{"id":6765,"date":"2026-03-12T17:37:47","date_gmt":"2026-03-12T14:37:47","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=6765"},"modified":"2026-03-12T17:46:08","modified_gmt":"2026-03-12T14:46:08","slug":"z-endoxifen-duchenne-muscular-dystrophy-study","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/tr\/z-endoxifen-duchenne-muscular-dystrophy-study\/","title":{"rendered":"Atossa, Duchenne Fare Modelinde Kas Fonksiyonunda \u0130yile\u015fme G\u00f6steren Yeni (Z)-Endoxifen Ara\u015ft\u0131rmas\u0131n\u0131 Sundu"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong>Orlando&#039;da d\u00fczenlenen 2026 MDA Klinik ve Bilimsel Konferans\u0131&#039;nda, Atossa Therapeutics ara\u015ft\u0131rmac\u0131lar\u0131, (Z)-endoxifen ve bunun Duchenne kas distrofisi (DMD) i\u00e7in potansiyel kullan\u0131m\u0131 hakk\u0131nda yeni preklinik veriler sundular.<\/strong><\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u0130\u00e7indekiler<\/h2><nav><ul><li><a href=\"#what-is-z-endoxifen\">(Z)-Endoxifen nedir?<\/a><\/li><li><a href=\"#new-duchenne-research-z-endoxifen-improves-muscle-strength-in-preclinical-study\">(Z)-Endoxifen, Klinik \u00d6ncesi \u00c7al\u0131\u015fmada Kas G\u00fcc\u00fcn\u00fc Art\u0131r\u0131yor<\/a><\/li><li><a href=\"#improvements-in-muscle-strength-and-performance\">Kas G\u00fcc\u00fc ve Performans\u0131nda \u0130yile\u015fmeler<\/a><\/li><li><a href=\"#reduced-muscle-damage-and-healthier-body-composition\">Kas Hasar\u0131n\u0131n Azalmas\u0131 ve Daha Sa\u011fl\u0131kl\u0131 V\u00fccut Yap\u0131s\u0131<\/a><\/li><li><a href=\"#safety-findings\">G\u00fcvenlik Bulgular\u0131<\/a><\/li><li><a href=\"#what-happens-next\">Bundan sonra ne olacak?<\/a><\/li><li><a href=\"#why-new-duchenne-treatments-are-still-needed\">Duchenne hastal\u0131\u011f\u0131 i\u00e7in yeni tedavi y\u00f6ntemlerine neden hala ihtiya\u00e7 duyuluyor?<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-is-z-endoxifen\">(Z)-Endoxifen nedir?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>(Z)-endoxifen, Tamoksifen ile ili\u015fkili bir bile\u015fiktir ve Se\u00e7ici \u00d6strojen Resept\u00f6r Mod\u00fclat\u00f6rleri (SERM&#039;ler) ad\u0131 verilen bir ila\u00e7 grubuna aittir.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ara\u015ft\u0131rmac\u0131lar bunun a\u015fa\u011f\u0131daki biyolojik yollar\u0131 etkileyebilece\u011fine inan\u0131yor:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>kas iltihab\u0131<\/li>\n\n\n\n<li>fibrozis (kas skarla\u015fmas\u0131)<\/li>\n\n\n\n<li>kas yenilenmesi<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Baz\u0131 Duchenne tedavilerinin belirli genetik mutasyonlar\u0131 hedef almas\u0131n\u0131n aksine, (Z)-endoxifen potansiyel olarak bir\u00e7ok Duchenne mutasyonunda etkili olabilir ve bu da onu daha geni\u015f bir hasta grubuna uygulanabilir hale getirebilir.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Bu ila\u00e7 \u015fu anda Duchenne kas distrofisi veya ba\u015fka herhangi bir rahats\u0131zl\u0131k i\u00e7in onaylanmam\u0131\u015ft\u0131r.<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"new-duchenne-research-z-endoxifen-improves-muscle-strength-in-preclinical-study\">(Z)-Endoxifen, Klinik \u00d6ncesi \u00c7al\u0131\u015fmada Kas G\u00fcc\u00fcn\u00fc Art\u0131r\u0131yor<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Bu \u00e7al\u0131\u015fmada, Duchenne hastal\u0131\u011f\u0131n\u0131n ilerleyi\u015fini incelemek i\u00e7in en yayg\u0131n kullan\u0131lan laboratuvar modellerinden biri olan mdx5Cv fare modeli kullan\u0131lm\u0131\u015ft\u0131r.