{"id":4953,"date":"2025-10-30T11:58:41","date_gmt":"2025-10-30T08:58:41","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=4953"},"modified":"2025-10-30T11:58:42","modified_gmt":"2025-10-30T08:58:42","slug":"hansa-imlifidase-reduce-anti-aav-antibodies-and-allow-administration-of-gene-therapy","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/tr\/hansa-imlifidase-reduce-anti-aav-antibodies-and-allow-administration-of-gene-therapy\/","title":{"rendered":"Hansa&#039;n\u0131n Imlifidase&#039;\u0131 Anti-AAV Antikorlar\u0131n\u0131 Azalt\u0131yor ve Gen Terapisi Uygulamas\u0131na \u0130zin Veriyor"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Duchenne kas distrofisi (DMD) tedavisinde SRP-9001-104: \u00c7al\u0131\u015fmada Sarepta&#039;n\u0131n ELEVIDYS&#039;inin uygulanmas\u0131ndan \u00f6nce imlifidaz ile tedavi edilen \u00fc\u00e7 DMD hastas\u0131 i\u00e7in \u00fcst d\u00fczey sonu\u00e7lar bildirildi.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Sarepta ve Genethon taraf\u0131ndan desteklenen iki gen terapisi \u00e7al\u0131\u015fmas\u0131, imlifidaz\u0131n anti-AAV antikorlar\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde azaltarak gen terapisinin uygulanmas\u0131na olanak sa\u011flama yetene\u011fini desteklemektedir.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Y\u00fcksek Anti-AAV Antikorlar\u0131 Art\u0131k Gen Terapisi Uygulamas\u0131na Engel Olmayabilir<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Tek doz imlifidazdan sonra, hastalarda IgG antikorlar\u0131nda h\u0131zl\u0131 bir d\u00fc\u015f\u00fc\u015f g\u00f6zlemlendi ve ba\u015flang\u0131\u00e7 seviyesinden \u226595% daha d\u00fc\u015f\u00fck seviyelere indi. Ayr\u0131ca, mevcut anti-AAV antikorlar\u0131 1:400 titresinin alt\u0131na d\u00fc\u015ferek ELEVIDYS ile tedaviye olanak sa\u011flad\u0131. \u00c7al\u0131\u015fmada yeni bir g\u00fcvenlik sinyali g\u00f6zlemlenmedi. Bu ilk klinik veriler, imlifidaz\u0131n anti-AAV antikorlar\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde azaltarak gen terapilerinin uygulanmas\u0131na olanak sa\u011flama yetene\u011fini desteklemektedir. <a href=\"https:\/\/dmdwarrior.com\/tr\/high-anti-aav-antibodies-may-not-prevent-elevidys-administration\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u0130mlifidase Hakk\u0131nda Daha Fazla Bilgi Edinin<\/a>.<\/p>","protected":false},"excerpt":{"rendered":"<p>SRP-9001-104 in Duchenne muscular dystrophy (DMD): Topline results were reported for three patients with DMD treated with imlifidase prior to administration of Sarepta&#8217;s ELEVIDYS in the trial. Two gene therapy trials, one sponsored by Sarepta and the other sponsored by Genethon, support the ability of imlifidase to substantially reduce anti-AAV antibodies to allow administration of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4954,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[368,448,61,401],"class_list":["post-4953","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-aav-based-gene-therapy","tag-anti-aav","tag-gene-therapy","tag-hansa-biopharma"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/4953","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/comments?post=4953"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/4953\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media\/4954"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media?parent=4953"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/categories?post=4953"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/tags?post=4953"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}