{"id":5229,"date":"2025-11-25T17:51:34","date_gmt":"2025-11-25T14:51:34","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=5229"},"modified":"2025-11-25T18:10:05","modified_gmt":"2025-11-25T15:10:05","slug":"elevidys-gene-therapy-for-non-ambulant-children-with-dmd-fda-oks-endeavor-cohort-8-immunosuppression-study","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/ru\/elevidys-gene-therapy-for-non-ambulant-children-with-dmd-fda-oks-endeavor-cohort-8-immunosuppression-study\/","title":{"rendered":"\u0413\u0435\u043d\u043d\u0430\u044f \u0442\u0435\u0440\u0430\u043f\u0438\u044f ELEVIDYS \u0434\u043b\u044f \u043d\u0435\u0445\u043e\u0434\u044f\u0447\u0438\u0445 \u0434\u0435\u0442\u0435\u0439 \u0441 \u041c\u0414\u0414: FDA OKs ENDEAVOR, \u043a\u043e\u0433\u043e\u0440\u0442\u0430 8, \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u0438\u043c\u043c\u0443\u043d\u043e\u0441\u0443\u043f\u0440\u0435\u0441\u0441\u0438\u0438"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong>Sarepta Therapeutics \u043f\u043e\u0434\u0442\u0432\u0435\u0440\u0434\u0438\u043b, \u0447\u0442\u043e FDA \u0441\u0430\u043d\u043a\u0446\u0438\u043e\u043d\u0438\u0440\u043e\u0432\u0430\u043b \u043d\u0430\u0447\u0430\u043b\u043e \u0434\u043e\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f \u0432 \u043a\u043e\u0433\u043e\u0440\u0442\u0435 8 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f ENDEAVOR (\u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 9001-103).<\/strong> \u042d\u0442\u0430 \u0432\u0430\u0436\u043d\u0430\u044f \u043a\u043e\u0433\u043e\u0440\u0442\u0430 \u0441\u043f\u0435\u0446\u0438\u0430\u043b\u044c\u043d\u043e \u0441\u043e\u0437\u0434\u0430\u043d\u0430 \u0434\u043b\u044f \u043e\u0446\u0435\u043d\u043a\u0438 \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 \u0443\u0441\u0438\u043b\u0435\u043d\u043d\u043e\u0433\u043e \u0440\u0435\u0436\u0438\u043c\u0430 \u0438\u043c\u043c\u0443\u043d\u043e\u0441\u0443\u043f\u0440\u0435\u0441\u0441\u0438\u0432\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u043d\u0430\u0440\u044f\u0434\u0443 \u0441 \u043b\u0435\u0447\u0435\u043d\u0438\u0435\u043c \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u043c ELEVIDYS (\u0434\u0435\u043b\u0430\u043d\u0434\u0438\u0441\u0442\u0440\u043e\u0433\u0435\u043d \u043c\u043e\u043a\u0441\u0435\u043f\u0430\u0440\u0432\u043e\u0432\u0435\u043a-\u0440\u043e\u043a\u043b) \u0443 \u043d\u0435\u0445\u043e\u0434\u044f\u0447\u0438\u0445 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u043c\u044b\u0448\u0435\u0447\u043d\u043e\u0439 \u0434\u0438\u0441\u0442\u0440\u043e\u0444\u0438\u0435\u0439 \u0414\u044e\u0448\u0435\u043d\u043d\u0430 (\u041c\u0414\u0414).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u0418\u0441\u043f\u044b\u0442\u0430\u043d\u0438\u0435 ENDEAVOR (\u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 9001-103)<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u041e\u043a\u043e\u043b\u043e 25 \u043d\u0435\u0445\u043e\u0434\u044f\u0447\u0438\u0445 \u0443\u0447\u0430\u0441\u0442\u043d\u0438\u043a\u043e\u0432 \u043f\u043e\u043b\u0443\u0447\u0430\u0442 \u0441\u0438\u0440\u043e\u043b\u0438\u043c\u0443\u0441 \u0432 \u0440\u0430\u043c\u043a\u0430\u0445 \u0440\u0435\u0436\u0438\u043c\u0430 \u0432 \u0433\u0440\u0443\u043f\u043f\u0435 8 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f ENDEAVOR, \u043a\u043e\u0442\u043e\u0440\u043e\u0435, \u043a\u0430\u043a \u043e\u0436\u0438\u0434\u0430\u0435\u0442\u0441\u044f, \u043d\u0430\u0447\u043d\u0435\u0442\u0441\u044f \u0434\u043e \u043a\u043e\u043d\u0446\u0430 \u0433\u043e\u0434\u0430.