{"id":5164,"date":"2025-11-17T16:46:57","date_gmt":"2025-11-17T13:46:57","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=5164"},"modified":"2025-11-17T17:27:48","modified_gmt":"2025-11-17T14:27:48","slug":"ali-taghizadeh-announces-dmd-anka-mrna-therapy-currently-in-clinical-trial-in-turkiye","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/tr\/ali-taghizadeh-announces-dmd-anka-mrna-therapy-currently-in-clinical-trial-in-turkiye\/","title":{"rendered":"Ali Taghizadeh, T\u00fcrkiye&#039;de Klinik \u00c7al\u0131\u015fma A\u015famas\u0131nda Olan DMD ANKA mRNA Terapisini Duyurdu"},"content":{"rendered":"<p class=\"wp-block-paragraph\">T\u00fcrk farmakolog Do\u00e7. Dr. Ali Taghizade, Duchenne Musk\u00fcler Distrofisi i\u00e7in \u00fczerinde \u00e7al\u0131\u015ft\u0131\u011f\u0131 mRNA terapisini yurtd\u0131\u015f\u0131ndaki takip\u00e7ilerine \u0130ngilizce olarak duyurdu.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Do\u00e7ent Dr. Ali Taghizadeh, Duchenne kas distrofisi i\u00e7in geli\u015ftirdi\u011fi mRNA terapisi DMD ANKA hakk\u0131nda Instagram hesab\u0131ndan \u0130ngilizce bir bilgilendirme videosu payla\u015ft\u0131. <strong>Daha fazla bilgi edin<\/strong>: <a href=\"https:\/\/dmdwarrior.com\/tr\/mrna-duchenne-muscular-dystrophy-dmd-treatment\/\" target=\"_blank\" rel=\"noreferrer noopener\">DMD Tedavisinde mRNA \u00c7al\u0131\u015fmalar\u0131: Gelecekteki Terap\u00f6tik Adaylar<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">ANKA Ne Anlama Geliyor?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">ANKA, T\u00fcrk\u00e7e&#039;de Anka Ku\u015f anlam\u0131na gelen, \u0130ngilizce&#039;de ise Phoenix olarak bilinen mitolojik bir yarat\u0131kt\u0131r.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">DMD ANKA'n\u0131n Tan\u0131t\u0131m\u0131<\/h2>\n\n\n\n<blockquote class=\"instagram-media\" data-instgrm-captioned data-instgrm-permalink=\"https:\/\/www.instagram.com\/reel\/DRKA-1QAqO_\/?utm_source=ig_embed&amp;utm_campaign=loading\" data-instgrm-version=\"14\" style=\" background:#FFF; border:0; border-radius:3px; box-shadow:0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width:540px; min-width:326px; padding:0; width:99.375%; width:-webkit-calc(100% - 2px); width:calc(100% - 2px);\"><div style=\"padding:16px;\"> <a href=\"https:\/\/www.instagram.com\/reel\/DRKA-1QAqO_\/?utm_source=ig_embed&amp;utm_campaign=loading\" style=\" background:#FFFFFF; line-height:0; padding:0 0; text-align:center; text-decoration:none; width:100%;\" target=\"_blank\" rel=\"noopener\"> <div style=\" display: flex; flex-direction: row; align-items: center;\"> <div style=\"background-color: #F4F4F4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;\"><\/div> <div style=\"display: flex; flex-direction: column; flex-grow: 1; justify-content: center;\"> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;\"><\/div> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;\"><\/div><\/div><\/div><div style=\"padding: 19% 0;\"><\/div> <div style=\"display:block; height:50px; margin:0 auto 12px; width:50px;\"><svg width=\"50px\" height=\"50px\" viewbox=\"0 0 60 60\" version=\"1.1\" xmlns=\"https:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"https:\/\/www.w3.org\/1999\/xlink\"><g stroke=\"none\" stroke-width=\"1\" fill=\"none\" fill-rule=\"evenodd\"><g transform=\"translate(-511.000000, -20.000000)\" fill=\"#000000\"><g><path