{"id":2637,"date":"2025-01-28T16:56:15","date_gmt":"2025-01-28T13:56:15","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=2637"},"modified":"2026-03-19T10:42:50","modified_gmt":"2026-03-19T07:42:50","slug":"glucocorticoid-use-in-dmd-patients-and-impact-on-growth-effect","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/glucocorticoid-use-in-dmd-patients-and-impact-on-growth-effect\/","title":{"rendered":"DMD \u60a3\u8005\u4f7f\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u5bf9\u751f\u957f\u7684\u5f71\u54cd"},"content":{"rendered":"

\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7 (DMD) \u662f\u4e00\u79cd\u513f\u7ae5\u9057\u4f20\u6027\u75be\u75c5\uff0c\u5176\u7279\u5f81\u662f\u808c\u8089\u65e0\u529b\u548c\u9000\u5316\u3002\u8be5\u75c5\u4e3b\u8981\u5f71\u54cd\u7537\u6027\uff0c\u5bfc\u81f4\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u7f3a\u4e4f\uff0c\u800c\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u5bf9\u4e8e\u7a33\u5b9a\u548c\u5f3a\u5065\u7684\u808c\u8089\u81f3\u5173\u91cd\u8981\u3002\u60a3\u6709\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u513f\u7ae5\u5bff\u547d\u6709\u9650\uff0c\u5e76\u4e14\u7ecf\u5e38\u5728 30 \u5c81\u4e4b\u524d\u6216 30 \u5c81\u671f\u95f4\u51fa\u73b0\u5fc3\u810f\u6216\u547c\u5438\u8870\u7aed\uff1b\u9057\u61be\u7684\u662f\uff0c\u76ee\u524d\u5c1a\u65e0\u5df2\u77e5\u7684\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n\n\n\n

DMD \u7684\u808c\u8089\u9aa8\u9abc\u6548\u5e94\u4f1a\u4e25\u91cd\u635f\u5bb3\u60a3\u8005\u7684\u8fd0\u52a8\u6280\u80fd\uff0c\u5bf9\u751f\u6d3b\u8d28\u91cf\u9020\u6210\u91cd\u5927\u5f71\u54cd\u3002\u6b64\u5916\uff0c\u8eab\u6750\u77ee\u5c0f\u548c BMI\uff08\u8eab\u4f53\u8d28\u91cf\u6307\u6570\uff09\u8f83\u4f4e\u4e5f\u5f88\u5e38\u89c1\uff0c\u8fd9\u662f\u7531\u4e8e\u808c\u8089\u8d28\u91cf\u4e0b\u964d\u5bfc\u81f4\u751f\u957f\u53d1\u80b2\u53d7\u635f\uff0c\u4ece\u800c\u963b\u788d\u9aa8\u8f6c\u6362\u3002\u7cd6\u76ae\u8d28\u6fc0\u7d20 (GC) \u6cbb\u7597\u901a\u5e38\u4f1a\u52a0\u5267\u8fd9\u79cd\u60c5\u51b5\uff0c\u800c\u7cd6\u76ae\u8d28\u6fc0\u7d20 (GC) \u6cbb\u7597\u662f DMD \u7ba1\u7406\u7684\u57fa\u77f3\u3002<\/p>\n\n\n\n

\u6cfc\u5c3c\u677e\u548c\u5730\u592b\u53ef\u7279\u662f GC \u6cbb\u7597\u7684\u5178\u578b\u4f8b\u5b50\uff0c\u53ef\u7528\u4e8e\u589e\u52a0\u808c\u8089\u529b\u91cf\u3001\u5ef6\u957f\u6b65\u884c\u65f6\u95f4\u3001\u6539\u5584\u80ba\u529f\u80fd\u548c\u51cf\u5c11\u708e\u75c7\uff0c\u4ee5\u5e2e\u52a9\u808c\u8089\u6062\u590d\u3002\u4f46\u957f\u671f\u4f7f\u7528 GC \u4f1a\u6291\u5236\u751f\u957f\u6fc0\u7d20\u7684\u4ea7\u751f\uff0c\u4ece\u800c\u5bfc\u81f4\u53d1\u80b2\u8fdf\u7f13\u3002\u662f\u5426\u5e94\u51cf\u5c11\u6216\u4fc3\u8fdb\u751f\u957f\u6291\u5236\u4ecd\u5b58\u5728\u4e89\u8bae\u3002<\/p>\n\n\n\n