<\/li>\n\n\n\n<li>\u0423\u0441\u0438\u043b\u0435\u043d\u043d\u044b\u0439 \u0440\u0435\u0436\u0438\u043c \u0438\u043c\u043c\u0443\u043d\u043e\u0441\u0443\u043f\u0440\u0435\u0441\u0441\u0438\u0438 \u043f\u0440\u0435\u0434\u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d \u0434\u043b\u044f \u0441\u043d\u0438\u0436\u0435\u043d\u0438\u044f \u0440\u0438\u0441\u043a\u0430 \u043e\u0441\u0442\u0440\u043e\u0433\u043e \u043f\u043e\u0432\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u044f \u043f\u0435\u0447\u0435\u043d\u0438 (\u041e\u041f\u041f) \u0438 \u043e\u0441\u0442\u0440\u043e\u0439 \u043f\u0435\u0447\u0435\u043d\u043e\u0447\u043d\u043e\u0439 \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e\u0441\u0442\u0438 (\u041e\u041f\u041d), \u0441\u0432\u044f\u0437\u0430\u043d\u043d\u044b\u0445 \u0441 \u0433\u0435\u043d\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0435\u0439 AAV.<\/li>\n\n\n\n<li>\u0420\u0435\u0448\u0435\u043d\u0438\u044f \u043e \u0432\u043e\u0437\u043e\u0431\u043d\u043e\u0432\u043b\u0435\u043d\u0438\u0438 \u043a\u043e\u043c\u043c\u0435\u0440\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0434\u043e\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f \u0434\u043b\u044f \u044d\u0442\u043e\u0439 \u0433\u0440\u0443\u043f\u043f\u044b \u043d\u0430\u0441\u0435\u043b\u0435\u043d\u0438\u044f \u0431\u0443\u0434\u0443\u0442 \u043f\u0440\u0438\u043d\u0438\u043c\u0430\u0442\u044c\u0441\u044f \u0441\u043e\u0432\u043c\u0435\u0441\u0442\u043d\u043e \u0441 FDA \u043f\u043e\u0441\u043b\u0435 \u0430\u043d\u0430\u043b\u0438\u0437\u0430 \u0434\u0430\u043d\u043d\u044b\u0445 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u0414\u0430\u043d\u043d\u044b\u0435 \u043a\u043e\u0433\u043e\u0440\u0442\u044b 8 \u0431\u0443\u0434\u0443\u0442 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u044b \u0434\u043b\u044f \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u044f \u0442\u043e\u0433\u043e, \u043c\u043e\u0436\u0435\u0442 \u043b\u0438 \u0432\u0432\u0435\u0434\u0435\u043d\u0438\u0435 \u0441\u0438\u0440\u043e\u043b\u0438\u043c\u0443\u0441\u0430 \u0434\u043e \u0438 \u043f\u043e\u0441\u043b\u0435 \u0438\u043d\u0444\u0443\u0437\u0438\u0438 \u042d\u041b\u0415\u0412\u0418\u0414\u0418\u0421\u0410 \u043f\u043e\u043c\u043e\u0447\u044c \u0441\u043d\u0438\u0437\u0438\u0442\u044c \u043e\u0441\u0442\u0440\u043e\u0435 \u043f\u043e\u0432\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u0435 \u043f\u0435\u0447\u0435\u043d\u0438 (\u041e\u041f\u041f) \u2014 \u0438\u0437\u0432\u0435\u0441\u0442\u043d\u044b\u0439 \u0440\u0438\u0441\u043a, \u0441\u0432\u044f\u0437\u0430\u043d\u043d\u044b\u0439 \u0441 \u0433\u0435\u043d\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0435\u0439 AAV.