{"id":2386,"date":"2025-01-10T16:42:40","date_gmt":"2025-01-10T13:42:40","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=2386"},"modified":"2025-11-03T20:30:56","modified_gmt":"2025-11-03T17:30:56","slug":"plans-for-dyne-101-in-dm1-and-dyne-251-in-dmd-are-announced-by-dyne-therapeutics","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/ru\/plans-for-dyne-101-in-dm1-and-dyne-251-in-dmd-are-announced-by-dyne-therapeutics\/","title":{"rendered":"Dyne Therapeutics \u0430\u043d\u043e\u043d\u0441\u0438\u0440\u043e\u0432\u0430\u043b\u0430 \u043f\u043b\u0430\u043d\u044b \u043f\u043e \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044e DYNE-101 \u043f\u0440\u0438 DM1 \u0438 DYNE-251 \u043f\u0440\u0438 DMD"},"content":{"rendered":"<p class=\"wp-block-paragraph\">\u041a\u043e\u043c\u043f\u0430\u043d\u0438\u044f Dyne Therapeutics \u043e\u0431\u044a\u044f\u0432\u0438\u043b\u0430 \u043e \u043f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0434\u0430\u043d\u043d\u044b\u0445 \u0441\u0432\u043e\u0438\u0445 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u0432 DYNE-101 \u0438 DYNE-251 \u0432\u043e \u0432\u0440\u0435\u043c\u044f \u043c\u0435\u0440\u043e\u043f\u0440\u0438\u044f\u0442\u0438\u044f \u0434\u043b\u044f \u0438\u043d\u0432\u0435\u0441\u0442\u043e\u0440\u043e\u0432 10 \u044f\u043d\u0432\u0430\u0440\u044f 2025 \u0433\u043e\u0434\u0430. \u041f\u0440\u0435\u043f\u0430\u0440\u0430\u0442 DYNE-101 \u0434\u043b\u044f \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u043c\u0438\u043e\u0442\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0434\u0438\u0441\u0442\u0440\u043e\u0444\u0438\u0438 1-\u0433\u043e \u0442\u0438\u043f\u0430 (\u0421\u04141) \u043f\u0440\u043e\u0434\u0435\u043c\u043e\u043d\u0441\u0442\u0440\u0438\u0440\u043e\u0432\u0430\u043b \u0437\u043d\u0430\u0447\u0438\u0442\u0435\u043b\u044c\u043d\u0443\u044e \u043a\u043e\u0440\u0440\u0435\u043a\u0446\u0438\u044e \u0441\u043f\u043b\u0430\u0439\u0441\u0438\u043d\u0433\u0430 \u0438 \u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0435 \u0443\u043b\u0443\u0447\u0448\u0435\u043d\u0438\u044f, \u0447\u0442\u043e \u043f\u043e\u0437\u0432\u043e\u043b\u0438\u043b\u043e \u043a\u043e\u043c\u043f\u0430\u043d\u0438\u0438 Dyne \u0437\u0430\u043f\u043b\u0430\u043d\u0438\u0440\u043e\u0432\u0430\u0442\u044c \u0433\u043b\u043e\u0431\u0430\u043b\u044c\u043d\u0443\u044e \u0440\u0430\u0441\u0448\u0438\u0440\u0435\u043d\u043d\u0443\u044e \u0440\u0435\u0433\u0438\u0441\u0442\u0440\u0430\u0446\u0438\u043e\u043d\u043d\u0443\u044e \u043a\u043e\u0433\u043e\u0440\u0442\u0443 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f ACHIEVE \u0441 \u0440\u0435\u0433\u0438\u0441\u0442\u0440\u0430\u0446\u0438\u043e\u043d\u043d\u043e\u0439 \u0434\u043e\u0437\u043e\u0439 6,8 \u043c\u0433\/\u043a\u0433 Q8W \u0438 \u043f\u043e\u0442\u0435\u043d\u0446\u0438\u0430\u043b\u044c\u043d\u043e\u0439 \u043f\u043e\u0434\u0430\u0447\u0435\u0439 \u0437\u0430\u044f\u0432\u043a\u0438 \u043d\u0430 \u0443\u0441\u043a\u043e\u0440\u0435\u043d\u043d\u043e\u0435 \u043e\u0434\u043e\u0431\u0440\u0435\u043d\u0438\u0435 \u0432 \u0421\u0428\u0410 \u0432 \u043f\u0435\u0440\u0432\u043e\u0439 \u043f\u043e\u043b\u043e\u0432\u0438\u043d\u0435 2026 \u0433\u043e\u0434\u0430.