{"id":4841,"date":"2025-10-22T00:19:08","date_gmt":"2025-10-21T21:19:08","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=4841"},"modified":"2025-11-03T20:09:44","modified_gmt":"2025-11-03T17:09:44","slug":"satellos-first-adult-patient-lt-001-long-term-sat-3247-duchenne-muscular-dystrophy","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/tr\/satellos-first-adult-patient-lt-001-long-term-sat-3247-duchenne-muscular-dystrophy\/","title":{"rendered":"Satellos, Duchenne Musk\u00fcler Distrofisi&#039;nde SAT-3247&#039;nin A\u00e7\u0131k Etiketli, Uzun D\u00f6nemli Takip \u00c7al\u0131\u015fmas\u0131 Olan LT-001 Dozunun \u0130lk Yeti\u015fkin Hastaya Uyguland\u0131\u011f\u0131n\u0131 Duyurdu"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong>Satellos Bioscience, Duchenne kas distrofisi (Duchenne veya DMD) olan yeti\u015fkin erkeklerde SAT-3247&#039;nin a\u00e7\u0131k etiketli, uzun s\u00fcreli takip \u00e7al\u0131\u015fmas\u0131nda (LT-001) ilk hastaya doz verildi\u011fini duyurdu.<\/strong> SAT-3247, Duchenne hastal\u0131\u011f\u0131yla ya\u015fayan ki\u015filerde kaybedilen kaslar\u0131 onarmak ve yenilemek \u00fczere tasarlanm\u0131\u015f yeni bir oral k\u00fc\u00e7\u00fck molek\u00fcl tedavi aday\u0131d\u0131r.<br>&lt; <a href=\"https:\/\/dmdwarrior.com\/tr\/satellos-sat-3247-stem-cell-approach-may-restore-muscle-regeneration-in-duchenne-muscular-dystrophy\/\" target=\"_blank\" rel=\"noreferrer noopener\">SAT-3247 nedir<\/a> &gt;&gt;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00c7al\u0131\u015fma, daha \u00f6nce Faz 1b 28 g\u00fcnl\u00fck \u00e7al\u0131\u015fman\u0131n D B\u00f6l\u00fcm\u00fcn\u00fc tamamlam\u0131\u015f Duchenne hastalar\u0131n\u0131n uzun vadeli g\u00fcvenli\u011fini, MRI ile kas kompozisyonundaki de\u011fi\u015fiklikleri ve fonksiyonel sonu\u00e7lar\u0131n\u0131 de\u011ferlendirecektir. Tasar\u0131m, tedavi s\u00fcresince her \u00fc\u00e7 ayda bir hasta de\u011ferlendirmesi ve raporlamas\u0131na olanak tan\u0131r. \u015eirket, protokol\u00fc Avustralya&#039;da 10&#039;a kadar yeni kat\u0131l\u0131mc\u0131y\u0131 kapsayacak \u015fekilde geni\u015fletmek i\u00e7in \u00e7al\u0131\u015f\u0131yor ve \u00e7al\u0131\u015fmay\u0131 ABD&#039;de ba\u015flatmay\u0131 planl\u0131yor; her ikisi de d\u00fczenleyici ve klinik onaylara tabidir.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-vimeo wp-block-embed-vimeo\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Satellos: SAT-3247 Etki Mekanizmas\u0131\" src=\"https:\/\/player.vimeo.com\/video\/1111725853?h=ad68c0e107&amp;dnt=1&amp;app_id=122963\" width=\"696\" height=\"392\" frameborder=\"0\" allow=\"autoplay; fullscreen; picture-in-picture; clipboard-write; encrypted-media; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\"><\/iframe>\n<\/div><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u201cSatellos Kurucu Orta\u011f\u0131 ve CEO&#039;su Frank Gleeson, &quot;LT-001&#039;deki ilk hastaya doz vermek, Duchenne hastal\u0131\u011f\u0131yla ya\u015fayan insanlar i\u00e7in SAT-3247&#039;nin uzun vadeli potansiyelini ortaya \u00e7\u0131karmak i\u00e7in \u00e7al\u0131\u015f\u0131rken \u00f6nemli bir d\u00f6n\u00fcm noktas\u0131n\u0131 temsil ediyor&quot; dedi.