{"id":2386,"date":"2025-01-10T16:42:40","date_gmt":"2025-01-10T13:42:40","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=2386"},"modified":"2025-11-03T20:30:56","modified_gmt":"2025-11-03T17:30:56","slug":"plans-for-dyne-101-in-dm1-and-dyne-251-in-dmd-are-announced-by-dyne-therapeutics","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/plans-for-dyne-101-in-dm1-and-dyne-251-in-dmd-are-announced-by-dyne-therapeutics\/","title":{"rendered":"Dyne Therapeutics \u5ba3\u5e03\u8ba1\u5212\u5728 DM1 \u4e2d\u4f7f\u7528 DYNE-101\uff0c\u5728 DMD \u4e2d\u4f7f\u7528 DYNE-251"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Dyne Therapeutics \u5728 2025 \u5e74 1 \u6708 10 \u65e5\u7684\u6295\u8d44\u8005\u6d3b\u52a8\u4e2d\u516c\u5e03\u4e86\u5176\u7597\u6cd5 DYNE-101 \u548c DYNE-251 \u7684\u79ef\u6781\u4e34\u5e8a\u6570\u636e\u3002\u7528\u4e8e\u6cbb\u7597 1 \u578b\u5f3a\u76f4\u6027\u808c\u8425\u517b\u4e0d\u826f\u75c7 (DM1) \u7684 DYNE-101 \u8868\u73b0\u51fa\u663e\u7740\u7684\u526a\u63a5\u6821\u6b63\u548c\u529f\u80fd\u6539\u5584\uff0c\u4fc3\u4f7f Dyne \u8ba1\u5212\u5728 ACHIEVE \u8bd5\u9a8c\u4e2d\u8fdb\u884c\u5168\u7403\u6ce8\u518c\u6269\u5c55\u961f\u5217\uff0c\u6ce8\u518c\u5242\u91cf\u4e3a 6.8 mg\/kg Q8W\uff0c\u5e76\u53ef\u80fd\u5728 2026 \u5e74\u4e0a\u534a\u5e74\u63d0\u4ea4\u7f8e\u56fd\u52a0\u901f\u6279\u51c6\u7533\u8bf7\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e0e\u6b64\u540c\u65f6\uff0c\u9488\u5bf9\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7 (DMD) \u7684 DYNE-251 \u4e5f\u5728\u5bfb\u6c42\u7f8e\u56fd\u52a0\u901f\u5ba1\u6279\uff0c\u8be5\u5ba1\u6279\u4ee5\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u4e3a\u66ff\u4ee3\u7ec8\u70b9\uff0c\u9884\u8ba1 2025 \u5e74\u5e95\u5c06\u83b7\u5f97\u6570\u636e\uff0c\u4ee5\u652f\u6301 2026 \u5e74\u521d\u7684\u7533\u8bf7\u3002\u8fd9\u4e24\u4e2a\u9879\u76ee\u90fd\u6709\u671b\u6539\u53d8\u8fd9\u4e9b\u9057\u4f20\u75be\u75c5\u7684\u6cbb\u7597\u6a21\u5f0f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u9605\u8bfb\u66f4\u591a<\/strong>:\u00a0<a href=\"https:\/\/dmdwarrior.com\/zh\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u4e34\u5e8a\u8bd5\u9a8c\uff08\u6240\u6709\u7814\u7a76\u5217\u8868\uff09<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Dyne Therapeutics announced positive clinical data for its therapies DYNE-101 and DYNE-251 during an investor event on January 10, 2025. DYNE-101 for myotonic dystrophy type 1 (DM1) demonstrated significant splicing correction and functional improvements, leading Dyne to plan a global Registrational Expansion Cohort of the ACHIEVE trial with a registrational dose of 6.8 mg\/kg Q8W [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2388,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[118,66,143,144,145],"class_list":["post-2386","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-duchenne","tag-duchenne-muscular-dystrophy","tag-dyne","tag-dyne-101","tag-dyne-251"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/2386","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=2386"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/2386\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/2388"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=2386"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=2386"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=2386"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}