{"id":4953,"date":"2025-10-30T11:58:41","date_gmt":"2025-10-30T08:58:41","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=4953"},"modified":"2025-10-30T11:58:42","modified_gmt":"2025-10-30T08:58:42","slug":"hansa-imlifidase-reduce-anti-aav-antibodies-and-allow-administration-of-gene-therapy","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/ru\/hansa-imlifidase-reduce-anti-aav-antibodies-and-allow-administration-of-gene-therapy\/","title":{"rendered":"\u041f\u0440\u0435\u043f\u0430\u0440\u0430\u0442 \u2019\u0418\u043c\u043b\u0438\u0444\u0438\u0434\u0430\u0437\u0430\u00bb \u043a\u043e\u043c\u043f\u0430\u043d\u0438\u0438 Hansa \u0441\u043d\u0438\u0436\u0430\u0435\u0442 \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043a \u0410\u0410\u0412 \u0438 \u043f\u043e\u0437\u0432\u043e\u043b\u044f\u0435\u0442 \u043f\u0440\u043e\u0432\u043e\u0434\u0438\u0442\u044c \u0433\u0435\u043d\u043d\u0443\u044e \u0442\u0435\u0440\u0430\u043f\u0438\u044e"},"content":{"rendered":"<p class=\"wp-block-paragraph\">SRP-9001-104 \u043f\u0440\u0438 \u043c\u044b\u0448\u0435\u0447\u043d\u043e\u0439 \u0434\u0438\u0441\u0442\u0440\u043e\u0444\u0438\u0438 \u0414\u044e\u0448\u0435\u043d\u043d\u0430 (\u041c\u0414\u0414): \u0411\u044b\u043b\u0438 \u043f\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u043b\u0435\u043d\u044b \u043e\u0441\u043d\u043e\u0432\u043d\u044b\u0435 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u044b \u0434\u043b\u044f \u0442\u0440\u0435\u0445 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u041c\u0414\u0414, \u043f\u043e\u043b\u0443\u0447\u0430\u0432\u0448\u0438\u0445 \u0438\u043c\u043b\u0438\u0444\u0438\u0434\u0430\u0437\u0443 \u043f\u0435\u0440\u0435\u0434 \u0432\u0432\u0435\u0434\u0435\u043d\u0438\u0435\u043c \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430 \u042d\u041b\u0415\u0412\u0418\u0414\u0418\u0421 \u043a\u043e\u043c\u043f\u0430\u043d\u0438\u0438 Sarepta \u0432 \u0445\u043e\u0434\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0414\u0432\u0430 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u0433\u0435\u043d\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438, \u043e\u0434\u043d\u043e \u0438\u0437 \u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u0441\u043f\u043e\u043d\u0441\u0438\u0440\u043e\u0432\u0430\u043b\u043e\u0441\u044c Sarepta, \u0430 \u0434\u0440\u0443\u0433\u043e\u0435 \u2014 Genethon, \u043f\u043e\u0434\u0442\u0432\u0435\u0440\u0436\u0434\u0430\u044e\u0442 \u0441\u043f\u043e\u0441\u043e\u0431\u043d\u043e\u0441\u0442\u044c \u0438\u043c\u043b\u0438\u0444\u0438\u0434\u0430\u0437\u044b \u0441\u0443\u0449\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e \u0441\u043d\u0438\u0436\u0430\u0442\u044c \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043a AAV, \u0447\u0442\u043e \u043f\u043e\u0437\u0432\u043e\u043b\u044f\u0435\u0442 \u043f\u0440\u043e\u0432\u043e\u0434\u0438\u0442\u044c \u0433\u0435\u043d\u043d\u0443\u044e \u0442\u0435\u0440\u0430\u043f\u0438\u044e.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u0412\u044b\u0441\u043e\u043a\u0438\u0439 \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043a \u0410\u0410\u0412 \u0431\u043e\u043b\u044c\u0448\u0435 \u043d\u0435 \u043c\u043e\u0436\u0435\u0442 \u0431\u044b\u0442\u044c \u043f\u0440\u0435\u043f\u044f\u0442\u0441\u0442\u0432\u0438\u0435\u043c \u0434\u043b\u044f \u043f\u0440\u043e\u0432\u0435\u0434\u0435\u043d\u0438\u044f \u0433\u0435\u043d\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u041f\u043e\u0441\u043b\u0435 \u043e\u0434\u043d\u043e\u043a\u0440\u0430\u0442\u043d\u043e\u0433\u043e \u0432\u0432\u0435\u0434\u0435\u043d\u0438\u044f \u0438\u043c\u043b\u0438\u0444\u0438\u0434\u0430\u0437\u044b \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u043d\u0430\u0431\u043b\u044e\u0434\u0430\u043b\u043e\u0441\u044c \u0431\u044b\u0441\u0442\u0440\u043e\u0435 \u0441\u043d\u0438\u0436\u0435\u043d\u0438\u0435 \u0443\u0440\u043e\u0432\u043d\u044f \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043a\u043b\u0430\u0441\u0441\u0430 IgG \u0434\u043e \u0443\u0440\u043e\u0432\u043d\u044f \u226595% \u043d\u0438\u0436\u0435 \u0438\u0441\u0445\u043e\u0434\u043d\u043e\u0433\u043e. \u041a\u0440\u043e\u043c\u0435 \u0442\u043e\u0433\u043e, \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0443\u0436\u0435 \u0441\u0443\u0449\u0435\u0441\u0442\u0432\u0443\u044e\u0449\u0438\u0445 \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043a AAV \u0441\u043d\u0438\u0437\u0438\u043b\u0441\u044f \u0434\u043e \u0443\u0440\u043e\u0432\u043d\u044f \u043d\u0438\u0436\u0435 1:400, \u0447\u0442\u043e \u043f\u043e\u0437\u0432\u043e\u043b\u0438\u043b\u043e \u043d\u0430\u0447\u0430\u0442\u044c \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u043c \u042d\u041b\u0415\u0412\u0418\u0414\u0418\u0421. \u0412 \u0445\u043e\u0434\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u043d\u0435 \u0431\u044b\u043b\u043e \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u043e \u043d\u043e\u0432\u044b\u0445 \u0441\u0438\u0433\u043d\u0430\u043b\u043e\u0432 \u0431\u0435\u0437\u043e\u043f\u0430\u0441\u043d\u043e\u0441\u0442\u0438. \u042d\u0442\u0438 \u043f\u0435\u0440\u0432\u044b\u0435 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0434\u0430\u043d\u043d\u044b\u0435 \u043f\u043e\u0434\u0442\u0432\u0435\u0440\u0436\u0434\u0430\u044e\u0442 \u0441\u043f\u043e\u0441\u043e\u0431\u043d\u043e\u0441\u0442\u044c \u0438\u043c\u043b\u0438\u0444\u0438\u0434\u0430\u0437\u044b \u0441\u0443\u0449\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e \u0441\u043d\u0438\u0436\u0430\u0442\u044c \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043a AAV, \u0447\u0442\u043e \u043f\u043e\u0437\u0432\u043e\u043b\u044f\u0435\u0442 \u043f\u0440\u043e\u0432\u043e\u0434\u0438\u0442\u044c \u0433\u0435\u043d\u043d\u0443\u044e \u0442\u0435\u0440\u0430\u043f\u0438\u044e. <a href=\"https:\/\/dmdwarrior.com\/ru\/high-anti-aav-antibodies-may-not-prevent-elevidys-administration\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u0423\u0437\u043d\u0430\u0439\u0442\u0435 \u0431\u043e\u043b\u044c\u0448\u0435 \u043e\u0431 \u0438\u043c\u043b\u0438\u0444\u0438\u0434\u0430\u0437\u0435<\/a>.<\/p>","protected":false},"excerpt":{"rendered":"<p>SRP-9001-104 in Duchenne muscular dystrophy (DMD): Topline results were reported for three patients with DMD treated with imlifidase prior to administration of Sarepta&#8217;s ELEVIDYS in the trial. Two gene therapy trials, one sponsored by Sarepta and the other sponsored by Genethon, support the ability of imlifidase to substantially reduce anti-AAV antibodies to allow administration of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4954,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[368,448,61,401],"class_list":["post-4953","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-aav-based-gene-therapy","tag-anti-aav","tag-gene-therapy","tag-hansa-biopharma"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/posts\/4953","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/comments?post=4953"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/posts\/4953\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/media\/4954"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/media?parent=4953"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/categories?post=4953"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/tags?post=4953"}],"curies":[{"name":"WP","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}