{"id":5285,"date":"2025-12-03T17:41:43","date_gmt":"2025-12-03T14:41:43","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=5285"},"modified":"2025-12-03T17:52:01","modified_gmt":"2025-12-03T14:52:01","slug":"capricor-therapeutics-announces-positive-topline-results","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/tr\/capricor-therapeutics-announces-positive-topline-results\/","title":{"rendered":"Capricor Therapeutics, Duchenne Musk\u00fcler Distrofi'de Deramiocel'in Pivotal Faz 3 HOPE-3 \u00c7al\u0131\u015fmas\u0131ndan Olumlu \u00dcst D\u00fczey Sonu\u00e7lar Duyurdu"},"content":{"rendered":"

HOPE-3, Duchenne kas distrofisi olan erkek ve gen\u00e7 erkeklerde Deramiocel'i de\u011ferlendiren randomize, \u00e7ift k\u00f6r, plasebo kontroll\u00fc, Faz 3 klinik bir \u00e7al\u0131\u015fmad\u0131r. \u00c7al\u0131\u015fmaya, 20 \u00f6nde gelen ABD klinik merkezinden 106 kat\u0131l\u0131mc\u0131 randomize olarak kat\u0131lm\u0131\u015ft\u0131r. Kat\u0131l\u0131mc\u0131lara, 12 ayl\u0131k bir s\u00fcre boyunca her \u00fc\u00e7 ayda bir inf\u00fczyon ba\u015f\u0131na 150 milyon h\u00fccre dozunda intraven\u00f6z Deramiocel veya plasebo uygulanm\u0131\u015ft\u0131r.<\/p>\n\n\n\n

Kat\u0131l\u0131mc\u0131lar\u0131n ortalama ya\u015f\u0131 yakla\u015f\u0131k 15'ti ve hepsi \u00e7al\u0131\u015fma boyunca stabil bir kortikosteroid tedavisi g\u00f6r\u00fcyordu. Ba\u015flang\u0131\u00e7 \u200b\u200bdemografik \u00f6zellikleri tedavi kollar\u0131 aras\u0131nda iyi dengelenmi\u015fti; yakla\u015f\u0131k '\u0131 ba\u015flang\u0131\u00e7ta kardiyak ila\u00e7lar al\u0131yordu ve 'inden fazlas\u0131na klinik olarak kardiyomiyopati tan\u0131s\u0131 konmu\u015ftu. Deramiocel, \u00f6nceki klinik deneyimlerle uyumlu, olumlu bir g\u00fcvenlik ve tolerabilite profili s\u00fcrd\u00fcrd\u00fc. >>>\u00a0Deramiocel nedir? CAP-1002 ne i\u015fe yarar?<\/a><\/p>\n\n\n\n

\u00dcst D\u00fczey Etkinlik Sonu\u00e7lar\u0131<\/h2>\n\n\n\n
Son nokta<\/strong><\/td>% \u0130lerlemenin Yava\u015flamas\u0131<\/strong>3<\/strong><\/sup>
(Deramiocel ve Plasebo)<\/strong><\/td>		p de\u011feri<\/strong><\/td><\/tr>
\u00dcst Ekstremite Performans\u0131 (PUL v2.0) Toplam Puan\u0131<\/strong>\u00b9
(Birincil, n=105)<\/td>		54%<\/td>p=0,029<\/td><\/tr>
Sol Ventrik\u00fcl Ejeksiyon Fraksiyonu (LVEF %)<\/strong>\u00b2
(Anahtar \u0130kincil, n=83)<\/td>		91%<\/td>p=0,041<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

\u00b9 n, 12. ayda de\u011ferlendirilebilir PUL v2.0 de\u011ferlendirmelerine sahip ITT pop\u00fclasyonundaki hasta say\u0131s\u0131n\u0131 yans\u0131t\u0131r.
\u00b2 n, 12. ayda merkezi olarak incelenen ve de\u011ferlendirilebilen kardiyak MRI LVEF de\u011ferlendirmelerine sahip ITT pop\u00fclasyonundaki hasta say\u0131s\u0131n\u0131 yans\u0131tmaktad\u0131r.
3 <\/sup>Yava\u015flama y\u00fczdesi, tedavi fark\u0131n\u0131n plasebodaki ba\u015flang\u0131\u00e7 seviyesinden de\u011fi\u015fime b\u00f6l\u00fcnmesiyle hesaplan\u0131r.<\/p>\n\n\n\n

Bu Sayfay\u0131 Takip Edin<\/strong> >>> Duchenne i\u00e7in T\u00fcm Klinik Ara\u015ft\u0131rmalar<\/a><\/p>","protected":false},"excerpt":{"rendered":"

HOPE-3 is a randomized, double-blind, placebo-controlled, Phase 3 clinical trial evaluating Deramiocel in boys and young men with Duchenne muscular dystrophy. The study randomized 106 participants across 20 leading U.S. clinical sites. Participants received intravenous Deramiocel at 150 million cells per infusion or placebo every three months for a 12-month period. The average age of […]<\/p>\n","protected":false},"author":1,"featured_media":5287,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[86,87,303,137,85],"class_list":["post-5285","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-capricor","tag-capricor-therapeutics","tag-cell-therapy","tag-clinical-trial","tag-deramiocel"],"subtitle":"Capricor Therapeutics, Duchenne kas distrofisi (DMD) tedavisi i\u00e7in \u015eirketin deneysel h\u00fccre terapisi olan Deramiocel'i de\u011ferlendiren \u00f6nemli Faz 3 HOPE-3 denemesinden olumlu \u00fcst d\u00fczey sonu\u00e7lar duyurdu.","_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/5285","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/comments?post=5285"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/5285\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media\/5287"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media?parent=5285"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/categories?post=5285"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/tags?post=5285"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}