DMD \u60a3\u8005\u8eab\u9ad8\u53d8\u5316\u7684\u7814\u7a76\u7ed3\u679c<\/h2>\n\n\n\n

\u7814\u7a76\u8868\u660e\uff0cDMD \u60a3\u8005\u7684\u751f\u957f\u969c\u788d\u7a0b\u5ea6\u53d7 GC \u6cbb\u7597\u7684\u79cd\u7c7b\u3001\u5242\u91cf\u548c\u6301\u7eed\u65f6\u95f4\u5f71\u54cd\u3002\u4f8b\u5982\uff0c\u5df2\u7ecf\u8bc1\u660e\uff0c\u5728 DMD \u7684\u95e8\u8bca\u9636\u6bb5\uff0c\u66ff\u4ee3\u6cfc\u5c3c\u677e\u6cbb\u7597\u65b9\u6848\u5bf9\u8eab\u9ad8\u6216\u4f53\u91cd\u6ca1\u6709\u660e\u663e\u7684\u8d1f\u9762\u5f71\u54cd\u3002\u6b64\u5916\uff0c\u63a5\u53d7\u751f\u957f\u6fc0\u7d20\u6cbb\u7597\u7684 DMD \u60a3\u8005\u8868\u73b0\u51fa\u66f4\u5feb\u7684\u53d1\u80b2\u901f\u5ea6\uff0c\u800c\u4e0d\u4f1a\u635f\u5bb3\u4ed6\u4eec\u7684\u5fc3\u810f\u3001\u80ba\u6216\u8fd0\u52a8\u80fd\u529b\u3002<\/p>\n\n\n\n

\u6709\u8da3\u7684\u662f\uff0c\u7814\u7a76\u8868\u660e\uff0c\u8eab\u6750\u77ee\u5c0f\u7684 DMD \u60a3\u8005\u5728\u4e34\u5e8a\u4e0a\u53ef\u80fd\u53d7\u76ca\u3002\u60a3\u6709 DMD \u7684\u5e7c\u513f\u53ef\u4ee5\u8d70\u8def\uff0c\u4f46\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\uff0c\u4ed6\u4eec\u5931\u53bb\u4e86\u8fd9\u79cd\u80fd\u529b\uff0c\u8fd9\u8868\u660e\u8eab\u9ad8\u4e0b\u964d\u4e86\u529f\u80fd\u3002<\/p>\n\n\n\n

\u65e9\u671f\u7814\u7a76\u53d1\u73b0\uff0cDMD \u7537\u6027\u513f\u7ae5\u7684\u8eab\u9ad8\u4e0e\u4e34\u5e8a\u7ed3\u679c\u5b58\u5728\u663e\u8457\u76f8\u5173\u6027\u3002\u591a\u5e74\u6765\uff0c\u76f8\u5173\u7814\u7a76\u4e5f\u8bc1\u5b9e\u4e86\u8fd9\u4e00\u70b9\uff0c\u8868\u660e\u751f\u957f\u6291\u5236\u53ef\u80fd\u662f\u5ef6\u7f13 DMD \u75c5\u7a0b\u7684\u6709\u6548\u7b56\u7565\u3002\u8fd9\u79cd\u73b0\u8c61\u53ef\u80fd\u662f\u7531\u4e8e\u6bcf\u6839\u808c\u7ea4\u7ef4\u8d1f\u8377\u5448\u6307\u6570\u589e\u52a0\u5e26\u6765\u7684\u673a\u68b0\u5e94\u53d8\uff0c\u52a0\u901f\u4e86\u808c\u7ea4\u7ef4\u7684\u635f\u5931\u548c\u7ed3\u6784\u635f\u4f24\u3002\u56e0\u6b64\uff0c\u901a\u8fc7\u975e\u8d1f\u91cd\u6d3b\u52a8\u548c\u63a7\u5236\u4f53\u91cd\u53ef\u4ee5\u51cf\u5c11\u808c\u7ea4\u7ef4\u7684\u538b\u529b\u5e76\u4fdd\u6301\u5176\u529f\u80fd\u3002<\/p>\n\n\n\n

