{"id":1855,"date":"2024-12-12T14:23:56","date_gmt":"2024-12-12T11:23:56","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=1855"},"modified":"2024-12-12T14:26:49","modified_gmt":"2024-12-12T11:26:49","slug":"18-digit-code-wnt7a-that-allows-proteins-to-hitch-a-ride-around-the-body","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/tr\/18-digit-code-wnt7a-that-allows-proteins-to-hitch-a-ride-around-the-body\/","title":{"rendered":"Ara\u015ft\u0131rmac\u0131lar, Proteinlerin V\u00fccutta Dola\u015fmas\u0131n\u0131 Sa\u011flayan 18 Haneli Kodu (Wnt7a) Ke\u015ffettiler"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong>Ottawa \u00dcniversitesi ve Ottawa Hastanesi&#039;nden ara\u015ft\u0131rmac\u0131lar, proteinlerin v\u00fccutta hareket eden ve biyokimyasal bilgileri ileten k\u00fc\u00e7\u00fck, kopar\u0131lm\u0131\u015f h\u00fccre par\u00e7alar\u0131 olan ekzosomlara ba\u011flanmak i\u00e7in kullanabilecekleri 18 haneli bir kod (Wnt7a) buldular.<\/strong> Science Advances&#039;ta yay\u0131mlanan bulgunun, ekzosomlar\u0131 \u00e7e\u015fitli hastal\u0131klara y\u00f6nelik ila\u00e7lar\u0131 ta\u015f\u0131mak i\u00e7in kullanmay\u0131 ama\u00e7layan yeni ortaya \u00e7\u0131kan ekzosom tedavisi alan\u0131 i\u00e7in \u00f6nemli sonu\u00e7lar\u0131 bulunuyor.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00c7al\u0131\u015fman\u0131n k\u0131demli yazar\u0131, Ottawa Hastanesi Rejeneratif T\u0131p Program\u0131 direkt\u00f6r\u00fc ve Ottawa \u00dcniversitesi profes\u00f6r\u00fc Dr. Michael Rudnicki&#039;ye g\u00f6re, &quot;Proteinler v\u00fccudun kendi \u00fcretti\u011fi ila\u00e7lard\u0131r, ancak v\u00fccutta iyi bir \u015fekilde dola\u015fmazlar.&quot;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&quot;Bu bulgu sayesinde art\u0131k v\u00fccuttaki herhangi bir proteini ta\u015f\u0131mak i\u00e7in eksozomlar\u0131 kullanabiliriz. <strong>\u0130la\u00e7 geli\u015ftirme alan\u0131nda tamamen yeni bir alana eri\u015fim sa\u011fl\u0131yor.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dr. Rudnicki ve meslekta\u015flar\u0131, geli\u015fim, b\u00fcy\u00fcme, rejenerasyon ve kanser i\u00e7in gerekli olan Wnt7a adl\u0131 bir proteinin ekzosom hedefleme posta kodu veya zip kodu i\u00e7erdi\u011fini buldular. \u0130lk olarak Wnt7a&#039;n\u0131n ekzosomlara ba\u011flanma yetene\u011fini g\u00f6sterdiler. Daha sonra, ekzosom hedeflemesinden sorumlu en k\u0131sa b\u00f6lgeyi belirleyene kadar Wnt7a proteininin birka\u00e7 b\u00f6lgesini ortadan kald\u0131rd\u0131lar.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Bu 18 amino asitli bile\u015fene Ekzom Ba\u011flay\u0131c\u0131 Peptit (EBP) ad\u0131 verildi. Daha sonra EBP&#039;nin herhangi bir proteini ekzosomlara hedeflemek i\u00e7in kullan\u0131labilece\u011fini ve ekzosomlardaki koatomerler olarak bilinen proteinlerle etkile\u015fime girdi\u011fini buldular.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dr. Michael Rudnicki&#039;nin grubunda eski doktora sonras\u0131 ara\u015ft\u0131rmac\u0131 olan ve \u015fu anda \u0130spanya&#039;daki Biyolojik Bilimlerde Kooperatif Ara\u015ft\u0131rma Merkezi&#039;nde (CIC bioGUNE) \u00e7al\u0131\u015fan ilk yazar Dr. Uxia Gurriaran-Rodriguez, &quot;Ara\u015ft\u0131rmac\u0131lar y\u0131llard\u0131r Wnt7a&#039;y\u0131 bir kas rejenerasyon ilac\u0131na d\u00f6n\u00fc\u015ft\u00fcrmeye \u00e7al\u0131\u015f\u0131yorlar, ancak Wnt7a&#039;y\u0131 v\u00fccut s\u0131v\u0131s\u0131yla iyi kar\u0131\u015fmayan ya\u011fl\u0131 molek\u00fcllerle kapl\u0131 oldu\u011fu i\u00e7in v\u00fccudun her yerine ula\u015ft\u0131rmak \u00e7ok zor.&quot; dedi.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u201cArt\u0131k Wnt7a&#039;n\u0131n ekzosomlara nas\u0131l ba\u011fland\u0131\u011f\u0131n\u0131 bildi\u011fimize g\u00f6re bu sorunu \u00e7\u00f6zd\u00fck ve art\u0131k Duchenne kas distrofisi gibi y\u0131k\u0131c\u0131 hastal\u0131klara y\u00f6nelik ila\u00e7lar\u0131n geli\u015ftirilmesini h\u0131zland\u0131rabiliriz.\u201d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Kaynak:<\/strong> https:\/\/www.ohri.ca\/newsroom\/story\/view\/1742?l=en<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Ara\u015ft\u0131rma:<\/strong> https:\/\/www.science.org\/doi\/10.1126\/sciadv.ado5914<\/p>","protected":false},"excerpt":{"rendered":"<p>Researchers from the University of Ottawa and The Ottawa Hospital have found an 18-digit code (Wnt7a) that proteins can use to bind to exosomes, which are tiny, pinched-off fragments of cells that move throughout the body and transmit biochemical information. The finding, which was reported in Science Advances, has significant ramifications for the emerging field [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1857,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[37,36,40,38,39,35],"class_list":["post-1855","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-exosome-therapy","tag-exosomes","tag-michael-rudnicki","tag-ottawa","tag-university-of-ottawa","tag-wnt7a"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/1855","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/comments?post=1855"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/1855\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media\/1857"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media?parent=1855"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/categories?post=1855"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/tags?post=1855"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}