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sonu\u00e7lar birka\u00e7 umut verici etki g\u00f6sterdi:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Bu \u00e7al\u0131\u015fmada, Duchenne kas distrofisi (DMD) preklinik ara\u015ft\u0131rmalar\u0131 i\u00e7in g\u00fcvenilir ve tekrarlanabilir bir standart olan mdx5Cv distrofik fare modeli kullan\u0131lm\u0131\u015ft\u0131r.<\/li>\n\n\n\n<li>(Z)-Endoxifen, hem gen\u00e7 hem de yeti\u015fkin distrofik farelerde kas g\u00fcc\u00fcn\u00fc ve motor performans\u0131n\u0131 iyile\u015ftirdi.<\/li>\n\n\n\n<li>Tedavi, kas kas\u0131lmas\u0131na ba\u011fl\u0131 kas hasar\u0131na kar\u015f\u0131 direnci art\u0131rd\u0131.<\/li>\n\n\n\n<li>V\u00fccut kompozisyonunda olumlu de\u011fi\u015fiklikler g\u00f6zlemlendi; bunlar aras\u0131nda kas k\u00fctlesinde art\u0131\u015f ve ya\u011f k\u00fctlesinde azalma yer almaktad\u0131r.<\/li>\n\n\n\n<li>Kas hasar\u0131n\u0131n temel biyokimyasal ve histolojik belirte\u00e7leri azald\u0131.<\/li>\n\n\n\n<li>Tedavi iyi tolere edildi ve \u00e7al\u0131\u015fma s\u00fcresince herhangi bir olumsuz bulgu g\u00f6zlemlenmedi.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Daha fazla bilgi edin:\u00a0<a href=\"https:\/\/dmdwarrior.com\/tr\/biomarkers-in-duchenne-muscular-dystrophy\/\" target=\"_blank\" rel=\"noreferrer noopener\">DMD&#039;de Biyobelirte\u00e7ler<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"improvements-in-muscle-strength-and-performance\">Kas G\u00fcc\u00fc ve Performans\u0131nda \u0130yile\u015fmeler<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u00c7al\u0131\u015fmada, hem gen\u00e7 hem de yeti\u015fkin distrofik farelerin (Z)-endoxifen ile tedavi edildikten sonra kas fonksiyonlar\u0131nda iyile\u015fme ya\u015fad\u0131\u011f\u0131 tespit edildi.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ba\u015fl\u0131ca bulgular \u015funlard\u0131r:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Kas g\u00fcc\u00fcnde art\u0131\u015f<\/li>\n\n\n\n<li>Daha iyi motor performans\u0131<\/li>\n\n\n\n<li>Kas kas\u0131lmas\u0131 s\u0131ras\u0131nda kas yaralanmas\u0131na kar\u015f\u0131 daha y\u00fcksek diren\u00e7.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Bu geli\u015fmeler, tedavinin kas liflerini hasardan korumaya yard\u0131mc\u0131 olabilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"reduced-muscle-damage-and-healthier-body-composition\">Kas Hasar\u0131n\u0131n Azalmas\u0131 ve Daha Sa\u011fl\u0131kl\u0131 V\u00fccut Yap\u0131s\u0131<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Ara\u015ft\u0131rmac\u0131lar ayr\u0131ca kas hasar\u0131yla ba\u011flant\u0131l\u0131 \u00e7e\u015fitli biyolojik belirte\u00e7lerde iyile\u015fmeler g\u00f6zlemledi.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tedavi \u015fu sonu\u00e7lar\u0131 g\u00f6sterdi:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Kas hasar\u0131 biyobelirte\u00e7lerinin daha d\u00fc\u015f\u00fck seviyeleri<\/li>\n\n\n\n<li>Daha sa\u011fl\u0131kl\u0131 kas dokusu yap\u0131s\u0131<\/li>\n\n\n\n<li>Artan ya\u011fs\u0131z kas k\u00fctlesi<\/li>\n\n\n\n<li>V\u00fccut ya\u011f\u0131nda azalma<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Bu bulgular, ilac\u0131n Duchenne hastal\u0131\u011f\u0131n\u0131n ilerlemesinin birden fazla y\u00f6n\u00fcn\u00fc ele almaya yard\u0131mc\u0131 olabilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"safety-findings\">G\u00fcvenlik Bulgular\u0131<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Hayvanlar \u00fczerinde yap\u0131lan \u00e7al\u0131\u015fmada tedavi iyi tolere edildi ve ara\u015ft\u0131rmac\u0131lar tedavi s\u0131ras\u0131nda \u00f6nemli bir yan etki bildirmedi.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Bu sonu\u00e7lar cesaret verici olsa da, ara\u015ft\u0131rma hen\u00fcz klinik \u00f6ncesi a\u015famada, yani laboratuvar modelleri \u00fczerinde y\u00fcr\u00fct\u00fcld\u00fc ve Duchenne hastalar\u0131 \u00fczerinde hen\u00fcz ger\u00e7ekle\u015ftirilmedi.