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0412 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u0431\u0443\u0434\u0443\u0442 \u0432\u043a\u043b\u044e\u0447\u0435\u043d\u044b \u043e\u043a\u043e\u043b\u043e 25 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0438\u0437 \u0421\u0428\u0410, \u043d\u0435 \u0441\u043f\u043e\u0441\u043e\u0431\u043d\u044b\u0445 \u043f\u0435\u0440\u0435\u0434\u0432\u0438\u0433\u0430\u0442\u044c\u0441\u044f \u0441\u0430\u043c\u043e\u0441\u0442\u043e\u044f\u0442\u0435\u043b\u044c\u043d\u043e. \u0420\u0435\u0436\u0438\u043c \u0438\u043c\u043c\u0443\u043d\u043e\u0441\u0443\u043f\u0440\u0435\u0441\u0441\u0438\u0438 \u0431\u0443\u0434\u0435\u0442 \u0432\u043a\u043b\u044e\u0447\u0430\u0442\u044c 14-\u0434\u043d\u0435\u0432\u043d\u043e\u0435 \u0432\u0432\u0435\u0434\u0435\u043d\u0438\u0435 \u0441\u0438\u0440\u043e\u043b\u0438\u043c\u0443\u0441\u0430 \u0432 \u043f\u0435\u0440\u0438\u043e\u0434 \u0438\u043d\u0444\u0443\u0437\u0438\u0438 (\u0434\u043e \u0432\u0432\u0435\u0434\u0435\u043d\u0438\u044f \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430 \u042d\u041b\u0415\u0412\u0418\u0414\u0418\u0421) \u0438 \u0431\u0443\u0434\u0435\u0442 \u043f\u0440\u043e\u0434\u043e\u043b\u0436\u0430\u0442\u044c\u0441\u044f \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 12 \u043d\u0435\u0434\u0435\u043b\u044c \u043f\u043e\u0441\u043b\u0435 \u0432\u0432\u0435\u0434\u0435\u043d\u0438\u044f \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430 \u042d\u041b\u0415\u0412\u0418\u0414\u0418\u0421.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0423\u0437\u043d\u0430\u0442\u044c \u0431\u043e\u043b\u044c\u0448\u0435<\/strong>: <a href=\"https:\/\/dmdwarrior.com\/ru\/frequently-asked-questions-about-elevidys-used-for-duchenne-muscular-dystrophy\/\">\u0427\u0430\u0441\u0442\u043e \u0437\u0430\u0434\u0430\u0432\u0430\u0435\u043c\u044b\u0435 \u0432\u043e\u043f\u0440\u043e\u0441\u044b \u043e Elevidys<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Sarepta Therapeutics confirmed that the FDA has sanctioned the start of dosing in Cohort 8 of the ENDEAVOR (Study 9001-103) trial. This crucial cohort is specifically designed to assess an enhanced immunosuppressive regimen alongside ELEVIDYS (delandistrogene moxeparvovec-rokl) treatment for non-ambulant Duchenne muscular dystrophy (DMD) patients. ENDEAVOR (Study 9001-103) Trial Data from Cohort 8 will be [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":5231,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[121,33,179,61,65],"class_list":["post-5229","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-delandistrogene-moxeparvovec","tag-elevidys","tag-elevidys-gene-therapy","tag-gene-therapy","tag-sarepta"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/posts\/5229","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/comments?post=5229"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/posts\/5229\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/media\/5231"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/media?parent=5229"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/categories?post=5229"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/tags?post=5229"}],"curies":[{"name":"WP","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}