{"id":2961,"date":"2025-02-18T15:46:12","date_gmt":"2025-02-18T12:46:12","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=2961"},"modified":"2025-03-07T12:57:05","modified_gmt":"2025-03-07T09:57:05","slug":"solid-biosciences-reports-positive-initial-clinical-data-from-next-generation-duchenne-gene-therapy-candidate-sgt-003","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/solid-biosciences-reports-positive-initial-clinical-data-from-next-generation-duchenne-gene-therapy-candidate-sgt-003\/","title":{"rendered":"Solid Biosciences \u62a5\u544a\u4e0b\u4e00\u4ee3\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u57fa\u56e0\u7597\u6cd5\u5019\u9009\u836f\u7269 SGT-003 \u7684\u521d\u6b65\u4e34\u5e8a\u6570\u636e\u5448\u9633\u6027"},"content":{"rendered":"

Solid Biosciences \u662f\u4e00\u5bb6\u751f\u547d\u79d1\u5b66\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u7528\u4e8e\u795e\u7ecf\u808c\u8089\u548c\u5fc3\u810f\u75be\u75c5\u7684\u7cbe\u51c6\u57fa\u56e0\u836f\u7269\u3002\u8be5\u516c\u53f8\u4eca\u5929\u5ba3\u5e03\u4e86\u7b2c 1\/2 \u671f INSPIRE DUCHENNE \u8bd5\u9a8c\u7684\u79ef\u6781\u521d\u6b65\u6570\u636e\uff0c\u8be5\u8bd5\u9a8c\u8bc4\u4f30\u4e86 SGT-003\uff0cSGT-003 \u662f\u4e00\u79cd\u7528\u4e8e\u6cbb\u7597\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7 (Duchenne) \u7684\u4e0b\u4e00\u4ee3\u57fa\u56e0\u6cbb\u7597\u5019\u9009\u4ea7\u54c1\u3002\u524d\u4e09\u540d\u53c2\u4e0e\u8005\u62a5\u544a\u7684\u4e2d\u671f 90 \u5929\u6d3b\u68c0\u6570\u636e\u663e\u793a\uff0c\u5fae\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u7684\u5e73\u5747\u8868\u8fbe\u4e3a 110%\uff08\u901a\u8fc7\u86cb\u767d\u8d28\u5370\u8ff9\u6cd5\u6d4b\u91cf\uff09\uff0c\u5e76\u4e14\u591a\u79cd\u751f\u7269\u6807\u5fd7\u7269\uff08\u808c\u8089\u5065\u5eb7\u548c\u5f39\u6027\u6307\u6807\uff09\u6709\u6240\u6539\u5584\u3002<\/p>\n\n\n\n

\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u57fa\u56e0\u6cbb\u7597\u5019\u9009\u836f\u7269 SGT-003 \u7684\u4e34\u5e8a\u6570\u636e<\/h2>\n\n\n\n
    \n
  1. 110%\uff08N=3\uff09\u7684\u5e73\u5747\u5fae\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u8868\u8fbe\u548c\u89c2\u5bdf\u5230\u7684\u591a\u4e2a\u5176\u4ed6\u808c\u8089\u5065\u5eb7\u751f\u7269\u6807\u5fd7\u7269\u7684\u663e\u8457\u6539\u5584\u652f\u6301\u4e86 SGT-003 \u4f5c\u4e3a\u4e0b\u4e00\u4ee3\u3001\u4e00\u6d41\u7684\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u57fa\u56e0\u6cbb\u7597\u5019\u9009\u836f\u7269\u7684\u6f5c\u529b\u3002<\/li>\n\n\n\n
  2. \u89c2\u5bdf\u5230\u4ee4\u4eba\u9f13\u821e\u7684\u6f5c\u5728\u5fc3\u810f\u76ca\u5904\u7684\u65e9\u671f\u4fe1\u53f7\u3002<\/li>\n\n\n\n
  3. \u622a\u81f3 2025 \u5e74 2 \u6708 11 \u65e5\uff0c6 \u540d\u670d\u7528 SGT-003 \u7684\u53c2\u4e0e\u8005\u8010\u53d7\u6027\u826f\u597d\uff0c\u672a\u89c2\u5bdf\u5230\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002<\/li>\n\n\n\n
  4. \u53c2\u4e0e\u8005\u62db\u52df\u4ecd\u5728\u7ee7\u7eed\uff0c\u7b2c 7 \u540d\u53c2\u4e0e\u8005\u5c06\u4e8e 2025 \u5e74 2 \u6708 17 \u65e5\u670d\u836f\uff1b\u516c\u53f8\u9884\u8ba1\u5230 2025 \u5e74\u7b2c\u56db\u5b63\u5ea6\u5c06\u62db\u52df\u7ea6 20 \u540d\u53c2\u4e0e\u8005\u3002<\/li>\n<\/ol>","protected":false},"excerpt":{"rendered":"

    Solid Biosciences, a life sciences company developing precision genetic medicines for neuromuscular and cardiac diseases, today announced positive initial data from the Phase 1\/2 INSPIRE DUCHENNE trial evaluating SGT-003, a next-generation gene therapy product candidate intended for the treatment of Duchenne muscular dystrophy (Duchenne). Interim 90-day biopsy data reported in the first three participants showed […]<\/p>\n","protected":false},"author":1,"featured_media":2963,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[137,110,170,109],"class_list":["post-2961","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-clinical-trial","tag-sgt-003","tag-sgt-003-gene-therapy","tag-solid-biosciences"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/2961","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=2961"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/2961\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/2963"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=2961"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=2961"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=2961"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}