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-happens-next\">Bundan sonra ne olacak?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u00d6nleyici nitelikteki cesaret verici sonu\u00e7lar, daha ileri ara\u015ft\u0131rmalar\u0131 desteklemektedir.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Gelecekteki ad\u0131mlar \u015funlar\u0131 i\u00e7erebilir:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Ek laboratuvar \u00e7al\u0131\u015fmalar\u0131<\/li>\n\n\n\n<li>G\u00fcvenlik testleri<\/li>\n\n\n\n<li>Duchenne hastalar\u0131nda yap\u0131lan klinik \u00e7al\u0131\u015fmalar<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>ABD'de FDA, Duchenne kas distrofisi i\u00e7in yeni tedavilere duyulan acil ihtiyac\u0131 kabul ederek, (Z)-endoxifen'e yetim ila\u00e7 stat\u00fcs\u00fc vermi\u015ftir.<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"why-new-duchenne-treatments-are-still-needed\">Duchenne hastal\u0131\u011f\u0131 i\u00e7in yeni tedavi y\u00f6ntemlerine neden hala ihtiya\u00e7 duyuluyor?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Duchenne kas distrofisi, distrofin genindeki mutasyonlardan kaynaklanan nadir bir genetik hastal\u0131kt\u0131r. Erken \u00e7ocukluk d\u00f6neminde ba\u015flayan ilerleyici kas dejenerasyonuna yol a\u00e7ar.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Duchenne kas distrofisi olan \u00e7ocuklarda kas g\u00fcc\u00fc giderek azal\u0131r ve bu durum \u015funlara yol a\u00e7abilir:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Y\u00fcr\u00fcme yetene\u011finin kayb\u0131<\/li>\n\n\n\n<li>Kalp komplikasyonlar\u0131<\/li>\n\n\n\n<li><a href=\"https:\/\/dmdwarrior.com\/tr\/respiratory-health-care-in-duchenne-muscular-dystrophy\/\" target=\"_blank\" data-type=\"post\" data-id=\"6477\" rel=\"noreferrer noopener\">Solunum problemleri<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Gen terapileri ve ekzon atlama ila\u00e7lar\u0131 gibi tedavilerdeki ilerlemelere ra\u011fmen, bir\u00e7ok aile hala ek tedavi se\u00e7eneklerine ihtiya\u00e7 duymaktad\u0131r.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Bu Sayfay\u0131 Takip Edin<\/strong>&nbsp;&gt;&gt;&gt;&nbsp;<a href=\"https:\/\/dmdwarrior.com\/tr\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">Duchenne i\u00e7in T\u00fcm Klinik Ara\u015ft\u0131rmalar<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>At the 2026 MDA Clinical &amp; Scientific Conference in Orlando, researchers from Atossa Therapeutics presented new preclinical data about (Z)-endoxifen and its potential use for Duchenne muscular dystrophy (DMD). What Is (Z)-Endoxifen? (Z)-endoxifen is a compound related to Tamoxifen and belongs to a group of medicines called Selective Estrogen Receptor Modulators (SERMs). Researchers believe it [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":6767,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[461,462,464,463],"class_list":["post-6765","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-z-endoxifen","tag-atossa-therapeutics","tag-endoxifen","tag-tamoxifen"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/6765","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/comments?post=6765"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/6765\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media\/6767"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media?parent=6765"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/categories?post=6765"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/tags?post=6765"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}