{"id":1458,"date":"2024-10-04T10:49:58","date_gmt":"2024-10-04T10:49:58","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=1458"},"modified":"2024-10-04T10:49:59","modified_gmt":"2024-10-04T10:49:59","slug":"satellos-produced-near-normal-levels-of-dystrophin-in-experiment-with-dogs-with-dmd-with-sat-3247","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/tr\/satellos-produced-near-normal-levels-of-dystrophin-in-experiment-with-dogs-with-dmd-with-sat-3247\/","title":{"rendered":"Satellos, SAT-3247 ile DMD&#039;li K\u00f6pekler \u00dczerinde Yap\u0131lan Deneyde Neredeyse Normal Distrofin Seviyeleri \u00dcretti"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Satellos Bioscience Inc. taraf\u0131ndan yap\u0131lan a\u00e7\u0131klamaya g\u00f6re, DMD&#039;li k\u00f6pekler \u00fczerinde yap\u0131lan bir deneyde, SAT-3247 ad\u0131 verilen terapiyle deneklerde distrofinin neredeyse normal seviyelerde \u00fcretildi\u011fi g\u00f6r\u00fcld\u00fc. Bu geli\u015fme, Duchenne hastal\u0131\u011f\u0131yla stresli g\u00fcnler ge\u00e7iren ailelere umut oldu.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Analiz, diyafram, kuadriseps ve bald\u0131r kaslar\u0131 da dahil olmak \u00fczere kas gruplar\u0131nda kas morfolojisinde iyile\u015fme ve rejenerasyon seviyelerinde art\u0131\u015f g\u00f6sterdi<\/li>\n\n\n\n<li>Satellos&#039;un tescilli k\u00fc\u00e7\u00fck molek\u00fcl\u00fc SAT-3247 ile g\u00fcnl\u00fck, oral tedavinin d\u00f6rt ay boyunca uygulanmas\u0131n\u0131n ard\u0131ndan herhangi bir olumsuz olay veya hematoloji veya klinik kimyada \u00f6nemli bir de\u011fi\u015fiklik g\u00f6zlemlenmedi.<\/li>\n\n\n\n<li>2024 D\u00fcnya Kas Toplulu\u011fu Y\u0131ll\u0131k Kongresi&#039;nde sunulacak veriler<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Satellos Bioscience Inc. (\u201cSatellos\u201d veya \u201c\u015eirket\u201d) (TSX: MSCL, OTCQB: MSCLF), kas hastal\u0131klar\u0131 ve bozukluklar\u0131n\u0131n tedavisini iyile\u015ftirmek i\u00e7in yeni k\u00fc\u00e7\u00fck molek\u00fcl terap\u00f6tik yakla\u015f\u0131mlar\u0131 geli\u015ftiren halka a\u00e7\u0131k bir biyoteknoloji \u015firketi, bug\u00fcn 8-12 Ekim 2024 tarihleri aras\u0131nda Prag&#039;da ger\u00e7ekle\u015fecek olan D\u00fcnya Kas Derne\u011fi&#039;nin 29. Y\u0131ll\u0131k Kongresi&#039;nde bir veri sunumu yapaca\u011f\u0131n\u0131 duyurdu. Sunum, Duchenne kas distrofisi (\u201cDuchenne\u201d veya \u201cDMD\u201d) k\u00f6pek modelinde SAT-3247&#039;nin a\u00e7\u0131k etiketli pilot \u00e7al\u0131\u015fmas\u0131 s\u0131ras\u0131nda toplanan temel verilere genel bir bak\u0131\u015f sunacakt\u0131r.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Verilerin ilk \u00f6zeti a\u015fa\u011f\u0131da sunulmu\u015ftur. SAT-3247 ile d\u00f6rt ayl\u0131k tedaviden sonra:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Tedavi edilen hayvanlarda, ge\u00e7mi\u015f kar\u015f\u0131la\u015ft\u0131rma verileriyle kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda kas fonksiyonunun sa\u011fl\u0131kl\u0131, hastal\u0131ks\u0131z, ya\u015fa e\u015fle\u015ftirilmi\u015f hayvan seviyelerine yak\u0131n bir seviyede geri d\u00f6nd\u00fc\u011f\u00fc g\u00f6r\u00fcld\u00fc.<\/li>\n\n\n\n<li>Hayvanlarda diyafram, gastroknemius medialis (bald\u0131r) ve vastus lateralis&#039;te (kuadriseps) Rejeneratif \u0130ndeks&#039;te (RI) art\u0131\u015flar g\u00f6r\u00fcld\u00fc. Bu, daha \u00f6nce bildirilen biseps femoris&#039;te g\u00f6sterilen RI&#039;daki geli\u015fmelere ektir.<\/li>\n\n\n\n<li>Herhangi bir olumsuz olay veya hematoloji veya klinik kimyada \u00f6nemli bir de\u011fi\u015fiklik g\u00f6zlenmedi.