\u5bf9\u4e8e\u60a3\u8005\u548c\u62a4\u7406\u4eba\u5458\u6765\u8bf4\uff0cDMD \u4f1a\u9020\u6210\u7279\u522b\u7684\u60c5\u611f\u548c\u8eab\u4f53\u56f0\u6270\u3002\u6cbb\u7597\u8ba1\u5212\u5e94\u9488\u5bf9\u6bcf\u4f4d\u60a3\u8005\u91cf\u8eab\u5b9a\u5236\uff0c\u65e2\u8981\u8003\u8651\u5230\u5bf9\u751f\u957f\u7684\u53ef\u80fd\u5f71\u54cd\uff0c\u4e5f\u8981\u8003\u8651\u5230 GC \u7597\u6cd5\u7684\u4f18\u52bf\u3002\u968f\u7740\u79d1\u5b66\u7684\u8fdb\u6b65\uff0c\u8003\u8651\u75c5\u60c5\u8fdb\u5c55\u548c\u751f\u6d3b\u8d28\u91cf\u7684\u5168\u9762\u6cbb\u7597\u65b9\u6848\u4ecd\u7136\u81f3\u5173\u91cd\u8981\u3002<\/p>\n\n\n\n

\u9605\u8bfb\u66f4\u591a\uff1a<\/strong> FDA \u6279\u51c6\u7684\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7 (DMD) \u6cbb\u7597\u65b9\u6cd5<\/a><\/p>\n\n\n\n

\u53c2\u8003\uff1a<\/p>\n\n\n\n

    \n
  1. \u4e3a\u4ec0\u4e48\u8eab\u6750\u77ee\u5c0f\u5bf9\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u6709\u76ca\u3002<\/a><\/li>\n\n\n\n
  2. \u751f\u957f\u6fc0\u7d20\u6cbb\u7597\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u548c\u7cd6\u76ae\u8d28\u6fc0\u7d20\u5f15\u8d77\u7684\u8eab\u6750\u77ee\u5c0f\u7684\u513f\u7ae5\u3002<\/a><\/li>\n\n\n\n
  3. \u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u60a3\u8005\u7684\u8eab\u6750\u77ee\u5c0f\uff1a\u9488\u5bf9 34 \u540d\u60a3\u8005\u7684\u7814\u7a76\u3002<\/a><\/li>\n\n\n\n
  4. \u4e00\u7cfb\u5217\u4f7f\u7528 10 \u5929\u670d\u7528\/10 \u5929\u505c\u7528\u6cfc\u5c3c\u677e\u65b9\u6848\u7684\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u60a3\u8005\u7684\u8eab\u9ad8\u548c\u4f53\u91cd\u5747\u6b63\u5e38\u3002<\/a><\/li>\n\n\n\n
  5. \u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7537\u5b69\u7684\u751f\u957f\u3001\u9752\u6625\u671f\u53d1\u80b2\u548c\u9aa8\u9abc\u5065\u5eb7\u3002<\/a><\/li>\n\n\n\n
  6. \u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u8eab\u9ad8\u548c\u4e34\u5e8a\u75c5\u7a0b\u4e4b\u95f4\u7684\u5173\u7cfb\u3002<\/a><\/li>\n<\/ol>","protected":false},"excerpt":{"rendered":"

    A childhood hereditary disorder known as Duchenne muscular dystrophy (DMD) is characterized by increasing muscle weakening and degradation. It mainly affects men and results in a deficiency of dystrophin, which is essential for stable and strong muscles. Children with DMD have a limited life expectancy and frequently experience cardiac or respiratory failure before or during […]<\/p>\n","protected":false},"author":1,"featured_media":2641,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[563],"tags":[211,379,209,210,212],"class_list":["post-2637","post","type-post","status-publish","format-standard","has-post-thumbnail","category-care-guidelines","tag-deflazacort","tag-dmd-care","tag-glucocorticoid","tag-prednisone","tag-steroid"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/2637","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=2637"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/2637\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/2641"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=2637"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=2637"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=2637"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}