d=\"M556.869,30.41 C554.814,30.41 553.148,32.076 553.148,34.131 C553.148,36.186 554.814,37.852 556.869,37.852 C558.924,37.852 560.59,36.186 560.59,34.131 C560.59,32.076 558.924,30.41 556.869,30.41 M541,60.657 C535.114,60.657 530.342,55.887 530.342,50 C530.342,44.114 535.114,39.342 541,39.342 C546.887,39.342 551.658,44.114 551.658,50 C551.658,55.887 546.887,60.657 541,60.657 M541,33.886 C532.1,33.886 524.886,41.1 524.886,50 C524.886,58.899 532.1,66.113 541,66.113 C549.9,66.113 557.115,58.899 557.115,50 C557.115,41.1 549.9,33.886 541,33.886 M565.378,62.101 C565.244,65.022 564.756,66.606 564.346,67.663 C563.803,69.06 563.154,70.057 562.106,71.106 C561.058,72.155 560.06,72.803 558.662,73.347 C557.607,73.757 556.021,74.244 553.102,74.378 C549.944,74.521 548.997,74.552 541,74.552 C533.003,74.552 532.056,74.521 528.898,74.378 C525.979,74.244 524.393,73.757 523.338,73.347 C521.94,72.803 520.942,72.155 519.894,71.106 C518.846,70.057 518.197,69.06 517.654,67.663 C517.244,66.606 516.755,65.022 516.623,62.101 C516.479,58.943 516.448,57.996 516.448,50 C516.448,42.003 516.479,41.056 516.623,37.899 C516.755,34.978 517.244,33.391 517.654,32.338 C518.197,30.938 518.846,29.942 519.894,28.894 C520.942,27.846 521.94,27.196 523.338,26.654 C524.393,26.244 525.979,25.756 528.898,25.623 C532.057,25.479 533.004,25.448 541,25.448 C548.997,25.448 549.943,25.479 553.102,25.623 C556.021,25.756 557.607,26.244 558.662,26.654 C560.06,27.196 561.058,27.846 562.106,28.894 C563.154,29.942 563.803,30.938 564.346,32.338 C564.756,33.391 565.244,34.978 565.378,37.899 C565.522,41.056 565.552,42.003 565.552,50 C565.552,57.996 565.522,58.943 565.378,62.101 M570.82,37.631 C570.674,34.438 570.167,32.258 569.425,30.349 C568.659,28.377 567.633,26.702 565.965,25.035 C564.297,23.368 562.623,22.342 560.652,21.575 C558.743,20.834 556.562,20.326 553.369,20.18 C550.169,20.033 549.148,20 541,20 C532.853,20 531.831,20.033 528.631,20.18 C525.438,20.326 523.257,20.834 521.349,21.575 C519.376,22.342 517.703,23.368 516.035,25.035 C514.368,26.702 513.342,28.377 512.574,30.349 C511.834,32.258 511.326,34.438 511.181,37.631 C511.035,40.831 511,41.851 511,50 C511,58.147 511.035,59.17 511.181,62.369 C511.326,65.562 511.834,67.743 512.574,69.651 C513.342,71.625 514.368,73.296 516.035,74.965 C517.703,76.634 519.376,77.658 521.349,78.425 C523.257,79.167 525.438,79.673 528.631,79.82 C531.831,79.965 532.853,80.001 541,80.001 C549.148,80.001 550.169,79.965 553.369,79.82 C556.562,79.673 558.743,79.167 560.652,78.425 C562.623,77.658 564.297,76.634 565.965,74.965 C567.633,73.296 568.659,71.625 569.425,69.651 C570.167,67.743 570.674,65.562 570.82,62.369 C570.966,59.17 571,58.147 571,50 C571,41.851 570.966,40.831 570.82,37.631\"><\/path><\/g><\/g><\/g><\/svg><\/div><div style=\"padding-top: 8px;\"> <div style=\" color:#3897f0; font-family:Arial,sans-serif; font-size:14px; font-style:normal; font-weight:550; line-height:18px;\">Bu g\u00f6nderiyi Instagram&#039;da g\u00f6r<\/div><\/div><div style=\"padding: 12.5% 0;\"><\/div> <div style=\"display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;\"><div> <div style=\"background-color: #F4F4F4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);\"><\/div> <div style=\"background-color: #F4F4F4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;\"><\/div> <div style=\"background-color: #F4F4F4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);\"><\/div><\/div><div