{"id":3015,"date":"2025-02-25T19:19:23","date_gmt":"2025-02-25T16:19:23","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=3015"},"modified":"2025-02-25T19:19:25","modified_gmt":"2025-02-25T16:19:25","slug":"nanoparticles-used-as-vehicle-to-deliver-micrornas-to-cells-and-treat-duchenne-muscular-dystrophy","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/tr\/nanoparticles-used-as-vehicle-to-deliver-micrornas-to-cells-and-treat-duchenne-muscular-dystrophy\/","title":{"rendered":"Nanopartik\u00fcller, MikroRNA&#039;lar\u0131 H\u00fccrelere Ta\u015f\u0131mak ve Duchenne Kas Distrofisini Tedavi Etmek \u0130\u00e7in Ara\u00e7 Olarak Kullan\u0131l\u0131yor"},"content":{"rendered":"<p class=\"wp-block-paragraph\">IMDEA Nanociencia Enstit\u00fcs\u00fc (Madrid), Universit\u00e0 Cattolica del Sacro Cuore (Roma) ve Bordeaux \u00dcniversitesi aras\u0131ndaki i\u015f birli\u011fiyle ara\u015ft\u0131rmac\u0131lar, bug\u00fcne kadar tedavisi olmayan bir hastal\u0131k olan Duchenne kas distrofisine kar\u015f\u0131 mikroRNA&#039;lar\u0131n terap\u00f6tik da\u011f\u0131t\u0131m\u0131nda \u00f6nemli bir at\u0131l\u0131m ger\u00e7ekle\u015ftirdiler.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ara\u015ft\u0131rmac\u0131lar, terap\u00f6tik mikroRNA&#039;lar\u0131 kas k\u00f6k h\u00fccrelerine ta\u015f\u0131mak i\u00e7in ara\u00e7 olarak nanopartik\u00fcller kullanan kas distrofisini tedavi etmek i\u00e7in bir strateji geli\u015ftirdiler. Nanopartik\u00fcller, kas k\u00f6k h\u00fccrelerinin i\u00e7ine girdikten sonra kas liflerinin \u00fcretimini uyarmak i\u00e7in mikroRNA&#039;y\u0131 serbest b\u0131rak\u0131r.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>IMDEA Nanociencia ara\u015ft\u0131rmac\u0131lar\u0131, mikroRNA&#039;lar\u0131 h\u00fccrelere ula\u015ft\u0131rmak ve Duchenne Musk\u00fcler Distrofisini tedavi etmek i\u00e7in nanopartik\u00fclleri ara\u00e7 olarak kullan\u0131yorlar.<\/strong><\/li>\n\n\n\n<li>Tedavinin, di\u011fer organlarda birikmesini \u00f6nleyerek, sadece kas k\u00f6k h\u00fccrelerine \u00f6zel olarak verilmesi m\u00fcmk\u00fcnd\u00fcr.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Ara\u015ft\u0131rmac\u0131lar \u00e7al\u0131\u015fmalar\u0131nda, se\u00e7ici olarak belirli di\u011fer molek\u00fclleri (bu durumda kas k\u00f6k h\u00fccrelerinde bulunan proteinler) tan\u0131yan bir molek\u00fcl olan aptamer geli\u015ftirdiler. <strong>Aptameri bir nanopartik\u00fclle birle\u015ftirerek, mikroRNA&#039;y\u0131 kas k\u00f6k h\u00fccrelerine b\u00fcy\u00fck bir hassasiyetle salmay\u0131 ve kas rejenerasyonunu yeniden aktive etmeyi ba\u015fard\u0131lar.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00c7al\u0131\u015fman\u0131n ba\u015f yazar\u0131 \u00c1lvaro Somoza sonu\u00e7lar hakk\u0131nda olduk\u00e7a heyecanl\u0131: \u201c\u0130ki \u00e7ok dikkat \u00e7ekici nokta var, birincisi, tedavinin etkinli\u011fini art\u0131ran istenen organa etkili bir mikroRNA iletimi. \u00d6te yandan, bu yakla\u015f\u0131m beyin, b\u00f6brekler veya karaci\u011fer gibi di\u011fer organlarda birikimi \u00f6nl\u00fcyor, bu da yan etkileri \u00f6nlemek i\u00e7in \u00e7ok \u00f6nemli.\u201d.<\/p>","protected":false},"excerpt":{"rendered":"<p>In a collaboration between the IMDEA Nanociencia Institute (Madrid), Universit\u00e0 Cattolica del Sacro Cuore (Rome), and the University of Bordeaux, researchers have made an important breakthrough in the therapeutic delivery of microRNAs against Duchenne muscular dystrophy, a disease with no cure, to date. Researchers have developed a strategy to treat muscular dystrophy, which uses nanoparticles [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3017,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[267,268,266],"class_list":["post-3015","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-imdea-nanociencia","tag-microrna","tag-nanoparticles"],"subtitle":"Ara\u015ft\u0131rmac\u0131lar, sistemin h\u00fccresel ve hayvan modellerindeki aktivitesini raporlam\u0131\u015f ve sadece h\u00fccresel d\u00fczeyde kas yenilenmesini de\u011fil, fonksiyonel d\u00fczeyde de iyile\u015fmeyi g\u00f6zlemlemi\u015flerdir. Tedavi edilen farelerin kaslar\u0131 iyile\u015fmi\u015f, tedavi sonras\u0131nda daha g\u00fc\u00e7l\u00fc hale gelmi\u015f ve b\u00f6ylece farelerin fonksiyonel kapasitesi artm\u0131\u015ft\u0131r.","_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/3015","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/comments?post=3015"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/3015\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media\/3017"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media?parent=3015"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/categories?post=3015"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/tags?post=3015"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}