{"id":3206,"date":"2025-03-13T17:18:48","date_gmt":"2025-03-13T14:18:48","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=3206"},"modified":"2025-03-13T17:18:49","modified_gmt":"2025-03-13T14:18:49","slug":"metagenomi-new-crispr-system-vk-cast-enables-large-gene-integration","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/metagenomi-new-crispr-system-vk-cast-enables-large-gene-integration\/","title":{"rendered":"Metagenomi \u7684\u65b0 CRISPR \u7cfb\u7edf (VK CAST) \u53ef\u5b9e\u73b0\u5927\u89c4\u6a21\u57fa\u56e0\u6574\u5408"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Metagenomi \u662f\u4e00\u5bb6\u7cbe\u51c6\u57fa\u56e0\u836f\u7269\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u5229\u7528\u5176\u4e13\u6709\u7684\u57fa\u56e0\u7f16\u8f91\u5de5\u5177\u7bb1\u4e3a\u60a3\u8005\u5f00\u53d1\u6cbb\u7597\u836f\u7269\uff0c\u4eca\u5929\u8be5\u516c\u53f8\u5728\u300a\u81ea\u7136\u901a\u8baf\u300b\u6742\u5fd7\u4e0a\u53d1\u8868\u4e86\u4e00\u7bc7\u8bba\u6587\uff0c\u63cf\u8ff0\u4e86\u5176\u7528\u4e8e\u5c06\u5927\u578b\u9776\u5411\u57fa\u56e0\u6574\u5408\u5230\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u7684\u65b0\u578b\u7d27\u51d1\u578b CAST \u7cfb\u7edf\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Metagenomi \u7684 CAST \u7cfb\u7edf\u662f\u5f00\u53d1\u6cbb\u7597\u6027\u57fa\u56e0\u836f\u7269\u7684\u6f5c\u5728\u89e3\u51b3\u65b9\u6848\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u81ea\u7136\u7cfb\u7edf\u6267\u884c\u7740\u57fa\u56e0\u7f16\u8f91\u9886\u57df\u7684\u4e00\u9879\u5173\u952e\u4efb\u52a1\uff1a\u7cbe\u786e\u3001\u53ef\u7f16\u7a0b\u5730\u6574\u5408\u5927\u578b\u57fa\u56e0\u8d27\u7269\u3002 <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u9879\u6280\u672f\u6709\u53ef\u80fd\u89e3\u51b3\u7531\u4efb\u4f55\u529f\u80fd\u4e27\u5931\u7a81\u53d8\u5f15\u8d77\u7684\u5927\u91cf\u590d\u6742\u9057\u4f20\u75be\u75c5\uff0c\u4f8b\u5982\u5a01\u5c14\u900a\u6c0f\u75c5\u3001\u56ca\u6027\u7ea4\u7ef4\u5316\u548c\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u3002\u65b0\u53d1\u5e03\u7684\u6570\u636e\u5c55\u793a\u4e86\u4e00\u79cd\u5c06\u6cbb\u7597\u57fa\u56e0\u7cbe\u786e\u6574\u5408\u5230\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u7684\u4e00\u6d41\u65b9\u6cd5\uff0c\u8fd9\u79cd\u65b9\u6cd5\u5efa\u7acb\u5728\u5148\u524d\u53d1\u73b0\u7684\u57fa\u7840\u4e0a\uff0c\u8fd9\u4e9b\u53d1\u73b0\u786e\u7acb\u4e86\u8fd9\u4e9b\u7cfb\u7edf\u7684\u6f5c\u529b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Metagenomi \u7684\u65b0\u578b\u7d27\u51d1\u578b Cas12k CAST \u7cfb\u7edf\u662f\u5229\u7528\u8be5\u516c\u53f8\u7684 AI \u9a71\u52a8\u5b8f\u57fa\u56e0\u7ec4\u5b66\u5e73\u53f0\u53d1\u73b0\u7684\uff0c\u5e76\u8f6c\u5316\u4e3a\u5728\u4eba\u7c7b\u7ec6\u80de\u4e2d\u5b9e\u73b0\u53ef\u7f16\u7a0b\u548c\u9776\u5411\u57fa\u56e0\u7ec4\u6574\u5408\u3002Metgenomi \u79d1\u5b66\u5bb6\u5c55\u793a\u4e86\u5c06\u591a\u4e2a\u8d27\u7269\u6574\u5408\u5230\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u5df2\u77e5\u7684\u5b89\u5168\u6e2f\u4f4d\u70b9\uff0c\u8bf4\u660e\u4e86\u8be5\u7cfb\u7edf\u7684\u4f4d\u70b9\u7279\u5f02\u6027\u3001\u53ef\u7f16\u7a0b\u6027\u548c\u591a\u529f\u80fd\u6027\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8be5\u7814\u7a76\u91cd\u70b9\u4ecb\u7ecd\u4e86 CAST \u5728\u6cbb\u7597\u5e94\u7528\u65b9\u9762\u7684\u91cd\u5927\u8fdb\u5c55\uff0c\u5305\u62ec\u91cd\u65b0\u5b9a\u4f4d\u5230\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u7684\u5b89\u5168\u6e2f\u4f4d\u70b9\u3001\u5b8c\u5168\u6574\u5408\u6cbb\u7597\u76f8\u5173\u57fa\u56e0\u4ee5\u53ca\u4f7f\u7528\u201c\u4e00\u4f53\u5316\u201dmRNA \u7b80\u5316\u9012\u9001\u3002\u8fd9\u4e9b\u53d1\u73b0\u4e3a\u5f00\u53d1\u4f53\u5185\u57fa\u56e0\u7f16\u8f91\u7597\u6cd5\u7684\u5927\u578b\u9776\u5411\u57fa\u56e0\u7ec4\u6574\u5408\u65b9\u6cd5\u63d0\u4f9b\u4e86\u65b0\u7684\u89c1\u89e3\u3002\u672a\u6765\u7684\u5de5\u4f5c\u5c06\u4fa7\u91cd\u4e8e\u6269\u5c55\u8fd9\u4e9b\u529f\u80fd\u5e76\u4f18\u5316\u7cfb\u7edf\u4ee5\u7528\u4e8e\u4e34\u5e8a\u5e94\u7528\uff0c\u9884\u8ba1 2025 \u5e74\u5c06\u53d6\u5f97\u66f4\u591a\u8fdb\u5c55\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>Metagenomi, a precision genetic medicines company committed to developing curative therapeutics for patients using its proprietary gene editing toolbox, today announced a publication in the journal Nature Communications describing its novel, compact CAST system for large, targeted gene integration into the human genome. Metagenomi\u2019s CAST systems are a potential solution for development of curative genetic [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3207,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[290,291,289],"class_list":["post-3206","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-crispr","tag-metagenomi","tag-v-k-cast"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/3206","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=3206"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/3206\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/3207"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=3206"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=3206"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=3206"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}