Cedars-Sinai'deki Smidt Kalp Enstit\u00fcs\u00fc'nden gelen yeni bir ara\u015ft\u0131rmaya g\u00f6re, h\u00fccre tedavisi, Duchenne kas distrofisine benzer bir hastal\u0131\u011fa sahip laboratuvar farelerinde kas yap\u0131s\u0131n\u0131 ve i\u015flevini koruyor.<\/p>\n\n\n\n
Duchenne kas distrofisi, \u00e7o\u011funlukla erkek \u00e7ocuklar\u0131n\u0131 etkileyen ve kaslar\u0131n\u0131n o kadar zay\u0131flamas\u0131na neden olan nadir g\u00f6r\u00fclen kal\u0131tsal bir hastal\u0131kt\u0131r ki sonunda y\u00fcr\u00fcme yetene\u011fini kaybederler. Kalp ve akci\u011fer kaslar\u0131 da zamanla zay\u0131flayarak erken \u00f6l\u00fcme yol a\u00e7ar.<\/p>\n\n\n\n
Stem Cell Reports'ta a\u00e7\u0131klanan tedavi, dokuyu onarma potansiyeline sahip kalp h\u00fccreleri olan kardiyosfer k\u00f6kenli h\u00fccreleri (CDC'ler) kullan\u0131yor. Smidt Kalp Enstit\u00fcs\u00fc'n\u00fcn y\u00f6netici direkt\u00f6r\u00fc ve \u00e7al\u0131\u015fman\u0131n ortak yazarlar\u0131ndan Dr. Eduardo Marb\u00e1n, CDC'lerin laboratuvarda nas\u0131l izole edilip b\u00fcy\u00fct\u00fclece\u011fini ve bir hastaya nas\u0131l geri a\u015f\u0131lanaca\u011f\u0131n\u0131 ke\u015ffetti. K\u00f6k H\u00fccre Raporlar\u0131<\/a> \u2013<\/p>\n\n\n\n Klinik bir \u00e7al\u0131\u015fma, CDC'lerin Duchenne kas distrofisi olan yeti\u015fkinlerde zay\u0131flam\u0131\u015f kaslar\u0131n daha da zay\u0131flamas\u0131n\u0131 \u00f6nleyebilece\u011fini g\u00f6stermi\u015ftir. Klinik \u00e7al\u0131\u015fmalar ayr\u0131ca CDC'lerin Duchenne ile ili\u015fkili kalp hasar\u0131n\u0131 onarabilece\u011fini de g\u00f6stermi\u015ftir. CDC'lere dayanan deramiocel adl\u0131 bir h\u00fccre tedavisi, Duchenne hastalar\u0131nda kalp yetmezli\u011fi ve iskelet miyopatisinde iyile\u015fmeleri do\u011frulamak i\u00e7in tekrarlanan dozlarla ileri klinik test a\u015famas\u0131ndad\u0131r. Deramiocel nedir? CAP-1002 ne i\u015fe yarar?<\/a> \u2013<\/p>\n\n\n\n Smidt Kalp Enstit\u00fcs\u00fc'nde yard\u0131mc\u0131 do\u00e7ent ve \u00e7al\u0131\u015fman\u0131n ilgili yazar\u0131 olan Dr. Russell G. Rogers, "Yeni ara\u015ft\u0131rmam\u0131z, bu rahats\u0131zl\u0131\u011fa sahip gen\u00e7 fareleri CDC'lere maruz b\u0131rakt\u0131\u011f\u0131m\u0131zda, kas zay\u0131fl\u0131\u011f\u0131n\u0131n geli\u015fmesini ba\u015ftan \u00f6nleyebilece\u011fimizi g\u00f6steriyor" dedi.<\/p>\n\n\n\n Ara\u015ft\u0131rmac\u0131lar, Duchenne kas distrofisi olan laboratuvar farelerine bir y\u0131l boyunca ayl\u0131k olarak h\u00fccre tedavisi uygulad\u0131lar. Bir y\u0131l\u0131n sonunda, h\u00fccre tedavisi g\u00f6ren fareler egzersiz dayan\u0131kl\u0131l\u0131\u011f\u0131n\u0131 ve kas g\u00fcc\u00fcn\u00fc korudu; bu, farelerin gen\u00e7kenkine benzerdi. Ancak h\u00fccre tedavisi g\u00f6rmeyen fareler, Duchenne kas distrofisinin do\u011fal seyri s\u0131ras\u0131nda oldu\u011fu gibi, egzersiz yapma yeteneklerini kaybettiler ve kaslar\u0131 zay\u0131flad\u0131.<\/p>","protected":false},"excerpt":{"rendered":" A cell therapy preserves muscle structure and function in laboratory mice with a type of disease similar to Duchenne muscular dystrophy, according to new research from the Smidt Heart Institute at Cedars-Sinai. Duchenne muscular dystrophy is a rare, inherited disorder that mostly affects boys and causes their muscles to weaken so much they eventually lose […]<\/p>\n","protected":false},"author":1,"featured_media":4282,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[303],"class_list":["post-4279","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-cell-therapy"],"subtitle":"Tedavisi olmayan dejeneratif bir kas hastal\u0131\u011f\u0131 olan DMD i\u00e7in onaylanan en erken h\u00fccre tedavisi olabilecek tedavi, ba\u015flang\u0131\u00e7ta iskelet kas\u0131na de\u011fil, kalbe odaklanan ara\u015ft\u0131rmalardan ortaya \u00e7\u0131kt\u0131.","_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/4279","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/comments?post=4279"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/4279\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media\/4282"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media?parent=4279"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/categories?post=4279"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/tags?post=4279"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}