{"id":4576,"date":"2025-09-25T16:23:32","date_gmt":"2025-09-25T13:23:32","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=4576"},"modified":"2025-09-25T16:23:33","modified_gmt":"2025-09-25T13:23:33","slug":"spot-mrna03-gene-therapy-early-phase-1-clinical-trial-nct07188012","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/ru\/spot-mrna03-gene-therapy-early-phase-1-clinical-trial-nct07188012\/","title":{"rendered":"\u0413\u0435\u043d\u043d\u0430\u044f \u0442\u0435\u0440\u0430\u043f\u0438\u044f SPOT-mRNA03 \u0434\u043b\u044f \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u043c\u044b\u0448\u0435\u0447\u043d\u043e\u0439 \u0434\u0438\u0441\u0442\u0440\u043e\u0444\u0438\u0438 \u0414\u044e\u0448\u0435\u043d\u043d\u0430 \u043d\u0430\u0447\u0430\u043b\u0430 \u0440\u0430\u043d\u043d\u044e\u044e \u0444\u0430\u0437\u0443 1 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0438\u0441\u043f\u044b\u0442\u0430\u043d\u0438\u0439"},"content":{"rendered":"<p class=\"wp-block-paragraph\">\u0420\u0430\u043d\u043d\u0435\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u0444\u0430\u0437\u044b 1 (NCT07188012) \u0433\u0435\u043d\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 SPOT-mRNA03 \u0434\u043b\u044f \u043c\u044b\u0448\u0435\u0447\u043d\u043e\u0439 \u0434\u0438\u0441\u0442\u0440\u043e\u0444\u0438\u0438 \u0414\u044e\u0448\u0435\u043d\u043d\u0430 (\u041c\u0414\u0414), \u0440\u0430\u0437\u0440\u0430\u0431\u043e\u0442\u0430\u043d\u043d\u043e\u0435 Shanghai Siponuoyin Biotechnology, \u043f\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u043b\u044f\u0435\u0442 \u0441\u043e\u0431\u043e\u0439 \u043f\u0438\u043b\u043e\u0442\u043d\u043e\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u0431\u0435\u0437\u043e\u043f\u0430\u0441\u043d\u043e\u0441\u0442\u0438 \u0438 \u044d\u043a\u0441\u043f\u0440\u0435\u0441\u0441\u0438\u0438 \u0434\u0438\u0441\u0442\u0440\u043e\u0444\u0438\u043d\u0430 \u0432 \u0441\u043a\u0435\u043b\u0435\u0442\u043d\u044b\u0445 \u043c\u044b\u0448\u0446\u0430\u0445 \u043f\u043e\u0441\u043b\u0435 \u0432\u0432\u0435\u0434\u0435\u043d\u0438\u044f.<\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u041e\u0433\u043b\u0430\u0432\u043b\u0435\u043d\u0438\u0435<\/h2><nav><ul><li><a href=\"#what-is-spot-m-rna-03-gene-therapy\">\u0427\u0442\u043e \u0442\u0430\u043a\u043e\u0435 \u0433\u0435\u043d\u043d\u0430\u044f \u0442\u0435\u0440\u0430\u043f\u0438\u044f SPOT-mRNA03<\/a><\/li><li><a href=\"#spot-m-rna-03-gene-therapy-early-phase-1-nct-07188012\">\u0413\u0435\u043d\u043d\u0430\u044f \u0442\u0435\u0440\u0430\u043f\u0438\u044f SPOT-mRNA03, \u0440\u0430\u043d\u043d\u044f\u044f \u0444\u0430\u0437\u0430 1 \u2013 NCT07188012<\/a><\/li><li><a href=\"#how-to-participate-in-the-sgt-003-clinical-trial\">\u041a\u0430\u043a \u043f\u0440\u0438\u043d\u044f\u0442\u044c \u0443\u0447\u0430\u0441\u0442\u0438\u0435 \u0432 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u043c \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0438 SPOT-mRNA03<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-is-spot-m-rna-03-gene-therapy\"><strong>\u0427\u0442\u043e \u0442\u0430\u043a\u043e\u0435 \u0433\u0435\u043d\u043d\u0430\u044f \u0442\u0435\u0440\u0430\u043f\u0438\u044f SPOT-mRNA03<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>SPOT-mRNA03 \u2014 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442 \u0433\u0435\u043d\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u043c\u044b\u0448\u0435\u0447\u043d\u043e\u0439 \u0434\u0438\u0441\u0442\u0440\u043e\u0444\u0438\u0438 \u0414\u044e\u0448\u0435\u043d\u043d\u0430 (\u041c\u0414\u0414).