of-deramiocel-for-the-treatment-of-duchenne-muscular-dystrophy\/","title":{"rendered":"Capricor Therapeutics \u516c\u5e03\u79ef\u6781\u6570\u636e\uff0c\u8bc1\u660e Deramiocel \u5bf9\u6cbb\u7597\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u5177\u6709\u957f\u671f\u7597\u6548"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Capricor Therapeutics \u662f\u4e00\u5bb6\u5f00\u53d1\u8f6c\u5316\u7ec6\u80de\u548c\u5916\u6ccc\u4f53\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u7f55\u89c1\u75be\u75c5\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u4eca\u5929\u5ba3\u5e03\u4e86\u8be5\u516c\u53f8\u6b63\u5728\u8fdb\u884c\u7684 HOPE-2 \u5f00\u653e\u6807\u7b7e\u6269\u5c55\uff08\u201cOLE\u201d\uff09\u4e34\u5e8a\u8bd5\u9a8c\u7684\u957f\u671f\u79ef\u6781\u7ed3\u679c\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u8be5\u516c\u53f8\u7684\u4e3b\u8981\u8d44\u4ea7 deramiocel \u6709\u53ef\u80fd\u51cf\u7f13\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7 (\u201cDMD\u201d) \u60a3\u8005\u7684\u75c5\u60c5\u53d1\u5c55\u5e76\u4fdd\u6301\u4e0a\u80a2\u529f\u80fd\u3002\u4eca\u5e74\u7684\u808c\u8089\u840e\u7f29\u75c7\u534f\u4f1a\u4e34\u5e8a\u548c\u79d1\u5b66\u4f1a\u8bae\u4e8e 3 \u6708 16 \u65e5\u81f3 19 \u65e5\u5728\u5fb7\u514b\u8428\u65af\u5dde\u8fbe\u62c9\u65af\u4e3e\u884c\uff0c\u8be5\u6570\u636e\u4f5c\u4e3a\u6700\u65b0\u7a81\u7834\u6d77\u62a5\u8fdb\u884c\u4e86\u5c55\u793a\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Capricor Therapeutics Deramiocel \u4e34\u5e8a\u8bd5\u9a8c<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u961f\u5217\u5339\u914d\u5916\u90e8\u6bd4\u8f83\u5206\u6790\u4e2d\uff0c\u8be5\u7814\u7a76\u663e\u793a\uff0c\u63a5\u53d7\u5fb7\u62c9\u7c73\u5965\u585e\u5c14\u6cbb\u7597\u4e09\u5e74\u7684\u60a3\u8005\u7684\u4e0a\u80a2\u8868\u73b0 (PUL 2.0) \u603b\u5206\u5e73\u5747\u4e0b\u964d 3.46 \u5206\uff0c\u800c\u5916\u90e8\u6bd4\u8f83\u7ec4\u4e0b\u964d 7.19 \u5206 (p=0.019)\u3002\u8fd9\u76f8\u5f53\u4e8e\u75be\u75c5\u8fdb\u5c55\u51cf\u7f13\uff0c\u589e\u5f3a\u4e86\u5fb7\u62c9\u7c73\u5965\u585e\u5c14\u7684\u6f5c\u5728\u957f\u671f\u6cbb\u7597\u8010\u4e45\u6027\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5176\u4ed6\u53d1\u73b0\u5305\u62ec\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6cbb\u7597\u6548\u679c\u9010\u5e74\u63d0\u9ad8<\/strong> \u2013 \u63a5\u53d7 deramiocel \u6cbb\u7597\u7684\u60a3\u8005\u7684\u75c5\u60c5\u8fdb\u5c55\u51cf\u7f13\uff0c\u7b2c\u4e00\u5e74\u5e73\u5747\u5e74 PUL 2.0 \u4e0b\u964d 1.8 \u5206\uff0c\u7b2c\u4e8c\u5e74\u4e0b\u964d 1.2 \u5206\uff0c\u7b2c\u4e09\u5e74\u4e0b\u964d 1.1 \u5206\u3002<\/li>\n\n\n\n<li><strong>\u6f5c\u5728\u7684\u75be\u75c5\u6539\u5584\u4f5c\u7528<\/strong> \u2013 \u5728 1 \u5e74\u7684\u6cbb\u7597\u95f4\u9694\u671f\u95f4\uff0c\u6700\u521d\u968f\u673a\u63a5\u53d7 deramiocel \u6cbb\u7597\u7684\u60a3\u8005\u4e0e\u672a\u63a5\u53d7\u6cbb\u7597\u7684\u60a3\u8005\uff08\u6bcf\u5e74 3.7 \u5206\uff09\u76f8\u6bd4\uff0c\u89c6\u529b\u4e0b\u964d\u901f\u5ea6\u8f83\u6162\uff08\u6bcf\u5e74 2.8 \u5206\uff09\u3002<\/li>\n\n\n\n<li><strong>\u5b89\u5168\u6027\u826f\u597d<\/strong> \u2013 Deramiocel \u8010\u53d7\u6027\u826f\u597d\uff0c\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u4fe1\u53f7\uff0c\u5e76\u7ee7\u7eed\u4fdd\u6301\u826f\u597d\u7684\u957f\u671f\u6548\u76ca\u98ce\u9669\u72b6\u51b5\u3002<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Positive long-term results from the company&#8217;s ongoing HOPE-2 open label extension (&#8220;OLE&#8221;) clinical trial were announced today by Capricor Therapeutics, a biotechnology company that develops transformative cell and exosome-based therapeutics for the treatment of rare diseases. These results show that the company&#8217;s lead asset, deramiocel, has the potential to slow the progression of the disease [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3241,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[90,87,89,85,301,297],"class_list":["post-3240","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-cap-1002","tag-capricor-therapeutics","tag-cardiomyopathy","tag-deramiocel","tag-hope-2","tag-muscular-dystrophy-association"],"subtitle":"Capricor \u9996\u5e2d\u6267\u884c\u5b98 Linda Marb\u00e1n \u535a\u58eb\u8868\u793a\uff1a\u201c\u5bf9\u4e8e\u4e0e\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u4f5c\u6597\u4e89\u7684\u60a3\u8005\u548c\u5bb6\u5c5e\u6765\u8bf4\uff0c\u65f6\u95f4\u5c31\u662f\u529b\u91cf\u3002\u8fd9\u4e9b\u6570\u636e\u8868\u660e\u9aa8\u9abc\u808c\u529f\u80fd\u53ef\u4ee5\u957f\u671f\u4fdd\u6301\uff0c\u8fd9\u8fdb\u4e00\u6b65\u8bc1\u660e Deramiocel \u4e0d\u4ec5\u80fd\u51cf\u7f13\u75be\u75c5\u53d1\u5c55\uff0c\u8fd8\u80fd\u6539\u5199\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u60a3\u8005\u7684\u672a\u6765\u53d1\u5c55\u8f68\u8ff9\u3002\u201d","_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/3240","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=3240"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/3240\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/3241"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=3240"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=3240"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=3240"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}