{"id":1957,"date":"2024-12-24T21:03:48","date_gmt":"2024-12-24T18:03:48","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=1957"},"modified":"2024-12-24T21:03:50","modified_gmt":"2024-12-24T18:03:50","slug":"splicer-gene-editing-tool-holds-a-lot-of-potential-to-treat-duchenne-muscular-dystrophy","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/tr\/splicer-gene-editing-tool-holds-a-lot-of-potential-to-treat-duchenne-muscular-dystrophy\/","title":{"rendered":"SPLICER Gen D\u00fczenleme Arac\u0131 Duchenne Kas Distrofisini Tedavi Etmek \u0130\u00e7in B\u00fcy\u00fck Bir Potansiyele Sahip"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Illinois Urbana-Champaign \u00dcniversitesi ara\u015ft\u0131rmac\u0131lar\u0131n\u0131n raporuna g\u00f6re, h\u00fccresel mekanizman\u0131n hastal\u0131klardan sorumlu genlerin baz\u0131 k\u0131s\u0131mlar\u0131n\u0131 atlamas\u0131na yard\u0131mc\u0131 olan yeni bir gen d\u00fczenleme arac\u0131, Alzheimer hastal\u0131\u011f\u0131n\u0131n fare modelinde amiloid-beta plak \u00f6nc\u00fcllerinin olu\u015fumunu azaltmak i\u00e7in uyguland\u0131.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">SPLICER, Duchenne kas distrofisi veya Huntington hastal\u0131\u011f\u0131 gibi yanl\u0131\u015f katlanm\u0131\u015f veya toksik proteinler \u00fcreten mutasyonlar\u0131n neden oldu\u011fu sa\u011fl\u0131k ko\u015fullar\u0131 i\u00e7in \u00f6zel ilgi \u00e7ekici olan ekzon atlama ad\u0131 verilen bir gen d\u00fczenleme yakla\u015f\u0131m\u0131n\u0131 kullan\u0131r.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Biyom\u00fchendislik profes\u00f6r\u00fc Perez-Pinera, &quot;Ancak Alzheimer, Parkinson, Huntington veya Duchenne kas distrofisi gibi hastal\u0131klar i\u00e7in bu yakla\u015f\u0131m \u00e7ok fazla potansiyel bar\u0131nd\u0131r\u0131yor. Bir sonraki ad\u0131m, bu hastal\u0131klarda hedeflenen ekzonlar\u0131 \u00e7\u0131karman\u0131n g\u00fcvenli\u011fine bakmak ve toksik veya \u00f6nemli bir i\u015flevi eksik olan yeni bir protein yaratmad\u0131\u011f\u0131m\u0131zdan emin olmakt\u0131r. Ayr\u0131ca daha uzun vadeli hayvan \u00e7al\u0131\u015fmalar\u0131 yapmam\u0131z ve hastal\u0131\u011f\u0131n zamanla ilerleyip ilerlemedi\u011fini g\u00f6rmemiz gerekir.&quot; dedi.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.nature.com\/articles\/s41467-024-54529-y\" target=\"_blank\" rel=\"noreferrer noopener\">Devam\u0131n\u0131 oku<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>A new gene editing tool that helps cellular machinery skip parts of genes responsible for diseases has been applied to reduce the formation of amyloid-beta plaque precursors in a mouse model of Alzheimer&#8217;s disease, researchers at the University of Illinois Urbana-Champaign report. SPLICER uses a gene editing approach called exon skipping, which is of particular [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1959,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[59,60],"class_list":["post-1957","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-splicer","tag-splicer-gene-editing"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/1957","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/comments?post=1957"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/1957\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media\/1959"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media?parent=1957"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/categories?post=1957"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/tags?post=1957"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}