{"id":1957,"date":"2024-12-24T21:03:48","date_gmt":"2024-12-24T18:03:48","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=1957"},"modified":"2024-12-24T21:03:50","modified_gmt":"2024-12-24T18:03:50","slug":"splicer-gene-editing-tool-holds-a-lot-of-potential-to-treat-duchenne-muscular-dystrophy","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/zh\/splicer-gene-editing-tool-holds-a-lot-of-potential-to-treat-duchenne-muscular-dystrophy\/","title":{"rendered":"SPLICER \u57fa\u56e0\u7f16\u8f91\u5de5\u5177\u5728\u6cbb\u7597\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u65b9\u9762\u5177\u6709\u5de8\u5927\u6f5c\u529b"},"content":{"rendered":"<p class=\"wp-block-paragraph\">\u4f0a\u5229\u8bfa\u4f0a\u5927\u5b66\u5384\u5df4\u7eb3-\u9999\u69df\u5206\u6821\u7684\u7814\u7a76\u4eba\u5458\u62a5\u544a\u79f0\uff0c\u4e00\u79cd\u65b0\u7684\u57fa\u56e0\u7f16\u8f91\u5de5\u5177\u53ef\u4ee5\u5e2e\u52a9\u7ec6\u80de\u673a\u5236\u8df3\u8fc7\u5bfc\u81f4\u75be\u75c5\u7684\u57fa\u56e0\u90e8\u5206\uff0c\u5df2\u88ab\u7528\u4e8e\u51cf\u5c11\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5c0f\u9f20\u6a21\u578b\u4e2d\u6dc0\u7c89\u6837\u03b2\u6591\u5757\u524d\u4f53\u7684\u5f62\u6210\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">SPLICER \u4f7f\u7528\u4e00\u79cd\u79f0\u4e3a\u5916\u663e\u5b50\u8df3\u8dc3\u7684\u57fa\u56e0\u7f16\u8f91\u65b9\u6cd5\uff0c\u8fd9\u79cd\u65b9\u6cd5\u5bf9\u4e8e\u7531\u4ea7\u751f\u9519\u8bef\u6298\u53e0\u6216\u6709\u6bd2\u86cb\u767d\u8d28\u7684\u7a81\u53d8\u5f15\u8d77\u7684\u5065\u5eb7\u72b6\u51b5\u7279\u522b\u6709\u7528\uff0c\u4f8b\u5982\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u6216\u4ea8\u5ef7\u987f\u6c0f\u75c5\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u751f\u7269\u5de5\u7a0b\u5b66\u6559\u6388\u4f69\u96f7\u65af-\u76ae\u6d85\u62c9\u8868\u793a\uff1a\u201c\u4f46\u5bf9\u4e8e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u3001\u5e15\u91d1\u68ee\u75c5\u3001\u4ea8\u5ef7\u987f\u75c5\u6216\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u7b49\u75be\u75c5\uff0c\u8fd9\u79cd\u65b9\u6cd5\u5177\u6709\u5f88\u5927\u7684\u6f5c\u529b\u3002\u4e0b\u4e00\u6b65\u662f\u7814\u7a76\u5728\u8fd9\u4e9b\u75be\u75c5\u4e2d\u53bb\u9664\u76ee\u6807\u5916\u663e\u5b50\u7684\u5b89\u5168\u6027\uff0c\u5e76\u786e\u4fdd\u6211\u4eec\u4e0d\u4f1a\u4ea7\u751f\u6709\u6bd2\u6216\u7f3a\u4e4f\u5173\u952e\u529f\u80fd\u7684\u65b0\u86cb\u767d\u8d28\u3002\u6211\u4eec\u8fd8\u9700\u8981\u8fdb\u884c\u957f\u671f\u7684\u52a8\u7269\u7814\u7a76\uff0c\u770b\u770b\u75be\u75c5\u662f\u5426\u4f1a\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u800c\u53d1\u5c55\u3002\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.nature.com\/articles\/s41467-024-54529-y\" target=\"_blank\" rel=\"noreferrer noopener\">\u9605\u8bfb\u66f4\u591a<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>A new gene editing tool that helps cellular machinery skip parts of genes responsible for diseases has been applied to reduce the formation of amyloid-beta plaque precursors in a mouse model of Alzheimer&#8217;s disease, researchers at the University of Illinois Urbana-Champaign report. SPLICER uses a gene editing approach called exon skipping, which is of particular [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1959,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[59,60],"class_list":["post-1957","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-splicer","tag-splicer-gene-editing"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/1957","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/comments?post=1957"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/posts\/1957\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media\/1959"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/media?parent=1957"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/categories?post=1957"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/zh\/wp-json\/wp\/v2\/tags?post=1957"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}