{"id":5177,"date":"2025-11-18T18:34:47","date_gmt":"2025-11-18T15:34:47","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=5177"},"modified":"2025-11-18T18:34:48","modified_gmt":"2025-11-18T15:34:48","slug":"potential-of-sat-3247-to-restore-muscle-regeneration-in-duchenne-published-in-nature","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/tr\/potential-of-sat-3247-to-restore-muscle-regeneration-in-duchenne-published-in-nature\/","title":{"rendered":"SAT-3247&#039;nin Duchenne Hastal\u0131\u011f\u0131nda Kas Yenilenmesini Geri Kazand\u0131rma Potansiyeli Nature Dergisinde Yay\u0131mland\u0131"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Satellos, Ottawa Hastanesi Ara\u015ft\u0131rma Enstit\u00fcs\u00fc&#039;ndeki (OHRI) bir bilimsel ekibin, Duchenne kas distrofisi ve di\u011fer hastal\u0131klar\u0131n alt\u0131nda yatan nedeni tedavi etme konusundaki \u015firketin yenilik\u00e7i yakla\u015f\u0131m\u0131n\u0131 do\u011frulayan yeni ara\u015ft\u0131rmas\u0131n\u0131n Nature Communications&#039;da yay\u0131nland\u0131\u011f\u0131n\u0131 duyurdu. &gt;&gt; <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-64999-3\" target=\"_blank\" rel=\"noreferrer noopener\">Yay\u0131na buradan ula\u015fabilirsiniz<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">OHRI ara\u015ft\u0131rmac\u0131lar\u0131 taraf\u0131ndan kaleme al\u0131nan ve aralar\u0131nda Satellos kurucu orta\u011f\u0131 ve Ba\u015f Ke\u015fif Sorumlusu, OHRI k\u0131demli bilim insan\u0131 ve Sprott K\u00f6k H\u00fccre Ara\u015ft\u0131rma Merkezi direkt\u00f6r\u00fc Dr. Michael Rudnicki&#039;nin de bulundu\u011fu makale, Duchenne kas distrofisinin (DMD, Duchenne) fetal geli\u015fim s\u0131ras\u0131nda, i\u00e7sel kas k\u00f6k h\u00fccresi i\u015flev bozuklu\u011fuyla karakterize bir k\u00f6k h\u00fccre hastal\u0131\u011f\u0131 olarak ba\u015flad\u0131\u011f\u0131n\u0131 ortaya koyuyor. Distrofin yoklu\u011funda, ara\u015ft\u0131rmac\u0131lar kas k\u00f6k h\u00fccrelerinin polaritesini kaybetti\u011fini ve daha az miyojenik progenit\u00f6r \u00fcretti\u011fini, bunun da daha az ve daha k\u00fc\u00e7\u00fck kas lifleriyle sonu\u00e7land\u0131\u011f\u0131n\u0131 g\u00f6sterdi. Bu de\u011fi\u015fikliklerin, iltihaplanma veya doku dejenerasyonu ortaya \u00e7\u0131kmadan \u00f6nce fetal kas geli\u015fimi s\u0131ras\u0131nda ortaya \u00e7\u0131kt\u0131\u011f\u0131 dikkat \u00e7ekicidir.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00d6nemlisi, ara\u015ft\u0131rmac\u0131lar distrofin eksikli\u011fi olan kas k\u00f6k h\u00fccrelerinin polariteye ula\u015fmak, yeni progenit\u00f6r h\u00fccreler \u00fcretmek ve AAK1 proteininin aktivitesini bloke ederek normal miktarda kas olu\u015fturmak \u00fczere ind\u00fcklenebilece\u011fini g\u00f6sterdiler; bu bulgular, SAT-3247 gibi bir AAK1 inhibit\u00f6r\u00fcn\u00fcn Duchenne&#039;de kas rejenerasyonunu geri kazand\u0131rma potansiyelini destekliyor.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Duchenne i\u00e7in geli\u015ftirilmekte olan ve DMD hastalar\u0131n\u0131n kaslar\u0131n\u0131 korumaya yard\u0131mc\u0131 olmak i\u00e7in bir distrofin formu \u00fcretmelerine yard\u0131mc\u0131 olmaya odaklanan tedavi yakla\u015f\u0131mlar\u0131n\u0131n aksine, Satellos&#039;nin farkl\u0131la\u015ft\u0131r\u0131lm\u0131\u015f yakla\u015f\u0131m\u0131, AAK1&#039;in hedeflenen inhibisyonu yoluyla Duchenne ile ya\u015fayan ki\u015filerde kas rejenerasyonunu geri kazand\u0131rmay\u0131 ama\u00e7l\u0131yor.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cMakalenin k\u0131demli yazar\u0131 Dr. Rudnicki, &quot;Bu bulgular, Duchenne&#039;in kas k\u00f6k h\u00fccrelerinin kas in\u015fa edip koruyamamas\u0131ndan kaynakland\u0131\u011f\u0131n\u0131 a\u00e7\u0131k\u00e7a ortaya koyuyor; miyofiber k\u0131r\u0131lganl\u0131\u011f\u0131 veya hasar\u0131na dair herhangi bir kan\u0131t yok,&quot; dedi. &quot;AAK1&#039;i mod\u00fcle ederek, distrofik modellerde polariteyi d\u00fczenlemek, k\u00f6k h\u00fccre fonksiyonunu normalle\u015ftirmek ve kas olu\u015fumunu art\u0131rmak i\u00e7in g\u00fc\u00e7l\u00fc bir yol g\u00f6sterdik ve bu da rejeneratif tedavi stratejilerine giden g\u00fc\u00e7l\u00fc bir yola i\u015faret ediyor.&quot;\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Satellos&#039;nin kurucu orta\u011f\u0131 ve CEO&#039;su Frank Gleeson, &quot;Bu bulgular, k\u00f6k h\u00fccre i\u015flev bozuklu\u011funun d\u00fczeltilmesinin Duchenne&#039;in seyrini de\u011fi\u015ftirmek i\u00e7in elzem oldu\u011funa dair inanc\u0131m\u0131z\u0131 daha da do\u011fruluyor. Dr. Rudnicki ve OHRI meslekta\u015flar\u0131n\u0131, daha etkili m\u00fcdahalelere kap\u0131 a\u00e7abilecek kas biyolojisini ortaya \u00e7\u0131kar\u0131p do\u011frulad\u0131klar\u0131 i\u00e7in tebrik ediyoruz.&quot; dedi.\u201c<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Bu Sayfay\u0131 Takip Edin<\/strong>&nbsp;&gt;&gt;&gt;&nbsp;<a href=\"https:\/\/dmdwarrior.com\/tr\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">Duchenne i\u00e7in T\u00fcm Klinik Ara\u015ft\u0131rmalar<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Satellos announced the publication in Nature Communications of new research from a scientific team at the Ottawa Hospital Research Institute (OHRI) that validates the company\u2019s novel approach to treating the underlying cause of Duchenne muscular dystrophy and other diseases. >> Publication available here. The paper \u2014 authored by OHRI researchers, including Satellos co-founder and Chief [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":5179,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[456,254,40,251,252,253],"class_list":["post-5177","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-aak1-inhibitor","tag-frank-gleeson","tag-michael-rudnicki","tag-sat-3247","tag-satellos","tag-satellos-bioscience"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/5177","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/comments?post=5177"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/5177\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media\/5179"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media?parent=5177"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/categories?post=5177"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/tags?post=5177"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}