style=\"margin-left: 8px;\"> <div style=\" background-color: #F4F4F4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;\"><\/div> <div style=\" width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg)\"><\/div><\/div><div style=\"margin-left: auto;\"> <div style=\" width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);\"><\/div> <div style=\" background-color: #F4F4F4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);\"><\/div> <div style=\" width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);\"><\/div><\/div><\/div> <div style=\"display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;\"> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;\"><\/div> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;\"><\/div><\/div><\/a><p style=\" color:#c9c8cd; font-family:Arial,sans-serif; font-size:14px; line-height:17px; margin-bottom:0; margin-top:8px; overflow:hidden; padding:8px 0 7px; text-align:center; text-overflow:ellipsis; white-space:nowrap;\"><a href=\"https:\/\/www.instagram.com\/reel\/DRKA-1QAqO_\/?utm_source=ig_embed&amp;utm_campaign=loading\" style=\" color:#c9c8cd; font-family:Arial,sans-serif; font-size:14px; font-style:normal; font-weight:normal; line-height:17px; text-decoration:none;\" target=\"_blank\" rel=\"noopener\">DMD Hastal\u0131\u011f\u0131, Ali Taghizadeh (@alitgzd)&#039;in bir g\u00f6nderisini payla\u015ft\u0131<\/a><\/p><\/div><\/blockquote>\n<script async src=\"\/\/www.instagram.com\/embed.js\"><\/script>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Videonun tam metni \u015f\u00f6yle:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Herkese merhaba, ben Ali Taghizadeh.<br>Bilecik \u015eeyh Edebali \u00dcniversitesi&#039;ndenim.<br>T\u0131bbi Farmakoloji alan\u0131nda do\u00e7entim.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">T\u00fcrkiye d\u0131\u015f\u0131nda ya\u015fayan yabanc\u0131lara DMD ANKA&#039;m\u0131z\u0131 tan\u0131tmak istiyorum.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">DMD ANKA\u2019y\u0131 \u00fc\u00e7 ayr\u0131 ba\u015fl\u0131kta de\u011ferlendirebiliriz.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Birincisi DMD ANKA\u2019da kulland\u0131\u011f\u0131m\u0131z mRNA dizisidir.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Bildi\u011finiz gibi distrofin, v\u00fccuttaki en b\u00fcy\u00fck proteine ve en b\u00fcy\u00fck mRNA dizisine sahip olan proteindir.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Yakla\u015f\u0131k on be\u015f bin fosfat i\u00e7eriyor ve bu molek\u00fcl\u00fc stabilize etmek \u00e7ok zor ve bu, bilim insanlar\u0131 i\u00e7in b\u00fcy\u00fck bir zorluk. Art\u0131k hi\u00e7bir kimyasal ve zararl\u0131 madde kullanmadan \u00fcretebiliyor ve stabilize edebiliyoruz.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0130kinci ad\u0131mda DMD ANKA&#039;n\u0131n h\u00fccre d\u00f6ng\u00fcleri veya h\u00fccre fizyolojisi ile ilgilenmesini istiyoruz.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Yani hastaya DMD ANKA verdi\u011fimizde, kan yoluyla DMD ANKA&#039;n\u0131n h\u00fccrelere ula\u015fmas\u0131n\u0131 ve daha sonra fizyolojik olarak h\u00fccrelere ayr\u0131lmas\u0131n\u0131 istiyoruz, bu benim \u00fcr\u00fcn\u00fcm ve bunu DNA&#039;m\u0131zdan \u00fcrettim ve bu mRNA retik\u00fcler endoplazmik sistem (Ras) taraf\u0131ndan proteine \u00e7evrildi ve sonra h\u00fccrelerin i\u00e7ine yerle\u015ftirildi.