{"id":2380,"date":"2025-01-10T11:32:46","date_gmt":"2025-01-10T08:32:46","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=2380"},"modified":"2025-03-27T16:49:38","modified_gmt":"2025-03-27T13:49:38","slug":"nippon-shinyaku-releases-first-clinical-trial-first-in-human-of-brogidirsen-ns-089-ncnp-02-for-the-treatment-of-duchenne","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/nippon-shinyaku-releases-first-clinical-trial-first-in-human-of-brogidirsen-ns-089-ncnp-02-for-the-treatment-of-duchenne\/","title":{"rendered":"\u65e5\u672c\u65b0\u836f\u53d1\u5e03 Brogidirsen NS-089\/NCNP-02 \u6cbb\u7597\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u9996\u6b21\u4e34\u5e8a\u8bd5\u9a8c\uff08\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\uff09"},"content":{"rendered":"<p class=\"wp-block-paragraph\">\u7f8e\u56fd\u56fd\u5bb6\u795e\u7ecf\u75c5\u5b66\u548c\u7cbe\u795e\u75c5\u5b66\u4e2d\u5fc3\u5ba3\u5e03\u5728\u300aCell Reports Medicine\u300b\u4e0a\u53d1\u8868\u4e00\u7bc7\u7814\u7a76\u8bba\u6587\uff0c\u8be6\u7ec6\u4ecb\u7ecd\u4e86\u4e00\u9879\u7531\u7814\u7a76\u4eba\u5458\u53d1\u8d77\u7684 NS-089\/NCNP-02\uff08\u79f0\u4e3a\u201cbrogidirsen\u201d\uff09\u8bd5\u9a8c\u7684\u7ed3\u679c\u3002\u8fd9\u79cd\u7528\u4e8e\u6cbb\u7597\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7 (DMD) \u7684\u521b\u65b0\u7597\u6cd5\u7531\u7f8e\u56fd\u56fd\u5bb6\u795e\u7ecf\u75c5\u5b66\u548c\u7cbe\u795e\u75c5\u5b66\u4e2d\u5fc3\u4e0e\u65e5\u672c\u65b0\u836f\u682a\u5f0f\u4f1a\u793e\u8054\u5408\u5f00\u53d1\uff0c\u4ee3\u8868\u4e86\u5916\u663e\u5b50 44 \u8df3\u8dc3\u7597\u6cd5\u7684\u91cd\u5927\u8fdb\u5c55\u3002<\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u76ee\u5f55<\/h2><nav><ul><li><a href=\"#key-findings-from-brogidirsen-include\">Brogidirsen\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c<\/a><\/li><li><a href=\"#what-is-brogidirsen\">Brogidirsen \u662f\u4ec0\u4e48\uff1f<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"key-findings-from-brogidirsen-include\">Brogidirsen\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Brogidirsen \u5728 DMD \u60a3\u8005\u7684\u8bd5\u9a8c\u4e2d\u663e\u793a\u51fa\u5242\u91cf\u4f9d\u8d56\u6027\u7684\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u6062\u590d\u3002<\/li>\n\n\n\n<li>\u9ad8\u5242\u91cf brogidirsen \u5728 DMD \u961f\u5217\u4e2d\u8fbe\u5230\u4e86\u6b63\u5e38\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u6c34\u5e73\u7684 24.47%\u3002<\/li>\n\n\n\n<li>\u8bd5\u9a8c\u8868\u660e\uff0c\u8be5\u6cbb\u7597\u5177\u6709\u7a33\u5b9a\u6216\u6539\u5584\u8fd0\u52a8\u529f\u80fd\u7684\u6cbb\u7597\u6548\u679c\uff0c\u5e76\u4e14\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u6ca1\u6709\u4e25\u91cd\u7684\u4e0d\u826f\u4e8b\u4ef6\u3002<\/li>\n\n\n\n<li>\u5df2\u786e\u5b9a DMD \u7684\u8840\u6e05\u751f\u7269\u6807\u5fd7\u7269\uff0c\u5305\u62ec PADI2\u3001TTN\u3001MYOM2 \u548c MYLPF\u3002<\/li>\n\n\n\n<li>Brogidirsen \u5728 DMD \u5c3f\u6db2\u6765\u6e90\u7684\u7ec6\u80de\u4e2d\u8868\u73b0\u51fa\u5f88\u9ad8\u7684\u6548\u7387\uff0c\u652f\u6301\u4eba\u4f53\u8bd5\u9a8c\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-is-brogidirsen\">Brogidirsen \u662f\u4ec0\u4e48\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Brogidirsen\uff08NS-089\/NCNP-02\uff09\u662f\u7531\u65e5\u672c\u65b0\u836f\u548cNCNP\u5171\u540c\u53d1\u73b0\u7684\u6838\u9178\u836f\u7269\uff0c\u6709\u671b\u6210\u4e3a\u6cbb\u7597\u56e0\u5916\u663e\u5b5044\u8df3\u8dc3\u800c\u5bfc\u81f4\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u57fa\u56e0\u7a81\u53d8\u7684DMD\u60a3\u8005\u7684\u6cbb\u7597\u836f\u7269\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4e86\u89e3\u66f4\u591a\uff1a<\/strong> <a href=\"https:\/\/dmdwarrior.com\/zh\/upcoming-exon-44-skipping-therapies-for-dmd\/\" data-type=\"post\" data-id=\"2811\">\u5373\u5c06\u63a8\u51fa\u7684\u7528\u4e8e\u6cbb\u7597\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7684\u5916\u663e\u5b50 44 \u8df3\u8dc3\u7597\u6cd5<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>The National Center of Neurology and Psychiatry is announced the publication of a research paper in Cell Reports Medicine detailing the results of an investigator-initiated trial for NS-089\/NCNP-02, known as &#8220;brogidirsen.&#8221; This innovative treatment for Duchenne muscular dystrophy (DMD), jointly developed with Nippon Shinyaku Co., Ltd., represents a significant advancement in exon 44 skipping therapy. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2383,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[138,137,141,127,77,142,136,139,140],"class_list":["post-2380","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-brogidirsen","tag-clinical-trial","tag-exon-44","tag-exon-44-skipping","tag-exon-skipping","tag-japan","tag-nippon-shinyaku","tag-ns-089","tag-ns-089-ncnp-02"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/2380","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=2380"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/2380\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/2383"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=2380"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=2380"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=2380"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}