{"id":4860,"date":"2025-10-22T15:58:01","date_gmt":"2025-10-22T12:58:01","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=4860"},"modified":"2025-11-03T19:58:19","modified_gmt":"2025-11-03T16:58:19","slug":"lymphatic-system-duchenne-muscular-dystrophy-dmd","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/tr\/lymphatic-system-duchenne-muscular-dystrophy-dmd\/","title":{"rendered":"Lenfatik Sistem DMD \u0130lerlemesinin Arkas\u0131ndaki \u0130tici G\u00fc\u00e7 Olabilir"},"content":{"rendered":"

Texas A&M \u00dcniversitesi Naresh K. Vashisht T\u0131p Fak\u00fcltesi'nden Dr. Mendell Rimer ve Dr. Mariappan Muthuchamy ile Texas A&M Veterinerlik Fak\u00fcltesi ve Biomedical Bilimleri'nden Dr. Peter Nghiem'in rehberli\u011findeki bir grup bilim insan\u0131, yak\u0131n zamanda ger\u00e7ekle\u015ftirdikleri iki \u00e7al\u0131\u015fmada, s\u0131v\u0131 dengesini ve ba\u011f\u0131\u015f\u0131kl\u0131k fonksiyonunu d\u00fczenlemeye yard\u0131mc\u0131 olan lenfatik a\u011fdaki sorunlar\u0131n Duchenne kas distrofisi (DMD) ve Amyotrofik lateral skleroz (ALS) geli\u015fimine aktif olarak katk\u0131da bulunabilece\u011fini ortaya koydu.<\/p>\n\n\n\n

Ulusal Bilimler Akademisi Bildirileri (PNAS) ve Hastal\u0131k Modelleri ve Mekanizmalar\u0131 (DMM) dergilerinde yay\u0131nlanan \u00e7\u0131\u011f\u0131r a\u00e7\u0131c\u0131 \u00e7al\u0131\u015fmalar, lenfatik disfonksiyonun kronik inflamasyonun basit bir yan etkisi olmad\u0131\u011f\u0131n\u0131, ayn\u0131 zamanda hastal\u0131\u011f\u0131n ilerlemesinin arkas\u0131ndaki itici g\u00fc\u00e7 olabilece\u011fini g\u00f6stermektedir.DMM<\/a> Ve PNAS<\/a>)<\/p>\n\n\n\n

\u201cMuthuchamy, "Lenf sisteminin bu hastal\u0131klarla do\u011frudan ili\u015fkili oldu\u011fu ilk kez ortaya \u00e7\u0131kt\u0131," dedi. "Bulgular\u0131m\u0131z yeni ara\u015ft\u0131rma alanlar\u0131 a\u00e7\u0131yor ve sonunda yeni te\u015fhis veya tedavi yakla\u015f\u0131mlar\u0131na yol a\u00e7abilir."\u201d<\/p>\n\n\n\n

Duchenne kas distrofisi veya k\u0131saca DMD, d\u00fcnya \u00e7ap\u0131nda yakla\u015f\u0131k her 5.000 erkek \u00e7ocuktan birini etkiliyor ve ciddi kas dejenerasyonuna neden oluyor. Ara\u015ft\u0131rmalar geleneksel olarak kas dokusunun kendisine odaklan\u0131rken, Texas A&M ekibi dikkatini ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccrelerini dola\u015ft\u0131ran ve at\u0131klar\u0131 temizleyen lenf sistemine \u00e7evirdi.Duchenne Nedir?<\/a>)<\/p>\n\n\n\n

\"Lenfatik<\/figure><\/a><\/div>\n\n\n\n

Doktora sonras\u0131 bilim insan\u0131 Dr. Bhuvaneshwaran Subramanian ve lisans\u00fcst\u00fc \u00f6\u011frencileri Shedreanna Johnson ve Akshaya Narayanan liderli\u011findeki ve Muthuchamy, Rimer ve Peter P. Nghiem'in k\u0131demli katk\u0131lar\u0131yla y\u00fcr\u00fct\u00fclen DMD \u00e7al\u0131\u015fmas\u0131nda, ekip, DMD'de eksik olan protein olan distrofin kayb\u0131n\u0131n lenfatik yap\u0131 ve i\u015flevi bozdu\u011funu ke\u015ffetti. Bu bozulmalar, iltihaplanma ba\u015flamadan \u00f6nce bile erken d\u00f6nemde ortaya \u00e7\u0131k\u0131yor ve bu da lenfatik i\u015flev bozuklu\u011funun DMD'de g\u00f6r\u00fclen kas hasar\u0131n\u0131 tetikleyebilece\u011fini g\u00f6steriyor.<\/p>\n\n\n\n

Mikroskopi g\u00f6r\u00fcnt\u00fcleri, hastal\u0131kl\u0131 hayvan modellerindeki lenf damarlar\u0131n\u0131n normal hizalanmalar\u0131n\u0131 kaybetti\u011fini ve damar duvarlar\u0131nda d\u00fczensiz lifler oldu\u011funu ortaya koymu\u015ftur. Baz\u0131 DMD modellerinde, kas fonksiyonunu iyile\u015ftirmeye yard\u0131mc\u0131 olan distrofin geninin daha k\u00fc\u00e7\u00fck bir versiyonu olan mikrodistrofin tedavisi, lenf damarlar\u0131n\u0131n zararl\u0131 iltihab\u0131n\u0131 ve anormal b\u00fcy\u00fcmesini de azaltm\u0131\u015ft\u0131r. Bu bulgu, lenf ve kas sistemlerinin yak\u0131ndan ba\u011flant\u0131l\u0131 oldu\u011funu g\u00f6stererek DMD i\u00e7in yeni tedavi olanaklar\u0131n\u0131n kap\u0131s\u0131n\u0131 a\u00e7m\u0131\u015ft\u0131r.<\/p>\n\n\n\n

\u201cMuthuchamy, "Lenfatik fonksiyonu geri kazand\u0131rabilirsek, iltihab\u0131 azaltabilir ve hastal\u0131\u011f\u0131n ilerlemesini yava\u015flatabiliriz," dedi. "Bu, bu hastal\u0131klar\u0131n nas\u0131l geli\u015fti\u011fi ve onlar\u0131 nas\u0131l tedavi edebilece\u011fimiz konusunda tamamen yeni bir d\u00fc\u015f\u00fcnce tarz\u0131."\u201d<\/p>\n\n\n\n

Devam\u0131n\u0131 oku<\/strong>:\u00a0Duchenne \u0130\u00e7in Klinik Ara\u015ft\u0131rmalar (T\u00fcm Ara\u015ft\u0131rmalar\u0131n Listesi)<\/a><\/p>","protected":false},"excerpt":{"rendered":"

In two recent studies, a team of scientists under the guidance of Mendell Rimer, PhD, and Mariappan Muthuchamy, PhD, at the Texas A&M University Naresh K. Vashisht College of Medicine and Peter Nghiem, DVM, PhD, at the Texas A&M College of Veterinary Medicine and Biomedical Sciences, revealed that problems in the lymphatic network\u2014which helps regulate […]<\/p>\n","protected":false},"author":1,"featured_media":4862,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[118,444],"class_list":["post-4860","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-duchenne","tag-lymphatic-system"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/4860","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/comments?post=4860"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/4860\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media\/4862"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media?parent=4860"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/categories?post=4860"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/tags?post=4860"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}