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u041c\u0435\u0436\u0434\u0443 \u0442\u0435\u043c, DYNE-251, \u043d\u0430\u0446\u0435\u043b\u0435\u043d\u043d\u044b\u0439 \u043d\u0430 \u043c\u044b\u0448\u0435\u0447\u043d\u0443\u044e \u0434\u0438\u0441\u0442\u0440\u043e\u0444\u0438\u044e \u0414\u044e\u0448\u0435\u043d\u043d\u0430 (\u041c\u0414\u0414), \u0442\u0430\u043a\u0436\u0435 \u043f\u0440\u043e\u0445\u043e\u0434\u0438\u0442 \u0443\u0441\u043a\u043e\u0440\u0435\u043d\u043d\u043e\u0435 \u043e\u0434\u043e\u0431\u0440\u0435\u043d\u0438\u0435 \u0432 \u0421\u0428\u0410 \u043d\u0430 \u043e\u0441\u043d\u043e\u0432\u0435 \u0434\u0438\u0441\u0442\u0440\u043e\u0444\u0438\u043d\u0430 \u0432 \u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435 \u0441\u0443\u0440\u0440\u043e\u0433\u0430\u0442\u043d\u043e\u0439 \u043a\u043e\u043d\u0435\u0447\u043d\u043e\u0439 \u0442\u043e\u0447\u043a\u0438, \u0438 \u043e\u0436\u0438\u0434\u0430\u0435\u0442\u0441\u044f, \u0447\u0442\u043e \u0434\u0430\u043d\u043d\u044b\u0435 \u0431\u0443\u0434\u0443\u0442 \u043f\u043e\u043b\u0443\u0447\u0435\u043d\u044b \u043a \u043a\u043e\u043d\u0446\u0443 2025 \u0433\u043e\u0434\u0430 \u0434\u043b\u044f \u043f\u043e\u0434\u0434\u0435\u0440\u0436\u043a\u0438 \u043f\u043e\u0434\u0430\u0447\u0438 \u0437\u0430\u044f\u0432\u043a\u0438 \u0432 \u043d\u0430\u0447\u0430\u043b\u0435 2026 \u0433\u043e\u0434\u0430. \u041e\u0431\u0435 \u043f\u0440\u043e\u0433\u0440\u0430\u043c\u043c\u044b \u0434\u0435\u043c\u043e\u043d\u0441\u0442\u0440\u0438\u0440\u0443\u044e\u0442 \u043f\u0435\u0440\u0441\u043f\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c \u0432 \u0442\u0440\u0430\u043d\u0441\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u0438 \u043f\u0430\u0440\u0430\u0434\u0438\u0433\u043c \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u044d\u0442\u0438\u0445 \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0427\u0438\u0442\u0430\u0442\u044c \u0434\u0430\u043b\u0435\u0435<\/strong>:\u00a0<a href=\"https:\/\/dmdwarrior.com\/ru\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0438\u0441\u043f\u044b\u0442\u0430\u043d\u0438\u044f \u043c\u044b\u0448\u0435\u0447\u043d\u043e\u0439 \u0434\u0438\u0441\u0442\u0440\u043e\u0444\u0438\u0438 \u0414\u044e\u0448\u0435\u043d\u043d\u0430 (\u0441\u043f\u0438\u0441\u043e\u043a \u0432\u0441\u0435\u0445 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0439)<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Dyne Therapeutics announced positive clinical data for its therapies DYNE-101 and DYNE-251 during an investor event on January 10, 2025. DYNE-101 for myotonic dystrophy type 1 (DM1) demonstrated significant splicing correction and functional improvements, leading Dyne to plan a global Registrational Expansion Cohort of the ACHIEVE trial with a registrational dose of 6.8 mg\/kg Q8W [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2388,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[118,66,143,144,145],"class_list":["post-2386","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-duchenne","tag-duchenne-muscular-dystrophy","tag-dyne","tag-dyne-101","tag-dyne-251"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/posts\/2386","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/comments?post=2386"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/posts\/2386\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/media\/2388"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/media?parent=2386"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/categories?post=2386"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ru\/wp-json\/wp\/v2\/tags?post=2386"}],"curies":[{"name":"WP","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}