<\/strong> \u201c&quot;\u0130lk Faz 1b yeti\u015fkin \u00e7al\u0131\u015fmas\u0131nda g\u00f6zlemlenen faydalar\u0131n uzun vadeli takiplerimizde g\u00fc\u00e7lendi\u011fini ve korundu\u011funu g\u00f6r\u00fcrsek, Duchenne&#039;in etkilerini tersine \u00e7evirebilecek bir tedaviye bir ad\u0131m daha yakla\u015fm\u0131\u015f olaca\u011f\u0131z; b\u00f6ylece bu y\u0131k\u0131c\u0131 hastal\u0131kla ya\u015fayan hastalar ve aileleri i\u00e7in ger\u00e7ek ve kal\u0131c\u0131 bir fark yarataca\u011f\u0131z.&quot;\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Daha fazla bilgi edin<\/strong>: <a href=\"https:\/\/dmdwarrior.com\/tr\/satellos-sat-3247-phase-2-clinical-study-ready-to-launch\/\" target=\"_blank\" rel=\"noreferrer noopener\">Satellos, Duchenne Musk\u00fcler Distrofi Tedavisi \u0130\u00e7in SAT-3247&#039;nin 2. Faz Klinik \u00c7al\u0131\u015fmas\u0131n\u0131 Ba\u015flatmaya Haz\u0131rlan\u0131yor<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Deneme, klinik n\u00f6rolog ve n\u00f6rofizyolog Dr. Gayatri Jain ile i\u015f birli\u011fi i\u00e7inde Avustralya, Melbourne&#039;deki St Vincent Hastanesi&#039;nde devam ediyor. Dr. Jain, &quot;LT-001&#039;e ilk hastan\u0131n kaydoldu\u011funu g\u00f6rmek, Duchenne toplulu\u011fu i\u00e7in umut verici bir an,&quot; dedi. &quot;SAT-3247&#039;nin uzun vadeli g\u00fcvenli\u011fini de\u011ferlendirmeyi ve SAT-3247&#039;nin zaman i\u00e7inde fonksiyonel iyile\u015fmeleri nas\u0131l s\u00fcrd\u00fcrebilece\u011fini ve kas kompozisyonunu nas\u0131l olumlu etkileyebilece\u011fini, hastalar\u0131n g\u00fcnl\u00fck ya\u015famlar\u0131n\u0131 iyile\u015ftirme potansiyeli hakk\u0131nda de\u011ferli bilgiler sunmay\u0131 d\u00f6rt g\u00f6zle bekliyoruz.&quot;\u201c<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Devam\u0131n\u0131 oku<\/strong>:\u00a0<a href=\"https:\/\/dmdwarrior.com\/tr\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">Duchenne \u0130\u00e7in Klinik Ara\u015ft\u0131rmalar (T\u00fcm Ara\u015ft\u0131rmalar\u0131n Listesi)<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Satellos Bioscience, announced that the first patient has been dosed in the open-label, long-term follow-up study (LT-001) of SAT-3247 in adult males with Duchenne muscular dystrophy (Duchenne, or DMD). SAT-3247 is a novel oral small molecule therapeutic candidate designed to repair and regenerate muscle that is lost in people living with Duchenne.&lt;&lt; What is SAT-3247 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4843,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[137,242,440,251,252,253],"class_list":["post-4841","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-clinical-trial","tag-clinical-trials","tag-lt-001","tag-sat-3247","tag-satellos","tag-satellos-bioscience"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/4841","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/comments?post=4841"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/4841\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media\/4843"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media?parent=4841"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/categories?post=4841"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/tags?post=4841"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}