{"id":5035,"date":"2025-11-03T19:16:32","date_gmt":"2025-11-03T16:16:32","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=5035"},"modified":"2025-11-03T19:20:11","modified_gmt":"2025-11-03T16:20:11","slug":"capricor-therapeutics-publishes-peer-reviewed-study-about-cell-therapy-deramiocel","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/tr\/capricor-therapeutics-publishes-peer-reviewed-study-about-cell-therapy-deramiocel\/","title":{"rendered":"Capricor Therapeutics, Deramiocel H\u00fccre Terapisi Hakk\u0131nda Hakemli Bir \u00c7al\u0131\u015fma Yay\u0131nlad\u0131"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Capricor Therapeutics, uluslararas\u0131 hakemli bir dergi olan Biomedicines&#039;te, Capricor&#039;nin \u00f6nc\u00fc ara\u015ft\u0131rma \u00fcr\u00fcn\u00fc olan ve \u015fu anda Duchenne kas distrofisi (DMD) tedavisi i\u00e7in ge\u00e7 a\u015famada geli\u015ftirilmekte olan Deramiocel&#039;nin anti-fibrotik etki mekanizmas\u0131n\u0131 karakterize etmek \u00fczere tasarlanm\u0131\u015f yeni bir in-vitro potens analizini a\u00e7\u0131klayan bir yay\u0131n duyurdu. &gt;&gt;&gt; <a href=\"https:\/\/dmdwarrior.com\/tr\/what-is-deramiocel\/\" target=\"_blank\" rel=\"noreferrer noopener\">Deramiocel nedir? CAP-1002 ne i\u015fe yarar?<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&quot;Deramiocel&#039;de CDC&#039;lerin Anti-Fibrotik Etki Mekanizmas\u0131n\u0131 G\u00f6steren Yeni Bir \u0130n Vitro Potansiyel Testi&quot; ba\u015fl\u0131kl\u0131 yay\u0131n, Deramiocel&#039;nin aktif bile\u015feni olan kardiyosfer k\u00f6kenli h\u00fccrelerin (CDC&#039;ler) biyolojik aktivitesini daha da a\u00e7\u0131klayan sonu\u00e7lar ortaya koydu. \u00c7al\u0131\u015fma, CDC&#039;lerin salg\u0131lad\u0131klar\u0131 ekzosomlar ve \u00e7\u00f6z\u00fcn\u00fcr fakt\u00f6rler arac\u0131l\u0131\u011f\u0131yla, in vitro birincil insan fibroblastlar\u0131nda kolajen I ve III gen ekspresyonunu bask\u0131lad\u0131\u011f\u0131n\u0131 ve bu durumun hastal\u0131k ilerlemesiyle ili\u015fkili fibrotik s\u00fcre\u00e7leri d\u00fczenleme potansiyellerini destekledi\u011fini buldu.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Bulgular, y\u00fczlerce Deramiocel \u00fcretim partisinde tutarl\u0131yd\u0131 ve anti-fibrotik etki mekanizmas\u0131n\u0131 ortaya koydu. Bu, in vivo farmakodinamik \u00e7al\u0131\u015fmalar ve DMD hastalar\u0131nda kardiyak fonksiyonun stabilizasyonunu g\u00f6steren d\u00f6rt y\u0131l\u0131 a\u015fk\u0131n klinik verilerle de \u00f6rt\u00fc\u015fmektedir. Bu analiz, kalite kontroll\u00fc \u00fcretim ko\u015fullar\u0131 alt\u0131nda Deramiocel&#039;nin partiden partiye biyoaktivitesini ve etkinli\u011fini de\u011ferlendirmeye yard\u0131mc\u0131 olmak \u00fczere bir ara\u00e7 olarak geli\u015ftirilmi\u015f ve do\u011frulanm\u0131\u015ft\u0131r. Bu sayede, geli\u015ftirme s\u00fcreci ilerledik\u00e7e Capricor&#039;nin \u00fcr\u00fcn tutarl\u0131l\u0131\u011f\u0131n\u0131 ve kalitesini sa\u011flama yetene\u011fi art\u0131r\u0131lm\u0131\u015ft\u0131r.