<\/strong> \u041f\u043e\u0441\u043b\u0435 \u0432\u0432\u0435\u0434\u0435\u043d\u0438\u044f \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430\u043c \u0441 \u041c\u0414\u0414 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u044b\u0439 \u0442\u0430\u0440\u0433\u0435\u0442\u043d\u044b\u0439 \u043f\u0435\u043f\u0442\u0438\u0434 \u043d\u0430 \u043c\u0435\u043c\u0431\u0440\u0430\u043d\u0435 \u0412\u0412 \u043c\u043e\u0436\u0435\u0442 \u043d\u0430\u043f\u0440\u0430\u0432\u043b\u044f\u0442\u044c SPOT-mRNA03 \u0432 \u043c\u044b\u0448\u0435\u0447\u043d\u044b\u0435 \u043a\u043b\u0435\u0442\u043a\u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430, \u043e\u0431\u0435\u0441\u043f\u0435\u0447\u0438\u0432\u0430\u044f \u0442\u0440\u0430\u043d\u0441\u043b\u044f\u0446\u0438\u044e \u0438 \u0441\u0435\u043a\u0440\u0435\u0446\u0438\u044e \u044d\u043d\u0434\u043e\u0433\u0435\u043d\u043d\u043e\u0433\u043e \u043f\u043e\u043b\u043d\u043e\u0440\u0430\u0437\u043c\u0435\u0440\u043d\u043e\u0433\u043e \u0438\u043d\u0442\u0430\u043a\u0442\u043d\u043e\u0433\u043e \u0434\u0438\u0441\u0442\u0440\u043e\u0444\u0438\u043d\u0430 \u043a\u043b\u0435\u0442\u043a\u0430\u043c\u0438 \u0441 \u0434\u0435\u0444\u0438\u0446\u0438\u0442\u043e\u043c \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u0430 \u0434\u0438\u0441\u0442\u0440\u043e\u0444\u0438\u043d\u0430, \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u044f \u0432\u043d\u0443\u0442\u0440\u0438\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u044b\u0435 \u0440\u0438\u0431\u043e\u0441\u043e\u043c\u044b \u0438 \u0430\u043c\u0438\u043d\u043e\u043a\u0438\u0441\u043b\u043e\u0442\u044b.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"spot-m-rna-03-gene-therapy-early-phase-1-nct-07188012\"><strong>\u0413\u0435\u043d\u043d\u0430\u044f \u0442\u0435\u0440\u0430\u043f\u0438\u044f SPOT-mRNA03, \u0440\u0430\u043d\u043d\u044f\u044f \u0444\u0430\u0437\u0430 1 \u2013 NCT07188012<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u042d\u0442\u043e \u043e\u0434\u043d\u043e\u0446\u0435\u043d\u0442\u0440\u043e\u0432\u043e\u0435, \u043e\u0442\u043a\u0440\u044b\u0442\u043e\u0435, \u043d\u0435 \u0438\u043c\u0435\u044e\u0449\u0435\u0435 \u0430\u043d\u0430\u043b\u043e\u0433\u043e\u0432 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u0441 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u0435\u043c \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430 SPOT-mRNA03, \u0432\u0432\u043e\u0434\u0438\u043c\u043e\u0433\u043e \u0432\u043d\u0443\u0442\u0440\u0438\u0432\u0435\u043d\u043d\u043e \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430\u043c \u0441 \u041c\u0414\u0414. \u041f\u043e\u043b\u043d\u043e\u0440\u0430\u0437\u043c\u0435\u0440\u043d\u0430\u044f \u043c\u0420\u041d\u041a \u0434\u0438\u0441\u0442\u0440\u043e\u0444\u0438\u043d\u0430 \u0441\u043e\u0434\u0435\u0440\u0436\u0438\u0442\u0441\u044f \u0432\u043e \u0432\u043d\u0435\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u044b\u0445 \u0432\u0435\u0437\u0438\u043a\u0443\u043b\u0430\u0445 (\u0412\u0412), \u043d\u0430\u043f\u0440\u0430\u0432\u043b\u0435\u043d\u043d\u044b\u0445 \u0432 \u043c\u044b\u0448\u0435\u0447\u043d\u0443\u044e \u0442\u043a\u0430\u043d\u044c, \u043d\u0430\u0437\u044b\u0432\u0430\u0435\u043c\u044b\u0445 SPOT-mRNA03. \u041c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u044b\u0435 \u0442\u0430\u0440\u0433\u0435\u0442\u0438\u043d\u0433\u043e\u0432\u044b\u0435 \u043f\u0435\u043f\u0442\u0438\u0434\u044b \u043d\u0430 \u043c\u0435\u043c\u0431\u0440\u0430\u043d\u0435 \u0412\u0412 \u043e\u0431\u0435\u0441\u043f\u0435\u0447\u0438\u0432\u0430\u044e\u0442 SPOT-mRNA03 \u0435\u0433\u043e \u0441\u043f\u043e\u0441\u043e\u0431\u043d\u043e\u0441\u0442\u044c \u043a \u0442\u0430\u0440\u0433\u0435\u0442\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044e, \u0447\u0442\u043e \u043f\u043e\u0437\u0432\u043e\u043b\u044f\u0435\u0442 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u0442\u044c \u043c\u0420\u041d\u041a \u0434\u0438\u0441\u0442\u0440\u043e\u0444\u0438\u043d\u0430 \u0432 \u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430 \u0433\u0435\u043d\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u041c\u0414\u0414.