{"id":3206,"date":"2025-03-13T17:18:48","date_gmt":"2025-03-13T14:18:48","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=3206"},"modified":"2025-03-13T17:18:49","modified_gmt":"2025-03-13T14:18:49","slug":"metagenomi-new-crispr-system-vk-cast-enables-large-gene-integration","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/tr\/metagenomi-new-crispr-system-vk-cast-enables-large-gene-integration\/","title":{"rendered":"Metagenomi&#039;nin Yeni CRISPR Sistemi (VK CAST) B\u00fcy\u00fck Gen Entegrasyonunu Sa\u011fl\u0131yor"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Hastalar i\u00e7in \u00f6zel gen d\u00fczenleme ara\u00e7lar\u0131n\u0131 kullanarak iyile\u015ftirici tedaviler geli\u015ftirmeye kendini adam\u0131\u015f hassas genetik ila\u00e7lar \u015firketi Metagenomi, bug\u00fcn Nature Communications dergisinde insan genomuna b\u00fcy\u00fck, hedefli gen entegrasyonu i\u00e7in yeni, kompakt CAST sistemini anlatan bir yay\u0131n duyurdu.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Metagenomi&#039;nin CAST sistemleri, gen d\u00fczenleme alan\u0131nda kritik bir g\u00f6revi yerine getirmeleri nedeniyle, iyile\u015ftirici genetik ila\u00e7lar\u0131n geli\u015ftirilmesi i\u00e7in potansiyel bir \u00e7\u00f6z\u00fcmd\u00fcr: b\u00fcy\u00fck gen kargolar\u0131n\u0131n hassas, programlanabilir entegrasyonu. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Bu teknoloji, Wilson hastal\u0131\u011f\u0131, kistik fibroz ve Duchenne Musk\u00fcler Distrofi gibi herhangi bir fonksiyon kayb\u0131 mutasyonu nedeniyle olu\u015fan karma\u015f\u0131k genetik hastal\u0131klar\u0131n b\u00fcy\u00fck bir koleksiyonunu ele alma potansiyeline sahiptir. Yeni yay\u0131nlanan veriler, bu sistemlerin potansiyelini belirleyen \u00f6nceki bulgulara dayanarak, terap\u00f6tik genleri insan genomuna hassas bir \u015fekilde entegre etmeye y\u00f6nelik birinci s\u0131n\u0131f bir yakla\u015f\u0131m\u0131 g\u00f6stermektedir.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Metagenomi&#039;nin yenilik\u00e7i, kompakt Cas12k CAST sistemi, \u015firketin yapay zeka destekli metagenomik platformu kullan\u0131larak ke\u015ffedildi ve insan h\u00fccrelerinde programlanabilir ve hedeflenen genomik entegrasyon elde etmek i\u00e7in \u00e7evrildi. Metagenomi bilim insanlar\u0131, sistemin b\u00f6lgeye \u00f6zg\u00fc, programlanabilir ve \u00e7ok y\u00f6nl\u00fc niteliklerini g\u00f6stererek, insan genomunda bilinen bir g\u00fcvenli liman b\u00f6lgesine birden fazla kargo entegrasyonunu g\u00f6sterdi.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00c7al\u0131\u015fma, insan genomunda g\u00fcvenli bir liman b\u00f6lgesine yeniden hedefleme yetene\u011fi, terap\u00f6tik a\u00e7\u0131dan ilgili bir genin tam entegrasyonu ve &#039;hepsi bir arada&#039; mRNA kullan\u0131larak da\u011f\u0131t\u0131m\u0131n kolayla\u015ft\u0131r\u0131lmas\u0131 dahil olmak \u00fczere, CAST&#039;\u0131n terap\u00f6tik uygulamalar i\u00e7in \u00e7evirisine y\u00f6nelik \u00f6nemli ilerlemeleri vurgulamaktad\u0131r. Bu bulgular, in vivo gen d\u00fczenleme terap\u00f6tiklerinin geli\u015ftirilmesi i\u00e7in b\u00fcy\u00fck, hedefli genomik entegrasyon yakla\u015f\u0131mlar\u0131na ili\u015fkin yeni i\u00e7g\u00f6r\u00fcler sunmaktad\u0131r. Gelecekteki \u00e7al\u0131\u015fmalar, bu yeteneklerin geni\u015fletilmesine ve sistemin klinik uygulamalar i\u00e7in optimize edilmesine odaklanacak ve 2025&#039;te ek ilerlemeler bekleniyor.<\/p>","protected":false},"excerpt":{"rendered":"<p>Metagenomi, a precision genetic medicines company committed to developing curative therapeutics for patients using its proprietary gene editing toolbox, today announced a publication in the journal Nature Communications describing its novel, compact CAST system for large, targeted gene integration into the human genome. Metagenomi\u2019s CAST systems are a potential solution for development of curative genetic [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3207,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[290,291,289],"class_list":["post-3206","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-crispr","tag-metagenomi","tag-v-k-cast"],"subtitle":"Metagenomi, b\u00fcy\u00fck gen entegrasyonu i\u00e7in yeni, kompakt CRISPR ili\u015fkili transpozaz (CAST) sistemini sergileyen \u00e7\u0131\u011f\u0131r a\u00e7\u0131c\u0131 ara\u015ft\u0131rmas\u0131n\u0131 Nature Communications'da yay\u0131nlad\u0131. \u015eirketin yapay zeka destekli metagenomik platformu, terap\u00f6tik genleri insan genomuna hassas bir \u015fekilde entegre edebilen kompakt bir Cas12k CAST sistemi ke\u015ffetti.","_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/3206","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/comments?post=3206"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/3206\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media\/3207"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media?parent=3206"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/categories?post=3206"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/tags?post=3206"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}