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cCapricor \u0130cra Kurulu Ba\u015fkan\u0131 Dr. Linda Marb\u00e1n, &quot;Bu yay\u0131n, kardiyosferden t\u00fcretilen h\u00fccrelerin Duchenne kas distrofisinin ilerlemesinin alt\u0131nda yatan fibrotik ve inflamatuar yollar\u0131 nas\u0131l d\u00fczenleyebilece\u011fini a\u00e7\u0131klayan giderek artan kan\u0131tlara katk\u0131da bulunuyor,&quot; dedi. &quot;Tekrarlanabilir ve kantitatif bir test olu\u015fturarak, Deramiocel&#039;nin biyolojik profiline dair anlay\u0131\u015f\u0131m\u0131z\u0131 g\u00fc\u00e7lendirdik ve Duchenne program\u0131m\u0131z ilerledik\u00e7e \u00fcr\u00fcn tutarl\u0131l\u0131\u011f\u0131n\u0131 sa\u011flama yetene\u011fimizi geli\u015ftirdik.&quot;\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Deramiocel, DMD tedavisi i\u00e7in Faz 3 HOPE-3 denemesinde de\u011ferlendirilmektedir ve en g\u00fcncel verilerin 2025 y\u0131l\u0131n\u0131n d\u00f6rd\u00fcnc\u00fc \u00e7eyre\u011finin ortalar\u0131nda sunulmas\u0131 beklenmektedir. Bu verilerin al\u0131nmas\u0131n\u0131n ard\u0131ndan Capricor, CRL&#039;ye verdi\u011fi yan\u0131tla birlikte Biyolojik Lisans Ba\u015fvurusunu (BLA) yeniden sunmay\u0131 beklemektedir. &gt;&gt;&gt; <strong><a href=\"https:\/\/dmdwarrior.com\/tr\/biologics-license-application-bla\/\" target=\"_blank\" data-type=\"post\" data-id=\"5027\" rel=\"noreferrer noopener\">Biyolojik Lisans Ba\u015fvurusu (BLA) Nedir?<\/a><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Bu yay\u0131n\u0131 tamamlamak i\u00e7in Capricor, Deramiocel&#039;nin etki mekanizmas\u0131n\u0131 a\u00e7\u0131klayan k\u0131sa bir e\u011fitim videosu yay\u0131nlad\u0131: <a href=\"https:\/\/www.capricor.com\/our-science\" target=\"_blank\" rel=\"noreferrer noopener\">Buradan \u0130zleyin<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Devam\u0131n\u0131 oku<\/strong>:&nbsp;<a href=\"https:\/\/dmdwarrior.com\/tr\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">Duchenne \u0130\u00e7in Klinik Ara\u015ft\u0131rmalar (T\u00fcm Ara\u015ft\u0131rmalar\u0131n Listesi)<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Capricor Therapeutics announced the publication in Biomedicines, an international peer-reviewed journal, describing a novel in-vitro potency assay designed to characterize the anti-fibrotic mechanism of action of the Capricor\u2019s lead investigational product, Deramiocel, which is currently in late-stage development for the treatment of Duchenne muscular dystrophy (DMD). >>> What is Deramiocel? What Does CAP-1002 Do? The [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":5036,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[90,86,87,89,85,362],"class_list":["post-5035","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-cap-1002","tag-capricor","tag-capricor-therapeutics","tag-cardiomyopathy","tag-deramiocel","tag-dmd-cardiomyopathy"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/5035","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/comments?post=5035"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/5035\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media\/5036"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media?parent=5035"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/categories?post=5035"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/tags?post=5035"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}