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u041d\u0430\u0447\u0430\u043b\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f (\u043f\u0440\u0435\u0434\u043f\u043e\u043b\u0430\u0433\u0430\u0435\u043c\u043e\u0435)<\/strong>: 2025-08-06<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u041f\u0435\u0440\u0432\u0438\u0447\u043d\u043e\u0435 \u0437\u0430\u0432\u0435\u0440\u0448\u0435\u043d\u0438\u0435 (\u043f\u0440\u0435\u0434\u043f\u043e\u043b\u0430\u0433\u0430\u0435\u043c\u043e\u0435)<\/strong>: 2026-12<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0417\u0430\u0432\u0435\u0440\u0448\u0435\u043d\u0438\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f (\u043f\u0440\u0435\u0434\u043f\u043e\u043b\u0430\u0433\u0430\u0435\u043c\u043e\u0435)<\/strong>: 2026-12<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u041a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u043e \u0443\u0447\u0430\u0441\u0442\u043d\u0438\u043a\u043e\u0432 (\u043f\u0440\u0435\u0434\u043f\u043e\u043b\u0430\u0433\u0430\u0435\u043c\u043e\u0435)<\/strong>: 6<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0422\u0438\u043f \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f<\/strong>: \u0420\u0430\u043d\u043d\u044f\u044f \u0444\u0430\u0437\u0430 1<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0420\u0430\u0441\u043f\u043e\u043b\u043e\u0436\u0435\u043d\u0438\u0435<\/strong>: <a href=\"https:\/\/maps.app.goo.gl\/Z2CyEqLydJ4Kxh9aA\" target=\"_blank\" rel=\"noreferrer noopener\">\u0428\u0430\u043d\u0445\u0430\u0439\u0441\u043a\u0438\u0439 \u0434\u0435\u0442\u0441\u043a\u0438\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0446\u0435\u043d\u0442\u0440<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0412\u043e\u0437\u0440\u0430\u0441\u0442, \u043f\u043e\u0434\u0445\u043e\u0434\u044f\u0449\u0438\u0439 \u0434\u043b\u044f \u043e\u0431\u0443\u0447\u0435\u043d\u0438\u044f<\/strong>: \u043e\u0442 2 \u0434\u043e 6 \u043b\u0435\u0442 (\u0441\u0430\u043c\u0446\u044b, \u0441\u043f\u043e\u0441\u043e\u0431\u043d\u044b\u0435 \u043f\u0435\u0440\u0435\u0434\u0432\u0438\u0433\u0430\u0442\u044c\u0441\u044f)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u041e\u0441\u043d\u043e\u0432\u043d\u044b\u0435 \u043a\u0440\u0438\u0442\u0435\u0440\u0438\u0438 \u0432\u043a\u043b\u044e\u0447\u0435\u043d\u0438\u044f \u0438 \u0438\u0441\u043a\u043b\u044e\u0447\u0435\u043d\u0438\u044f. \u2013 <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT07188012\" target=\"_blank\" rel=\"noreferrer noopener\">NCT07188012<\/a> \u2013<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"how-to-participate-in-the-sgt-003-clinical-trial\"><strong>\u041a\u0430\u043a \u043f\u0440\u0438\u043d\u044f\u0442\u044c \u0443\u0447\u0430\u0441\u0442\u0438\u0435 \u0432 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u043c \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0438 SPOT-mRNA03<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0427\u0442\u043e\u0431\u044b \u043f\u0440\u0438\u043d\u044f\u0442\u044c \u0443\u0447\u0430\u0441\u0442\u0438\u0435 \u0432 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u043c \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0438 \u043f\u0435\u0440\u0432\u043e\u0439 \u0444\u0430\u0437\u044b \u0433\u0435\u043d\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 SPOT-mRNA03, \u0432\u044b \u043c\u043e\u0436\u0435\u0442\u0435 \u0432\u043e\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u0442\u044c\u0441\u044f \u043a\u043e\u043d\u0442\u0430\u043a\u0442\u043d\u043e\u0439 \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u0435\u0439, \u0443\u043a\u0430\u0437\u0430\u043d\u043d\u043e\u0439 \u043d\u0438\u0436\u0435.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0418\u043c\u044f<\/strong>: \u0423\u0438\u043d\u0441\u0442\u043e\u043d \u0422\u0430\u0443\u043d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u041d\u043e\u043c\u0435\u0440 \u0442\u0435\u043b\u0435\u0444\u043e\u043d\u0430<\/strong>: 212-920-5501<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u042d\u043b\u0435\u043a\u0442\u0440\u043e\u043d\u043d\u0430\u044f \u043f\u043e\u0447\u0442\u0430<\/strong>: Winston.town@spotbiosystems.com<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>The early phase 1 study (NCT07188012) of SPOT-mRNA03 gene therapy for Duchenne Muscular Dystrophy (DMD) developed by Shanghai Siponuoyin Biotechnology is a pilot study of the safety and expression of dystrophin in skeletal muscles after administration. What is SPOT-mRNA03 Gene Therapy SPOT-mRNA03 is the gene therapy product for Duchenne Muscular Dystrophy (DMD). 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