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u00dc\u00e7\u00fcnc\u00fc ad\u0131m\u0131m\u0131z h\u00fccrelerin ilk saatlerde iyile\u015fmeye ve yenilenmeye ba\u015flamas\u0131d\u0131r, bu da h\u00fccre fizyolojisine mRNA&#039;m\u0131z\u0131n dahil olmas\u0131d\u0131r.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00c7ok \u00f6nemlidir \u00e7\u00fcnk\u00fc fonksiyonel bir distrofinle bir ad\u0131m atmak istedi\u011fimizde, bunun benim mRNA&#039;m oldu\u011funu anlayabilmek i\u00e7in onu hissetmemiz ve onu proteine \u00e7evirmem ve ayn\u0131 zamanda i\u015fini yapmas\u0131 i\u00e7in h\u00fccrenin onu i\u015flemesine izin verecek olan membrana g\u00f6ndermem gerekir.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00c7ok \u00f6nemlidir \u00e7\u00fcnk\u00fc fibrozis ve v\u00fccudun h\u00fccreler taraf\u0131ndan yapt\u0131\u011f\u0131 t\u00fcm iltihap i\u015flemleri.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Fibrozis ve inflamasyonu sonland\u0131rmak istedi\u011fimizde bunu h\u00fccrelerle oyun oynayarak yapmam\u0131z gerekiyor.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Yani distrofin membrana yerle\u015fip distroglikanlara ba\u011fland\u0131ktan sonra sarkoglikanlar incelendi\u011finde ve alfa aktin afferent ve antin\u00f6ronlar kas ile beyin aras\u0131nda yay \u015feklinde yaylar olu\u015fturup, tekrar iyile\u015fip, tekrar rejenerasyona u\u011frad\u0131\u011f\u0131nda fibrozis ortadan kalkacakt\u0131r.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Bu bizim i\u00e7in \u00f6nemli \u00e7\u00fcnk\u00fc DMD ANKA hem yeti\u015fkinlerde hem de Duchenne Musk\u00fcler Distrofisi olan \u00e7ocuklarda kullan\u0131labiliyor.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Bu Sayfay\u0131 Takip Edin<\/strong>&nbsp;&gt;&gt;&gt;&nbsp;<a href=\"https:\/\/dmdwarrior.com\/tr\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">Duchenne i\u00e7in T\u00fcm Klinik Ara\u015ft\u0131rmalar<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Turkish pharmacologist Assoc. Prof. Dr. Ali Taghizadeh announced in English to his followers abroad the mRNA therapy he is working on for Duchenne Muscular Dystrophy. Associate Professor Dr. Ali Taghizadeh shared an English-language information video on his Instagram account about DMD ANKA, the mRNA therapy he developed for Duchenne muscular dystrophy. Learn More: mRNA Studies [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":5165,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[345,333,359,202,455],"class_list":["post-5164","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-ali-taghizadeh","tag-dmd-anka","tag-full-length-dystrophin","tag-mrna","tag-mrna-therapy"],"subtitle":"T\u00fcrkiye'de Duchenne kas distrofisi i\u00e7in geli\u015ftirilme a\u015famas\u0131nda olan DMD ANKA mRNA terapisi, Do\u00e7. Dr. Ali Taghizadeh taraf\u0131ndan duyuruldu.","_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/5164","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/comments?post=5164"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/5164\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media\/5165"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media?parent=5164"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/categories?post=5164"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/tags?post=5164"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}