<\/li>\n\n\n\n<li>Duchenne hastal\u0131\u011f\u0131n\u0131 modifiye eden bir tedaviyle tutarl\u0131 olabilecek bir bulgu olan kreatin kinaz d\u00fczeylerinde d\u00fc\u015f\u00fc\u015f e\u011filimleri kaydedildi.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cDMD&#039;nin k\u00f6pek modelinde yay\u0131nlanan do\u011fal tarih verileri ve di\u011fer terap\u00f6tik m\u00fcdahalelerle kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, tedaviden d\u00f6rt ay sonra rejenerasyon ve kas g\u00fcc\u00fcnde sa\u011fl\u0131kl\u0131 seviyelere yak\u0131n g\u00f6zlemlenen iyile\u015fmelerin \u00e7\u0131\u011f\u0131r a\u00e7\u0131c\u0131 oldu\u011funa inan\u0131yoruz,\u201d diyor Satellos Bioscience&#039;\u0131n Kurucu Orta\u011f\u0131 ve CEO&#039;su Frank Gleeson. \u201cK\u00f6pek modeli, fare modellerinden daha \u015fiddetli kabul ediliyor ve potansiyel olarak bir tedavinin insanlara aktar\u0131labilirli\u011finin daha b\u00fcy\u00fck bir testini temsil ediyor. Oral k\u00fc\u00e7\u00fck molek\u00fcl\u00fcm\u00fcz SAT-3247 ile tedavinin b\u00f6ylesine \u00e7arp\u0131c\u0131 iyile\u015fmeler g\u00f6stermesinden dolay\u0131 \u00e7ok mutluyuz. Bu son derece \u00fcmit verici sonu\u00e7lar, SAT-3247&#039;nin Duchenne ile ya\u015fayan hastalara yard\u0131mc\u0131 olmak i\u00e7in anlaml\u0131 bir hastal\u0131k de\u011fi\u015ftirici ila\u00e7 sunma potansiyeline olan inanc\u0131m\u0131z\u0131 g\u00fc\u00e7lendiriyor.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Kas distrofisinin k\u00f6pek modeli daha \u015fiddetli bir klinik fenotipi temsil eder ve DMD&#039;li ki\u015filerde g\u00f6zlemlenen hastal\u0131k ilerlemesini yans\u0131t\u0131r. Bu pilot \u00e7al\u0131\u015fmada, her hayvan (n=2) d\u00f6rt ay boyunca g\u00fcnl\u00fck oral dozda SAT-3247 ile tedavi edildi. Bu \u00e7ok parametreli pilot \u00e7al\u0131\u015fma klinik kimyay\u0131, hematolojiyi, kas fonksiyonunu \u00f6l\u00e7t\u00fc ve geni\u015f \u00f6l\u00e7ekli bir kas histolojisi \u00e7al\u0131\u015fmas\u0131 i\u00e7eriyordu. Kas histolojisinden, hasarl\u0131 ve \u00f6lmekte olan kas liflerinin say\u0131s\u0131na g\u00f6re yeni rejenerasyonlu kas liflerinin say\u0131s\u0131n\u0131n bir \u00f6l\u00e7\u00fcs\u00fc olan Rejeneratif \u0130ndeks (RI) hesaplamas\u0131 yap\u0131ld\u0131.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Bu \u00e7al\u0131\u015fmadan elde edilen veriler, \u201cSAT-3247: \u0130skelet Kas\u0131 Rejenerasyonunun Kritik Etkili AAK1&#039;i Hedefleyen Oral K\u00fc\u00e7\u00fck Molek\u00fcl \u0130nhibit\u00f6r\u00fc\u201d ba\u015fl\u0131kl\u0131 bir posterde sunulacakt\u0131r. Poster, ir.satellos.com adresindeki Satellos web sitesinin Etkinlikler ve Sunumlar sayfas\u0131ndan edinilebilir.<\/p>","protected":false},"excerpt":{"rendered":"<p>According to the announcement made by Satellos Bioscience Inc., in an experiment conducted on dogs with DMD, it was seen that dystrophin was produced at near normal levels in the subjects with the therapy called SAT-3247. This development gave hope to families going through stressful days with Duchenne disease. Satellos Bioscience Inc. (\u201cSatellos\u201d or the [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1459,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[],"class_list":["post-1458","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/1458","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/comments?post=1458"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/posts\/1458\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media\/1459"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/media?parent=1458"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/categories?post=1458"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/tr\/wp-json\/wp\/v2\/tags?post=1458"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}