{"id":2159,"date":"2024-12-30T16:44:16","date_gmt":"2024-12-30T13:44:16","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=2159"},"modified":"2024-12-30T16:46:51","modified_gmt":"2024-12-30T13:46:51","slug":"zebrafish-modeling-shows-promise-in-duchenne-dmd-research","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/tr\/zebrafish-modeling-shows-promise-in-duchenne-dmd-research\/","title":{"rendered":"Zebra Bal\u0131\u011f\u0131 Modellemesi Duchenne (DMD) Ara\u015ft\u0131rmas\u0131nda Umut Vaat Ediyor"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Zebra bal\u0131\u011f\u0131 (Danio rerio), kas-iskelet sistemi geli\u015fimini ve ili\u015fkili hastal\u0131klar\u0131n patofizyolojisini ara\u015ft\u0131rmak i\u00e7in de\u011ferli bir model organizma olarak ortaya \u00e7\u0131km\u0131\u015ft\u0131r. Zebra bal\u0131\u011f\u0131ndaki temel genler ve biyolojik s\u00fcre\u00e7ler insanlardakilere \u00e7ok benzerdir ve h\u0131zl\u0131 geli\u015fim ve \u015feffaf embriyolar, zebra bal\u0131\u011f\u0131n\u0131 kemik ve kas olu\u015fumunun yan\u0131 s\u0131ra kas-iskelet sistemi bozukluklar\u0131n\u0131n alt\u0131nda yatan molek\u00fcler mekanizmalar\u0131n in vivo \u00e7al\u0131\u015fmalar\u0131 i\u00e7in ideal hale getirir.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ara\u015ft\u0131rmalar, zebra bal\u0131\u011f\u0131n\u0131n \u00e7e\u015fitli kas-iskelet sistemi bozukluklar\u0131n\u0131n modellenmesinde kullan\u0131\u015fl\u0131l\u0131\u011f\u0131na odaklan\u0131yor; \u00f6zellikle osteoporoz ve osteogenesis imperfecta gibi kemik hastal\u0131klar\u0131 ve Duchenne kas distrofisi gibi kas bozukluklar\u0131 \u00fczerinde duruluyor.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.mdpi.com\/2073-4409\/14\/1\/28\" target=\"_blank\" rel=\"noreferrer noopener\">Devam\u0131n\u0131 oku<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Zebrafish (Danio rerio) has emerged as a valuable model organism for investigating musculoskeletal development and the pathophysiology of associated diseases. Key genes and biological processes in zebrafish are very similar to those in humans, and the rapid development and transparent embryos make zebrafish ideal for in vivo studies of bone and muscle formation as well [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2160,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[70,72,71],"class_list":["post-2159","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-crispr-cas9","tag-gene-editing","tag-zebrafish"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/2159","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/comments?post=2159"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/2159\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media\/2160"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media?parent=2159"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/categories?post=2159"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/tags?post=2159"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}